LOCUS       NM_001039483            4474 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus transmembrane and coiled-coil domains 1 (Tmco1), mRNA.
ACCESSION   NM_001039483
VERSION     NM_001039483.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4474)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4474)
  AUTHORS   Yang,K.Y., Zhao,S., Feng,H., Shen,J., Chen,Y., Wang,S.T.,
            Wang,S.J., Zhang,Y.X., Wang,Y., Guo,C., Liu,H. and Tang,T.S.
  TITLE     Ca2+ homeostasis maintained by TMCO1 underlies corpus callosum
            development via ERK signaling
  JOURNAL   Cell Death Dis 13 (8), 674 (2022)
   PUBMED   35927240
  REMARK    GeneRIF: Ca(2+) homeostasis maintained by TMCO1 underlies corpus
            callosum development via ERK signaling.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4474)
  AUTHORS   Wang,X., Wang,Q.C., Sun,Z., Li,T., Yang,K., An,C., Guo,C. and
            Tang,T.S.
  TITLE     ER stress mediated degradation of diacylglycerol acyltransferase
            impairs mitochondrial functions in TMCO1 deficient cells
  JOURNAL   Biochem Biophys Res Commun 512 (4), 914-920 (2019)
   PUBMED   30929916
  REMARK    GeneRIF: The role of TMCO1 in regulating lipid-metabolism and
            mitochondrial function.
REFERENCE   4  (bases 1 to 4474)
  AUTHORS   Li,J., Liu,C., Li,Y., Zheng,Q., Xu,Y., Liu,B., Sun,W., Li,Y.,
            Ji,S., Liu,M., Zhang,J., Zhao,D., Du,R., Liu,Z., Zhong,G., Sun,C.,
            Wang,Y., Song,J., Zhang,S., Qin,J., Ling,S., Wang,X. and Li,Y.
  TITLE     TMCO1-mediated Ca2+ leak underlies osteoblast functions via CaMKII
            signaling
  JOURNAL   Nat Commun 10 (1), 1589 (2019)
   PUBMED   30962442
  REMARK    GeneRIF: An essential role of TMCO1 in osteogenesis mediated by
            local Ca(2+)/CaMKII signaling in osteoblasts.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4474)
  AUTHORS   Sun,Z., Zhang,H., Wang,X., Wang,Q.C., Zhang,C., Wang,J.Q.,
            Wang,Y.H., An,C.Q., Yang,K.Y., Wang,Y., Gao,F., Guo,C. and
            Tang,T.S.
  TITLE     TMCO1 is essential for ovarian follicle development by regulating
            ER Ca2+ store of granulosa cells
  JOURNAL   Cell Death Differ 25 (9), 1686-1701 (2018)
   PUBMED   29467381
  REMARK    GeneRIF: Tmco1 is required for ovarian follicle development, which
            is closely linked with the role of TMCO1 in maintaining normal ER
            Ca2+ store in GCs. Deletion of Tmco1 can cause ER Ca2+ overloaded
            in GCs followed by ER stress and oxidative stress.
REFERENCE   6  (bases 1 to 4474)
  AUTHORS   Wang,Q.C., Zheng,Q., Tan,H., Zhang,B., Li,X., Yang,Y., Yu,J.,
            Liu,Y., Chai,H., Wang,X., Sun,Z., Wang,J.Q., Zhu,S., Wang,F.,
            Yang,M., Guo,C., Wang,H., Zheng,Q., Li,Y., Chen,Q., Zhou,A. and
            Tang,T.S.
  TITLE     TMCO1 Is an ER Ca(2+) Load-Activated Ca(2+) Channel
  JOURNAL   Cell 165 (6), 1454-1466 (2016)
   PUBMED   27212239
  REMARK    GeneRIF: TMCO1 provides a protective mechanism to prevent
            overfilling of endoplasmic reticulum stores with Ca(2+) ions
REFERENCE   7  (bases 1 to 4474)
  AUTHORS   Hald,J., Galbo,T., Rescan,C., Radzikowski,L., Sprinkel,A.E.,
            Heimberg,H., Ahnfelt-Ronne,J., Jensen,J., Scharfmann,R.,
            Gradwohl,G., Kaestner,K.H., Stoeckert,C. Jr., Jensen,J.N. and
            Madsen,O.D.
