LOCUS       NM_028953               4073 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus transmembrane channel-like gene family 1 (Tmc1), mRNA.
ACCESSION   NM_028953
VERSION     NM_028953.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4073)
  AUTHORS   Wang,P., Miller,K.K., He,E., Dhawan,S.S., Cunningham,C.L. and
            Grillet,N.
  TITLE     LOXHD1 is indispensable for maintaining TMC1 auditory
            mechanosensitive channels at the site of force transmission
  JOURNAL   Nat Commun 15 (1), 7865 (2024)
   PUBMED   39256406
  REMARK    Erratum:[Nat Commun. 2024 Oct 15;15(1):8878. doi:
            10.1038/s41467-024-52972-5.. PMID: 39406713]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4073)
  AUTHORS   Harmon,T.C., Madlon-Kay,S., Pearson,J. and Mooney,R.
  TITLE     Vocalization modulates the mouse auditory cortex even in the
            absence of hearing
  JOURNAL   Cell Rep 43 (8), 114611 (2024)
   PUBMED   39116205
REFERENCE   3  (bases 1 to 4073)
  AUTHORS   Lee,J.H., Perez-Flores,M.C., Park,S., Kim,H.J., Chen,Y., Kang,M.,
            Kersigo,J., Choi,J., Thai,P.N., Woltz,R.L., Perez-Flores,D.C.,
            Perkins,G., Sihn,C.R., Trinh,P., Zhang,X.D., Sirish,P., Dong,Y.,
            Feng,W.W., Pessah,I.N., Dixon,R.E., Sokolowski,B., Fritzsch,B.,
            Chiamvimonvat,N. and Yamoah,E.N.
  TITLE     The Piezo channel is a mechano-sensitive complex component in the
            mammalian inner ear hair cell
  JOURNAL   Nat Commun 15 (1), 526 (2024)
   PUBMED   38228630
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4073)
  AUTHORS   Beurg,M., Schwalbach,E.T. and Fettiplace,R.
  TITLE     LHFPL5 is a key element in force transmission from the tip link to
            the hair cell mechanotransducer channel
  JOURNAL   Proc Natl Acad Sci U S A 121 (3), e2318270121 (2024)
   PUBMED   38194445
REFERENCE   5  (bases 1 to 4073)
  AUTHORS   Tao,Y., Lamas,V., Du,W., Zhu,W., Li,Y., Whittaker,M.N., Zuris,J.A.,
            Thompson,D.B., Rameshbabu,A.P., Shu,Y., Gao,X., Hu,J.H., Pei,C.,
            Kong,W.J., Liu,X., Wu,H., Kleinstiver,B.P., Liu,D.R. and Chen,Z.Y.
  TITLE     Treatment of monogenic and digenic dominant genetic hearing loss by
            CRISPR-Cas9 ribonucleoprotein delivery in vivo
  JOURNAL   Nat Commun 14 (1), 4928 (2023)
   PUBMED   37582836
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4073)
  AUTHORS   Webster,D.B.
  TITLE     Degeneration followed by partial regeneration of the organ of Corti
            in deafness (dn/dn) mice
  JOURNAL   Exp Neurol 115 (1), 27-31 (1992)
   PUBMED   1728569
REFERENCE   7  (bases 1 to 4073)
  AUTHORS   Horner,K.C., Lenoir,M. and Bock,G.R.
  TITLE     Distortion product otoacoustic emissions in hearing-impaired mutant
            mice
  JOURNAL   J Acoust Soc Am 78 (5), 1603-1611 (1985)
   PUBMED   4067076
REFERENCE   8  (bases 1 to 4073)
  AUTHORS   Steel,K.P. and Bock,G.R.
  TITLE     Electrically-evoked responses in animals with progressive spiral
            ganglion degeneration
  JOURNAL   Hear Res 15 (1), 59-67 (1984)
   PUBMED   6541219
REFERENCE   9  (bases 1 to 4073)
  AUTHORS   Pujol,R., Shnerson,A., Lenoir,M. and Deol,M.S.
  TITLE     Early degeneration of sensory and ganglion cells in the inner ear
            of mice with uncomplicated genetic deafness (dn): preliminary
            observations
  JOURNAL   Hear Res 12 (1), 57-63 (1983)
   PUBMED   6662828
REFERENCE   10 (bases 1 to 4073)
  AUTHORS   Bock,G.R., Frank,M.P. and Steel,K.P.
