LOCUS       NM_027154               2325 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus transmembrane BAX inhibitor motif containing 1
            (Tmbim1), mRNA.
ACCESSION   NM_027154
VERSION     NM_027154.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2325)
  AUTHORS   Zhao,G.N., Tian,Z.W., Tian,T., Zhu,Z.P., Zhao,W.J., Tian,H.,
            Cheng,X., Hu,F.J., Hu,M.L., Tian,S., Ding,T., Chen,S., Ji,Y.X.,
            Zhang,P., Zhang,X.J., She,Z.G., Yuan,Y., Chen,W., Bai,L. and Li,H.
  TITLE     TMBIM1 is an inhibitor of adipogenesis and its depletion promotes
            adipocyte hyperplasia and improves obesity-related metabolic
            disease
  JOURNAL   Cell Metab 33 (8), 1640-1654 (2021)
   PUBMED   34107313
  REMARK    GeneRIF: TMBIM1 is an inhibitor of adipogenesis and its depletion
            promotes adipocyte hyperplasia and improves obesity-related
            metabolic disease.
REFERENCE   2  (bases 1 to 2325)
  AUTHORS   Gong,F., Gu,J. and Wang,H.
  TITLE     Up regulated Tmbim1 activation promotes high fat diet (HFD)-induced
            cardiomyopathy by enhancement of inflammation and oxidative stress
  JOURNAL   Biochem Biophys Res Commun 504 (4), 797-804 (2018)
   PUBMED   30217448
  REMARK    GeneRIF: Tmbim1 is a key suppressor of metabolic stress-induced
            cardiomyopathy.Tmbim1 was highly expressed in hearts of mice fed
            high fat diet.
REFERENCE   3  (bases 1 to 2325)
  AUTHORS   Deng,K.Q., Zhao,G.N., Wang,Z., Fang,J., Jiang,Z., Gong,J.,
            Yan,F.J., Zhu,X.Y., Zhang,P., She,Z.G. and Li,H.
  TITLE     Targeting Transmembrane BAX Inhibitor Motif Containing 1 Alleviates
            Pathological Cardiac Hypertrophy
  JOURNAL   Circulation 137 (14), 1486-1504 (2018)
   PUBMED   29229612
REFERENCE   4  (bases 1 to 2325)
  AUTHORS   Zhao,G.N., Zhang,P., Gong,J., Zhang,X.J., Wang,P.X., Yin,M.,
            Jiang,Z., Shen,L.J., Ji,Y.X., Tong,J., Wang,Y., Wei,Q.F., Wang,Y.,
            Zhu,X.Y., Zhang,X., Fang,J., Xie,Q., She,Z.G., Wang,Z., Huang,Z.
            and Li,H.
  TITLE     Tmbim1 is a multivesicular body regulator that protects against
            non-alcoholic fatty liver disease in mice and monkeys by targeting
            the lysosomal degradation of Tlr4
  JOURNAL   Nat Med 23 (6), 742-752 (2017)
   PUBMED   28481357
  REMARK    GeneRIF: TMBIM1 is an effective suppressor of steatohepatitis and a
            previously unknown regulator of the multivesicular body
            (MVB)-lysosomal pathway. Tmbim1 expression in hepatocytes
            substantially inhibited high-fat diet-induced insulin resistance,
            hepatic steatosis and inflammation in mice. Overexpression of
            Tmbim1 in the liver effectively inhibited a severe form of NAFLD in
            mice.
REFERENCE   5  (bases 1 to 2325)
  AUTHORS   Zhao,H., Ito,A., Sakai,N., Matsuzawa,Y., Yamashita,S. and Nojima,H.
  TITLE     RECS1 is a negative regulator of matrix metalloproteinase-9
            production and aged RECS1 knockout mice are prone to aortic
            dilation
  JOURNAL   Circ J 70 (5), 615-624 (2006)
   PUBMED   16636500
  REMARK    GeneRIF: RECS1 negatively regulates aortic MMP-9 production and
            knocking out RECS1 induces susceptibility to aortic dilation as
            well as cystic medial degeneration in the aged mice.
REFERENCE   6  (bases 1 to 2325)
  AUTHORS   Zhao,H., Ito,A., Kimura,S.H., Yabuta,N., Sakai,N., Ikawa,M.,
            Okabe,M., Matsuzawa,Y., Yamashita,S. and Nojima,H.
  TITLE     RECS1 deficiency in mice induces susceptibility to cystic medial
            degeneration
  JOURNAL   Genes Genet Syst 81 (1), 41-50 (2006)
   PUBMED   16607040
  REMARK    GeneRIF: An endosomal/lysosomal membrane protein which plays
            protective roles in vascular remodeling
REFERENCE   7  (bases 1 to 2325)
  AUTHORS   Yoshisue,H., Suzuki,K., Kawabata,A., Ohya,T., Zhao,H., Sakurada,K.,
            Taba,Y., Sasaguri,T., Sakai,N., Yamashita,S., Matsuzawa,Y. and
            Nojima,H.