  TITLE     Pancreatic islet and progenitor cell surface markers with cell
            sorting potential
  JOURNAL   Diabetologia 55 (1), 154-165 (2012)
   PUBMED   21947380
REFERENCE   8  (bases 1 to 4474)
  AUTHORS   Cheung,C.C., Martin,I.C., Zenger,K.R., Donald,J.A., Thomson,P.C.,
            Moran,C. and Buckley,M.F.
  TITLE     Quantitative trait loci for steady-state platelet count in mice
  JOURNAL   Mamm Genome 15 (10), 784-797 (2004)
   PUBMED   15520881
REFERENCE   9  (bases 1 to 4474)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 4474)
  AUTHORS   Eddleston,J., Murdoch,J.N., Copp,A.J. and Stanier,P.
  TITLE     Physical and transcriptional map of a 3-Mb region of mouse
            chromosome 1 containing the gene for the neural tube defect mutant
            loop-tail (Lp)
  JOURNAL   Genomics 56 (2), 149-159 (1999)
   PUBMED   10051400
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK004504.1, AK037709.1 and AC113970.8.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC019761.1, BQ964764.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-66                AK004504.1         2-67
            67-841              AK037709.1         2-776
            842-1283            AC113970.8         90768-91209
            1284-4474           AK037709.1         777-3967
FEATURES             Location/Qualifiers
     source          1..4474
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 74.69 cM"
     gene            1..4474
                     /gene="Tmco1"
                     /gene_synonym="1190006A08Rik; 4930403O06Rik; ESTM39"
                     /note="transmembrane and coiled-coil domains 1"
                     /db_xref="GeneID:68944"
                     /db_xref="MGI:MGI:1921173"
     exon            1..264
                     /gene="Tmco1"
                     /gene_synonym="1190006A08Rik; 4930403O06Rik; ESTM39"
                     /inference="alignment:Splign:2.1.0"
     CDS             195..761
                     /gene="Tmco1"
                     /gene_synonym="1190006A08Rik; 4930403O06Rik; ESTM39"
                     /note="transmembrane and coiled-coil domain-containing
                     protein 1; CLAC channel; GEL complex subunit TMCO1"
                     /codon_start=1
                     /product="calcium load-activated calcium channel"
                     /protein_id="NP_001034572.1"
                     /db_xref="CCDS:CCDS15456.1"
                     /db_xref="GeneID:68944"
                     /db_xref="MGI:MGI:1921173"
                     /translation="MSTMFADTLLIVFISVCTALLAEGITWVLVYRTDKYKRLKAEVE
                     KQSKKLEKKKETITESAGRQQKKKIERQEEKLKNNNRDLSMVRMKSMFAIGFCFTALM
                     GMFNSIFDGRVVAKLPFTPLSYIQGLSHRNLLGDDTTDCSFIFLYILCTMSIRQNIQK
                     ILGLAPSRAATKQAGGFLGPPPPSGKFS"
     exon            265..342
                     /gene="Tmco1"
                     /gene_synonym="1190006A08Rik; 4930403O06Rik; ESTM39"
                     /inference="alignment:Splign:2.1.0"
     exon            343..402
                     /gene="Tmco1"
                     /gene_synonym="1190006A08Rik; 4930403O06Rik; ESTM39"
                     /inference="alignment:Splign:2.1.0"
     exon            403..449
                     /gene="Tmco1"
                     /gene_synonym="1190006A08Rik; 4930403O06Rik; ESTM39"
                     /inference="alignment:Splign:2.1.0"
     exon            450..517
                     /gene="Tmco1"
                     /gene_synonym="1190006A08Rik; 4930403O06Rik; ESTM39"
                     /inference="alignment:Splign:2.1.0"
