LOCUS       NM_172051               5528 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus transmembrane and coiled coil domains 3 (Tmcc3),
            transcript variant 1, mRNA.
ACCESSION   NM_172051
VERSION     NM_172051.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5528)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5528)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5528)
  AUTHORS   Sohn,W.J., Kim,J.Y., Kim,D., Park,J.A., Lee,Y. and Kwon,H.J.
  TITLE     Expression and characterization of transmembrane and coiled-coil
            domain family 3
  JOURNAL   BMB Rep 49 (11), 629-634 (2016)
   PUBMED   27697108
REFERENCE   4  (bases 1 to 5528)
  AUTHORS   Shimogori,T., Lee,D.A., Miranda-Angulo,A., Yang,Y., Wang,H.,
            Jiang,L., Yoshida,A.C., Kataoka,A., Mashiko,H., Avetisyan,M.,
            Qi,L., Qian,J. and Blackshaw,S.
  TITLE     A genomic atlas of mouse hypothalamic development
  JOURNAL   Nat Neurosci 13 (6), 767-775 (2010)
   PUBMED   20436479
REFERENCE   5  (bases 1 to 5528)
  AUTHORS   Evsikov,A.V., Graber,J.H., Brockman,J.M., Hampl,A., Holbrook,A.E.,
            Singh,P., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB619673.1 and AK132545.1.
            
            On Dec 12, 2009 this sequence version replaced NM_172051.2.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK132545.1, AK083129.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                BB619673.1         2-23
            23-4674             AK132545.1         1-4652
            4675-5528           AK132545.1         4654-5507
FEATURES             Location/Qualifiers
     source          1..5528
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 48.88 cM"
     gene            1..5528
                     /gene="Tmcc3"
                     /gene_synonym="A230066D03Rik; C630016B22Rik; Gm1556;
                     Tmcc1"
                     /note="transmembrane and coiled coil domains 3"
                     /db_xref="GeneID:319880"
                     /db_xref="MGI:MGI:2442900"
     exon            1..248
                     /gene="Tmcc3"
                     /gene_synonym="A230066D03Rik; C630016B22Rik; Gm1556;
                     Tmcc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             171..1604
                     /gene="Tmcc3"
                     /gene_synonym="A230066D03Rik; C630016B22Rik; Gm1556;
                     Tmcc1"
                     /note="isoform a is encoded by transcript variant 1;
                     transmembrane and coiled coil domains 1; transmembrane and
                     coiled-coil domains protein 3; transmembrane and
                     coiled-coil domain protein 3"
                     /codon_start=1
                     /product="transmembrane and coiled-coil domain protein 3
                     isoform a"
                     /protein_id="NP_742048.2"
                     /db_xref="CCDS:CCDS24134.1"
                     /db_xref="GeneID:319880"
                     /db_xref="MGI:MGI:2442900"
                     /translation="MPGSDTALTVDRTYSDPGRHHRCKSRVDRHDMNTLSLPLNIRRG
                     GSDTNLNFDVPDGILDFHKVKLNADSLRQKILKVTEQIKIEQTSRDGNVAEYLKLVSS
                     ADKQQAGRIKQVFEKKNQKSAHSIAQLQKKLEQYHRKLREIEQNGVTRSSKDISKDSL
                     KEIHHSLKDAHVKSRTAPHCLESSKSSMPGVSLTPPVFVFNKSREFANLIRNKFGSAD
                     NIAHLKNSLEEFRPEASPRAYGGSATIVNKPKYGSDDECSSGTSGSADSNGNQSFGAG
                     GTSTLDSQGKIAKIMEELREIKVTQTQLAEDIEALKVQFKREYGFISQTLQEERYRYE
                     RLEDQLHDLTELHQHETANLKQELASAEEKVAYQAYERSRDIQEALESCQTRISKLEL
                     HQQEQQTLQTDAVNAKVLLGKCINVVLAFMTVILVCVSTLAKFVSPMMKSRSHILGTF
                     FAVTLLAIFCKNWDHILCAIERIIIPR"
     exon            249..1165
                     /gene="Tmcc3"
                     /gene_synonym="A230066D03Rik; C630016B22Rik; Gm1556;
                     Tmcc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1301
