LOCUS       NM_172476               4536 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus transmembrane channel-like gene family 7 (Tmc7), mRNA.
ACCESSION   NM_172476 XM_913351
VERSION     NM_172476.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4536)
  AUTHORS   Wang,J., Yin,Y., Yang,L., Qin,J., Wang,Z., Qiu,C., Gao,Y., Lu,G.,
            Gao,F., Chen,Z.J., Zhang,X., Liu,H. and Liu,Z.
  TITLE     TMC7 deficiency causes acrosome biogenesis defects and male
            infertility in mice
  JOURNAL   Elife 13, 95888 (2024)
   PUBMED   39269275
  REMARK    GeneRIF: TMC7 deficiency causes acrosome biogenesis defects and
            male infertility in mice.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4536)
  AUTHORS   Zhang,X., Shao,J., Wang,C., Liu,C., Hao,H., Li,X., An,Y., He,J.,
            Zhao,W., Zhao,Y., Kong,Y., Jia,Z., Wan,S., Yuan,Y., Zhang,H.,
            Zhang,H. and Du,X.
  TITLE     TMC7 functions as a suppressor of Piezo2 in primary sensory neurons
            blunting peripheral mechanotransduction
  JOURNAL   Cell Rep 43 (4), 114014 (2024)
   PUBMED   38568807
REFERENCE   3  (bases 1 to 4536)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 4536)
  AUTHORS   Kurima,K., Yang,Y., Sorber,K. and Griffith,A.J.
  TITLE     Characterization of the transmembrane channel-like (TMC) gene
            family: functional clues from hearing loss and epidermodysplasia
            verruciformis
  JOURNAL   Genomics 82 (3), 300-308 (2003)
   PUBMED   12906855
REFERENCE   5  (bases 1 to 4536)
  AUTHORS   Keresztes,G., Mutai,H. and Heller,S.
  TITLE     TMC and EVER genes belong to a larger novel family, the TMC gene
            family encoding transmembrane proteins
  JOURNAL   BMC Genomics 4 (1), 24 (2003)
   PUBMED   12812529
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124444.4 and AC122912.2.
            
            On Mar 29, 2023 this sequence version replaced NM_172476.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK083189.1, AK132820.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-125               AC124444.4         84557-84681
            126-366             AC122912.2         249575-249815       c
            367-515             AC122912.2         247607-247755       c
            516-683             AC122912.2         244381-244548       c
            684-766             AC122912.2         242246-242328       c
            767-912             AC122912.2         239213-239358       c
            913-1060            AC122912.2         236088-236235       c
            1061-1234           AC122912.2         234526-234699       c
            1235-1392           AC122912.2         233325-233482       c
            1393-1510           AC122912.2         230994-231111       c
            1511-1608           AC122912.2         230707-230804       c
            1609-1795           AC122912.2         228992-229178       c
            1796-1926           AC122912.2         226689-226819       c
            1927-2082           AC122912.2         225276-225431       c
            2083-2161           AC122912.2         222805-222883       c
            2162-4536           AC122912.2         219233-221607       c
FEATURES             Location/Qualifiers
     source          1..4536
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 63.44 cM"
     gene            1..4536
                     /gene="Tmc7"
                     /gene_synonym="1700030H01Rik; C230064B05; C630024K23Rik"
                     /note="transmembrane channel-like gene family 7"
                     /db_xref="GeneID:209760"
                     /db_xref="MGI:MGI:2443317"
     exon            1..125
                     /gene="Tmc7"