  TITLE     Preservation of central auditory function in the deafness mouse
  JOURNAL   Brain Res 239 (2), 608-612 (1982)
   PUBMED   7093705
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC102790.7 and AC162458.4.
            
            On Dec 20, 2006 this sequence version replaced NM_028953.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF417579.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN00849374,
                                           SAMN00849377 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-59                AC102790.7         162207-162265       c
            60-167              AC102790.7         148968-149075       c
            168-215             AC102790.7         121566-121613       c
            216-378             AC102790.7         114923-115085       c
            379-507             AC102790.7         108849-108977       c
            508-598             AC102790.7         78461-78551         c
            599-680             AC102790.7         76404-76485         c
            681-787             AC102790.7         67068-67174         c
            788-886             AC102790.7         64738-64836         c
            887-1029            AC162458.4         189885-190027       c
            1030-1174           AC162458.4         185187-185331       c
            1175-1369           AC162458.4         184040-184234       c
            1370-1549           AC162458.4         181809-181988       c
            1550-1720           AC162458.4         181512-181682       c
            1721-1849           AC162458.4         173644-173772       c
            1850-1917           AC162458.4         162133-162200       c
            1918-2157           AC162458.4         156534-156773       c
            2158-2283           AC162458.4         153050-153175       c
            2284-2362           AC162458.4         147326-147404       c
            2363-2414           AC162458.4         147119-147170       c
            2415-4073           AC162458.4         140992-142650       c
FEATURES             Location/Qualifiers
     source          1..4073
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 13.98 cM"
     gene            1..4073
                     /gene="Tmc1"
                     /gene_synonym="4933416G09Rik; Beethoven; Bth; CWEA1; dn;
                     TMC1ex1"
                     /note="transmembrane channel-like gene family 1"
                     /db_xref="GeneID:13409"
                     /db_xref="MGI:MGI:2151016"
     exon            1..59
                     /gene="Tmc1"
                     /gene_synonym="4933416G09Rik; Beethoven; Bth; CWEA1; dn;
                     TMC1ex1"
                     /inference="alignment:Splign:2.1.0"
     exon            60..167
                     /gene="Tmc1"
                     /gene_synonym="4933416G09Rik; Beethoven; Bth; CWEA1; dn;
                     TMC1ex1"
                     /inference="alignment:Splign:2.1.0"
     CDS             164..2437
                     /gene="Tmc1"
                     /gene_synonym="4933416G09Rik; Beethoven; Bth; CWEA1; dn;
                     TMC1ex1"
                     /note="transmembrane, cochlear expressed 1; deafness
                     protein; transmembrane cochlear-expressed protein 1"
                     /codon_start=1
                     /product="transmembrane channel-like protein 1"
                     /protein_id="NP_083229.1"
                     /db_xref="CCDS:CCDS50403.1"
                     /db_xref="GeneID:13409"
