LOCUS       NP_862904                722 aa            linear   ROD 08-APR-2025
DEFINITION  transmembrane channel-like protein 8 isoform C [Mus musculus].
ACCESSION   NP_862904
VERSION     NP_862904.1
DBSOURCE    REFSEQ: accession NM_181856.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 722)
  AUTHORS   Wong,M., Tu,H.F., Tseng,S.H., Mellinger-Pilgrim,R., Best,S.,
            Tsai,H.L., Xing,D., Hung,C.F., Lambert,P.F. and Roden,R.B.S.
  TITLE     MmuPV1 infection of Tmc6/Ever1 or Tmc8/Ever2 deficient FVB mice as
            a model of betaHPV in typical epidermodysplasia verruciformis
  JOURNAL   PLoS Pathog 21 (1), e1012837 (2025)
   PUBMED   39813296
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 722)
  AUTHORS   Torres,A.D., King,R.E., Uberoi,A., Buehler,D., Yoshida,S.,
            Ward-Shaw,E. and Lambert,P.F.
  TITLE     Deficiency in Ever2 does not increase susceptibility of mice to
            pathogenesis by the mouse papillomavirus, MmuPV1
  JOURNAL   J Virol 98 (7), e0017424 (2024)
   PUBMED   38869286
  REMARK    GeneRIF: Deficiency in Ever2 does not increase susceptibility of
            mice to pathogenesis by the mouse papillomavirus, MmuPV1.
REFERENCE   3  (residues 1 to 722)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (residues 1 to 722)
  AUTHORS   Wu,C.J., Li,X., Sommers,C.L., Kurima,K., Huh,S., Bugos,G., Dong,L.,
            Li,W., Griffith,A.J. and Samelson,L.E.
  TITLE     Expression of a TMC6-TMC8-CIB1 heterotrimeric complex in
            lymphocytes is regulated by each of the components
  JOURNAL   J Biol Chem 295 (47), 16086-16099 (2020)
   PUBMED   32917726
  REMARK    GeneRIF: Expression of a TMC6-TMC8-CIB1 heterotrimeric complex in
            lymphocytes is regulated by each of the components.
REFERENCE   5  (residues 1 to 722)
  AUTHORS   Kurima,K., Yang,Y., Sorber,K. and Griffith,A.J.
  TITLE     Characterization of the transmembrane channel-like (TMC) gene
            family: functional clues from hearing loss and epidermodysplasia
            verruciformis
  JOURNAL   Genomics 82 (3), 300-308 (2003)
   PUBMED   12906855
REFERENCE   6  (residues 1 to 722)
  AUTHORS   Keresztes,G., Mutai,H. and Heller,S.
  TITLE     TMC and EVER genes belong to a larger novel family, the TMC gene
            family encoding transmembrane proteins
  JOURNAL   BMC Genomics 4 (1), 24 (2003)
   PUBMED   12812529
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL645856.5.
            
            Transcript Variant: This variant (C) differs in the 5' UTR, lacks a
            portion of the 5' coding region, initiates translation at a
            downstream start codon and uses an alternate in-frame splice site
            in the 5' coding region, compared to variant A. The resulting
            protein (isoform C) has a distinct N-terminus and is shorter than
            isoform A.
            
            Sequence Note: This RefSeq record was created from genomic sequence
            data to make the sequence consistent with the reference genome
            assembly. The genomic coordinates used for the transcript record
            were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK156764.1, SRR13422590.620801.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..722
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 82.96 cM"
     Protein         1..722
                     /product="transmembrane channel-like protein 8 isoform C"
                     /note="epidermodysplasia verruciformis 2; transmembrane
                     channel-like protein 8; epidermodysplasia verruciformis
                     protein 2 homolog; transmembrane channel-like 8"
                     /calculated_mol_wt=82198
     Region          1..21
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TN58.2)"
     Site            6
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q7TN58.2)"
     Site            18
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q7TN58.2)"
     Site            119..139
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TN58.2)"
     Site            184
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q7TN58.2)"
     Site            205..225
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TN58.2)"
     Site            308..328
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TN58.2)"
     Region          366..534
                     /region_name="TMC domain.
                     /evidence=ECO:0000250|UniProtKB:Q8IU68"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TN58.2)"
     Site            375
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q7TN58.2)"
     Site            376..396
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TN58.2)"
     Region          422..532
                     /region_name="TMC"
                     /note="TMC domain; pfam07810"
                     /db_xref="CDD:462275"
     Site            431..451
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TN58.2)"
     Site            493..513
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TN58.2)"
     Site            537..557
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TN58.2)"
     Site            571
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q7TN58.2)"
     Site            599..619
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TN58.2)"
     Region          658..722
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TN58.2)"
     Site            658
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q7TN58.2)"
     Site            663
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q7TN58.2)"
     Site            673
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q7TN58.2)"
     Site            698
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q7TN58.2)"
     CDS             1..722
                     /gene="Tmc8"
                     /gene_synonym="Ever2; EVIN2; mFLJ00400"
                     /coded_by="NM_181856.2:173..2341"
                     /note="isoform C is encoded by transcript variant C"
                     /db_xref="CCDS:CCDS25689.1"
                     /db_xref="GeneID:217356"
                     /db_xref="MGI:MGI:2669037"
ORIGIN      
        1 mfrqwsvqsg paprrpesqa aseelweqev erlcasrtpv rmlpyamadk rfirelrepe
       61 gvkttfwqrw hrprrvarqh lreaeqrlar gfglwegaly eigglfgtgi qsyftflrfl
      121 lllnlltmll tacfvllplv wlrppelgpa lklrlqcsss plpqsdiprf hnplwniltg
      181 rafnntylfy gayragpess seysirlayl lspmvclllc fcgilqrmae glpqqtllgq
      241 ryrtplsakv fsswdfcirv weaatikkhe isnelkmele egrrvelaqq qtraqkacrl
      301 ltylrtnili vllvvgaisa ifwatkysqd nkeeslflvl qylppgvisl vnflgpqlft
      361 vliqlenypp gtevnltliw cvvlklaslg mfsfslgqtv lcigrnktsc esygynacdy
      421 qcwensvgee lykliifnfl ltvafaflvs lprrllverf sgwfwtwldr eeflvpknvl
      481 divaaqtvtw mglfycpllp llnsvflflt fyikkytllr nsrasprrfr assstfffhl
      541 vlllglllaa vplayvisst hsswdcglft nysapwqvvp elvalqlplp sqralrylss
      601 hafsfpllil lsivltvcis qsranaraiq glrkqlvwqv qekwhlvddl srllpelspe
      661 pgsphsrasr prsfcpgfpc pgspgprtpr lapsnrlsss slgapsasvp asrfhfpsrt
      721 el
//