                     /gene="Tmcc3"
                     /gene_synonym="A230066D03Rik; C630016B22Rik; Gm1556;
                     Tmcc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..5528
                     /gene="Tmcc3"
                     /gene_synonym="A230066D03Rik; C630016B22Rik; Gm1556;
                     Tmcc1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5501..5506
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmcc3"
                     /gene_synonym="A230066D03Rik; C630016B22Rik; Gm1556;
                     Tmcc1"
                     /note="hexamer: AATAAA"
     polyA_site      5528
                     /gene="Tmcc3"
                     /gene_synonym="A230066D03Rik; C630016B22Rik; Gm1556;
                     Tmcc1"
                     /note="major polyA site"
ORIGIN      
        1 gggcggcggc gcagggccgc ggggtgtcgg cagcagctgc agcggcccgc gccaccccct
       61 cggccgcggc tccggggcga gggtgagcgg agcacggcga gcagctgcca cccggcgccg
      121 agtggagcgg cagccccgga ggacgcaaag ttgtcagtct aagcgcagac atgccgggca
      181 gcgacacggc gctcaccgtg gaccggacct actcagaccc cggccggcac caccgctgca
      241 agagccgggt ggaccgccat gacatgaata ccctcagcct acccctgaac atacgccgag
      301 ggggatcaga caccaacctc aacttcgatg tccccgatgg catcctggat ttccacaagg
      361 tcaaactcaa tgcggacagc ctgagacaaa aaatcttaaa ggtgacggag cagataaaga
      421 tcgagcagac gtcccgagat gggaacgttg cagagtatct gaaactggtc agcagtgcag
      481 acaagcagca ggctggacgc atcaagcagg tctttgagaa gaaaaaccag aagtcagccc
      541 actccatcgc ccaacttcag aagaagttgg agcagtatca cagaaagctc agggagatcg
      601 aacagaatgg cgtgaccagg agctcaaagg acatctctaa agacagcctg aaggaaatac
      661 accactctct gaaggatgcc cacgtgaaat ctcgaactgc tccccactgc ctggagagca
      721 gtaaatctag catgccaggg gtatccctca cgccccccgt gtttgtcttc aataagtcca
      781 gagagtttgc caacttgatc cggaataagt ttggcagtgc agataacatt gctcacttga
      841 agaattccct ggaagagttc aggcccgaag ccagccccag ggcttacggc ggaagcgcta
      901 ccatcgtgaa caaacctaag tacggcagcg atgacgaatg ttctagtggc acatccggct
      961 cagcggacag caatgggaac cagtcctttg gggctggtgg gaccagcacc ctggacagcc
     1021 aggggaagat tgccaagatc atggaggaac tgagggagat caaggttacc caaacccagc
     1081 tggcggaaga catcgaggca ctgaaggtgc agtttaagag agaatatggc tttatctctc
     1141 agactctgca agaggagaga tacaggtatg agcgacttga agaccagctc catgacctga
     1201 cagagctgca ccagcatgag acagccaatc tgaagcagga attggccagc gctgaggaga
     1261 aggtggccta ccaggcctat gagcgctcaa gggacatcca ggaagccttg gaatcttgcc
     1321 agacccgcat ctctaagctc gagctgcatc agcaggaaca gcagaccctg cagacggatg
     1381 ccgtgaacgc caaggtcctg ctggggaagt gcatcaacgt ggttctggcc ttcatgacgg
     1441 tcatcctggt gtgtgtgtcc accctggcca agtttgtctc gcccatgatg aagagccgct
     1501 cccacatcct tggcaccttc tttgctgtga ctcttctcgc catattctgt aaaaactggg
     1561 accatatctt gtgtgccata gaaaggataa tcatcccgag atgagccgct gcttcctgcc
     1621 ttcacatcct cttaaagatt ttattttgaa gaaaaccctg tgcatactac caaaatttct
     1681 gaatggacgg ctgtgccaaa gacggcgcga gagggaccag agctacgtgc ggtgtaaata
     1741 agtagagact cttaacccag tagcagatgc caacactgtc cctgtatgtg gttaacgtga
     1801 aactgtccca gagtcctcct caaggggctc actgccttaa tcagagccga tctcgagccc
     1861 acctgttgag ctcagcacag caaagccctt gttctttggg cgccatgatt gctaactgct
     1921 gtgttctgag ttccccctga ccagcaagaa tatggctagg acttggggaa gtgagcaaac
     1981 aggaactggc agggttgagc tcctgggggc ctatggaagc tcagtgagtc tctctgtgat
     2041 ctctcctact tgtccatggg tggctctgtg ccctactatg tacccagtgt tcacagcggt
     2101 caatggtgta tgtcctcata acgtgggaat cttctacctg cttatccagc cgtagtagtg
     2161 cactttacaa ggtagacact gggatttaca gccaggcttt cctcttatgc ccagagcacc
     2221 acacacctga ttccatcttg cgtggttagc agtgctctgc cctcagagca ttcggctggg
     2281 ctgttgtcaa actgtagctt gggtaactca gggtcctgcg agcatccctg gggaggcagt
     2341 gcgtaggcga ctgttaactg tgataaatgc cctgagacga caggatgcac tttacgtgat
     2401 tcactttact tgcgggtctg tggggatctg actgcaaagc ttgttcagga aatgaaaacg