                     /db_xref="MGI:MGI:2151016"
                     /translation="MLQIQVEEKEEDTEESSSEEEEDKLPRRESLRPKRKRTRDVINE
                     DDPEPEPEDEETRKAREKERRRRLRRGAEEEEEIDEEELERLKALLDENRQMIATVKC
                     KPWKMEKKIEVLKEAKKFVSENEGALGKGKGKKWFAFKMMMAKKWAKFLRDFENFKAA
                     CVPWENKIKAIESQFGSSVASYFLFLRWMYGVNMVLFVLTFSLIMLPEYLWGLPYGSL
                     PRKTVPRAEEASAANFGVLYDFNGLAQYSVLFYGYYDNKRTIGWLNFRLPLSYFLVGI
                     MCIGYSFLVVLKAMTKNIGDDGGGDDNTFNFSWKVFCSWDYLIGNPETADNKFNSITM
                     NFKEAIIEERAAQVEENIHLIRFLRFLANFFVFLTLGASGYLIFWAVKRSQEFAQQDP
                     DTLGWWEKNEMNMVMSLLGMFCPTLFDLFAELEDYHPLIALKWLLGRIFALLLGNLYV
                     FILALMDEINNKIEEEKLVKANITLWEANMIKAYNESLSGLSGNTTGAPFFVHPADVP
                     RGPCWETMVGQEFVRLTVSDVLTTYVTILIGDFLRACFVRFCNYCWCWDLEYGYPSYT
                     EFDISGNVLALIFNQGMIWMGSFFAPSLPGINILRLHTSMYFQCWAVMCCNVPEARVF
                     KASRSNNFYLGMLLLILFLSTMPVLYMIVSLPPSFDCGPFSGKNRMFEVIGETLEHDF
                     PSWMAKILRQLSNPGLVIAVILVMVLTIYYLNATAKGQKAANLDLKKKMKQQALENKM
                     RNKKMAAARAAAAAGGQ"
     exon            168..215
                     /gene="Tmc1"
                     /gene_synonym="4933416G09Rik; Beethoven; Bth; CWEA1; dn;
                     TMC1ex1"
                     /inference="alignment:Splign:2.1.0"
     exon            216..378
                     /gene="Tmc1"
                     /gene_synonym="4933416G09Rik; Beethoven; Bth; CWEA1; dn;
                     TMC1ex1"
                     /inference="alignment:Splign:2.1.0"
     exon            379..507
                     /gene="Tmc1"
                     /gene_synonym="4933416G09Rik; Beethoven; Bth; CWEA1; dn;
                     TMC1ex1"
                     /inference="alignment:Splign:2.1.0"
     exon            508..598
                     /gene="Tmc1"
                     /gene_synonym="4933416G09Rik; Beethoven; Bth; CWEA1; dn;
                     TMC1ex1"
                     /inference="alignment:Splign:2.1.0"
     exon            599..680
                     /gene="Tmc1"
                     /gene_synonym="4933416G09Rik; Beethoven; Bth; CWEA1; dn;
                     TMC1ex1"
                     /inference="alignment:Splign:2.1.0"
     exon            681..787
                     /gene="Tmc1"
                     /gene_synonym="4933416G09Rik; Beethoven; Bth; CWEA1; dn;
                     TMC1ex1"
                     /inference="alignment:Splign:2.1.0"
     exon            788..886
                     /gene="Tmc1"
                     /gene_synonym="4933416G09Rik; Beethoven; Bth; CWEA1; dn;
                     TMC1ex1"
                     /inference="alignment:Splign:2.1.0"
     exon            887..1029
                     /gene="Tmc1"
                     /gene_synonym="4933416G09Rik; Beethoven; Bth; CWEA1; dn;
                     TMC1ex1"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1174
                     /gene="Tmc1"
                     /gene_synonym="4933416G09Rik; Beethoven; Bth; CWEA1; dn;
                     TMC1ex1"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1369
                     /gene="Tmc1"
                     /gene_synonym="4933416G09Rik; Beethoven; Bth; CWEA1; dn;
                     TMC1ex1"
                     /inference="alignment:Splign:2.1.0"
     exon            1370..1549
                     /gene="Tmc1"
                     /gene_synonym="4933416G09Rik; Beethoven; Bth; CWEA1; dn;
                     TMC1ex1"
