LOCUS       NM_177695               4316 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus transmembrane channel-like gene family 3 (Tmc3), mRNA.
ACCESSION   NM_177695
VERSION     NM_177695.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4316)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4316)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4316)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   4  (bases 1 to 4316)
  AUTHORS   Beurg,M., Kim,K.X. and Fettiplace,R.
  TITLE     Conductance and block of hair-cell mechanotransducer channels in
            transmembrane channel-like protein mutants
  JOURNAL   J Gen Physiol 144 (1), 55-69 (2014)
   PUBMED   24981230
REFERENCE   5  (bases 1 to 4316)
  AUTHORS   Kurima,K., Yang,Y., Sorber,K. and Griffith,A.J.
  TITLE     Characterization of the transmembrane channel-like (TMC) gene
            family: functional clues from hearing loss and epidermodysplasia
            verruciformis
  JOURNAL   Genomics 82 (3), 300-308 (2003)
   PUBMED   12906855
REFERENCE   6  (bases 1 to 4316)
  AUTHORS   Keresztes,G., Mutai,H. and Heller,S.
  TITLE     TMC and EVER genes belong to a larger novel family, the TMC gene
            family encoding transmembrane proteins
  JOURNAL   BMC Genomics 4 (1), 24 (2003)
   PUBMED   12812529
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY236491.1, AY263157.1 and AC158576.3.
            
            On Jul 25, 2006 this sequence version replaced NM_177695.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY263157.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN01164137,
                                           SAMN01164142 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1812              AY236491.1         5-1816
            1813-2008           AY263157.1         1814-2009
            2009-2242           AY236491.1         2013-2246
            2243-2410           AY263157.1         2244-2411
            2411-2454           AC158576.3         114950-114993
            2455-4316           AY263157.1         2456-4317
FEATURES             Location/Qualifiers
     source          1..4316
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 47.43 cM"
     gene            1..4316
                     /gene="Tmc3"
                     /gene_synonym="9030203A06"
                     /note="transmembrane channel-like gene family 3"
                     /db_xref="GeneID:233424"
                     /db_xref="MGI:MGI:2669033"
     exon            1..250
                     /gene="Tmc3"
                     /gene_synonym="9030203A06"
                     /inference="alignment:Splign:2.1.0"
     CDS             162..3554
                     /gene="Tmc3"
                     /gene_synonym="9030203A06"
                     /codon_start=1
                     /product="transmembrane channel-like protein 3"
                     /protein_id="NP_808363.3"
                     /db_xref="CCDS:CCDS40012.1"
                     /db_xref="GeneID:233424"
                     /db_xref="MGI:MGI:2669033"
                     /translation="MKTSKASQRYRSIRRNASQCYLYQDSLLLGNSDDSFNADETGDS
                     SDPEQIFQNIQFQKDLMANIRCRPWTMGQKLRALRRAKEIVLKFEGRLTRTRGYQAAG
                     AELWRKFARLACNFVVIFIPWEMRIKKIESHFGSGVASYFIFLRWLFGINIVLTVMTG
                     AFVVLPELIAGQPFGSTASKTIPREQITSAQDLDTVWSLGGYLQYSVLFYGYYGRERR
                     IGRAGYRLPLAYFLVGMAVFAYSFIVLLKKMAKNSRTSLASASNENYTFCWRVFCAWD
