LOCUS       NM_026669               2397 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus transmembrane BAX inhibitor motif containing 6
            (Tmbim6), transcript variant 4, mRNA.
ACCESSION   NM_026669
VERSION     NM_026669.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2397)
  AUTHORS   Blanc,M., Habbouche,L., Xiao,P., Lebeaupin,C., Janona,M.,
            Vaillant,N., Irondelle,M., Gilleron,J., Murcy,F., Rousseau,D.,
            Luci,C., Barouillet,T., Marchetti,S., Lacas-Gervais,S.,
            Yvan-Charvet,L., Gual,P., Cardozo,A.K. and Bailly-Maitre,B.
  TITLE     Bax Inhibitor-1 preserves pancreatic beta-cell proteostasis by
            limiting proinsulin misfolding and programmed cell death
  JOURNAL   Cell Death Dis 15 (5), 334 (2024)
   PUBMED   38744890
  REMARK    GeneRIF: Bax Inhibitor-1 preserves pancreatic beta-cell
            proteostasis by limiting proinsulin misfolding and programmed cell
            death.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2397)
  AUTHORS   Chen,W., DU,H., Sha,Y., Zhou,Y., Liang,J., Chen,Y., Ma,Q., Wu,X.
            and Qian,G.
  TITLE     [Long noncoding RNA H19 promotes vascular calcification by
            repressing the Bax inhibitor 1/optic atrophy 1 pathway]
  JOURNAL   Nan Fang Yi Ke Da Xue Xue Bao 43 (9), 1469-1475 (2023)
   PUBMED   37814860
  REMARK    GeneRIF: [Long noncoding RNA H19 promotes vascular calcification by
            repressing the Bax inhibitor 1/optic atrophy 1 pathway].
REFERENCE   3  (bases 1 to 2397)
  AUTHORS   Yi,S.J., Jang,Y.J., Lee,S., Cho,S.J., Kang,K., Park,J.I.,
            Chae,H.J., Kim,H.R. and Kim,K.
  TITLE     TMBIM6 deficiency leads to bone loss by accelerating
            osteoclastogenesis
  JOURNAL   Redox Biol 64, 102804 (2023)
   PUBMED   37399733
  REMARK    GeneRIF: TMBIM6 deficiency leads to bone loss by accelerating
            osteoclastogenesis.
            Erratum:[Redox Biol. 2023 Oct;66:102844. doi:
            10.1016/j.redox.2023.102844.. PMID: 37591763]
REFERENCE   4  (bases 1 to 2397)
  AUTHORS   Zhou,H., Dai,Z., Li,J., Wang,J., Zhu,H., Chang,X. and Wang,Y.
  TITLE     TMBIM6 prevents VDAC1 multimerization and improves mitochondrial
            quality control to reduce sepsis-related myocardial injury
  JOURNAL   Metabolism 140, 155383 (2023)
   PUBMED   36603706
  REMARK    GeneRIF: TMBIM6 prevents VDAC1 multimerization and improves
            mitochondrial quality control to reduce sepsis-related myocardial
            injury.
REFERENCE   5  (bases 1 to 2397)
  AUTHORS   Ma,L., Liao,L., Zhou,N., Tao,H., Zhou,H., Tan,Y., Chen,W., Cao,F.
            and Chen,X.
  TITLE     Transmembrane BAX inhibitor motif containing 6 suppresses
            presenilin-2 to preserve mitochondrial integrity after myocardial
            ischemia-reperfusion injury
  JOURNAL   Int J Biol Sci 19 (4), 1228-1240 (2023)
   PUBMED   36923943
  REMARK    GeneRIF: Transmembrane BAX inhibitor motif containing 6 suppresses
            presenilin-2 to preserve mitochondrial integrity after myocardial
            ischemia-reperfusion injury.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2397)
  AUTHORS   Bailly-Maitre,B., Fondevila,C., Kaldas,F., Droin,N., Luciano,F.,
            Ricci,J.E., Croxton,R., Krajewska,M., Zapata,J.M.,
            Kupiec-Weglinski,J.W., Farmer,D. and Reed,J.C.
  TITLE     Cytoprotective gene bi-1 is required for intrinsic protection from
            endoplasmic reticulum stress and ischemia-reperfusion injury
  JOURNAL   Proc Natl Acad Sci U S A 103 (8), 2809-2814 (2006)
   PUBMED   16478805
  REMARK    GeneRIF: BI-1 provides endogenous protection of liver and kidney
            from endoplasmic reticulum stress and ischemia-reperfusion injury.
REFERENCE   7  (bases 1 to 2397)
  AUTHORS   Chae,H.J., Kim,H.R., Xu,C., Bailly-Maitre,B., Krajewska,M.,
            Krajewski,S., Banares,S., Cui,J., Digicaylioglu,M., Ke,N.,
            Kitada,S., Monosov,E., Thomas,M., Kress,C.L., Babendure,J.R.,
            Tsien,R.Y., Lipton,S.A. and Reed,J.C.
