LOCUS       NP_598608                643 aa            linear   ROD 18-JUN-2024
DEFINITION  transmembrane 9 superfamily member 4 precursor [Mus musculus].
ACCESSION   NP_598608
VERSION     NP_598608.2
DBSOURCE    REFSEQ: accession NM_133847.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 643)
  AUTHORS   Zhao,R., Liao,W., Tan,D., Huang,H., Hu,C. and Chen,M.
  TITLE     Comparative analysis of the expression patterns of TM9SF family
            members in mice
  JOURNAL   Gene Expr Patterns 52, 119366 (2024)
   PUBMED   38719197
REFERENCE   2  (residues 1 to 643)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (residues 1 to 643)
  AUTHORS   Xie,M., Mak,J.W.Y., Yu,H., Cheng,C.T.Y., Chan,H.C.H., Chan,T.T.,
            Lau,L.H.S., Wong,M.T.L., Ko,W.H., Jiang,L. and Yao,X.
  TITLE     TM9SF4 Is a Crucial Regulator of Inflammation and ER Stress in
            Inflammatory Bowel Disease
  JOURNAL   Cell Mol Gastroenterol Hepatol 14 (2), 245-270 (2022)
   PUBMED   35398597
REFERENCE   4  (residues 1 to 643)
  AUTHORS   Yu,L., Xie,M., Zhang,F., Wan,C. and Yao,X.
  TITLE     TM9SF4 is a novel regulator in lineage commitment of bone marrow
            mesenchymal stem cells to either osteoblasts or adipocytes
  JOURNAL   Stem Cell Res Ther 12 (1), 573 (2021)
   PUBMED   34774100
  REMARK    GeneRIF: TM9SF4 is a novel regulator in lineage commitment of bone
            marrow mesenchymal stem cells to either osteoblasts or adipocytes.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 643)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 643)
  AUTHORS   Sun,L., Meng,Z., Zhu,Y., Lu,J., Li,Z., Zhao,Q., Huang,Y., Jiang,L.
            and Yao,X.
  TITLE     TM9SF4 is a novel factor promoting autophagic flux under amino acid
            starvation
  JOURNAL   Cell Death Differ 25 (2), 368-379 (2018)
   PUBMED   29125601
REFERENCE   7  (residues 1 to 643)
  AUTHORS   Liakath-Ali,K., Vancollie,V.E., Heath,E., Smedley,D.P., Estabel,J.,
            Sunter,D., Ditommaso,T., White,J.K., Ramirez-Solis,R., Smyth,I.,
            Steel,K.P. and Watt,F.M.
  TITLE     Novel skin phenotypes revealed by a genome-wide mouse reverse
            genetic screen
  JOURNAL   Nat Commun 5, 3540 (2014)
   PUBMED   24721909
  REMARK    Publication Status: Online-Only
REFERENCE   8  (residues 1 to 643)
  AUTHORS   Jensen,P., Magdaleno,S., Lehman,K.M., Rice,D.S., Lavallie,E.R.,
            Collins-Racie,L., McCoy,J.M. and Curran,T.
  TITLE     A neurogenomics approach to gene expression analysis in the
            developing brain
  JOURNAL   Brain Res Mol Brain Res 132 (2), 116-127 (2004)
   PUBMED   15582152
REFERENCE   9  (residues 1 to 643)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (residues 1 to 643)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Hara,Y., Nagase,T.,
            Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: I. The complete nucleotide sequences of 100 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 9 (5), 179-188 (2002)
   PUBMED   12465718
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AL807380.6.
            
            On Jun 9, 2003 this sequence version replaced NP_598608.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK083541.1, AK088012.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..643
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 75.41 cM"
     Protein         1..643
                     /product="transmembrane 9 superfamily member 4 precursor"
                     /note="transmembrane 9 superfamily protein member 4"
                     /calculated_mol_wt=72085
     sig_peptide     1..23
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8BH24.1)"
                     /calculated_mol_wt=2626
     mat_peptide     24..643
                     /product="Transmembrane 9 superfamily member 4.
                     /id=PRO_0000311810"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BH24.1)"
                     /calculated_mol_wt=72085
     Region          55..600
                     /region_name="EMP70"
                     /note="Endomembrane protein 70; pfam02990"
                     /db_xref="CDD:460774"
     Site            283..303
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BH24.1)"
     Site            313
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:Q92544; propagated from
                     UniProtKB/Swiss-Prot (Q8BH24.1)"
     Site            348..368
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BH24.1)"
     Site            378..398
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BH24.1)"
     Site            418..438
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BH24.1)"
     Site            451..471
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BH24.1)"
     Site            503..523
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BH24.1)"
     Site            537..557
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BH24.1)"
     Site            572..592
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BH24.1)"
     Site            600..620
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BH24.1)"
     CDS             1..643
                     /gene="Tm9sf4"
                     /gene_synonym="B930079E06; mKIAA0255"
                     /coded_by="NM_133847.3:257..2188"
                     /db_xref="CCDS:CCDS16906.1"
                     /db_xref="GeneID:99237"
                     /db_xref="MGI:MGI:2139220"
ORIGIN      
        1 maaamiwwpr fllllcltck gstfyvpgva pinfhqndpv eikavkltss rtqlpyeyys
       61 lpfcqpikit ykaenlgevl rgdrivntpf qvlmnsekkc evlcnqsnkp itltveqsrl
      121 vaeriteeyy vhliadnlpv atrlelyssn rdsddkkkek dvqfehgyrl gftdvnkiyl
      181 hnhlsfilyy hredmeedqe htyrvvrfev ipqsirledl ktgekssctl peganslpqe
      241 idptkenqly ftysvhwees dikwasrwdt yltmsdvqih wfsiinsvvv vfflsgilsm
      301 iiirtlrkdi anynkeddie dtmeesgwkl vhgdvfrppq ypmilssllg sgiqlfcmil
      361 ivifvamlgm lspssrgalm ttacflfmfm gvfggfsagr lyrtlkghrw kkgafctatl
      421 ypgvvfgicf vlncfiwgkh ssgavpfptm vallcmwfgi slplvylgyy fgfrkqpydn
      481 pvrtnqiprq ipeqrwymnr fvgilmagil pfgamfielf fifsaiwenq fyylfgflfl
      541 vfiilvvscs qisivmvyfq lcaedyrwww rnflvsggsa fyvlvyaify fvnkldivef
      601 ipsllyfgyt tlmvlsfwll tgtigfyaay mfvrkiyaav kid
//
