LOCUS       NM_001105252            3774 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus transmembrane channel-like gene family 5 (Tmc5),
            transcript variant 1, mRNA.
ACCESSION   NM_001105252
VERSION     NM_001105252.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3774)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3774)
  AUTHORS   Kurima,K., Yang,Y., Sorber,K. and Griffith,A.J.
  TITLE     Characterization of the transmembrane channel-like (TMC) gene
            family: functional clues from hearing loss and epidermodysplasia
            verruciformis
  JOURNAL   Genomics 82 (3), 300-308 (2003)
   PUBMED   12906855
REFERENCE   3  (bases 1 to 3774)
  AUTHORS   Keresztes,G., Mutai,H. and Heller,S.
  TITLE     TMC and EVER genes belong to a larger novel family, the TMC gene
            family encoding transmembrane proteins
  JOURNAL   BMC Genomics 4 (1), 24 (2003)
   PUBMED   12812529
REFERENCE   4  (bases 1 to 3774)
  AUTHORS   Carninci,P., Waki,K., Shiraki,T., Konno,H., Shibata,K., Itoh,M.,
            Aizawa,K., Arakawa,T., Ishii,Y., Sasaki,D., Bono,H., Kondo,S.,
            Sugahara,Y., Saito,R., Osato,N., Fukuda,S., Sato,K., Watahiki,A.,
            Hirozane-Kishikawa,T., Nakamura,M., Shibata,Y., Yasunishi,A.,
            Kikuchi,N., Yoshiki,A., Kusakabe,M., Gustincich,S., Beisel,K.,
            Pavan,W., Aidinis,V., Nakagawara,A., Held,W.A., Iwata,H., Kono,T.,
            Nakauchi,H., Lyons,P., Wells,C., Hume,D.A., Fagiolini,M.,
            Hensch,T.K., Brinkmeier,M., Camper,S., Hirota,J., Mombaerts,P.,
            Muramatsu,M., Okazaki,Y., Kawai,J. and Hayashizaki,Y.
  TITLE     Targeting a complex transcriptome: the construction of the mouse
            full-length cDNA encyclopedia
  JOURNAL   Genome Res 13 (6B), 1273-1289 (2003)
   PUBMED   12819125
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK028404.1, BY777312.1, AC124444.4 and AV371065.1.
            
            ##Evidence-Data-START##
            CDS exon combination :: BC108382.1, AK028404.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN00849381, SAMN00849382 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-248               AK028404.1         2-249
            249-607             BY777312.1         16-374
            608-1284            AK028404.1         740-1416
            1285-1285           AC124444.4         42035-42035         c
            1286-2882           AK028404.1         1418-3014
            2883-3485           AK028404.1         3016-3618
            3486-3770           AK028404.1         3620-3904
            3771-3774           AV371065.1         250-253
FEATURES             Location/Qualifiers
     source          1..3774
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 63.44 cM"
     gene            1..3774
                     /gene="Tmc5"
                     /gene_synonym="4932443L08Rik"
                     /note="transmembrane channel-like gene family 5"
                     /db_xref="GeneID:74424"
                     /db_xref="MGI:MGI:1921674"
     exon            1..248
                     /gene="Tmc5"
                     /gene_synonym="4932443L08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            249..372
                     /gene="Tmc5"
                     /gene_synonym="4932443L08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            373..1188
                     /gene="Tmc5"
                     /gene_synonym="4932443L08Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             449..3352
                     /gene="Tmc5"
                     /gene_synonym="4932443L08Rik"
                     /note="isoform a is encoded by transcript variant 1;
                     transmembrane channel-like protein 5"
                     /codon_start=1
                     /product="transmembrane channel-like protein 5 isoform a"
                     /protein_id="NP_001098722.1"
                     /db_xref="CCDS:CCDS52374.1"
                     /db_xref="GeneID:74424"
                     /db_xref="MGI:MGI:1921674"
                     /translation="MSSFHQNSSYMEDADYPGYSGSRNHTHNYLETQDYPEFPGSQNN
                     PGFHHPRSNPHSSGSRTNPDYPYFQEEPDYPGSLSNTVYQDTRSHPFSAHSRTRPDYE
                     SSIEPDYNDFRSESYHAGLPMEPDYPGSQSHPGFAGVGRSSMNYTGPRTNLGYLGSLE