     exon            518..662
                     /gene="Tmco1"
                     /gene_synonym="1190006A08Rik; 4930403O06Rik; ESTM39"
                     /inference="alignment:Splign:2.1.0"
     exon            663..4474
                     /gene="Tmco1"
                     /gene_synonym="1190006A08Rik; 4930403O06Rik; ESTM39"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1255..1260
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmco1"
                     /gene_synonym="1190006A08Rik; 4930403O06Rik; ESTM39"
                     /note="hexamer: AATAAA"
     polyA_site      1282
                     /gene="Tmco1"
                     /gene_synonym="1190006A08Rik; 4930403O06Rik; ESTM39"
                     /note="major polyA site"
     regulatory      3997..4002
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmco1"
                     /gene_synonym="1190006A08Rik; 4930403O06Rik; ESTM39"
                     /note="hexamer: ATTAAA"
     polyA_site      4022
                     /gene="Tmco1"
                     /gene_synonym="1190006A08Rik; 4930403O06Rik; ESTM39"
     regulatory      4378..4383
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmco1"
                     /gene_synonym="1190006A08Rik; 4930403O06Rik; ESTM39"
                     /note="hexamer: AATAAA"
     polyA_site      4398
                     /gene="Tmco1"
                     /gene_synonym="1190006A08Rik; 4930403O06Rik; ESTM39"
ORIGIN      
        1 gactatggcg gccagacggc gggagtgaag cctgtagttc cgggtcggcg ccccggaagc
       61 ggaagtgtag actcggggct gtcaaagttg tagcgctcct cgagggtcgg tcccgccacg
      121 tctcttcccg gtctctctgg ctctggagtg ctttcccccc gcggagggtg ggagcgcggg
      181 gacagacggg cgagatgagc accatgtttg cagacacgct gctcatcgtc tttatctccg
      241 tgtgcaccgc gctgctcgcc gagggcataa cctgggtcct ggtttacagg acagacaaat
      301 acaagagatt gaaggcagaa gtggaaaaac aaagtaaaaa attagagaag aagaaggaaa
      361 ctataacaga gtcagctggt cgacaacaga agaagaagat agagagacaa gaagagaaat
      421 taaagaacaa caatagagac ctgtcaatgg tacggatgaa atccatgttc gcgattggct
      481 tttgttttac tgccttaatg ggaatgttta attccatatt tgatggtaga gtggtggcaa
      541 agctcccctt cactcctctg tcttacatcc aaggactatc tcatcggaac ctgctgggag
      601 atgacaccac ggactgctcc ttcatcttcc tgtatatcct ctgtaccatg tcaattcgac
      661 aaaacatcca gaagattctt ggcctcgccc cttcacgagc tgccaccaag caggctggtg
      721 gatttcttgg cccaccacct ccgtctggga agttttcctg aaggaaagca gaattctgaa
      781 tttcctgtca tactttttag acattcacat cagacttaca gagcacctgg ccacattcta
      841 ggtttgtgtt atttctcagc tatggatatg atcaaatgag aacactgctt aactaatggg
      901 atagtgctat ggtcacggat ggcttcttta gtaataagtg cactcactgg ttacatttgg
      961 atggcttatg taaccacaaa catcatcttt cttgtctcac ttgagtattt cagtgtatgt
     1021 gccatataca cagaagcaga ctgtccatga acattaggag aaaaatagtt tatgtaacaa
     1081 cttcactgta attagttgtt gtgtttttta aaaagccaaa tatgtcactt tgtgttcgac
     1141 aatgagccaa atttttagat gtttcagtta gagaaatgtt tgattttttt gcatattaaa
     1201 aagagtattt tctgtaatct gaacataagg ataagcattg gcccaaaaag ctaaaataaa
     1261 gttttgtcat gttcttttac cagccttgtc tcctgttcaa aatgtgggat tgtcccagtg
     1321 tacactttga acgtgttcca gttggctttc tggtgttttg tcaaacactg gccagaacca
     1381 gaagcagctt aggggaggaa aggggttttc agcctatgct tccgggtcat agttcaccat
     1441 tgggggaaaa gaggttagaa ctccagcaag acccaaggcg gaagctgtgg aggatggcta
     1501 ccagctagct aactctgcct tgctctcagt tcgcctcctc ttagcagccg ggcccaccca
     1561 cctagaaaag ctcacatact gtaactgtgc agggttggag caggccctcc tccatcactc
     1621 accaatccag agactctcac agacatggct acaggccagt ctgacctagg gaacttctta
