LOCUS       NM_026281               3312 bp    mRNA    linear   ROD 26-JUN-2024
DEFINITION  Mus musculus transmembrane 7 superfamily member 3 (Tm7sf3), mRNA.
ACCESSION   NM_026281 XM_132970
VERSION     NM_026281.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3312)
  AUTHORS   Isaac,R., Bandyopadhyay,G., Rohm,T.V., Kang,S., Wang,J.,
            Pokhrel,N., Sakane,S., Zapata,R., Libster,A.M., Vinik,Y.,
            Berhan,A., Kisseleva,T., Borok,Z., Zick,Y., Telese,F.,
            Webster,N.J.G. and Olefsky,J.M.
  TITLE     TM7SF3 controls TEAD1 splicing to prevent MASH-induced liver
            fibrosis
  JOURNAL   Cell Metab 36 (5), 1030-1043 (2024)
   PUBMED   38670107
REFERENCE   2  (bases 1 to 3312)
  AUTHORS   Wu,Y.J., He,Q., Shang,M., Yin,Y.X., Li,Y., Du,X. and Li,X.R.
  TITLE     The NF-kappaB signalling pathway and TM7SF3 contribute to liver
            fibrosis caused by secreted phospholipase A2 of Clonorchis sinensis
  JOURNAL   Parasit Vectors 14 (1), 152 (2021)
   PUBMED   33691755
  REMARK    GeneRIF: The NF-kappaB signalling pathway and TM7SF3 contribute to
            liver fibrosis caused by secreted phospholipase A2 of Clonorchis
            sinensis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3312)
  AUTHORS   Isaac,R., Goldstein,I., Furth,N., Zilber,N., Streim,S.,
            Boura-Halfon,S., Elhanany,E., Rotter,V., Oren,M. and Zick,Y.
  TITLE     TM7SF3, a novel p53-regulated homeostatic factor, attenuates
            cellular stress and the subsequent induction of the unfolded
            protein response
  JOURNAL   Cell Death Differ 24 (1), 132-143 (2017)
   PUBMED   27740623
REFERENCE   4  (bases 1 to 3312)
  AUTHORS   Liu,X., Jiao,Y., Cao,Y., Deng,N., Ma,Y., Hasty,K.A., Kang,A.,
            Chen,H., Stuart,J.M. and Gu,W.
  TITLE     Decreased expression levels of Ifi genes is associated to the
            increased resistance to spontaneous arthritis disease in mice
            deficiency of IL-1RA
  JOURNAL   BMC Immunol 17 (1), 25 (2016)
   PUBMED   27480124
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3312)
  AUTHORS   Beck,A., Isaac,R., Lavelin,I., Hart,Y., Volberg,T.,
            Shatz-Azoulay,H., Geiger,B. and Zick,Y.
  TITLE     An siRNA screen identifies transmembrane 7 superfamily member 3
            (TM7SF3), a seven transmembrane orphan receptor, as an inhibitor of
            cytokine-induced death of pancreatic beta cells
  JOURNAL   Diabetologia 54 (11), 2845-2855 (2011)
   PUBMED   21853325
  REMARK    GeneRIF: Data indicate that TM7SF3 plays a role in inhibition of
            cytokine-induced cell death/apoptosis in pancreatic beta cells and
            in inhibition of insulin secretion from pancreatic beta cells.
REFERENCE   6  (bases 1 to 3312)
  AUTHORS   Nathan,B.M., Hodges,C.A., Supelak,P.J., Burrage,L.C., Nadeau,J.H.
            and Palmert,M.R.
  TITLE     A quantitative trait locus on chromosome 6 regulates the onset of
            puberty in mice
  JOURNAL   Endocrinology 147 (11), 5132-5138 (2006)
   PUBMED   16873534
REFERENCE   7  (bases 1 to 3312)
  AUTHORS   Cobellis,G., Nicolaus,G., Iovino,M., Romito,A., Marra,E.,
            Barbarisi,M., Sardiello,M., Di Giorgio,F.P., Iovino,N., Zollo,M.,
            Ballabio,A. and Cortese,R.
  TITLE     Tagging genes with cassette-exchange sites
  JOURNAL   Nucleic Acids Res 33 (4), e44 (2005)
   PUBMED   15741177
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 3312)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124128.11 and AK010720.1.
