LOCUS       NM_178874               3544 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus transmembrane and coiled-coil domains 2 (Tmcc2),
            transcript variant 1, mRNA.
ACCESSION   NM_178874
VERSION     NM_178874.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3544)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3544)
  AUTHORS   Ren,R., Xing,H., Wang,X., Du,H., Wang,Y. and Xu,Z.
  TITLE     Loss of TMCC2 activates endoplasm reticulum stress and causes
            auditory hair cell death
  JOURNAL   Hum Mol Genet 32 (10), 1622-1633 (2023)
   PUBMED   36617157
  REMARK    GeneRIF: Loss of TMCC2 activates endoplasm reticulum stress and
            causes auditory hair cell death.
REFERENCE   3  (bases 1 to 3544)
  AUTHORS   Kumari,R., Grzywa,T.M., Malecka-Gieldowska,M., Tyszkowska,K.,
            Wrzesien,R., Ciepiela,O., Nowis,D. and Kazmierczak,P.
  TITLE     Ablation of Tmcc2 Gene Impairs Erythropoiesis in Mice
  JOURNAL   Int J Mol Sci 23 (9), 5263 (2022)
   PUBMED   35563652
  REMARK    GeneRIF: Ablation of Tmcc2 Gene Impairs Erythropoiesis in Mice.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3544)
  AUTHORS   Dumitriu,B., Bhattaram,P., Dy,P., Huang,Y., Quayum,N., Jensen,J.
            and Lefebvre,V.
  TITLE     Sox6 is necessary for efficient erythropoiesis in adult mice under
            physiological and anemia-induced stress conditions
  JOURNAL   PLoS One 5 (8), e12088 (2010)
   PUBMED   20711497
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3544)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CD354506.1, CA320803.1 and BC052035.1.
            
            On Jul 24, 2015 this sequence version replaced NM_178874.2.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC052035.1, SRR1660815.189004.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139, SAMN01164141
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                CD354506.1         1-17
            18-105              CA320803.1         4-91
            106-3544            BC052035.1         1-3439
FEATURES             Location/Qualifiers
     source          1..3544
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 57.24 cM"
     gene            1..3544
                     /gene="Tmcc2"
                     /gene_synonym="1110063G11Rik"
                     /note="transmembrane and coiled-coil domains 2"
                     /db_xref="GeneID:68875"
                     /db_xref="MGI:MGI:1916125"
     exon            1..410
                     /gene="Tmcc2"
                     /gene_synonym="1110063G11Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             204..2324
                     /gene="Tmcc2"
                     /gene_synonym="1110063G11Rik"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transmembrane and coiled-coil domains protein 2"
                     /codon_start=1
                     /product="transmembrane and coiled-coil domains protein 2
                     isoform 1"
                     /protein_id="NP_849205.1"
                     /db_xref="CCDS:CCDS15284.1"
                     /db_xref="GeneID:68875"
                     /db_xref="MGI:MGI:1916125"