                     /gene_synonym="1700030H01Rik; C230064B05; C630024K23Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..2242
                     /gene="Tmc7"
                     /gene_synonym="1700030H01Rik; C230064B05; C630024K23Rik"
                     /codon_start=1
                     /product="transmembrane channel-like protein 7"
                     /protein_id="NP_766064.2"
                     /db_xref="CCDS:CCDS21772.1"
                     /db_xref="GeneID:209760"
                     /db_xref="MGI:MGI:2443317"
                     /translation="MSEGSAGDPGHGSSRQRAVHPENLSLGSSCFSPPVNFLQELPSY
                     RSVARRRTNILSRDKQSGTLLKPTDSFSCQLDGGITENLNSQSIRKYALNISEKRRLR
                     DIQETQMKYLSEWDQWKRYSSKSWKRFLEKAREMTTHLELWRKDIRSIEGKFGTGIQS
                     YFSFLRFLVVLNLVIFLIIFMLVLLPILLTKYKITNSTFVLIPFKDMDIQCTLYPISS
                     SGLIYFYSYIIDLLSGTGFLEETSLFYGHYTIDGVKFQSFTYDLPLAYLISTIAYLAL
                     SLLWIVKRSVEGFKINLIRSEEHFQSYCNKIFAGWDFCITNRSMAELKHSSLRYELRA
                     DLEEERIRQKIAERTSEETIRIYTLRLFLNCIVLAVLAACFYAIYLATAFSQEHMKKE
                     IDKMVFGENLLILYLPSIVITLANFITPIIFAKIIHYEDYSPGFEIRLTILRCVFMRL
                     ATICVLVFTLGSKITSCGDSTCELCGYNQKLYPCWETQVGQEMYKLMIFDFIIILAVT
                     LFVDFPRKLLVTYCASSKLIQCWGQQEFAIPDNVLGIVYGQTICWIGAFFSPLLPAIA
                     TLKFVIIFYVKELSLLYTCRPSPRQFRASNSNFFFLLVLLIGLCLAIIPLTISMARIP
                     SSKACGPFTNFNTTWEVIPQTVSTFPSSLQTLIHAVTSEAFAVPFFMIICLVMFYFIA
                     LAGAHKQVVVQLREQLSLESRDKRYLIQKLTEAQREVRSQPASA"
     exon            126..366
                     /gene="Tmc7"
                     /gene_synonym="1700030H01Rik; C230064B05; C630024K23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            367..515
                     /gene="Tmc7"
                     /gene_synonym="1700030H01Rik; C230064B05; C630024K23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            516..683
                     /gene="Tmc7"
                     /gene_synonym="1700030H01Rik; C230064B05; C630024K23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            684..766
                     /gene="Tmc7"
                     /gene_synonym="1700030H01Rik; C230064B05; C630024K23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            767..912
                     /gene="Tmc7"
                     /gene_synonym="1700030H01Rik; C230064B05; C630024K23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1060
                     /gene="Tmc7"
                     /gene_synonym="1700030H01Rik; C230064B05; C630024K23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1234
                     /gene="Tmc7"
                     /gene_synonym="1700030H01Rik; C230064B05; C630024K23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..1392
                     /gene="Tmc7"
                     /gene_synonym="1700030H01Rik; C230064B05; C630024K23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1393..1510
                     /gene="Tmc7"
                     /gene_synonym="1700030H01Rik; C230064B05; C630024K23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1511..1608
                     /gene="Tmc7"
                     /gene_synonym="1700030H01Rik; C230064B05; C630024K23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1609..1795
                     /gene="Tmc7"
                     /gene_synonym="1700030H01Rik; C230064B05; C630024K23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1796..1926
                     /gene="Tmc7"
                     /gene_synonym="1700030H01Rik; C230064B05; C630024K23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1927..2082
                     /gene="Tmc7"
