LOCUS       NM_177412               5719 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus transmembrane and coiled coil domains 1 (Tmcc1),
            transcript variant 1, mRNA.
ACCESSION   NM_177412 XM_001479878 XM_001480143 XM_892747 XM_917443
VERSION     NM_177412.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5719)
  AUTHORS   Jo,D., Lim,Y.H., Jung,Y.S., Kim,Y.K. and Song,J.
  TITLE     Circular RNA Tmcc1 improves astrocytic glutamate metabolism and
            spatial memory via NF-kappaB and CREB signaling in a bile duct
            ligation mouse model: transcriptional and cellular analyses
  JOURNAL   J Neuroinflammation 20 (1), 121 (2023)
   PUBMED   37217942
  REMARK    GeneRIF: Circular RNA Tmcc1 improves astrocytic glutamate
            metabolism and spatial memory via NF-kappaB and CREB signaling in a
            bile duct ligation mouse model: transcriptional and cellular
            analyses.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5719)
  AUTHORS   Tomas-Roca,L., Perez-Aytes,A., Puelles,L. and Marin,F.
  TITLE     In silico identification of new candidate genes for hereditary
            congenital facial paresis
  JOURNAL   Int J Dev Neurosci 29 (4), 451-460 (2011)
   PUBMED   21345367
REFERENCE   3  (bases 1 to 5719)
  AUTHORS   van der Zwaag,B., Burbach,J.P., Scharfe,C., Oefner,P.J.,
            Brunner,H.G., Padberg,G.W. and van Bokhoven,H.
  TITLE     Identifying new candidate genes for hereditary facial paresis on
            chromosome 3q21-q22 by RNA in situ hybridization in mouse
  JOURNAL   Genomics 86 (1), 55-67 (2005)
   PUBMED   15953540
REFERENCE   4  (bases 1 to 5719)
  AUTHORS   Ballif,B.A., Villen,J., Beausoleil,S.A., Schwartz,D. and Gygi,S.P.
  TITLE     Phosphoproteomic analysis of the developing mouse brain
  JOURNAL   Mol Cell Proteomics 3 (11), 1093-1101 (2004)
   PUBMED   15345747
REFERENCE   5  (bases 1 to 5719)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY293575.1 and AK173022.1.
            
            On or before Aug 20, 2009 this sequence version replaced
            XM_001479878.1, XM_917443.2, XM_892747.2, XM_001480143.1.
            
            ##Evidence-Data-START##
            CDS exon combination :: AK173022.1, SRR1660813.97416.1
                                    [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN01164131, SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                BY293575.1         6-16
            12-5719             AK173022.1         1-5708
FEATURES             Location/Qualifiers
     source          1..5719
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 53.72 cM"
     gene            1..5719
                     /gene="Tmcc1"
                     /gene_synonym="3632431M01Rik; mKIAA0779"
                     /note="transmembrane and coiled coil domains 1"
                     /db_xref="GeneID:330401"
                     /db_xref="MGI:MGI:2442368"
     exon            1..117
                     /gene="Tmcc1"
                     /gene_synonym="3632431M01Rik; mKIAA0779"
                     /inference="alignment:Splign:2.1.0"
     exon            118..173
                     /gene="Tmcc1"
                     /gene_synonym="3632431M01Rik; mKIAA0779"
                     /inference="alignment:Splign:2.1.0"
     exon            174..864
                     /gene="Tmcc1"
