LOCUS       NM_145439               2945 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus transmembrane channel-like gene family 6 (Tmc6),
            transcript variant 1, mRNA.
ACCESSION   NM_145439
VERSION     NM_145439.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2945)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2945)
  AUTHORS   Wu,C.J., Li,X., Sommers,C.L., Kurima,K., Huh,S., Bugos,G., Dong,L.,
            Li,W., Griffith,A.J. and Samelson,L.E.
  TITLE     Expression of a TMC6-TMC8-CIB1 heterotrimeric complex in
            lymphocytes is regulated by each of the components
  JOURNAL   J Biol Chem 295 (47), 16086-16099 (2020)
   PUBMED   32917726
  REMARK    GeneRIF: Expression of a TMC6-TMC8-CIB1 heterotrimeric complex in
            lymphocytes is regulated by each of the components.
REFERENCE   3  (bases 1 to 2945)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2945)
  AUTHORS   Liakath-Ali,K., Vancollie,V.E., Heath,E., Smedley,D.P., Estabel,J.,
            Sunter,D., Ditommaso,T., White,J.K., Ramirez-Solis,R., Smyth,I.,
            Steel,K.P. and Watt,F.M.
  TITLE     Novel skin phenotypes revealed by a genome-wide mouse reverse
            genetic screen
  JOURNAL   Nat Commun 5, 3540 (2014)
   PUBMED   24721909
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2945)
  AUTHORS   Kurima,K., Yang,Y., Sorber,K. and Griffith,A.J.
  TITLE     Characterization of the transmembrane channel-like (TMC) gene
            family: functional clues from hearing loss and epidermodysplasia
            verruciformis
  JOURNAL   Genomics 82 (3), 300-308 (2003)
   PUBMED   12906855
REFERENCE   6  (bases 1 to 2945)
  AUTHORS   Keresztes,G., Mutai,H. and Heller,S.
  TITLE     TMC and EVER genes belong to a larger novel family, the TMC gene
            family encoding transmembrane proteins
  JOURNAL   BMC Genomics 4 (1), 24 (2003)
   PUBMED   12812529
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL645856.5, AK052814.1, AY263158.1 and BP767442.1.
            
            On Mar 1, 2018 this sequence version replaced NM_145439.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC058195.1, AY263158.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-71                AL645856.5         71265-71335         c
            72-668              AK052814.1         3-599
            669-2590            AY263158.1         585-2506
            2591-2945           BP767442.1         27-381              c
FEATURES             Location/Qualifiers
     source          1..2945
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 82.96 cM"
     gene            1..2945
                     /gene="Tmc6"
                     /gene_synonym="D11Ertd204e; EVER1"
                     /note="transmembrane channel-like gene family 6"
                     /db_xref="GeneID:217353"
                     /db_xref="MGI:MGI:1098686"
     exon            1..157
                     /gene="Tmc6"
                     /gene_synonym="D11Ertd204e; EVER1"
                     /inference="alignment:Splign:2.1.0"
     exon            158..286
                     /gene="Tmc6"
                     /gene_synonym="D11Ertd204e; EVER1"
                     /inference="alignment:Splign:2.1.0"
     exon            287..402
                     /gene="Tmc6"
                     /gene_synonym="D11Ertd204e; EVER1"
                     /inference="alignment:Splign:2.1.0"
     exon            403..498
                     /gene="Tmc6"