                     /gene_synonym="1700030H01Rik; C230064B05; C630024K23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2083..2161
                     /gene="Tmc7"
                     /gene_synonym="1700030H01Rik; C230064B05; C630024K23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2162..4536
                     /gene="Tmc7"
                     /gene_synonym="1700030H01Rik; C230064B05; C630024K23Rik"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2489
                     /gene="Tmc7"
                     /gene_synonym="1700030H01Rik; C230064B05; C630024K23Rik"
                     /note="major polyA site"
     regulatory      3308..3313
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmc7"
                     /gene_synonym="1700030H01Rik; C230064B05; C630024K23Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3336
                     /gene="Tmc7"
                     /gene_synonym="1700030H01Rik; C230064B05; C630024K23Rik"
     regulatory      3592..3597
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmc7"
                     /gene_synonym="1700030H01Rik; C230064B05; C630024K23Rik"
                     /note="hexamer: TATAAA"
     polyA_site      3612
                     /gene="Tmc7"
                     /gene_synonym="1700030H01Rik; C230064B05; C630024K23Rik"
     regulatory      4516..4521
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmc7"
                     /gene_synonym="1700030H01Rik; C230064B05; C630024K23Rik"
                     /note="hexamer: AATAAA"
     polyA_site      4536
                     /gene="Tmc7"
                     /gene_synonym="1700030H01Rik; C230064B05; C630024K23Rik"
                     /note="major polyA site"
ORIGIN      
        1 atctggaacc cgacaaggca gggccgccgg caggcggctg gagggtcctc gccgagccgt
       61 gatgagcgag ggcagcgcgg gcgacccggg ccacgggtcc agccggcagc gggccgtaca
      121 cccagagaac ctgtctctgg gttctagctg tttctctcca cctgtgaact tccttcaaga
      181 gctgccaagc tatcggtcag tggcacgtag gagaacaaac atcctctctc gggacaagca
      241 aagtggcacc ctgctgaagc cgacagactc tttcagttgc cagctggatg gaggaatcac
      301 agaaaacctc aacagccaat ccatccgcaa gtatgcactg aacatctctg agaagcggag
      361 actaagggac attcaggaaa cccaaatgaa gtatttatca gagtgggacc agtggaaacg
      421 gtacagcagc aagtcctgga agaggttcct agagaaagct cgagagatga caacccacct
      481 ggaactgtgg cgcaaagaca tccgcagcat tgaaggaaag tttggcacgg ggatccagtc
      541 ctacttctca ttcctgcggt tcctggtggt gctgaacctg gtgatattcc tgatcatctt
      601 catgttggtt ttgcttccaa tcctactcac caagtacaag attaccaaca gcacttttgt
      661 gctcatcccg ttcaaagaca tggatattca gtgcacactg tatccaataa gtagctctgg
      721 gctcatttac ttctacagtt acatcataga cctgctgtct ggaacaggat tcttggagga
      781 gaccagcctt ttttatgggc actacaccat tgatggtgta aagttccaga gcttcacgta
      841 tgacctgccc ctggcttact tgataagcac gattgcctac ctggccctga gcctcctttg
      901 gatcgtgaaa aggtcggtgg aagggttcaa gatcaacctg attcggagcg aggaacactt
      961 tcagagttac tgtaataaga tcttcgctgg ctgggacttc tgcatcacca accgcagcat
     1021 ggctgagctg aagcacagca gcttgcggta cgagctccga gcagatctgg aagaagagag
     1081 aatacgacag aaaatagcag aaaggacctc agaggagacc atccgcattt acactttgag
     1141 gctgtttttg aactgcattg tgcttgctgt gctagcggca tgcttttatg caatctacct
     1201 agcaactgcc ttctcacagg aacacatgaa aaaagaaatt gacaagatgg tttttgggga
     1261 gaacctgttg atattgtacc tcccgtccat tgtgattacc ctggccaatt tcattacccc
     1321 aatcatcttt gccaagatca tccactacga ggattactcg ccaggctttg agatccgcct
     1381 gacgattctt aggtgtgtct ttatgcggct ggccaccatc tgtgtgctgg tgttcacgct
     1441 gggctccaag atcacatcct gtggtgacag cacgtgtgaa ctctgcggct ataaccagaa
     1501 actctacccg tgctgggaga ctcaggtggg acaggaaatg tacaagctga tgatcttcga
     1561 cttcatcatc atcctggccg tgacgctgtt tgtggatttc cctaggaagc tcctggtgac