                     /gene_synonym="3632431M01Rik; mKIAA0779"
                     /inference="alignment:Splign:2.1.0"
     CDS             301..2250
                     /gene="Tmcc1"
                     /gene_synonym="3632431M01Rik; mKIAA0779"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transmembrane and coiled-coil domains protein 1"
                     /codon_start=1
                     /product="transmembrane and coiled-coil domains protein 1
                     isoform 1"
                     /protein_id="NP_803131.1"
                     /db_xref="CCDS:CCDS51881.1"
                     /db_xref="GeneID:330401"
                     /db_xref="MGI:MGI:2442368"
                     /translation="MEPSGSEQLYEDPDPGGKSQDAEARRQTESEQKLSKMTHNALEN
                     INVIGQGLKHLFQHQRRRSSVSPHDVQQIQTDPEPEVDLDSQNACAEIDGVSTHPTAL
                     NRVLQQIRVPPKMKRGTSLHSRRGKSEAPKGSPQINRKSGQEVAAVIQSGRPRSSSTT
                     DAPTSSSVMEIACAAGVCVPGEEATAERIERLEVSSLAQTSSAVASSTDGSIHTESVD
                     GIPDPQRTKAAIAHLQQKILKLTEQIKIAQTARDDNVAEYLKLANSADKQQAARIKQV
                     FEKKNQKSAQTILQLQKKLEHYHRKLREVEQNGIPRQPKDVFRDMHQGLKDVGAKVTG
                     FSEGVVDSVKGGFSSFSQATHSAAGAVVSKPREIASLIRNKFGSADNIPNLKDSLEEG
                     QVDDGGKALGVISNFQSSPKYGSEEDCSSATSGSVGANSTTGGIAVGASSSKTNTLDM
                     QSSGFDALLHEVQEIRETQARLEDSFETLKEHYQRDYSLIMQTLQEERYRCERLEEQL
                     NDLTELHQNEILNLKQELASMEEKIAYQSYERARDIQEALEACQTRISKMELQQQQQQ
                     VVQLEGLENATARNLLGKLINILLAVMAVLLVFVSTVANCVVPLMKTRNRTFSTLFLV
                     AFIAFLWKHWDALFSYVDRLFSPPR"
     exon            865..1799
                     /gene="Tmcc1"
                     /gene_synonym="3632431M01Rik; mKIAA0779"
                     /inference="alignment:Splign:2.1.0"
     exon            1800..1935
                     /gene="Tmcc1"
                     /gene_synonym="3632431M01Rik; mKIAA0779"
                     /inference="alignment:Splign:2.1.0"
     exon            1936..5719
                     /gene="Tmcc1"
                     /gene_synonym="3632431M01Rik; mKIAA0779"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2958..2963
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmcc1"
                     /gene_synonym="3632431M01Rik; mKIAA0779"
                     /note="hexamer: AATAAA"
     polyA_site      2993
                     /gene="Tmcc1"
                     /gene_synonym="3632431M01Rik; mKIAA0779"
                     /note="major polyA site"
     regulatory      3148..3153
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmcc1"
                     /gene_synonym="3632431M01Rik; mKIAA0779"
                     /note="hexamer: AATAAA"
     polyA_site      3174
                     /gene="Tmcc1"
                     /gene_synonym="3632431M01Rik; mKIAA0779"
                     /note="major polyA site"
ORIGIN      
        1 gggggggtgg tcggggtggg gatggaccgg gcgcggcggc ggcagctgca ggagccggcg
       61 ctggagaccg agccgcggcg ctggcggaga cgccggctgt ccgtcgtctc tccaccgctt
      121 ctcctaaaag gacatcagtg ccccaagtac gtgcttgagg gagagcaatg aaggtaggca
      181 tgaagcctcc atctctcagc tgcatgcatt gtcactcttg aagcaaatgc ctacctaatt
      241 tgacagtctc ggtgtgttta aaattttttg agtttgcaaa taagcttatt aagcttactg
      301 atggagcctt ccggcagtga acagttatat gaggaccctg atcctggagg caaatcccaa
      361 gatgcagaag ccaggaggca gacagagtca gaacaaaagt tatctaaaat gacccacaat