                     /inference="alignment:Splign:2.1.0"
     exon            1550..1720
                     /gene="Tmc1"
                     /gene_synonym="4933416G09Rik; Beethoven; Bth; CWEA1; dn;
                     TMC1ex1"
                     /inference="alignment:Splign:2.1.0"
     exon            1721..1849
                     /gene="Tmc1"
                     /gene_synonym="4933416G09Rik; Beethoven; Bth; CWEA1; dn;
                     TMC1ex1"
                     /inference="alignment:Splign:2.1.0"
     exon            1850..1917
                     /gene="Tmc1"
                     /gene_synonym="4933416G09Rik; Beethoven; Bth; CWEA1; dn;
                     TMC1ex1"
                     /inference="alignment:Splign:2.1.0"
     exon            1918..2157
                     /gene="Tmc1"
                     /gene_synonym="4933416G09Rik; Beethoven; Bth; CWEA1; dn;
                     TMC1ex1"
                     /inference="alignment:Splign:2.1.0"
     exon            2158..2283
                     /gene="Tmc1"
                     /gene_synonym="4933416G09Rik; Beethoven; Bth; CWEA1; dn;
                     TMC1ex1"
                     /inference="alignment:Splign:2.1.0"
     exon            2284..2362
                     /gene="Tmc1"
                     /gene_synonym="4933416G09Rik; Beethoven; Bth; CWEA1; dn;
                     TMC1ex1"
                     /inference="alignment:Splign:2.1.0"
     exon            2363..2414
                     /gene="Tmc1"
                     /gene_synonym="4933416G09Rik; Beethoven; Bth; CWEA1; dn;
                     TMC1ex1"
                     /inference="alignment:Splign:2.1.0"
     exon            2415..4073
                     /gene="Tmc1"
                     /gene_synonym="4933416G09Rik; Beethoven; Bth; CWEA1; dn;
                     TMC1ex1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttgcaattcc tgattagaga cattctggca ggataccttc aggatgccac ccaaaaaagg
       61 tgtgtctggc catttctgat gcaaggttgc ctgtcttcct cttagctcct gtcctggaca
      121 ttcattatca aggcacaaga ttacattcct cctcaactct tttatgttgc aaatccaagt
      181 ggaggagaaa gaagaggata cagaggaaag ctcaagtgaa gaagaagaag ataagctacc
      241 cagaagagag agcttgagac caaagaggaa acggaccaga gatgtcatca atgaggatga
      301 cccagaaccg gagccggagg atgaagaaac aagaaaggca agagaaaaag aaaggcggag
      361 gaggctgcgg agaggagcgg aagaagaaga agaaattgat gaagaggaat tagaacggtt
      421 aaaagcactg ctcgatgaga atagacaaat gatcgctact gtcaaatgta aaccttggaa
      481 aatggagaag aaaattgaag ttctcaagga agcaaagaaa tttgtgagtg agaatgaagg
      541 cgctcttggg aaaggaaagg gaaagaagtg gtttgcattt aagatgatga tggccaagaa
      601 atgggcaaaa ttcctccgag attttgagaa cttcaaagcg gcttgcgtcc catgggaaaa
      661 caaaatcaag gcaattgaaa gtcagtttgg ttcctcagtg gcctcgtact tcctgttcct
      721 caggtggatg tacggcgtca acatggttct ctttgtgttg accttcagcc tcatcatgtt
      781 accggagtac ctctggggtt taccgtacgg cagcttacct aggaaaacag tcccaagagc
      841 tgaagaagca tctgcagcca actttggtgt gttgtatgac ttcaatggcc tggcgcagta
      901 ctctgtcctc ttttatggct attacgacaa taaacgcacg atcggatggc tgaatttccg
      961 gctacctctt tcctacttcc tggtggggat tatgtgcatt ggatacagct tcctggttgt
     1021 cctcaaagcg atgaccaaaa atattggtga cgatggtggt ggcgatgaca acactttcaa
     1081 cttcagctgg aaggtgttct gtagctggga ctatctgatt ggtaaccctg aaacagccga
     1141 caacaagttt aactctatca cgatgaactt taaggaagcc atcatagaag agagagccgc
     1201 acaggtggag gagaacatcc acctcatcag atttctgagg tttctcgcta acttcttcgt