     1681 gttgatagtc cctcttgcca ggtgactctg ggttccataa aggtgacagt agaaacagta
     1741 cgaactgtaa gcttggaaag gaaagggaca gtgcagtgag gggaactcgt gcttgtctcg
     1801 aggactcctg cttgactggc agcagccgct gacggaagag gaagggctgc ttccccttta
     1861 ctggagagta gtatggagtt ccgtcccagc actagatgct catgggcact gccttgctgt
     1921 ttctagacct ttctgcgagc ataatatgtg ctgctatttc aaaggaagat ccatcgtgag
     1981 ctcaaactgc ccagggtagg atctttcttt ccttctctga cttgcattcc ctttatcaaa
     2041 tgttcattta ggattgcagg gtttagaaca ggaactatgg atggggagaa ccacacactt
     2101 acccatgggc atacacacac acacacacac acacacacac acacacacac acacacacat
     2161 acacacacac acacacacac acacacacac acacacacac acacacacat atacacacac
     2221 acatggaagt cccaacagta gtgcaagcgt tagccagcag tgtgagtgaa gtttctggaa
     2281 tgtaccgatt ttgataggga acagtgaaga ttgtttgggg tacatcccac tggggactca
     2341 gtcgtcgaat cactgagatt tcgggtaaca gttctctgat tttaattttc agaggctgct
     2401 ttttaagtga cttggtagtg ttgggaatca cacctgggac tgtgctcctt gcagataagc
     2461 actgtgccac tgagctctgt cctcagctcc agagattgta ctgtaatttc acgttacagc
     2521 catacagggt ttttagtggg tttctaggcc accagcaaaa atctgagtag atggaggtgg
     2581 ttgtgcttgt ttactgagtg taactgtgat cataagactc cacatgggag aaccatgggc
     2641 aggtgctaag gttatctgaa gtaatttaat tttaaaccag tgctggggtc atcgagaaca
     2701 cccctgcagt agtccttctg gggagcagat gaagtcctgt gtgtgtgtgt gtgtgtgtgt
     2761 gttgttgttg ttgttgttga ttagagcaca gccatggtaa ggacccccgt gtctcagacc
     2821 catgggaatg gcaagaccac cttgtgcaag gtttctcaga cctgtgcata gttgggttag
     2881 acttctctcc caaaatttct atttaagctt ctgatataag tcacttgtta aataattaac
     2941 agacctattt atgcctcagt tttctgatct gggaaagagt taataacctt gtgaaagccc
     3001 tttacagtct ccatgtagct gactctggac agagtctgcc tgactcctgc ccatcttgct
     3061 ttggttccta cagtttggat tgcataacat tggtctactt gttcttttaa ttagatatgt
     3121 tggttacata gtatttgctt ctatgaaaac taaattgaat ggtctagatt gacctaataa
     3181 gtcaagcttc ctgttcaggc caccattaca gaatagcatc catggccctg tgctacccca
     3241 tggccatggg cctcaacaat ggctacaagg tgacaaagaa cgtcagcagg ccagggcatg
     3301 gttatgccag ggggtgtcct ccaccaacac accagattcc tgccggacct gatcctggag
     3361 gcgtgcccct tcacaccgta ggagtggtgc actgaaggtc tccagggaca ggtgtgtgtt
     3421 catcattcaa acttgaggac ttgacccatg gtgggaggag cgaacagaag tctgaatgtt
     3481 gtccttaatt tcgtcacaca ctgtggctca tgagcactca catcatatac atctcccaca
     3541 cacatgctaa aaggaataaa taaaaagtta aaactaaggt gaatgctgaa gccacgggtg
     3601 gaagtttatg cctgtaatac cagcacttag gattggcagc aggaggatca gagaaggtca
     3661 agtcaacagc ctgagatatt tgagaccctg tctccgtaaa acaagcaaca ggtttagaga
     3721 tttttacatg atttgtcctc aaatcccata ctagtagatc agaaaaccag caaacactct
     3781 gacccttggg gttcgggttc cttgtctttc tacctcatag ctgcagtgct gactcctttg
     3841 gtcctgttaa agtcttcagt tacttagcgg gagtctcgag ttccactgcc ccgtgttcag
     3901 atggcttcat ggaaggtaag tacaaactct tagaaaaaat tgtgactaat ttgttaaaat
     3961 atttccttgc tccgataatc cgatctgaat atttttatta aaaagccttc tttaatgatg
     4021 aattaacgct tcctttaatt tattccactg ttgccacact gtaaggaagg agacaggtgc
     4081 aagtctagtg agatgataat caaatggcca ctttttgcag gtggaagcta aatatatttt
     4141 tgtatggatc caggattcat tggctgctga agaaattcaa tagagtcaag ggcttttttt
     4201 ttcttagtgc aaaagtagct ttcaggttta taattatttc agccattttc tgaacagcta
     4261 aatcgacctt cacagctgtc ttatgaagag agctaagaaa tcgcggagac tgcttgacct
     4321 ggtggtagaa gattccattc acaggaaaaa taaatgcgtt ttaaagcaag atgcgacaat
     4381 aaacacttca gcaccgtgct tttcctgctt gctttctaaa ctacaaccca gggaaaagca
     4441 tctattatca caatccaaat aaagaagttt cttg
//