     1621 ctactgtgcc tcctcaaagc tgatccagtg ctggggccag caggaattcg ccatccccga
     1681 caatgtcctg ggcatcgtgt acgggcagac catctgttgg attggagcct tcttctcccc
     1741 actcctccct gccattgcca ccttgaaatt cgttatcatc ttttatgtga aagagttgag
     1801 tcttctctac acctgcagac cctccccgag gcagttcaga gcatccaatt ctaacttctt
     1861 cttcctgctg gtgttgctga ttgggctgtg cctagcaatc atacctctga ccatcagcat
     1921 ggctcgcatc ccttcctcaa aagcctgcgg cccatttacc aacttcaaca ccacctggga
     1981 agtgattcct cagactgtga gcaccttccc cagctcgctg cagaccctga tccatgccgt
     2041 tacatcagaa gccttcgcgg tgcctttctt catgatcatc tgccttgtca tgttctactt
     2101 cattgcactg gctggagcac acaagcaggt ggttgtacag cttcgagagc agctgtccct
     2161 ggagagtcgt gacaagcgtt atcttatcca gaaactaaca gaagctcaaa gggaggtccg
     2221 gagccagccg gcttcagcat gaagatgctg cccgaaactt ctcaacacat agctctgatg
     2281 accctacaga gtccacctgg ggtttgagtg gaagtgactt ttggtggctt agccaaacag
     2341 gctgaccccc agcctgatcc ccagggagtg gtgactccac caaaacactt aacttctcga
     2401 gctgctcagc ctctcacgat cagagagggg agacttttat ttattttttg tttagacttt
     2461 tgtatatttt taaaaaaggg ttgtgtgtgt gtgtgtgtgt gtgttttttt ttttttttag
     2521 agtaaaactg agatttctcc gaaagccttc ccaggccgag tgaataccct ccaagatgcc
     2581 actggtgact tcaaattaaa cctgacttcc tttttcagat gagcaggaat cttcagatgc
     2641 tgaggcttag aacagctgat aggaacgtgg agaggccgtc ctggcagaaa ggcagaaagg
     2701 aaatccatcc ccgctgtgta ccccatcaca cttgaattcc cacccatgcc cagtcagtat
     2761 cacccccttg aggagaggac taggccaggt ggcaatttca gctttttgga acttttctcc
     2821 agccttgttc actcctccag ggaaagtgac cttagccaac tggttagcca ttagccttta
     2881 gtctccacct ggccccaatt tctaagattt ggtgacagaa ttgaagaggg gtttaacttt
     2941 gcaaggtgca caggcagttc ctctgttttc caagtgttat tcctcttccg tgcatggagc
     3001 tgttcattcc tgaaagatgc agagtgattc agagctaggc tgcaatatgc tttttggaat
     3061 tggagctggg tttaaggagc aggggtttta tgtatgattt caggtgtagg tccacagccc
     3121 agcctgttcc taagaacgcc ccataataca aacaaaggtt gggttctgat tacttaagta
     3181 cacatgtcaa agggctagat tttgtttgcc tgagtttaaa actttgtgtg tgtgttcctt
     3241 tgtttttata aaacattaca aagacagagt atctcttgag atctccagca tagtaaaagc
     3301 tgtatttaat aaatacctca tcataagcct cccttatggg gcgtcccttt tagtggtgtc
     3361 taatttgatc tgctttcact ttaaggtctt tgtcaatgta ctgcagtcct gtgatgggac
     3421 tgtggagtct ttactgtttt ccactggctc ctaaccttta aatttcaatt aatgtttcag
     3481 aaagctgcca agatggactt ccctgctctg atcactgcct tgttcctcaa aaatgattgg
     3541 cttccctctg ggagcaaagc aaactcgttg tagcttccat gtctgtgtgt gtataaaggg
     3601 tgctttgtca gatgtgtgtg tgtctgtgtg tattgatgtg tgtgtgtcca tatcttacat
     3661 gtgtgaattc gtataaaggg cccttggtga ggggtgtgtg tgtgtgtgtg catatgtaca
     3721 tctggaggcg gaactcatat cctcaagctc tacacaatca tttccgtcat cttccatgag
     3781 gctgttaacc tgggatattt ttgttcctgt gggaacatgt gctttgtaac attttcttgt
     3841 attttaagat ctatgagttt taaagcctaa caacaggagt tttgaataaa ccaaagttta
     3901 ctccattctc attctacaaa tcctggttgc tggcattttt gcctagtgcc ttcatgaagc
     3961 attcttgtcc tcactgtggc cctgaggata atctgctgtc ctatgtttgt aggaatggta
     4021 gataaaataa acaacatatt ttctttatta taaaacagat aacaaaatat gccaattggt
     4081 atgttggttt tagttagtgc tgctaatgtg tgcacctcct acttgaatat tttaataact
     4141 tggaataacc aggcaatgtc tgtatagctt taaagtgcgg ctctctaacg ggtgtgtgtt
     4201 aaactcctga ttccgtgtct tgaaagtttt agagtatggt tgtcctcaaa cccacagacg
     4261 ctcttcatca ctggttaagt gatgaagaga actgcaatac tcagtaaagt tgctctttgt
     4321 cactgcagtt agaggaagta gcattttgac atcgatggat gtgttagatg agtcttgtct
     4381 cctcttggct attaagaagc caaagaaaag caggtttgtg tgttttgaac gtcaaagaca
     4441 atatcttaag cattttatat cttgctacca ttgaaagcca ctgtttgtat ttattttaat
     4501 attctataaa tatataataa atattgaaag tagcta
//