     1261 gttcctcaca cttggtgcaa gtggatacct catcttttgg gctgtgaagc gatcccagga
     1321 gttcgcccag caagatcctg acacccttgg gtggtgggaa aaaaatgaaa tgaacatggt
     1381 aatgtccctc ctggggatgt tctgtcccac cctgtttgac ttatttgctg aactggaaga
     1441 ttaccatcct ctcattgctc tgaagtggct cctggggcgc atttttgctc ttcttctagg
     1501 caacttgtat gtattcattc tcgccttgat ggatgagatt aacaacaaga ttgaagagga
     1561 gaagcttgtg aaggccaata ttaccctgtg ggaagccaac atgattaagg cttacaatga
     1621 atctctctct gggctctctg ggaacaccac aggagcaccc tttttcgttc atcctgcaga
     1681 tgtccctcgc ggtccctgct gggaaacaat ggtggggcag gaattcgtgc gtctcaccgt
     1741 ttctgacgtc ctgaccactt acgtcacgat cctcattggc gacttcctca gagcatgttt
     1801 cgtgaggttc tgcaattact gctggtgctg ggacttagaa tatggatatc cttcatacac
     1861 agaattcgac atcagtggca acgtcctcgc tctgatcttc aaccaaggca tgatctggat
     1921 gggctccttc ttcgctccta gcctcccggg catcaacatc ctccgtctcc acacatccat
     1981 gtatttccag tgctgggctg tgatgtgctg caatgttccc gaggccaggg tgttcaaagc
     2041 ttccagatcc aacaacttct acctcggcat gctgctactc atcctcttcc tgtccaccat
     2101 gccggtcctg tacatgatcg tctccctccc gccatctttt gattgtgggc ccttcagtgg
     2161 taaaaacagg atgtttgaag tcatcggtga gaccctggaa catgacttcc caagctggat
     2221 ggcgaagatc ctgaggcagc tttctaaccc cggccttgtc attgctgtca ttctggtgat
     2281 ggtcctgacc atctattatc tcaatgctac tgccaagggc cagaaagcag cgaatctgga
     2341 cctcaaaaag aagatgaaac agcaagcttt ggagaacaaa atgcgaaaca agaaaatggc
     2401 agcggctcga gcagctgcag ctgctggtgg ccagtaattt tatcaaatgt cctggaggtg
     2461 cccagaagta ctcttcactt ctgtctttgt atggacagag tgagggccag tgaactgctg
     2521 ctctatactc taccaccaat gcaccatcat ggccgcagtc atgaccatct gtcaaggaat
     2581 catcagccct ctttgagcaa gaagaatctc accatattat ggatttttca agattctgac
     2641 tctctctctc tctctcctga caagttctca aacaaatgga gtttaaatgt gggtgtgatg
     2701 tagtgataca aattactggg taaaaatgat aggatacttt aaaaaagtca acatttcctc
     2761 atatggactt tttcttacac actggtctag tttcttaaat gagaggagag ctattacaac
     2821 atcctttgct atctaaattt ggaactatct gcatgaagca ttccttgtga tcattcattc
     2881 acttactgtt tcatgtgcac tgtttttctt actaattcat taagatgcta gagttgactt
     2941 ggttctcacc tatataaatg tcacattcat aaaatacaaa ttttaagaga attggctcac
     3001 ttttaaaata tagtattctc tgtcacctcc tttatttatt tatttattta tttatttatt
     3061 tatttattta tttatttatt ttgtcttgct acccatgaac ccaatcctca tatcggcact
     3121 tttgtatctg cagctggatt cagtatgaaa atcaagaggc ttttcaggag aaatgtgaca
     3181 tgtaatttga tattccctct attgctgact taacaatagt ttatcaccat gaggaggcat
     3241 gcaattctta gacgaactgt acctttatga gttcaggaga agaagacagc ataaacgagt
     3301 gctgtccagt cagagtctcc ttgctgaaag ctcaatgcta atctttcctg aacttagact
     3361 gttgtcgttt tcgctttttt tgttgagatt aggcctttag ttgaagcttt agcttatagc
     3421 catgtttaag catgtttatc taaagtctga gctgactgaa cggtagcact cagcgccctc
     3481 ctcgtcttgt gctgtgaact tagtaatatc ttctaactca cagcatcctt ttccagagct
     3541 aagccaaact caattccctg cagttcacat gctgagtttt gttgcccttt gacctactcc
     3601 ttctctttaa gcttctcttg gccatggaat gatcatactg ttctcttgcc aattcctgac
     3661 tcggttcttc caattacctt gtccagattg gcaactagtc ccagtcactc tcctaaccgc
     3721 attccttaga atcttgtatc tgtattctca gcgtagcatc tgtatatttt ctgtgatttt
     3781 tcatggttgt tattcttata tgcatggata atctttccta tctagacggt agctctatag
     3841 gaacatagat tatatcttct cattctttta tatgtctcat acagtgctgt gcacagttgg
     3901 acactgcata aatgcttctt aattaaattg aatcaatttg acttatcgca gttgagacaa
     3961 aacttgtgtt agttgtgtgg aaaatgttct atgatataag aaatggatta actgctgtca
     4021 gacttttgtt atcactagac tataatgcag caaataaaga tcgtgttgat ttc
//