            
            On Dec 27, 2006 this sequence version replaced NM_026281.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660813.172075.1,
                                           SRR1660815.255580.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-158               AC124128.11        156137-156294       c
            159-2077            AK010720.1         2-1920
            2078-3312           AC124128.11        123978-125212       c
FEATURES             Location/Qualifiers
     source          1..3312
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 77.7 cM"
     gene            1..3312
                     /gene="Tm7sf3"
                     /gene_synonym="2010003B14Rik; NARP1"
                     /note="transmembrane 7 superfamily member 3"
                     /db_xref="GeneID:67623"
                     /db_xref="MGI:MGI:1914873"
     exon            1..207
                     /gene="Tm7sf3"
                     /gene_synonym="2010003B14Rik; NARP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             132..1829
                     /gene="Tm7sf3"
                     /gene_synonym="2010003B14Rik; NARP1"
                     /codon_start=1
                     /product="transmembrane 7 superfamily member 3 precursor"
                     /protein_id="NP_080557.2"
                     /db_xref="CCDS:CCDS20699.1"
                     /db_xref="GeneID:67623"
                     /db_xref="MGI:MGI:1914873"
                     /translation="MWRLRLLVLAVLAAGSAEAQANSSDGFLEFSVGKFTYFVLSKSS
                     PQEAVLRHISSNVTFLLFQIHSQYQNTTVSFTKTLLPSTSGTGNDRGLVFILRPEQAV
                     CTWYLETGDTKPVQSVALTLSYSERDPIPGGCNLEFDLDIDPNLYLDYNFFETTIKFA
                     PANIGYARATEPPPCDVSTSRESRWRLRYDVYQYFLPEGDLTEASLLHHLQRMAQVAQ
                     VKASAIKVATLTADDKTAVSFSSLPGQGVIYNVIVWDPSLNTSAAYVPVHTYACSFES
                     VDGNCAFPGRVSTKVFSTLVALLGLFVCFFGHRFWKTDLFFIGFIFLGFFFYILITRL
                     TPLQYDVRLALTAVAGSFGGLLLVASWWRFGILTLCMLCVGLVLGFLVSSGTFFTPLG
                     NLNVFHDDGVFWVTFSCIALLVPVIFMGCLRILNILACGVVGSYSVVLAVNSYMFTSL
                     SYITLNVLRRALNTDFRGAVIRVPFQTNDYIILAVWGMLAVSGITLQIRRERGQPPFP
                     PHPYKLWKQERERRVTNILDPSHHIPPLRERLYGRVARIKELFQKEQPAGERTPLLL"
     exon            208..362
                     /gene="Tm7sf3"
                     /gene_synonym="2010003B14Rik; NARP1"
                     /inference="alignment:Splign:2.1.0"
     exon            363..513
                     /gene="Tm7sf3"
                     /gene_synonym="2010003B14Rik; NARP1"
                     /inference="alignment:Splign:2.1.0"
     exon            514..634
                     /gene="Tm7sf3"
                     /gene_synonym="2010003B14Rik; NARP1"
                     /inference="alignment:Splign:2.1.0"
     exon            635..806
                     /gene="Tm7sf3"
                     /gene_synonym="2010003B14Rik; NARP1"
                     /inference="alignment:Splign:2.1.0"
     exon            807..984
                     /gene="Tm7sf3"
                     /gene_synonym="2010003B14Rik; NARP1"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1071
                     /gene="Tm7sf3"
                     /gene_synonym="2010003B14Rik; NARP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1152
                     /gene="Tm7sf3"
                     /gene_synonym="2010003B14Rik; NARP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..1305
                     /gene="Tm7sf3"
                     /gene_synonym="2010003B14Rik; NARP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..1403
                     /gene="Tm7sf3"
                     /gene_synonym="2010003B14Rik; NARP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1404..1566
                     /gene="Tm7sf3"