                     /gene_synonym="D11Ertd204e; EVER1"
                     /inference="alignment:Splign:2.1.0"
     exon            499..657
                     /gene="Tmc6"
                     /gene_synonym="D11Ertd204e; EVER1"
                     /inference="alignment:Splign:2.1.0"
     exon            658..763
                     /gene="Tmc6"
                     /gene_synonym="D11Ertd204e; EVER1"
                     /inference="alignment:Splign:2.1.0"
     exon            764..860
                     /gene="Tmc6"
                     /gene_synonym="D11Ertd204e; EVER1"
                     /inference="alignment:Splign:2.1.0"
     exon            861..1118
                     /gene="Tmc6"
                     /gene_synonym="D11Ertd204e; EVER1"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1309
                     /gene="Tmc6"
                     /gene_synonym="D11Ertd204e; EVER1"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..1454
                     /gene="Tmc6"
                     /gene_synonym="D11Ertd204e; EVER1"
                     /inference="alignment:Splign:2.1.0"
     exon            1455..1610
                     /gene="Tmc6"
                     /gene_synonym="D11Ertd204e; EVER1"
                     /inference="alignment:Splign:2.1.0"
     exon            1611..1762
                     /gene="Tmc6"
                     /gene_synonym="D11Ertd204e; EVER1"
                     /inference="alignment:Splign:2.1.0"
     exon            1763..1942
                     /gene="Tmc6"
                     /gene_synonym="D11Ertd204e; EVER1"
                     /inference="alignment:Splign:2.1.0"
     exon            1943..2038
                     /gene="Tmc6"
                     /gene_synonym="D11Ertd204e; EVER1"
                     /inference="alignment:Splign:2.1.0"
     exon            2039..2114
                     /gene="Tmc6"
                     /gene_synonym="D11Ertd204e; EVER1"
                     /inference="alignment:Splign:2.1.0"
     exon            2115..2248
                     /gene="Tmc6"
                     /gene_synonym="D11Ertd204e; EVER1"
                     /inference="alignment:Splign:2.1.0"
     exon            2249..2425
                     /gene="Tmc6"
                     /gene_synonym="D11Ertd204e; EVER1"
                     /inference="alignment:Splign:2.1.0"
     exon            2426..2504
                     /gene="Tmc6"
                     /gene_synonym="D11Ertd204e; EVER1"
                     /inference="alignment:Splign:2.1.0"
     exon            2505..2572
                     /gene="Tmc6"
                     /gene_synonym="D11Ertd204e; EVER1"
                     /inference="alignment:Splign:2.1.0"
     exon            2573..2921
                     /gene="Tmc6"
                     /gene_synonym="D11Ertd204e; EVER1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2899..2904
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmc6"
                     /gene_synonym="D11Ertd204e; EVER1"
                     /note="hexamer: ATTAAA"
     polyA_site      2921
                     /gene="Tmc6"
                     /gene_synonym="D11Ertd204e; EVER1"
                     /note="major polyA site"
ORIGIN      
        1 gtgacctttg gggcccggtg ccacgtgggc gggcggtgag gctacctcca gctgccagtc
       61 tggaaaccat caaaactatg tacccttaat tactgtgtgc tgattctcct gctggtgggg
      121 ctgagacctc ggttccccgc ggcgggtgcg cgcacagatg ggctgtatgg ggttccacag