      421 gctctggaga acattaatgt gattggccaa ggcttgaagc atctcttcca gcaccagcgc
      481 aggaggtctt cagtgtctcc acacgatgtg cagcagattc agacagatcc agagcctgaa
      541 gtggatctgg acagtcagaa cgcatgtgct gagattgatg gtgtctccac ccatcccaca
      601 gctctgaatc gtgttctcca gcagatccga gtgccaccca agatgaagag agggacaagc
      661 ttgcatagta ggcggggcaa atcagaagcc ccaaagggaa gtccccaaat caacaggaaa
      721 tctggccaag aggtggcagc tgtaatacag tcaggtcgac ccaggtcttc atccacaact
      781 gatgctccta ccagctcttc tgtgatggaa atagcttgtg ctgctggtgt gtgtgtacct
      841 ggagaggagg caactgcaga acggatcgag cgtttggaag taagcagcct cgcccagact
      901 tccagtgccg tggcctccag cactgatggc agcatccaca cagagtctgt ggatggaata
      961 ccagatcctc agcgtacaaa agctgccatt gcacacctgc agcagaagat cctaaagctc
     1021 acagaacaga tcaagattgc acagacagcc cgagacgaca acgttgctga gtacttgaag
     1081 cttgccaaca gtgcagacaa gcagcaggct gctcgaatca aacaggtgtt tgagaagaaa
     1141 aaccagaaat ctgcgcagac cattctccag ctgcaaaaga agcttgagca ttaccaccga
     1201 aagctccgtg aggtggaaca gaatgggatt ccccgacagc ccaaggatgt cttcagggac
     1261 atgcaccagg gtctgaagga tgtgggtgca aaggtgactg gcttcagtga aggtgtagtg
     1321 gacagcgtca aaggtggatt ttccagcttc tcccaggcta cccattcagc agcaggggct
     1381 gtcgtctcca aacccagaga gattgcctca ctgattcgga acaaatttgg tagtgcagac
     1441 aatatcccta acctgaaaga ctcattagag gaaggacaag tggatgatgg gggaaaggct
     1501 ttaggggtga tttcaaactt tcagtcaagt ccaaaatatg gtagtgagga agattgttct
     1561 agtgccactt caggctcagt aggagccaac agtaccactg ggggcattgc tgtgggagca
     1621 tccagctcca aaaccaacac cctcgacatg cagagctcag ggtttgatgc actgctgcat
     1681 gaggtccagg agatccggga aacccaggcc agactggagg actccttcga gaccctcaag
     1741 gagcattatc agagggacta ctccttaata atgcagacct tacaggaaga gcggtataga
     1801 tgtgagcgac tggaagagca gctgaatgac ctgacagagc tgcaccagaa tgagatcctg
     1861 aacttaaagc aggagttggc cagcatggaa gagaaaatcg cctatcagtc atatgaacgg
     1921 gcccgggata tccaggaggc tctggaggcc tgtcaaaccc gcatttccaa gatggagctg
     1981 cagcagcaac agcagcaggt ggtgcaactg gaagggctgg agaatgccac tgcccgaaac
     2041 cttctgggca aactcatcaa tatcctcctt gctgtcatgg cagttctctt ggtctttgtg
     2101 tcaacagtag ccaactgtgt ggtccccctc atgaagacac gcaacaggac gttcagcact
     2161 ttattcctag tggctttcat tgcctttctt tggaagcact gggatgccct ctttagctac
     2221 gtggaccggc tcttctcacc ccccagatga tgctggcatg gaacgcagtg ctcttcaccg
     2281 tctggcgagt gcatgccaag agagctagac agcagcatta cccactctga agttttctac
     2341 aagagagttg agtgaatctg tttacattta ggataatgtt tttttcttca aaagacgcaa
     2401 ttgcaatagt attttttaga ttttatccaa gaagtttttt gggcaaaaat cttggatcat
     2461 ttttatgtag catgattttc cttgggatgc aaatctgaaa cagtccttta acatgaacaa
     2521 tctgcagcac actgaagggc attctgaatt gaagcttgga gaactgcact aaacccacta
     2581 aacagatgca aaaacctgac caggcccaac acccaccctg cctggctcct ctcctcatcc
     2641 agactaactc tactgtgaag tcccaccaca ttccaggttg gaattttaga ttcagggtgg
     2701 attttccctg ccgtggaaga acacaggcat ctccctagct ttctcacgct aaccctgaag
     2761 tatgatcact tctgaacctg ctcctttctt aactgccagg attggaagca agagcatcaa
     2821 gcccatagga tgactgcgca atcctgttca gtattgtgaa gtagccctta atcctaactt
     2881 ttaagcaaaa tcccttggcc gcacttttaa ggtttggttg ttttttatat atatatgtgt
     2941 atagttacca acttaaaaat aaaaaatccg aacaacatac ttgaagaatg taatactcaa
     3001 actctcagtg cttccttata atttctaata gaatttttta ttattgttat tattattggg