  TITLE     Large scale isolation of non-uniform shear stress-responsive genes
            from cultured human endothelial cells through the preparation of a
            subtracted cDNA library
  JOURNAL   Atherosclerosis 162 (2), 323-334 (2002)
   PUBMED   11996952
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY312755.1, AK152864.1 and BQ031095.1.
            
            On May 7, 2009 this sequence version replaced NM_027154.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660813.45386.1,
                                           SRR1660813.139961.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-158               BY312755.1         1-158
            159-2138            AK152864.1         2-1981
            2139-2325           BQ031095.1         1-187               c
FEATURES             Location/Qualifiers
     source          1..2325
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 38.53 cM"
     gene            1..2325
                     /gene="Tmbim1"
                     /gene_synonym="2310061B02Rik; mKIAA4161; RECS1; Tmbib1"
                     /note="transmembrane BAX inhibitor motif containing 1"
                     /db_xref="GeneID:69660"
                     /db_xref="MGI:MGI:1916910"
     exon            1..214
                     /gene="Tmbim1"
                     /gene_synonym="2310061B02Rik; mKIAA4161; RECS1; Tmbib1"
                     /inference="alignment:Splign:2.1.0"
     exon            215..456
                     /gene="Tmbim1"
                     /gene_synonym="2310061B02Rik; mKIAA4161; RECS1; Tmbib1"
                     /inference="alignment:Splign:2.1.0"
     CDS             255..1184
                     /gene="Tmbim1"
                     /gene_synonym="2310061B02Rik; mKIAA4161; RECS1; Tmbib1"
                     /note="transmembrane BAX inhibitor motif-containing
                     protein 1; responsive to centrifugal force and shear
                     stress gene 1 protein"
                     /codon_start=1
                     /product="protein lifeguard 3"
                     /protein_id="NP_081430.3"
                     /db_xref="CCDS:CCDS15044.1"
                     /db_xref="GeneID:69660"
                     /db_xref="MGI:MGI:1916910"
                     /translation="MSNPSAPPPYEDHNPLYPGSPPPGGYGQPSVLPGGYPAYPAYPQ
                     PGYGHPAGYPQPVPPVHPMPMNYGHDYNEEERAGSDSFRPGEWDDRKVRHSFIQKVYC
                     IISVQLLITVAIIAIFTFVEPVGKYVRNNVAVYYVSYAVFLVTYLTLACCQGPRRRFP
                     WNIILLTIFTLALGFVTGTISSMYETKAVIIAMIITAVVSISVTIFCFQTKVDFTSCT
                     GLFCVLGIVLMVTGIVTSIVLIFKYIYWLHMVYAALGAICFTLFLAYDTQLVLGNRKH
                     TISPEDYITGALQIYTDIVYIFTFVLQLVGSRD"
     exon            457..551
                     /gene="Tmbim1"
                     /gene_synonym="2310061B02Rik; mKIAA4161; RECS1; Tmbib1"
                     /inference="alignment:Splign:2.1.0"
     exon            552..616
                     /gene="Tmbim1"
                     /gene_synonym="2310061B02Rik; mKIAA4161; RECS1; Tmbib1"
                     /inference="alignment:Splign:2.1.0"
     exon            617..670
                     /gene="Tmbim1"
                     /gene_synonym="2310061B02Rik; mKIAA4161; RECS1; Tmbib1"
                     /inference="alignment:Splign:2.1.0"
     exon            671..721
                     /gene="Tmbim1"
                     /gene_synonym="2310061B02Rik; mKIAA4161; RECS1; Tmbib1"
                     /inference="alignment:Splign:2.1.0"
     exon            722..761
                     /gene="Tmbim1"
                     /gene_synonym="2310061B02Rik; mKIAA4161; RECS1; Tmbib1"
                     /inference="alignment:Splign:2.1.0"
     exon            762..799
                     /gene="Tmbim1"
                     /gene_synonym="2310061B02Rik; mKIAA4161; RECS1; Tmbib1"
                     /inference="alignment:Splign:2.1.0"
     exon            800..887
                     /gene="Tmbim1"