                     EPDYPGAQDNSYYHSGSRPHSNLPGSRRDAGYAGSRINSYPDDLGEPDYPGAENQPNS
                     PRFYGKPDYPGAEEGDGYSSSKSLAVIRRGNGPFGMLGRRNEDYPEGIGMVSMEMAGD
                     PRNGYVNPAYTRRISPVCPDRNLLLCAHDWHTSVQGQKLIASLIPMTTRDRIKTIRNQ
                     PRTMQEKRELRKIVDKEKNKQSHGILEANCCAQCLGSLSLTYRRTRNGLSELLNYITL
                     WQKRFKVIGGKFGTSVLSYFSFLRWLLKFNIFSFVMNFSFIIIPQFTVGAKNTLQFTG
                     LEFFTGAGYFGDTVMYYGFYTNSTIRHRMGGASYNMQLAYIFTIGACLVVCFFSLLFS
                     MAKYFRNNFINPHIYSRGIAKLIFCWDFTVTHEKAVKLKQKNLSTEIRENLSELRQEN
                     YRLTFNQQLTRFSAHVAAWLVSTGVTAACCVAVYYLAEYNSEFLKTHRNPGAVLLLPF
                     VVSCINLAVPRFYSMFRLVERYEIPRQEVYVLLVRNIFLKISIVGILCYYWLNIVALS
                     GEECWETLIGQDIYRLLLMDFVFSLADSLLGEFLRRLIGMKFTSLSLQEFDIARNVLE
                     LIYAQTLTWLGIFFCPLLPFIQMITLFIMFYVKNVSLMMNFQPPSKAWRASQMITFFI
                     FLLFFPSFTGVLCTLAITIWRLKPSADCGPFRGLPSFIQSIYSWIDTLSRRPGYLWVV
                     WIYQNLIGSVHFFFILTLIVLIITYLYWQITEGRKVMIRLLHEQIINEGKDKMFLIEK
                     LTKLQDMEKRVNPSALDLERREVEPQIPLHLEELGAAPDLRLRRSAQEENPIA"
     exon            1189..1292
                     /gene="Tmc5"
                     /gene_synonym="4932443L08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..1382
                     /gene="Tmc5"
                     /gene_synonym="4932443L08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1383..1482
                     /gene="Tmc5"
                     /gene_synonym="4932443L08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1483..1570
                     /gene="Tmc5"
                     /gene_synonym="4932443L08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1571..1819
                     /gene="Tmc5"
                     /gene_synonym="4932443L08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1820..1971
                     /gene="Tmc5"
                     /gene_synonym="4932443L08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1972..2116
                     /gene="Tmc5"
                     /gene_synonym="4932443L08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2117..2272
                     /gene="Tmc5"
                     /gene_synonym="4932443L08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2273..2424
                     /gene="Tmc5"
                     /gene_synonym="4932443L08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2425..2503
                     /gene="Tmc5"
                     /gene_synonym="4932443L08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2504..2601
                     /gene="Tmc5"
                     /gene_synonym="4932443L08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2602..2694
                     /gene="Tmc5"
                     /gene_synonym="4932443L08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2695..2770
                     /gene="Tmc5"
                     /gene_synonym="4932443L08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2771..2904
                     /gene="Tmc5"
                     /gene_synonym="4932443L08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2905..3078
                     /gene="Tmc5"
                     /gene_synonym="4932443L08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3079..3157
                     /gene="Tmc5"
                     /gene_synonym="4932443L08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3158..3262
                     /gene="Tmc5"
                     /gene_synonym="4932443L08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3263..3305
                     /gene="Tmc5"
                     /gene_synonym="4932443L08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3306..3774
                     /gene="Tmc5"
                     /gene_synonym="4932443L08Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgggagacag tagtgtgtgt acactggaac gagcagtagt tgtctatagc caccgtcttc
       61 agggacctgc tggatgctaa gaatactgta gccggcccct ggatactagg acgacacgcg
      121 gcagcctgcg cacagtccta ggtcctagct ggagcacact gtgagtgtga gagaggcgct
      181 gcgcccgggt gagacggttg ccctgcacgg agggtagcgg ctgtggcacg gaagcaggag
      241 ctacgcagag gacatcggag gaggagctcg ggctcaggaa gaaaagaaga gttggagccc
      301 cagcgagggc cttggtaaac cacaacgctc aaccaggcgc tggaatacaa agcagacaga