                     /translation="MKRCKSDELQQQQGEEDGAGMEDAACLLPGADLRHGEASSANSA
                     GGPTSDAGAAVAPNPGPRSKPPDLKKIQQLSEGSMFGHGLKHLFHSRRRSREREHQAS
                     QEAQQQQQQQGLSDQDSPDEKERSPEMHRVSYAVSLHDLPARPTAFNRVLQQIRSRPS
                     IKRGASLHSSGGSGGRRAKSSSLEPQRGSPHLLRKAPQDSSLAAILHQHQGRPRSSST
                     TDTALLLADGSSAYLLAEEAESIGDKGDKGDLVALSLPSGPGHGDSDGPISLDVPDGA
                     PDPQRTKAAIEHLHQKILKITEQIKIEQEARDDNVAEYLKLANNADKQQVSRIKQVFE
                     KKNQKSAQTIAQLHKKLEHYRRRLKEIEQNGPSRQPKDVLRDMQQGLKDVGANMRAGI
                     SGFGGGVVEGVKGSLSGLSQATHTAVVSKPREFASLIRNKFGSADNIAHLKDPMEDGP
                     PEEAARALSGSATLVSSPKYGSDDECSSASASSAGAGSNSGAGPGGALGSPRSNTLYG
                     APGNLDTLLEELREIKEGQSHLEDSMEDLKTQLQRDYTYMTQCLQEERYRYERLEEQL
                     NDLTELHQNEMTNLKQELASMEEKVAYQSYERARDIQEAVESCLTRVTKLELQQQQQQ
                     VVQLEGVENANARALLGKFINVILALMAVLLVFVSTIANFITPLMKTRLRITSTALLL
                     LVLFLLWKHWASLTYLLEHVLLPS"
     exon            411..935
                     /gene="Tmcc2"
                     /gene_synonym="1110063G11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1876
                     /gene="Tmcc2"
                     /gene_synonym="1110063G11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1877..2012
                     /gene="Tmcc2"
                     /gene_synonym="1110063G11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2013..3515
                     /gene="Tmcc2"
                     /gene_synonym="1110063G11Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3488..3493
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmcc2"
                     /gene_synonym="1110063G11Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3515
                     /gene="Tmcc2"
                     /gene_synonym="1110063G11Rik"
                     /note="major polyA site"
ORIGIN      
        1 gaactatcct aaggctcccc ctcttcgccc ctccctcatc ctcctttaaa aagataattt
       61 cttaaattca agaactcgtg atctgcctac tcccctcgtc cataatttaa accccaggtc
      121 ttttgagtgc aagagggggg tgcggtctct ccccaagata gcacgctaga aggacagatt
      181 ccccttgccg acccacttac accatgaaga ggtgcaaatc ggacgagctg cagcaacagc
      241 agggcgagga ggatggggct gggatggaag acgctgcttg ccttctgcca ggcgcggacc
      301 tccggcatgg ggaggcctcg agtgctaact ccgctggcgg gccaacttca gatgctggcg
      361 ctgcggtggc acccaacccg ggtccccgaa gcaagcctcc tgatttaaag aaaatccagc
      421 agctctcaga gggctccatg tttggccacg gcctgaagca cctgtttcac agccgccgca
      481 ggtcacggga gagggagcac caggcgtctc aggaggccca gcagcagcag caacagcagg
      541 gcctatccga tcaggactcc ccagatgaga aggaacgctc cccggagatg caccgcgtct
      601 cctatgctgt gtccctgcac gacctgcctg cccgacctac tgctttcaac cgggtgttac
      661 agcaaatccg ctccaggccc tccatcaagc ggggcgccag cctgcacagc agtggcggga
      721 gcggtggtcg ccgtgccaag agcagctccc tggagccaca gcgtggcagt cctcacctgc
      781 ttcgtaaggc cccccaggac agcagcctgg ccgccatcct gcaccagcac cagggccgac
      841 cccgttcctc ctctaccacc gacaccgcct tgctcctggc cgatggcagc agtgcgtacc
      901 tcctggctga ggaagcagag agcatcgggg acaagggtga caagggagat cttgtggccc
      961 tgagcctccc ctctggccct ggccatggtg actctgatgg acccatcagc ctggatgtgc