                     /gene_synonym="2310061B02Rik; mKIAA4161; RECS1; Tmbib1"
                     /inference="alignment:Splign:2.1.0"
     exon            888..983
                     /gene="Tmbim1"
                     /gene_synonym="2310061B02Rik; mKIAA4161; RECS1; Tmbib1"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1037
                     /gene="Tmbim1"
                     /gene_synonym="2310061B02Rik; mKIAA4161; RECS1; Tmbib1"
                     /inference="alignment:Splign:2.1.0"
     exon            1038..2309
                     /gene="Tmbim1"
                     /gene_synonym="2310061B02Rik; mKIAA4161; RECS1; Tmbib1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2283..2288
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmbim1"
                     /gene_synonym="2310061B02Rik; mKIAA4161; RECS1; Tmbib1"
                     /note="hexamer: AATAAA"
     polyA_site      2307
                     /gene="Tmbim1"
                     /gene_synonym="2310061B02Rik; mKIAA4161; RECS1; Tmbib1"
                     /note="major polyA site"
ORIGIN      
        1 ttccagtaaa tgtgaaccac tcacacctgg gtcgtggttg aggtctggag gggaccccag
       61 cgctccctgg aggtctcggg gtgccgggcg gctcctcccc actggcggcg gagagagacg
      121 gggcggggca cggagcccca gtccagcccg gcccagccca gtcctcgcca gcgcccggag
      181 gcccaggcgg atctcacggt ccggaacagc gcaggaccca gaagctgggg tttcccctca
      241 gcccttgagt ggccatgtcc aatcccagtg ccccacctcc ctatgaggac cacaaccccc
      301 tgtaccctgg ctctccacct cctggtggct acgggcagcc atctgtcctg ccaggtggtt
      361 atcccgccta ccctgcctac cctcaacctg gttacggtca tcctgctggc tacccacagc
      421 cggttcctcc cgtccatcca atgcccatga actacggcca tgactataat gaagaggaga
      481 gagcaggaag tgacagcttt cgtcctggag aatgggatga ccggaaagtt cgacattcct
      541 tcatccaaaa ggtgtattgc atcatttctg tccagctgct catcactgtg gccatcattg
      601 caatcttcac ctttgtggaa ccagtcggca aatacgtgag gaacaatgtg gctgtgtact
      661 acgtgtccta tgctgtcttc cttgtcacct acctgaccct tgcctgctgc cagggaccca
      721 ggcgccgatt cccatggaac atcatcttgc tcaccatctt tactttggct ttgggctttg
      781 tgacaggcac tatttccagt atgtatgaaa ccaaagctgt catcatagca atgatcatca
      841 ccgctgtggt atccatctct gtcaccatct tctgctttca gactaaggtg gacttcacct
      901 cgtgtacagg cctcttctgt gtgctgggaa tagtgctgat ggtgaccgga attgtcacaa
      961 gcatagtgct gatctttaaa tatatttact ggctccacat ggtctatgca gctctggggg
     1021 ccatctgttt caccctgttc ctggcttatg acacacagct ggtcctgggg aaccggaagc
     1081 acaccatcag cccggaggac tacatcacag gcgccctaca gatctacaca gatatagtct
     1141 atatcttcac gttcgtgctc cagctcgtag gaagtagaga ctgagagaaa gagagatgtc
     1201 cctttcactg gcctgggact caccctttcc tattgggctg ggccctaggt cccgtctccc
     1261 ctcaagtaat ctgctcagtt tcctctccgt cctggggatg ggaggacctc tggctgtgtt
     1321 cagtgagagc catgatgctg ggatcactgg cacctcttag cccttggtgg gcttggtaag
     1381 aactagtctg aaggtgtatc tccttccctt tacccatgac gagtatgcac caaactctgt
     1441 gtgtgtgtgt gggtgggtgt gtgtgggtgt gtgtagggga gtagggagcc tgtgaacaca
     1501 ggagctctga ggggaagagg ctcccctccc acctcggcca cagggttcta ggctaggagc
     1561 tggagctgtc tccctcctgg atccaataaa gccagatgct ttgcctccag ctccagtgct
     1621 cataggccac ttatgctgtc tgaactcttt aggcttggca tctcttagct ttagaagcta
     1681 gaagagatct gtgccctggg gtctctctgt tccaacccca tcttccagta acatgtatca
     1741 gttatttatc tggctagggg aaaaaagaca gtgagcagag tttcatcagt atgggggcta
     1801 aaccagaatg gcatccaccc tgcctggcgc ccagcctggc taccatccag acccaaagtg
     1861 ccttggggcc ttctgaggct tttaaaatcg gacctagagg gacctcctat tttgctctga
     1921 cacacagagg tggattgtgg gattctgggt gtggctggga agcagtctgg gtgagagata
     1981 agtggggaca gggaaagcgc cttgggtgcc ctctctggtc tgagaaacac tgaagtctac
     2041 tctggtacac aagttcaatc tgttctgtat tcccattggg agatttcaga ctaaaacccc
     2101 ctcttcaagc cagctgctgc tttctatgta atccaagtgc ctcctccggc tggtaccagg
     2161 atgggaacag aagccggttt atcaggtggg gtagaaacct tactagccca aggacatagt
     2221 tagagctatt ctgtccagta cttgattctg aatatatcac agagggacac aactagaaat
     2281 gtaataaagt tttatgtttg gcaggaagaa aaaaaaaaaa aaaaa
//
