LOCUS       NP_663414                810 aa            linear   ROD 08-APR-2025
DEFINITION  transmembrane channel-like protein 6 [Mus musculus].
ACCESSION   NP_663414
VERSION     NP_663414.3
DBSOURCE    REFSEQ: accession NM_145439.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 810)
  AUTHORS   Wong,M., Tu,H.F., Tseng,S.H., Mellinger-Pilgrim,R., Best,S.,
            Tsai,H.L., Xing,D., Hung,C.F., Lambert,P.F. and Roden,R.B.S.
  TITLE     MmuPV1 infection of Tmc6/Ever1 or Tmc8/Ever2 deficient FVB mice as
            a model of betaHPV in typical epidermodysplasia verruciformis
  JOURNAL   PLoS Pathog 21 (1), e1012837 (2025)
   PUBMED   39813296
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 810)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (residues 1 to 810)
  AUTHORS   Wu,C.J., Li,X., Sommers,C.L., Kurima,K., Huh,S., Bugos,G., Dong,L.,
            Li,W., Griffith,A.J. and Samelson,L.E.
  TITLE     Expression of a TMC6-TMC8-CIB1 heterotrimeric complex in
            lymphocytes is regulated by each of the components
  JOURNAL   J Biol Chem 295 (47), 16086-16099 (2020)
   PUBMED   32917726
  REMARK    GeneRIF: Expression of a TMC6-TMC8-CIB1 heterotrimeric complex in
            lymphocytes is regulated by each of the components.
REFERENCE   4  (residues 1 to 810)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 810)
  AUTHORS   Liakath-Ali,K., Vancollie,V.E., Heath,E., Smedley,D.P., Estabel,J.,
            Sunter,D., Ditommaso,T., White,J.K., Ramirez-Solis,R., Smyth,I.,
            Steel,K.P. and Watt,F.M.
  TITLE     Novel skin phenotypes revealed by a genome-wide mouse reverse
            genetic screen
  JOURNAL   Nat Commun 5, 3540 (2014)
   PUBMED   24721909
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 810)
  AUTHORS   Kurima,K., Yang,Y., Sorber,K. and Griffith,A.J.
  TITLE     Characterization of the transmembrane channel-like (TMC) gene
            family: functional clues from hearing loss and epidermodysplasia
            verruciformis
  JOURNAL   Genomics 82 (3), 300-308 (2003)
   PUBMED   12906855
REFERENCE   7  (residues 1 to 810)
  AUTHORS   Keresztes,G., Mutai,H. and Heller,S.
  TITLE     TMC and EVER genes belong to a larger novel family, the TMC gene
            family encoding transmembrane proteins
  JOURNAL   BMC Genomics 4 (1), 24 (2003)
   PUBMED   12812529
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL645856.5, AK052814.1, AY263158.1 and BP767442.1.
            
            On Nov 10, 2009 this sequence version replaced NP_663414.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC058195.1, AY263158.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..810
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 82.96 cM"
     Protein         1..810
                     /product="transmembrane channel-like protein 6"
                     /calculated_mol_wt=90445
     Region          1..26
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TN60.2)"
     Site            88
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q7Z403; propagated from
                     UniProtKB/Swiss-Prot (Q7TN60.2)"
     Site            93
                     /site_type="methylation"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0007744|PubMed:24129315; propagated from
                     UniProtKB/Swiss-Prot (Q7TN60.2)"
     Site            102
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q7TN60.2)"
     Site            104
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q7Z403; propagated from
                     UniProtKB/Swiss-Prot (Q7TN60.2)"
     Site            136
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q7TN60.2)"
     Site            206..226
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TN60.2)"
     Site            254..274
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TN60.2)"
     Site            311
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q7TN60.2)"
     Site            339..359
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TN60.2)"
     Site            430..450
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TN60.2)"
     Site            469..489
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TN60.2)"
     Site            505..525
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TN60.2)"
     Region          539..645
                     /region_name="TMC"
                     /note="TMC domain; pfam07810"
                     /db_xref="CDD:462275"
     Site            553..573
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TN60.2)"
     Site            604..624
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TN60.2)"
     Site            650..670
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TN60.2)"
     Site            722..742
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TN60.2)"
     Region          775..810
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TN60.2)"
     CDS             1..810
                     /gene="Tmc6"
                     /gene_synonym="D11Ertd204e; EVER1"
                     /coded_by="NM_145439.3:231..2663"
                     /db_xref="CCDS:CCDS25687.1"
                     /db_xref="GeneID:217353"
                     /db_xref="MGI:MGI:1098686"
ORIGIN      
        1 maqslalald vpettgdegl epspyeesev hdsfhqliqe qslrvaeegl ellplglgrg
       61 dqtlpglega palssatlri lasmpsrtig rsrgaiisqy ynrtvrlrrr ssrpllgnvv
      121 psarpslrly dleldstile edekrsllvk elqglsaaqr dhmvrnmpls lgekrclrek
      181 swspkgkrrh lqgrsgafsc csrlrytcml alhslglall sglyaarpwr yalkqiggqf
      241 gssvlsyflf lktllafnal mllpllaflv gvqaafppdp agpvptfsgl elltgggrft
      301 htvmyygyys nstlspscda preggqcspr lgslpynmpl aylftmgatf fltciilvys
      361 mshsfgesyr vgstkgihal tvfcswdykv tqkrasrvqq dsictqlkel laewhlrkrp
      421 rsvcgqlrqv vvlglgwllc lgstmgctva vltfsevmiq rpasggqgve alalplvvsv
      481 lnlgasylfr glatlerhds pvlevymaic rnlilkmavl gvlcyhwlgr rvatlqgqcw
      541 edfvgqelyr fmvvdfifml ldslfgelvw rlisekklkr gqkpefdiar nvldliygqt
      601 ltwlgvlfsp llpavqilrl lflfhikkas lmancqaprr pwlashmstv fltllcfpsf
      661 lgaavflcya vwqvrpsstc gpfrtlntmy eagtvwvrrl ehagsgaswl pwlhhflven
      721 tfflflasal llaviyfniq vvkgqrkvic llkeqirneg edkiflinkl hsvyeeegrs
      781 rpgrtqdtte ppawhedggd qkepcnprsp
//