                     YLIGNPEAAESKTAAILNSIREAILEEQEKKKNKNMAVTVCLRIIANILVLLSLAGSI
                     YLIYFVVDRSQKLEQSKKELTLWEKNEVSVVVSLVTMLAPSAFDLIAALEMYHPRTTL
                     RFQLARVLVLYLGNLYSLIIALLDKVNSMNIEEAATKNITSHWADAPTFSATRTVPEE
                     GQWPTPGSGAELRRNTSTWVVEETSFLTSITPHTKANKTVPYMQGPQGQCWETYVGQE
                     MLKLSVIDMLFTVASILLIDFFRGLFVRYLSDYWCWDLESKFPEYGEFKIAENVLHLV
                     YNQGMIWMGAFFSPCLPAFNVLKLIGLMYLRSWAVLTCNVPHQQVFRASRSNNFYLAM
                     LLFMLFLCMLPTIFAIVHYKPSLNCGPFSGQEKIYDIVSETIENDFPTWFHAVVGHIS
                     SPVVILPAVLLLFMLIYYLQSIARSLKLSSQQLRMQIQNARSEDKKKVAQMVEALAIP
                     SDARQAGSATEAESSENSKPKTLQARIQTHEESSKRLLKDSDLISQLSSVYMATSPNN
                     GHMLNFDSLSSKSLRMEAITRSLPQSPGQGSRDPCSPLLDGSRSRPEQDTNRHPHRPC
                     SSTSNLHKNRSCSSVTQTQPLKDVRSEPLSRKDFQPISPPFCGSGVSTLMTHDHSPRA
                     PRYYVVNERDSHKKTHRAFWPERHFKIDALGDIVELYPRNVQQYMSWVPNQPCSPQLS
                     EEEEEMLRRDLVQWSIPASSLTDLPRSSCFYTGDRSENNTRDPKYQRRVYYRSGDNSF
                     EDQLERPTFVHRKPRSRNGQYPQHALKARVKAKFEPSFTESDSVSAASSSDHQNSNND
                     QYLHVMSSQGRFPRSASQLGRRKAKSRQVLPTDLNDLICSNV"
     exon            251..397
                     /gene="Tmc3"
                     /gene_synonym="9030203A06"
                     /inference="alignment:Splign:2.1.0"
     exon            398..473
                     /gene="Tmc3"
                     /gene_synonym="9030203A06"
                     /inference="alignment:Splign:2.1.0"
     exon            474..555
                     /gene="Tmc3"
                     /gene_synonym="9030203A06"
                     /inference="alignment:Splign:2.1.0"
     exon            556..662
                     /gene="Tmc3"
                     /gene_synonym="9030203A06"
                     /inference="alignment:Splign:2.1.0"
     exon            663..761
                     /gene="Tmc3"
                     /gene_synonym="9030203A06"
                     /inference="alignment:Splign:2.1.0"
     exon            762..904
                     /gene="Tmc3"
                     /gene_synonym="9030203A06"
                     /inference="alignment:Splign:2.1.0"
     exon            905..1052
                     /gene="Tmc3"
                     /gene_synonym="9030203A06"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1096
                     /gene="Tmc3"
                     /gene_synonym="9030203A06"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1244
                     /gene="Tmc3"
                     /gene_synonym="9030203A06"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1354
                     /gene="Tmc3"
                     /gene_synonym="9030203A06"
                     /inference="alignment:Splign:2.1.0"
     exon            1355..1433
                     /gene="Tmc3"
                     /gene_synonym="9030203A06"
                     /inference="alignment:Splign:2.1.0"
     exon            1434..1682
                     /gene="Tmc3"
                     /gene_synonym="9030203A06"
                     /inference="alignment:Splign:2.1.0"
     exon            1683..1811
                     /gene="Tmc3"
                     /gene_synonym="9030203A06"
                     /inference="alignment:Splign:2.1.0"
     exon            1812..1879
                     /gene="Tmc3"
                     /gene_synonym="9030203A06"