     3061 gtttttttgg ttggttggtt ggttggtcgg gttttttggg gggtgaaggg gactgggttg
     3121 ggagggtctt ttattttttt cctctgaaat aaagcagtgc tgttttcaaa tgaagccgtg
     3181 tggatatttc agcgtgctgc tccctgttgt ctggaaacag ttgagttgga gcctgttgcc
     3241 aatgctgccc tctgccaccc tgtggctgcc ctggctctct ggtctctatc acccacacag
     3301 caccatctcc ccggcttggc ttggttagaa tggtgagggg tttacagggt aaggggacaa
     3361 gactacacac actagcgtgg taggactaga tttttgtttt ccccaccaag taaatgttca
     3421 cctgtgacct tgggctggga ttctctttag gaaaaaaggc tactactatg ttatgagagt
     3481 caaaaataac tccttgtgtt tgcttaattt attgtttaac accccctaac tgccgaaacc
     3541 aaagtgatac ggagtcgtct tgtctgcatt ttggcctcag catcattaac ttcaaagctt
     3601 tattctgtct gcctgagagg atccatggaa gatgattctc ccaaaaagca gaaaaagaaa
     3661 tgtcaggtta gaaggaccca agttctaggt gcacactttt gcaagcttcc tacaagccca
     3721 gactgactta cactaaccta actgctcagt ggctgtctag agacacttta ggaagataaa
     3781 ctgagcttga tcctcatcat atagccagtt ccatcactca ggtagtgcct gaatcaacct
     3841 tcagagcctg attagtcaca tatcattgga ggtcaaacgc catttccagt ggcctctctg
     3901 tgtgcccaca tgatgcaaag gggtcatgta ctatgccctg gacaaagaag tatgttttgc
     3961 ctatgtcccc ataccaggac cttctttcag aacgagggta gtattaccct atctgttgga
     4021 aaggatggtt tacatagcag ttccagcctc cttttgcttt ggccagttgg ccttctcact
     4081 ttgatagttt aactcaggta cccagtcttc actccatccc caggtgcttg ttcacctcat
     4141 taatgagcac ctagagcaag gaccaaaaga aggaaaacta attaaaacca atgcatattc
     4201 atgccaaaac aagtggtccc caagcctgtt taaaaggtta acttggcccg aaaatattgc
     4261 agcagcttca tgcaagaatt gccacaggac actatggcct tgctgggcta gcatttgctg
     4321 ctgtaatcta gttgctctgg tatagaagag aaccccatgg ggctgtggga gagacaattc
     4381 agtggcagcc cactggcttc tctacccatt ccacaggaac cctattccta cccccacccc
     4441 tgcccacaaa tgccactgtg atccacagct gaagttgttt ctaattgcct aaaggcagtc
     4501 tctgtgtctg gagcttcaaa gagacaggca gacctgcact aattcccttc ttcctctagc
     4561 agactgcctt gggaaggacc ttcagtccag gacagaccct gtcatggctt cttgctgtct
     4621 tacccttctc actcaccagg cccacagtcg cctgcactca gtgctgtttg taacacatct
     4681 gttattctgc ctacctgtac tttttgctgc ccatccctgt tgcctttgag tttcttggaa
     4741 ttgtggctgt cctcggaatc tcttttctat tcacagccct tctatagcct tgctctgatg
     4801 gttttagcac ttgatctgag agaagcttgc ccataattta atgcttcttt tccttaaaaa
     4861 ataaaaaaaa aaatcaaaaa aacccactaa agtgaagcat ttcttgattc ccttttccat
     4921 gctggtgcct agcccgggtg agtgaggctg gctgtgttgg cctgggtgac ttgtggttgt
     4981 agagttggcc atcattctgc actgttgata gctgtctgct ccagtttctg gtctttggta
     5041 tactcagtgt ggcccggtga tgaaggcttt ctactcctta acaggtacag ttggatccat
     5101 cgctgatggt gtttctttag ccccatccca attggcctaa aacatttgtc accagaacag
     5161 tggggaaaag ccttcctttc cagccatgtc tgacagtgag catgctttgg tgtggtcttc
     5221 actgcttttg gttttgcttc tgatcttgtg ttctaaggta ctcagtgaat cctggattct
     5281 gagtaagttc cagggttctg gccttgaagc cttggactac acacatttca aacaaaacca
     5341 aatgctgtcg tcgacaagcc agcacaggcg aagtgatggt tcccacagca cccccaataa
     5401 aaactgggat tttgaatgtg gctctacaag ttaaacattt ctgtgtgttg tgtatgctag
     5461 gtgatgccct cagaagggac tgactactag actgtaagtg tgttttatac aagtgtgtaa
     5521 gactaagact cacgtgcacg aatcgaagag taaagagaca atacttgtga acgtgtgaac
     5581 gttaacactg tagttgctag atcttaagct gctaattgtc gagagagaat tcagttgtgt
     5641 gctgtctggc tgctgtgcct tctcagcagc acttttgctg tacatacaat ggaaataaag
     5701 acctcagcta gaaacctgc
//
