LOCUS       NM_026617                808 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus transmembrane BAX inhibitor motif containing 4
            (Tmbim4), mRNA.
ACCESSION   NM_026617
VERSION     NM_026617.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 808)
  AUTHORS   Zhang,L., Toboso-Navasa,A., Gunawan,A., Camara,A., Nakagawa,R.,
            Finsterbusch,K., Chakravarty,P., Newman,R., Zhang,Y., Eilers,M.,
            Wack,A., Tolar,P., Toellner,K.M. and Calado,D.P.
  TITLE     Regulation of BCR-mediated Ca2+ mobilization by MIZ1-TMBIM4
            safeguards IgG1+ GC B cell-positive selection
  JOURNAL   Sci Immunol 9 (94), eadk0092 (2024)
   PUBMED   38579014
  REMARK    GeneRIF: Regulation of BCR-mediated Ca[2+] mobilization by
            MIZ1-TMBIM4 safeguards IgG1[+] GC B cell-positive selection.
REFERENCE   2  (bases 1 to 808)
  AUTHORS   Gatius,A., Tarabal,O., Cayuela,P., Casanovas,A., Piedrafita,L.,
            Salvany,S., Hernandez,S., Soler,R.M., Esquerda,J.E. and Caldero,J.
  TITLE     The Y172 Monoclonal Antibody Against p-c-Jun (Ser63) Is a Marker of
            the Postsynaptic Compartment of C-Type Cholinergic Afferent
            Synapses on Motoneurons
  JOURNAL   Front Cell Neurosci 13, 582 (2020)
   PUBMED   32038174
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 808)
  AUTHORS   Peviani,M., Salvaneschi,E., Bontempi,L., Petese,A., Manzo,A.,
            Rossi,D., Salmona,M., Collina,S., Bigini,P. and Curti,D.
  TITLE     Neuroprotective effects of the Sigma-1 receptor (S1R) agonist
            PRE-084, in a mouse model of motor neuron disease not linked to
            SOD1 mutation
  JOURNAL   Neurobiol Dis 62, 218-232 (2014)
   PUBMED   24141020
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC144942.4.
            
            On Apr 30, 2007 this sequence version replaced NM_026617.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK006207.1, BY706298.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-117               AC144942.4         55381-55497         c
            118-226             AC144942.4         48674-48782         c
            227-332             AC144942.4         46714-46819         c
            333-366             AC144942.4         43539-43572         c
            367-484             AC144942.4         42200-42317         c
            485-530             AC144942.4         40441-40486         c
            531-808             AC144942.4         39426-39703         c
FEATURES             Location/Qualifiers
     source          1..808
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 67.94 cM"
     gene            1..808
                     /gene="Tmbim4"
                     /gene_synonym="0610007H07Rik"
                     /note="transmembrane BAX inhibitor motif containing 4"
                     /db_xref="GeneID:68212"
                     /db_xref="MGI:MGI:1915462"
     exon            1..117
                     /gene="Tmbim4"
                     /gene_synonym="0610007H07Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             21..737
                     /gene="Tmbim4"
                     /gene_synonym="0610007H07Rik"
                     /note="transmembrane BAX inhibitor motif-containing
                     protein 4; Z-protein"
                     /codon_start=1
                     /product="protein lifeguard 4"
                     /protein_id="NP_080893.1"
                     /db_xref="CCDS:CCDS24205.1"
                     /db_xref="GeneID:68212"
                     /db_xref="MGI:MGI:1915462"
                     /translation="MADTDPGYPRSSIEDDFNYGSCVASASVHIRMAFLRKVYSILSL
                     QVLLTTVTSALFLYFQALRTFVHESPALIVVFALGSLGLIFALTLHRHTHPLNLYLLF
                     AFTLSESLAVAAVVTFYDVYLVLQAFIMTTAVFLGLTAYTLQSKRDFTKFGAGLFAGL
                     WILCLAGFLKLFFYSETMELVLASLGALLFCGFIIYDTHSLMHRLSPEEYVIAAISLY
                     MDIINLFLHLLKFLEAVNKK"
     exon            118..226
                     /gene="Tmbim4"
                     /gene_synonym="0610007H07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            227..332
                     /gene="Tmbim4"
                     /gene_synonym="0610007H07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            333..366
                     /gene="Tmbim4"
                     /gene_synonym="0610007H07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            367..484
                     /gene="Tmbim4"
                     /gene_synonym="0610007H07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            485..530
                     /gene="Tmbim4"
                     /gene_synonym="0610007H07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            531..808
                     /gene="Tmbim4"
                     /gene_synonym="0610007H07Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggcgggcac tgctggcgac atggccgaca cggacccggg ctatccccgc tcgtccatcg
       61 aggatgactt caactacggc agctgcgtgg cgtcggccag cgtgcacatc cgcatggcct
      121 ttctcagaaa agtctacagt atcctctctc tgcaagtcct cctgactaca gtgacctctg
      181 ccctgttcct gtatttccaa gctctgcgga catttgtcca tgaaagccct gccttaattg
      241 tggtgtttgc tctgggatct ctgggcttga tctttgcact gactctgcac agacacacgc
      301 atcctctgaa cctctatcta ctctttgcat ttacactgtc agaatccctg gccgtggcag
      361 ctgttgttac cttctatgat gtatatctgg ttctgcaagc gtttataatg actactgcag
      421 tctttcttgg cttgactgcc tatactctac aatcaaagag agatttcacc aaattcggag
      481 cagggttgtt tgctggtttg tggattttgt gcttggcagg attcttgaag ctgttttttt
      541 acagtgagac gatggagctg gtcttggcct ctctaggcgc cctcctcttc tgtgggttca
      601 tcatctatga tacacactcg ctgatgcaca gactctctcc cgaagagtac gtgatcgctg
      661 ccatcagtct ctacatggat atcatcaacc tcttcctgca cctgttgaag tttctggaag
      721 cagttaataa aaagtaaccg agcagtgttc agagacagtt ctattatgaa agacgcttga
      781 attaaactta aatgttaata ttaaaagc
//