  TITLE     BI-1 regulates an apoptosis pathway linked to endoplasmic reticulum
            stress
  JOURNAL   Mol Cell 15 (3), 355-366 (2004)
   PUBMED   15304216
REFERENCE   8  (bases 1 to 2397)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   9  (bases 1 to 2397)
  AUTHORS   Walter,L., Marynen,P., Szpirer,J., Levan,G. and Gunther,E.
  TITLE     Identification of a novel conserved human gene, TEGT
  JOURNAL   Genomics 28 (2), 301-304 (1995)
   PUBMED   8530040
  REMARK    GeneRIF: Discusses cloning of human testis enhanced gene transcript
            and its conservation in mouse and rat.
REFERENCE   10 (bases 1 to 2397)
  AUTHORS   Walter,L., Dirks,B., Rothermel,E., Heyens,M., Szpirer,C., Levan,G.
            and Gunther,E.
  TITLE     A novel, conserved gene of the rat that is developmentally
            regulated in the testis
  JOURNAL   Mamm Genome 5 (4), 216-221 (1994)
   PUBMED   8012111
  REMARK    GeneRIF: Discusses cloning of rat testis enhanced gene transcript
            and identification of its homolog in mouse.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY272301.1, AK139901.1, AK036782.1 and BE990530.1.
            
            On Jan 15, 2010 this sequence version replaced NM_026669.3.
            
            Transcript Variant: This variant (4) differs in the 5' UTR compared
            to variant 1. Variants 1 through 4 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK166935.1, AK036782.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                BY272301.1         2-40
            40-2211             AK139901.1         3-2174
            2212-2336           AK036782.1         2174-2298
            2337-2397           BE990530.1         8-68                c
FEATURES             Location/Qualifiers
     source          1..2397
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 56.13 cM"
     gene            1..2397
                     /gene="Tmbim6"
                     /gene_synonym="5031406P05Rik; Bi1; Tegt"
                     /note="transmembrane BAX inhibitor motif containing 6"
                     /db_xref="GeneID:110213"
                     /db_xref="MGI:MGI:99682"
     exon            1..94
                     /gene="Tmbim6"
                     /gene_synonym="5031406P05Rik; Bi1; Tegt"
                     /inference="alignment:Splign:2.1.0"
     exon            95..178
                     /gene="Tmbim6"
                     /gene_synonym="5031406P05Rik; Bi1; Tegt"
                     /inference="alignment:Splign:2.1.0"
     CDS             123..836
                     /gene="Tmbim6"
                     /gene_synonym="5031406P05Rik; Bi1; Tegt"
                     /note="BI-1; testis-enhanced gene transcript protein;
                     transmembrane BAX inhibitor motif-containing protein 6;
                     testis enhanced gene transcript"
                     /codon_start=1
                     /product="bax inhibitor 1"
                     /protein_id="NP_080945.1"
                     /db_xref="CCDS:CCDS37201.1"
                     /db_xref="GeneID:110213"
                     /db_xref="MGI:MGI:99682"
                     /translation="MNIFDRKINFDALLKFSHITPSTQQHLKKVYASFALCMFVAAAG
                     AYVHVVTHFIQAGLLSALGSLALMIWLMATPHSHETEQKRLGLLAGFAFLTGVGLGPA
                     LELCIAVNPSILPTAFMGTAMIFTCFSLSALYARRRSYLFLGGILMSAMSLMLLSSLG
                     NLFFGSIWLFQANLYLGLLVMCGFVLFDTQLIIEKAEHGDKDYIWHCVDLFLDFVTLF
                     RKLMLILAFNEKDKKKEKK"
     exon            179..287
                     /gene="Tmbim6"
                     /gene_synonym="5031406P05Rik; Bi1; Tegt"
                     /inference="alignment:Splign:2.1.0"
     exon            288..408
                     /gene="Tmbim6"
                     /gene_synonym="5031406P05Rik; Bi1; Tegt"
                     /inference="alignment:Splign:2.1.0"
     exon            409..457
                     /gene="Tmbim6"
                     /gene_synonym="5031406P05Rik; Bi1; Tegt"
                     /inference="alignment:Splign:2.1.0"
     exon            458..555
                     /gene="Tmbim6"
                     /gene_synonym="5031406P05Rik; Bi1; Tegt"