     1021 cagatggagc accggacccc cagcgaacta aggctgccat cgaacacctg caccaaaaga
     1081 tcttgaagat cactgagcag atcaagatcg agcaggaggc gcgggatgat aacgtggcag
     1141 agtacctgaa gctggccaac aatgcggaca agcagcaggt gtcgcgcatc aagcaggtgt
     1201 ttgaaaagaa gaaccagaag tccgcccaga ccatcgccca gctgcacaaa aaactggagc
     1261 actaccgtcg gcgcctgaag gaaatcgagc agaatgggcc ctcgcggcag cccaaggatg
     1321 tgctacgcga tatgcagcaa gggctgaagg atgtgggcgc caacatgcgt gccggcatta
     1381 gtggcttcgg gggtggtgtg gtggagggtg tcaagggcag tctttccggc ctctcgcaag
     1441 ctacccacac tgcggtggtg tccaagcccc gggagttcgc cagcctcatt cgcaacaagt
     1501 tcggcagtgc cgacaacatc gcccacctga aggaccccat ggaagatgga ccccctgaag
     1561 aggcagcccg ggcgctgagt ggcagtgcca cactggtgtc cagccccaag tacggcagtg
     1621 acgatgaatg ctcgagtgcc agtgccagct cagctggggc aggcagcaac tctggggctg
     1681 ggccaggagg tgcactggga agcccgagat ccaacactct ttatggtgcc cctggaaatc
     1741 tggacactct gctggaggaa ctgcgggaga taaaggaggg ccagtcacac ctggaggact
     1801 ccatggagga cttgaagact cagctgcaga gggactacac ctacatgacc cagtgcctgc
     1861 aagaagagcg ctacaggtat gagaggctgg aggaacagct gaacgacctg actgagcttc
     1921 accagaatga aatgaccaac ctaaagcagg agctggccag catggaggag aaggtggcct
     1981 accagtccta cgagagggcc cgggatatcc aggaggccgt ggagtcctgc ctgacccgag
     2041 tcaccaagct ggaactgcag cagcagcagc agcaagtggt gcagttagaa ggtgtggaga
     2101 acgccaacgc gcgcgccctg ctgggcaagt tcatcaacgt gatcctggca ctcatggccg
     2161 tgctgctggt gtttgtgtcc accattgcca acttcatcac ccccctcatg aagacgcgcc
     2221 tccggatcac cagcaccgcc ctcctgctcc tcgtcctctt cctactgtgg aagcactggg
     2281 cctccctcac ctacctcctg gagcatgtgc tgctgcccag ctgagcggct gccgccccac
     2341 cctgtgctct ccggatccca ctagccacag gcatctccag gagggcccgg ggctcctgcg
     2401 tccctcgggg tctgtcatgt gacctgtttg gcccctaact gtcccttctt ttcactgctt
     2461 ctgtctgaca ccatctccct ttcggcctga aggtttcaga gagggtgctc tgggctggag
     2521 ggagcaggga cactctcagc caaatggagc agtggggaga caccagggct gcattatttg
     2581 aattattttg cagccacatg ggacttttct gggttgacaa gaggatgctc tagtcatgta
     2641 agccactaag atagaaggcc agtctcagtt tccctaggga agagcccatc ctggaggcag
     2701 ccacagtttc ctcccatgga gatggtctgg ataaaagcca gtgggaggcc ctgctgagcc
     2761 tagagagtgc agaaagggga gggtccccag ccttggggcc agagggcagg cttggcacag
     2821 ccactgggag ctcagcctcc cctcctcctg cttctccttc cacttgagct ggtttgagac
     2881 tggtttctgg aggctgtggg gtgtaacttt gggtttgtat tttttctgct catctttctg
     2941 cctgtcaccg ggtgtgctgt ttttctgaaa aaaaaacagg ccccaagggc cctgagcctc
     3001 cagcccaaac ccttagacct ctgggatcac gttgagttct atttatttat ttacttattt
     3061 atttatttgt acccaccctt ccctcacttc tgcccagctg ggctccagag agaggaccct
     3121 gcccatcctc cttttgaagc caggacttat tcttggttca tcatactcca gaccatgtat
     3181 cctctggtgt cctggctgga agaaggggcg tgtggccatg cagcccgctc tcccaagctg
     3241 tcccagcaaa tgggcaggag gggcatggcc tcttttatat atatatatct atttatttta
     3301 tatgtgtgtt tgtgaggaag aggatatttg tcatttcctt aaggctctgg agtgttgtgt
     3361 tcgattctgc acagcccagc ctccccgagg gcctttccaa gcacagtggg gatttcttag
     3421 aacaggagag aggaatccat gaagcaggag aagcagtgcc tgccagctgt ggtggacctt
     3481 cctaagaaat aaatatcctt tatgttttca aaccaaaaaa aaaaaaaaaa aaaaaaaaaa
     3541 aaaa
//