     2461 aatgacgttt gtgttaccca gctttctttt ctcagagaca gcaaaatcaa acttcataac
     2521 tcaagtgtgt gtgtgtgctg aggcaggaca ctgggggcct aagagggatg tgaactttta
     2581 ggtctaatca aatggtggca agagtagtgg gagctcttga cccagatgag agcaggaggg
     2641 tcccttaggg acgcaaaggc catcaggaat aaaattaagt cctgcgctgg agtggagttg
     2701 ctgctgtctg tctcttaggt acacagataa gctctgaggt cacaggagaa atgcactgcc
     2761 ccatgagcag agagcctgca agagctgctg tgtcttgttc gatggctgcc atttactgac
     2821 aaacctggtt ttctgtgtac gccaccaaga ggagagagaa gattcttatt gtgtcctgtc
     2881 agccagccag tcaggtctct ggtcctcccc acccccaacc ccctccctgc tgaaggtgta
     2941 aaagatactc ttaaatgctt tcttccagaa gaacctctct tagatttaac tatcctcact
     3001 tgcaaatgga tgtccttagg gacactccac cccaccccac ccccggggca cattggggat
     3061 ggtggcatgt agcaagttag tacaaggcca ggttaggtga gtgggaccca cacagttcta
     3121 acctttgccc ctcacccact ccaacttcta agtcaataat tcatagtttt agtaaattca
     3181 caaagtattt aaccatcacc cctaaccaat tccagagcca tgcttttcca aaataataat
     3241 aataataata aatttaattt tataaaatac aaaggagttt gaaatcaggg atggggaagt
     3301 tcccagtacc acccctatct atggctttgt tcctacacgg gagacagagg tttctagtcc
     3361 aaaaaaaaaa aaaaaaaagg gaggaagaga gagacatgat cttcttttat tcttgtattt
     3421 tactggccag ctcccttacc tgtaggcccc agactccatc tgcctgtacc ctgaagcaag
     3481 ctgggctctg ctgggctccc attcctatct gtgaatattt ccaagtggca cttagggcgt
     3541 gccagggcct gggatgcccg tgaatgccgc tagcaggttt cagaaagagt ttgaatgcaa
     3601 ccttaagaga cttagctagg gctctgagag aatctgggaa gaggttctgt tctcacgcca
     3661 gcacctgccc cacccctaca ctgcctaacc ggaccactct tgattgacgc ttgccagacc
     3721 tgcaatctgt gtttcttctc cctgctgaga aagtccaaaa cagcacactc cacacccttc
     3781 agactgagct ttggacagaa tctgttagaa gcctccagca ccattgtgaa ttaatggagg
     3841 taggggtggg gcctccaaat cttggattcc ttctaaagag cttagatgct cattgcttcc
     3901 cattagatgt cagatcacct tctttgcctg ggcatgtgca gctctatggc atacttgttt
     3961 cggtctcacg gaaagtttgt gaagcttttg atatttttag caagagtgta tagttcaagg
     4021 agactttgac tcaacagttc ttcattctct caagggctat aaccccactc tcactctctt
     4081 gaacatgtaa catacatact gaagaaatga gttctataaa tatacaattg gcggtagcaa
     4141 tagagctgtg aggtaccctg gaattggaat cgatttgtaa ttgagtcagc gcatcttgtt
     4201 ttgcacttta tgttgggagt agacatctcg tgcatccctc gtgttgagag ccagttggag
     4261 gttagtgagc acgttccctg ttcgcctagg aacactggtg agagcttcta gatgctggac
     4321 gctgcgtctc tggttatcat gaccgatcat cagaagagtg attacggagg acagaacaga
     4381 actttaaaat actaagaata ataaatatta aaaaaaaaaa aaaaaagtaa gcagccactc
     4441 agtgaagcaa gtggtgacct caagtgctgt cgctgacttt ggactgtgaa ggcaggattt
     4501 cccatctcaa gctcctggct tgtggcttag tagtgttcag gtgttcttgt gttgtctgtt
     4561 ggtgttcatt cacattaata ctctgtagct cttgacttta tctaagcaat gccctcaatg
     4621 agttcttact gcctgactgc ctggccactt ctctaacatg gggggggggg ggggcaggcg
     4681 gatgagggag ctcttccccc caactccctc tcccaataat tagttacttt ggctcgtttg
     4741 ggttgaattt taaataccaa attacttttg tgttgaatgg cagtatatct atcatagggt
     4801 tgttgttgtt attgttgttt tgttctgatg ttgaatccag acctaattgc ctgggtttgg
     4861 aaaaacaaac gtactcattg ataagaacgt gtgtgatcaa acaacctatt ttggacgttt
     4921 tcttaattct gaccttgggc tgggatgtga gcacgggctt atgcagggag atggttcaaa
     4981 gctagcaggt aacctttaag gggcctaaaa agacaaatca cagaaaacaa ttagattggc
     5041 ctgtttgtat caaaaataaa gagctttaaa aacgtgtcat tgatgggaat tgggtaattt
     5101 gttataaata aagccaaatt atcattttct gccatggata cagttctctg cttaaagagt
     5161 ctggaagtga tgtgtaattc cttgggagtc tgagggagat ttacatgttg ctgtccgcat
     5221 atatttaaag catgtctatt gtgtttgtcc taaaagaaac atttcaacta accgtgctat
     5281 gtgtttcaga tacgcagggg caatagcagc gattctgatg taacatcagg aatgctgact
     5341 gtaacttctg ttggagaatt cccatctcat gggaagctac atagttttgt atctgcctaa
     5401 aattgtaatt tctctgtaga tcttccccac ggcggtgtta ttaatgaatt caaagcaggt
     5461 gccattattt tttaaacaat tgatgtttgc tttggtgtta aataaaagaa ctagatttct
     5521 taaatttt
//