                     /inference="alignment:Splign:2.1.0"
     exon            556..635
                     /gene="Tmbim6"
                     /gene_synonym="5031406P05Rik; Bi1; Tegt"
                     /inference="alignment:Splign:2.1.0"
     exon            636..736
                     /gene="Tmbim6"
                     /gene_synonym="5031406P05Rik; Bi1; Tegt"
                     /inference="alignment:Splign:2.1.0"
     exon            737..812
                     /gene="Tmbim6"
                     /gene_synonym="5031406P05Rik; Bi1; Tegt"
                     /inference="alignment:Splign:2.1.0"
     exon            813..2387
                     /gene="Tmbim6"
                     /gene_synonym="5031406P05Rik; Bi1; Tegt"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2363..2368
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmbim6"
                     /gene_synonym="5031406P05Rik; Bi1; Tegt"
                     /note="hexamer: AATAAA"
     polyA_site      2386
                     /gene="Tmbim6"
                     /gene_synonym="5031406P05Rik; Bi1; Tegt"
                     /note="major polyA site"
ORIGIN      
        1 gggtgtgggt agacttccag cgccaacccc cggagactca gagcacatcc ggttttagca
       61 gagcagggaa gctccggaga ggtgggctga gaagcggagg ctgctgaaca gactttggag
      121 ccatgaatat atttgatcgg aagatcaact ttgatgccct cttaaaattt tcccacataa
      181 ctccctcgac acagcagcac ctaaagaagg tctatgccag ttttgcacta tgtatgtttg
      241 tggcggcagc aggggcctat gtccatgtgg tcacacactt catccaggct ggcctactct
      301 ccgccctggg ctccttggcc ttgatgattt ggctgatggc aacacctcac agccatgaga
      361 ccgagcaaaa gagactggga cttctcgctg gcttcgcctt cctcacagga gtcggcctgg
      421 gacctgccct ggagctgtgc atcgctgtca accccagcat cctccccacg gccttcatgg
      481 gcacggccat gatcttcacc tgcttcagcc tgagcgccct gtatgcccgg cgccggagct
      541 acctgttttt aggaggtatc ttgatgtcag ccatgagcct catgctcctg tcctctctgg
      601 ggaacctttt ctttggctcc atttggctgt tccaggcaaa cctgtacctg ggactgctgg
      661 tcatgtgtgg ctttgtcctc tttgatactc agctcattat tgagaaggct gaacacggag
      721 ataaggatta catctggcac tgcgttgacc tcttcctaga tttcgttacc ctcttcagga
      781 agctcatgtt gatcctggcc ttcaatgaga aggacaagaa gaaagaaaag aagtgaccaa
      841 ctggccgtca gcctttccca gctcaccttc tcccccccac ccccccaccc ctgtttcttt
      901 gcacacatca caggtgtcgt gttctatgat aatgaaagca tcaggaaagc ttttgtactt
      961 agtggttttc tctattttga aattttttga tcaaaaactg attagtgaat atagtttgga
     1021 gtttggcttc gtgtcctggg ttcttccccg tcccttttct gtcagcccat cacagccacc
     1081 tgctctgctc agacagccag gcaccagaag tgagagcaga agtctgcatc ctgccgagcc
     1141 gccgcagacg gagccccgct gctgactgga ccctctctgg ccctgtggtt cggttctcac
     1201 agttccagtg agactgggca gcgtgtttgc ctgtcctgag gtgccaggcc tgcagagagt
     1261 ggactctggt gggtgcttcc ttcctctgct gcctaactga gtctggcaca ggctttctgc
     1321 cttgccatga ggaggaggtg tagacttgtg agtgctctct ccgctctgag tggccctcgg
     1381 ggaaccacct gctttccatc tgtggggtgg ggcgctcgct ccgagtatgt gtggcaaggt
     1441 ggaggccaca atgccaaggt tccctagtgt gtttttcttt gttggttctt aaaattatca
     1501 acctttgtta cggatgggcc tccactaggt ggctgtgggt aaagtcttgg ggggaggata
     1561 ggaaaggaga ccggctgagc ctcagggcta attgtactga gtaaggactg cagctcccgg
     1621 tgaccgcgag gagtcggtga ggtgggactg gtgactctca gaagctcctc ggtgcacttt
     1681 tgtctcggca gagctgggag ggagcaggcg ctcgcggaag cacgtcactt actgggtttg
     1741 ttcacctgtt tccagcaagt tttggtcttt tgggcagaag cctgttgacc aactgtgggc
     1801 caccacagtc tgcacagaaa ggtggcaccc ggagtggttg tggccctcac taccaagcca
     1861 cgggcagccc atttccagta ggatggcggt ttggatttct ttgctcagag ccaatgcagt
     1921 tgacacagtg gctgctgggt tactgtccca tgagactgta ctggacgggt gcagccagag
     1981 tggcgcagtg cactaaggtg ccggccgccc tgcctgcccg gtgcctccca ctgacctgag
     2041 cttactaagg gatggcagca gctccccaga aaaaaacgac actgcgagcc ctcgggacat
     2101 gactgagttc cacctcctga agccagactc cacctcttgt gcttttttgc ttgggaaaaa
     2161 ggagtttttc tttagaaaca gtgccaagaa tgatataaac tacttttaac taagatgcct
     2221 aacaggcttt taacacaggt gtccatctcc actctgtccc cggtctctgt cccagctcag
     2281 gctgcgttct ctaactcata ctgtgaagac aaccgtgttt ttgattaaaa aaaatatatc
     2341 tacatagtct taatttgtaa aaaataaaga aaattcctta acctttgaaa aaaaaaa
//