      361 tctgtgctaa aggttaataa aaaaggttcc tgggttgcta tggatatggg gatgctttaa
      421 cacaaccggg tgaagactct gcagcatcat gtcttccttc caccagaata gcagctacat
      481 ggaggatgct gactaccctg gttactcagg gtctcggaac cacacacaca actatttgga
      541 aactcaagat tatccggaat tcccaggctc tcagaacaat ccaggcttcc accaccccag
      601 aagcaacccg cattcttcgg gctctagaac aaacccagac tacccctact tccaagaaga
      661 accagattat cctggatctc tgagtaacac ggtctatcag gacaccagga gtcacccgtt
      721 ctctgcacat tccagaacaa ggccagacta tgagtcttca attgagccag actataatga
      781 cttcaggagt gaatcttacc acgcaggttt acccatggag cctgactacc ctggctctca
      841 gagccatcct ggttttgcag gcgtcggaag aagcagtatg aactatacag gccctagaac
      901 caatctaggc tatttgggat ctctggaaga accagactac cctggagctc aggataactc
      961 ttattatcat tctggctcca gaccccattc caacctgcca ggctccagaa gagatgcagg
     1021 ttatgctggg tccagaatca attcctaccc agatgatttg ggggaacctg attacccagg
     1081 tgctgagaat caaccaaact ctccccgttt ttacggaaag ccagactatc ctggtgctga
     1141 agagggtgat ggctatagct cttccaagtc cctggcagtc atcaggagag ggaatggccc
     1201 ctttggcatg ctcggcagga ggaatgaaga ttaccctgaa ggcattggaa tggtatccat
     1261 ggagatggca ggtgatccta gaaatggcta tgtgaatcct gcttacacaa gaagaattag
     1321 tcctgtctgt ccagatagaa acctattgct gtgcgcacat gattggcaca catcagtcca
     1381 aggacagaaa ctaattgcat ccctgattcc catgacaact agagacagaa tcaaaaccat
     1441 caggaaccag ccaaggacca tgcaagagaa gagagagctt agaaaaatag ttgacaaaga
     1501 aaaaaacaaa cagtcacatg gcatcctcga ggccaactgc tgtgctcagt gtctgggctc
     1561 cctttcactg acttaccgca ggaccaggaa cggcctttca gagctcctca attacatcac
     1621 cttgtggcag aagagattca aggtcatcgg aggcaagttt ggaaccagcg tcctgtccta
     1681 tttcagcttc ctgaggtggc ttttgaagtt caacatcttc tcattcgtca tgaacttcag
     1741 cttcatcatc atcccacaat tcaccgtggg tgcaaagaac accctccagt tcactggctt
     1801 ggagtttttc acaggggcgg gttattttgg ggacacggtg atgtactatg ggttctacac
     1861 caattctaca atccgacata ggatgggtgg agcatcctac aacatgcagc tggcctacat
     1921 cttcacgatc ggagcctgcc tggtcgtctg tttcttcagt ctactcttca gtatggccaa
     1981 gtacttccgg aacaacttca tcaaccccca catatactcc agagggattg ctaagctcat
     2041 cttttgctgg gacttcactg tcacccatga aaaagctgta aagctaaaac agaagaatct
     2101 gagcacggag atcagggaga acctgtctga gctccgccag gagaactaca ggctcacatt
     2161 caaccagcag ctgacccgat tttctgctca cgtagccgct tggctcgtct ctactggagt
     2221 gaccgcagcc tgctgtgtag ctgtctacta cttggctgag tataactctg agttcctgaa
     2281 gactcacagg aaccctgggg cggtgttgtt gctgcccttt gttgtgtcct gcatcaacct
     2341 ggccgtgcct cgcttctact ccatgttccg cctggtggag aggtatgaga taccaagaca
     2401 ggaagtctac gtcctcttgg tccgaaacat ctttttgaag atctccattg ttggaattct
     2461 ttgttactat tggctcaaca tcgtggccct gtctggcgaa gagtgctggg agaccctcat
     2521 tggccaggac atctaccggc tccttctcat ggacttcgtg ttctccttgg ccgattcctt
     2581 actgggggag tttctgagga ggctcattgg gatgaagttc accagtctca gcctacagga
     2641 gtttgacatt gccaggaatg ttctagaact gatctacgca caaactctga cctggcttgg
     2701 aattttcttc tgccctttgc tgccttttat ccaaatgatc actctcttca ttatgttcta
     2761 tgtcaaaaac gtcagcctga tgatgaactt ccagccccca agcaaggcct ggcgggcctc
     2821 acagatgata actttcttca ttttcttgct cttcttccca tccttcacgg gagtgctgtg
     2881 caccctggct atcaccatct ggagactgaa accttcggct gactgtggcc cgttccgagg
     2941 tctgccttcc ttcatccaat ccatctacag ctggattgac actctgagcc gcaggcctgg
     3001 ctacctgtgg gtcgtctgga tctaccagaa tctcattgga agtgtgcact tcttcttcat
     3061 cctcaccctc attgtgctaa tcatcaccta tctttactgg cagatcacag aggggaggaa
     3121 ggtcatgatt cgattgctcc atgaacagat cattaatgag ggcaaagata agatgttcct
     3181 gatagagaaa ttgaccaaac tacaggatat ggagaagaga gtcaacccca gtgcccttga
     3241 cctggaaagg agagaggtgg agccacaaat tcctttgcat ttggaggaac ttggtgctgc
     3301 tcctgacctg cgattgaggc ggtcagcaca agaggagaat cccatagcct gatcactgtt
     3361 gtgtgttgtg gaagcaagat gctggtcaaa gggaaaagaa ggtacatatg agaccacctc
     3421 cgtgacagat gggcctcagg agcttctcgg gagtggaatc caagcccgag gaatcggatc
     3481 cgcagtgcga acagctccat gaaagagggc atgccttatt tccaacctgg actgctgatt
     3541 tttcttccaa aacaaaatac ttggaacttt cctattaaaa ctgttaaaat gttgaaatta
     3601 ttccacaaac atctgggaag aggtaacctg ggaatgttgc atttttatct ttaagaaata
     3661 catgtctgcg tggtggggcc tttacgactc tcttcccaga cctggcaatg gtttagaaac
     3721 tggtgctaat attaatggtt cataatgaat aaaaaatgtg gtcgtcagtc tggg
//
