LOCUS       NM_029141               1680 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus transmembrane BAX inhibitor motif containing 7
            (Tmbim7), transcript variant 2, mRNA.
ACCESSION   NM_029141
VERSION     NM_029141.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1680)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1680)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. PMID: 29144450]
REFERENCE   3  (bases 1 to 1680)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC090443.4 and AC022236.4.
            
            On Sep 3, 2010 this sequence version replaced NM_029141.3.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the 5' coding region, compared to variant 1. It
            encodes isoform b which is shorter than isoform a.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK015666.1, BC115681.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-260               AC090443.4         2654-2913           c
            261-389             AC090443.4         2391-2519           c
            390-664             AC022236.4         185587-185861       c
            665-743             AC022236.4         183285-183363       c
            744-797             AC022236.4         182287-182340       c
            798-888             AC022236.4         180735-180825       c
            889-926             AC022236.4         177668-177705       c
            927-1014            AC022236.4         177499-177586       c
            1015-1104           AC022236.4         174433-174522       c
            1105-1152           AC022236.4         171294-171341       c
            1153-1680           AC022236.4         168076-168603       c
FEATURES             Location/Qualifiers
     source          1..1680
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 2.26 cM"
     gene            1..1680
                     /gene="Tmbim7"
                     /gene_synonym="4930403J02Rik; 4930500J03Rik;
                     4930511M11Rik; Lfg5; Lgf5; Tmbim1b"
                     /note="transmembrane BAX inhibitor motif containing 7"
                     /db_xref="GeneID:75010"
                     /db_xref="MGI:MGI:1922305"
     exon            1..260
                     /gene="Tmbim7"
                     /gene_synonym="4930403J02Rik; 4930500J03Rik;
                     4930511M11Rik; Lfg5; Lgf5; Tmbim1b"
                     /inference="alignment:Splign:2.1.0"
     exon            261..389
                     /gene="Tmbim7"
                     /gene_synonym="4930403J02Rik; 4930500J03Rik;
                     4930511M11Rik; Lfg5; Lgf5; Tmbim1b"
                     /inference="alignment:Splign:2.1.0"
     CDS             388..1296
                     /gene="Tmbim7"
                     /gene_synonym="4930403J02Rik; 4930500J03Rik;
                     4930511M11Rik; Lfg5; Lgf5; Tmbim1b"
                     /note="isoform b is encoded by transcript variant 2"
                     /codon_start=1
                     /product="bax inhibitor 1-like isoform b"
                     /protein_id="NP_083417.1"
                     /db_xref="CCDS:CCDS19067.1"
                     /db_xref="GeneID:75010"
                     /db_xref="MGI:MGI:1922305"
                     /translation="MKIDLEVSEPVNFSSGDHQHLVHTAAIKGNTGRLDQPFTASSGD
                     RVQEAVQYSHPRNRDGANTYAVQVSEDVTPSNETVNQSIPFENTSIRNDFIMKVFVVL
                     SIQLFITAVIIGIFVFCEPVRKWVIAKPWFLYALLPAVMILIFVLACCRDIRRQVPAN
                     YILLAFFTILEGLLLGSLSVFYRAEEILWAAGATTMVTLVLTLFALQTKWDFTLLNGV
                     MFVFTSVLLIYGIIALVIRSYWLHLVYSALGTLLFSIYLVMDVQMMVGGRYHYEINPE
                     EYIFAALNIYVDIISLFIFILDLIGR"
     exon            390..664
                     /gene="Tmbim7"
                     /gene_synonym="4930403J02Rik; 4930500J03Rik;
                     4930511M11Rik; Lfg5; Lgf5; Tmbim1b"
                     /inference="alignment:Splign:2.1.0"
     exon            665..743
                     /gene="Tmbim7"
                     /gene_synonym="4930403J02Rik; 4930500J03Rik;
                     4930511M11Rik; Lfg5; Lgf5; Tmbim1b"
                     /inference="alignment:Splign:2.1.0"
     exon            744..797