                     /inference="alignment:Splign:2.1.0"
     exon            1880..2008
                     /gene="Tmc3"
                     /gene_synonym="9030203A06"
                     /inference="alignment:Splign:2.1.0"
     exon            2009..2119
                     /gene="Tmc3"
                     /gene_synonym="9030203A06"
                     /inference="alignment:Splign:2.1.0"
     exon            2120..2245
                     /gene="Tmc3"
                     /gene_synonym="9030203A06"
                     /inference="alignment:Splign:2.1.0"
     exon            2246..2324
                     /gene="Tmc3"
                     /gene_synonym="9030203A06"
                     /inference="alignment:Splign:2.1.0"
     exon            2325..2367
                     /gene="Tmc3"
                     /gene_synonym="9030203A06"
                     /inference="alignment:Splign:2.1.0"
     exon            2368..2454
                     /gene="Tmc3"
                     /gene_synonym="9030203A06"
                     /inference="alignment:Splign:2.1.0"
     exon            2455..2710
                     /gene="Tmc3"
                     /gene_synonym="9030203A06"
                     /inference="alignment:Splign:2.1.0"
     exon            2711..4316
                     /gene="Tmc3"
                     /gene_synonym="9030203A06"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agatgcaggc agacatttgc tcctgtttct gaaggaggag agcaggtcaa ctctgcaggc
       61 ctctttcaga cagctcattt ggaacagaac cctgcctgca aaatcaaggc tttccaattc
      121 cctggctatc cctagggacc attggctaca gaccaggcct catgaaaacc tcaaaggcat
      181 cccagcgcta cagaagcatt cggagaaacg ccagccagtg ttatctctac caggactccc
      241 tgcttcttgg taactccgat gacagcttta atgctgatga aacgggagac agcagtgatc
      301 cggaacaaat cttccagaat atacagtttc agaaagatct catggcaaat atccgctgca
      361 gaccctggac catggggcag aaactgcggg cactgagacg agccaaggag attgtgctga
      421 agtttgaagg gaggctgacc aggactcgag gctaccaggc agcaggagca gagctctggc
      481 ggaaattcgc ccgtctggcc tgtaactttg tggtcatctt catcccctgg gaaatgagga
      541 taaagaaaat tgagagtcac ttcgggtctg gtgtggcctc ctacttcatc ttcctgaggt
      601 ggctatttgg gattaacata gtgctcacag tgatgaccgg tgcctttgtt gtccttcccg
      661 agctgatcgc aggccagccc tttggaagta cagccagcaa gaccattccc cgggagcaga
      721 tcacatctgc acaggatctg gacactgtct ggtccctggg gggctacctt caatactccg
      781 tcctgttcta cgggtactac ggaagagaga ggcggatcgg gagagccggc taccgcctgc
      841 ccttggcgta tttcctggtg gggatggcag tgtttgctta cagcttcatc gttctcttaa
      901 aaaagatggc taagaactcc cgcaccagcc tagccagtgc ttccaatgaa aattacacct
      961 tctgctggcg ggtgttttgt gcctgggatt atctcattgg gaacccagag gctgcagaaa
     1021 gcaaaacagc tgccatcttg aacagcatta gggaggccat actggaagag caagaaaaga
     1081 aaaaaaacaa aaacatggcg gtgactgtct gtctgagaat cattgccaac atcctggtgc
     1141 tcctctcact ggctggaagc atctatctca tctactttgt ggtggaccgg tcccagaagc
     1201 tggagcagtc gaagaaggag ctgacacttt gggaaaagaa tgaggtaagc gtggtggtct
     1261 ccctcgtcac catgctagca ccgtctgcct ttgacctcat cgctgccttg gagatgtatc
     1321 atccacggac gacactgcgc ttccagttag caagggtcct ggtactgtat ttaggaaatc
     1381 tctacagctt gatcattgct cttctggaca aagtgaacag catgaacatt gaggaagctg
     1441 ctactaaaaa cataacaagc cactgggcag atgctcccac cttctctgcc accaggacag
     1501 tgcctgaaga agggcagtgg cccacacctg gatcaggagc ggagctcagg agaaacacta
     1561 gcacatgggt cgtagaagag acaagctttc tgacttctat cacgccacat acaaaggcca