      181 gctgcgtcca gtctctgagc tcccctaggt ctgcagggta tagcacagcc atggctcagt
      241 cactggcttt agccctcgat gtcccggaga ccacgggaga cgaaggcctg gagcccagcc
      301 cctatgaaga aagtgaagtc catgactcct tccaccagct cattcaagag caaagccttc
      361 gggtggcgga ggaggggctg gagctactgc ccttgggtct aggcagaggt gaccagaccc
      421 tcccaggact tgaaggtgct cctgccctta gctcggccac tctccgcatc ctggccagca
      481 tgcccagccg taccattggt cgcagccgtg gggccatcat ctcccaatac tacaaccgca
      541 cagtgaggct tcggcgcagg agcagccggc ccttgctggg caatgtggtg ccctctgccc
      601 ggcccagcct tcgcctgtat gacctggagc tggactccac aatcttggag gaggatgaga
      661 agcggagcct gctagtaaag gagcttcaag gtctgtcggc ggcccagagg gaccacatgg
      721 tgcggaacat gcccttgagt ctgggtgaga agcgctgtct tcgagagaaa agttggagcc
      781 caaagggaaa gcggcggcac ctgcagggtc gaagcggggc cttctcctgc tgtagccggc
      841 tcagatacac ctgcatgctg gctcttcata gcctggggct ggcactgctc tcaggcctgt
      901 atgctgccag gccgtggcgc tatgctctga agcagatcgg tggccagttt ggctccagcg
      961 tcctctccta cttcctcttc ctcaagaccc tgttggcctt caacgcgctg atgttgctgc
     1021 ctttgctggc cttcctcgtg ggtgttcagg ctgcctttcc acctgaccca gcaggccccg
     1081 tgcctacgtt ttctggtctg gaactcctca caggcggggg ccggttcaca cacacagtta
     1141 tgtactacgg ctactacagt aacagcacgc tgagcccgtc atgtgacgcc cctcgggaag
     1201 gtggccagtg cagtcccagg ctgggcagcc tgccctataa catgccgctg gcctacctct
     1261 tcacaatggg ggccaccttc ttccttacct gcatcattct ggtatacagc atgtcccact
     1321 cctttgggga gagctaccgg gttggcagta ccaagggtat ccatgccctt acggtcttct
     1381 gctcctggga ctacaaggtg acacagaaga gggcttcccg tgtccaacag gacagcatct
     1441 gcactcagct gaaggagctg ttggctgaat ggcaccttcg aaagcgccct cggagtgtgt
     1501 gcgggcagct gaggcaggtc gtcgttctag gtctggggtg gctgctgtgt ctgggctcca
     1561 caatgggctg cacggtggct gtcctcacct tctcagaggt aatgattcag agacctgctt
     1621 ctggtggcca gggggtggag gcgttggcct tgcccctggt ggtcagtgtc cttaacctgg
     1681 gtgcctccta cctgttccgt ggtctagcca ctctggagcg acatgactcc cctgtgttgg
     1741 aggtatacat ggccatctgc aggaacctca tcctgaagat ggccgtcctg ggtgtgcttt
     1801 gctatcactg gctgggccgc agggtggcca ccctgcaggg tcagtgctgg gaggactttg
     1861 tgggccagga gctgtaccgc ttcatggtcg tggatttcat cttcatgctc ttggactccc
     1921 tttttggaga gttggtgtgg aggctcatct cagagaagaa gctcaagagg gggcagaagc
     1981 ctgagtttga cattgccagg aatgtgctgg acctgattta tggacagaca ctgacctggc
     2041 tgggcgtcct gttctcaccg ctcctgcctg cagtacagat tctccggctg ctcttccttt
     2101 tccacatcaa gaaggccagc ctgatggcca actgccaggc accacgccga ccctggctgg
     2161 cctcgcacat gagcactgtc ttcctcacct tgctctgctt cccgtcgttc ctgggcgctg
     2221 ctgttttcct ctgctatgct gtctggcagg tgaggccctc gagcacttgt ggccctttcc
     2281 ggactctgaa caccatgtat gaagcaggca cggtctgggt gcgtcgcctg gagcatgcag
     2341 gctccggagc ctcctggctg ccctggctgc accacttcct ggtggagaac actttcttcc
     2401 tcttcctggc ttcagccctg ctgctggctg tcatctactt caacatccag gtggtgaaag
     2461 gacaacggaa ggtcatctgc ctgctcaagg agcagatccg gaatgaagga gaggacaaga
     2521 tcttcctgat caacaagctt cactctgttt acgaggagga gggaaggagc aggcctggca
     2581 gaacccagga cactactgaa ccacctgcct ggcatgagga tggaggggac cagaaggaac
     2641 cctgtaaccc ccggtcacca tgatcctgca agcagagact tggacctgag atccccacag
     2701 gatgtggcag tagagtgact tcccatgaac tctagttggc atagagcaag aatgtgggat
     2761 gtgggacccc ttcccctggt agggtgtatc tacatagccc tggggtgtcc tggcactctg
     2821 ttgacctggc tgaccttgaa gtcagagatc cacctgcttc tcccttccaa gtgctgaaac
     2881 cagaggtgtg caccccctat taaatgggtt ttgctacatg aaaaaaaaaa aaaaaaaaaa
     2941 aaaaa
//