                     /gene="Tmbim7"
                     /gene_synonym="4930403J02Rik; 4930500J03Rik;
                     4930511M11Rik; Lfg5; Lgf5; Tmbim1b"
                     /inference="alignment:Splign:2.1.0"
     exon            798..888
                     /gene="Tmbim7"
                     /gene_synonym="4930403J02Rik; 4930500J03Rik;
                     4930511M11Rik; Lfg5; Lgf5; Tmbim1b"
                     /inference="alignment:Splign:2.1.0"
     exon            889..926
                     /gene="Tmbim7"
                     /gene_synonym="4930403J02Rik; 4930500J03Rik;
                     4930511M11Rik; Lfg5; Lgf5; Tmbim1b"
                     /inference="alignment:Splign:2.1.0"
     exon            927..1014
                     /gene="Tmbim7"
                     /gene_synonym="4930403J02Rik; 4930500J03Rik;
                     4930511M11Rik; Lfg5; Lgf5; Tmbim1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1104
                     /gene="Tmbim7"
                     /gene_synonym="4930403J02Rik; 4930500J03Rik;
                     4930511M11Rik; Lfg5; Lgf5; Tmbim1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1152
                     /gene="Tmbim7"
                     /gene_synonym="4930403J02Rik; 4930500J03Rik;
                     4930511M11Rik; Lfg5; Lgf5; Tmbim1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..1680
                     /gene="Tmbim7"
                     /gene_synonym="4930403J02Rik; 4930500J03Rik;
                     4930511M11Rik; Lfg5; Lgf5; Tmbim1b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1658..1663
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmbim7"
                     /gene_synonym="4930403J02Rik; 4930500J03Rik;
                     4930511M11Rik; Lfg5; Lgf5; Tmbim1b"
                     /note="hexamer: AATAAA"
     polyA_site      1680
                     /gene="Tmbim7"
                     /gene_synonym="4930403J02Rik; 4930500J03Rik;
                     4930511M11Rik; Lfg5; Lgf5; Tmbim1b"
                     /note="major polyA site"
ORIGIN      
        1 gctttgggga tagcatttga aatgtaaatg aagaaaatat ctaatttaaa aatgtgaaga
       61 aaaagaaaga aaaggaaaaa gaaagaaaaa ggaaaaagaa aagaacccct ctctcttcct
      121 gagaagaaag atcactcacc ctgtgtccca actgccactc ccttaactgt cgttcagaac
      181 ctggcttctc agctctgcta cctggctggc tgtttggatg gctgctggct cagcaggagt
      241 ctggagatct tgaggagcag gacactgtag ataccaactt ggttatttga gcatctttca
      301 gtgaccttca actttcgtga cgattccttt cacagaggag gagctccaga cactgttgca
      361 gagggaaata tttcttttgt catcaaaatg aaaatagact tggaggtcag tgagccagtc
      421 aactttagct ctggagatca tcaacatctg gttcatacag cagccattaa aggtaacact
      481 ggcagactgg atcagccctt cacagcttca tctggagaca gggtacaaga agccgtacaa
      541 tactcacatc caaggaatag agatggagca aatacctatg cagtacaagt ttctgaggat
      601 gttactccct caaatgagac tgtaaatcaa tccattccct ttgaaaacac gtctattcgt
      661 aatgatttca ttatgaaagt gtttgtcgtt ctgtccattc agctgttcat cactgcagtg
      721 attatcggca tctttgtttt ctgcgaacct gtaagaaagt gggtcatcgc caagccctgg
      781 ttcctgtatg cactcctccc agcagttatg attctgatct ttgtactcgc ttgctgcagg
      841 gatatccggc gccaagtgcc cgcaaactac attctcctgg cgttctttac cattctggaa
      901 ggcctgctgc tcggaagctt gtcagtcttc tacagagcag aagagatact atgggccgca
      961 ggagccacca ctatggtgac actagtgcta actttgtttg cgctacaaac aaaatgggat
     1021 tttaccctgc taaatggagt gatgtttgtt ttcaccagtg tgctacttat ctacgggatt
     1081 attgcacttg tgattcgatc atactggttg catctggtgt actcagcgct tggaacattg
     1141 ctcttctcca tatacctggt gatggacgtg caaatgatgg tgggggggcg ctaccattat
     1201 gagataaacc ccgaagagta catttttgct gctctgaaca tctacgtgga catcatcagc
     1261 cttttcattt ttattttgga cctgattgga cgatagctga tggccaaagc cagctaaggc
     1321 ccagaagagg aaaggtggga cacctatggt gtgtcgacag gttcaggcgt gtagcagtga
     1381 ccacttatag acccttttga gagtcactta ttcatctatc aatttaactg tatgtcaaaa
     1441 gaagctaaga attcagtaga tggtagctgt agctgttata attttgtttc ccttgacata
     1501 tggcaaaact ttcgtatcca tattgaaata tatcagatta ctataaattc agaaaaagag
     1561 tatcctaatc ataagctgac gtggatttag aaggtcctca atgctttggt gacgttttcc
     1621 aggtacaatt taaagctgtg agcaccagct ctacataaat aaagccgatt gtagaaaccc
//