     1621 acaagacagt gccctacatg cagggcccac aaggccagtg ctgggagaca tatgtcggcc
     1681 aggagatgct gaagctgtct gtcatcgaca tgctcttcac tgtggccagc atcctcctca
     1741 tagacttctt ccgaggactt tttgttcgct acctaagtga ctattggtgt tgggaccttg
     1801 aaagcaagtt tcctgaatat ggagaattca agattgccga gaatgtgctg caccttgtct
     1861 acaatcaagg catgatttgg atgggggcct tcttctctcc gtgtctgcca gcattcaatg
     1921 ttcttaagct cattgggctg atgtacctga ggagctgggc ggtgctgacc tgcaatgtac
     1981 cccaccagca agtgtttcga gcttccagat ccaacaactt ctacctggca atgctcctgt
     2041 tcatgttgtt cctttgcatg ctgcccacca tttttgccat tgtccactac aagccgtctc
     2101 tgaactgtgg tcccttcagc ggacaagaga aaatttatga catcgtgtcc gagacgatag
     2161 agaatgactt cccgacctgg tttcacgctg tagttggaca tatcagcagc cccgtggtga
     2221 tacttccagc tgtgctgctt ctgttcatgc tcatctacta ccttcagagc atcgcgagat
     2281 cactcaagct cagcagccag caactcagga tgcagatcca aaatgcgaga tctgaagata
     2341 agaaaaaggt tgcccaaatg gtagaggccc tagccatccc tagcgatgcc aggcaggcag
     2401 gctcagccac tgaagcagag tcgagtgaaa attcaaagcc aaagactctc caagctcgaa
     2461 tccagactca tgaggaaagc agcaagaggc ttctaaagga cagcgacctt atcagccagc
     2521 tgtcctcagt gtatatggca acatccccaa acaatggcca tatgcttaac ttcgactctc
     2581 tgagtagcaa gagcctcagg atggaggcaa tcacaaggtc cctgccacag agtcctggac
     2641 aagggtccag ggacccctgc tctcctcttc tagatggatc taggtcaagg ccagagcagg
     2701 acaccaacag gcatccacat aggccatgtt ccagcacaag caacctccac aagaacagat
     2761 cctgctcatc tgtgacacag acacagcccc tcaaagatgt ccgctcagag cctctttccc
     2821 ggaaagactt tcagccaatc agtcctcctt tctgtggatc tggggtctct accttgatga
     2881 cacatgacca cagtccccgt gctcccaggt actatgtggt taatgaacgt gactctcaca
     2941 aaaagaccca ccgagctttc tggccagaaa ggcatttcaa gatagatgct ttaggtgaca
     3001 ttgtagagct gtaccccagg aatgtgcagc agtacatgtc ctgggttccc aaccagcctt
     3061 gctctccaca gctgagtgaa gaagaggagg agatgctcag gagagatttg gtccagtggt
     3121 caatccctgc tagctccctg acagacctgc ctcggtcttc ttgtttttac actggtgaca
     3181 gatcagaaaa taacaccaga gaccctaaat accagcgaag ggtgtactac agatctgggg
     3241 ataatagttt tgaagaccag cttgagaggc ccacatttgt acacagaaag ccacgatcca
     3301 ggaacggcca atacccacag catgccctga aggccagagt caaggccaag ttcgagccgt
     3361 ccttcacaga atctgattct gtgtcagcag catccagcag tgaccatcaa aacagcaaca
     3421 atgaccaata cctgcatgtc atgtccagcc agggcagatt cccaaggtct gccagccagc
     3481 tgggcaggag gaaggccaag tccaggcagg tactacccac agatctaaat gatctaattt
     3541 gttcaaatgt ctaggcggtt caaatgttcc atgtcccttc ctaaagactg gatctctttg
     3601 gaaatattga gggcacatgg tcccaccctt tctgtaagag aggatctatc tgtgaggtgt
     3661 tagagatctg tggggctttt ttaggcttat gtattgatgc tgtctgaggt tctgagaccc
     3721 cgagggctgt aatttcctat tcaaagcaat gaggcgtgca tgaccattct cagtgtttat
     3781 ttacattaac catatcaggc tgtcatttca agaaaatgac aggcctttga ttccattcag
     3841 ggtgttcatg ctcacctgca agccagatat ctcatcggga ctgcaaaaac agtcatcacc
     3901 cttttcatcg ttaataatat tgagtgagtg ctttgcacta tggtcttttg acatacacat
     3961 atcagcactc catagtgagc acccaaaatc gggtggctac ccttgaagta ttcagagtac
     4021 atagtttatg aggacaatcg gtttagtaat ggccggtgtc atatgctgca aacttattta
     4081 actctgtatt actcagtcat agtacagatt agaaatgatc ccaagtttat agctgggctt
     4141 tcctggttca ctgggaagga tgggaattga gacttggtac catgctccgc tggaactgag
     4201 gttcaaacgt ccccaagacc acctgtcttt ttcacctctc agctctgatt ctgtgtttgc
     4261 agatcttgtt tccccccccc cccccctgtg ccaaaggact tcacttcagg tagaag
//