                     /gene_synonym="2010003B14Rik; NARP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1567..3312
                     /gene="Tm7sf3"
                     /gene_synonym="2010003B14Rik; NARP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3212..3217
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tm7sf3"
                     /gene_synonym="2010003B14Rik; NARP1"
                     /note="hexamer: AATAAA"
     polyA_site      3235
                     /gene="Tm7sf3"
                     /gene_synonym="2010003B14Rik; NARP1"
                     /note="major polyA site"
ORIGIN      
        1 gcgcgcccgg cggggctggg gcggcaggtg cacgcgcggg gccggcgcgc taaagcgatg
       61 cgcgcgggcg ctccggggta gcaagcgacc tggcctgcgc gcccctggcc cgcgcgcccc
      121 ggcccgcagc gatgtggcgg ctgcgcctgc tggtcctagc ggtgctggcg gcgggcagcg
      181 ccgaggccca ggcgaactcc agcgacggtt tccttgagtt ttctgtggga aaatttacat
      241 actttgtgct cagcaagtcc tctccgcagg aggccgtcct gcgccatatt tcaagcaatg
      301 tgacctttct tcttttccaa atacactcac agtatcagaa taccacggtt tcatttacta
      361 agactctcct tcccagcacg tcaggaacag gcaacgacag agggctggtc ttcattctta
      421 gaccggagca ggcagtgtgt acttggtact tggagacggg agacaccaag cctgtccaaa
      481 gcgtggccct tacgctctcc tactcagaaa gagatcccat tcctggaggc tgcaatttgg
      541 agtttgattt agatattgac cccaacctct atttggacta taattttttt gagacaacta
      601 tcaagttcgc accagcaaac ataggctatg caagggctac agagccccca ccgtgtgatg
      661 tgagcaccag ccgagagtcc aggtggaggc tgcgctatga cgtgtaccag tacttcctgc
      721 ccgagggcga cctcaccgag gcctctctgc tccatcatct tcagaggatg gcccaggtgg
      781 ctcaggtgaa ggccagtgcc atcaaggtgg ccaccctaac agctgacgat aaaacagccg
      841 tgtccttctc ttccctcccg ggacaaggag tcatctataa tgtcatcgtt tgggatccgt
      901 ccctcaatac ttctgctgct tatgtgcccg tgcacacata cgcctgcagc tttgagtcag
      961 tggatggtaa ctgtgctttt cctggaagag tatctacgaa agtgttctcc actttggttg
     1021 ccctgcttgg gctcttcgtt tgtttctttg gacacagatt ctggaaaaca gatttattct
     1081 tcattggctt catcttcctg gggttcttct tctacatcct gatcaccaga ctgacacccc
     1141 ttcagtatga cgttcgcctg gctctcaccg ctgtagctgg cagctttggt ggcctcctcc
     1201 tggtggcttc atggtggcga ttcgggatcc tcacactctg catgctgtgt gtgggactcg
     1261 tgctgggctt cctcgtgtct tctgggactt tcttcacgcc tctgggaaac ctaaatgttt
     1321 ttcatgatga tggagtgttc tgggtgacgt tctcctgcat agcgctgctt gttccagtca
     1381 tcttcatggg ctgcctaaga atcttgaaca tcctggcttg tggagtcgtg ggctcctact
     1441 ccgtggtgtt ggctgttaac agttacatgt tcacaagcct ctcctacatc accctgaacg
     1501 tcctcaggag agctctcaac acagatttcc gaggggctgt cattagagtg cctttccaga
     1561 ccaacgacta catcatcctg gccgtgtggg ggatgctggc tgtcagtgga attacacttc
     1621 agattcgaag agaaagagga cagccgcctt tccctcccca cccctacaag ctatggaagc
     1681 aagagagaga acgcagagtg accaacatcc tggaccccag ccatcacatc cctcccctga
     1741 gagagaggct ttatggtcgg gttgctcgga tcaaagagct cttccagaag gaacagccgg
     1801 ctggagagag gacacccttg cttctgtaga aggctgaggg tcagtgtgct tgccctggag
     1861 ttctcgtcta gactgcccag ttgtcccagg tccatgcagg gccagccagg gtgggtgaca
     1921 gggtgacgcc cccgtggatg tacagcagtg gagttagagg attctaagtg atatggtgag
     1981 aaaagtctcc aaaaagttgg ccgtagatgt ttttcctcat tttccacagt cttgagaagt
     2041 taccttttga tgattgatgt cttttataaa atacaccaaa aaataaaaat gtctccttga
     2101 agccctagtg ttttgttctt gtagcttctt ggacagttat gactcagtca gaacctgtgg
     2161 aggggaggca ggcagtgggt atttattcgc tttgtgtgta gaagtttagg gatttgattt
     2221 gggtccttga atgtcaagac taagggaaaa gtaacccccc ttttccttaa aagcagtctg
     2281 attatatttg gctgcatctt ataataaaat caggaaccct tttcatttat tttcaatatt
     2341 caaacgattt attttaaaaa ctggcaaatt atcctaacac gtaacaatgt agatttcctg
     2401 ttgttttgcc agttagtgct ttaagtggta aataactaaa ttttttctgt aatctaaaat
     2461 agctcagttt attaaagata ataaaacttt tatatgagta agttatttat agcccatttt
     2521 gtgttggggc catttagagc agtgttggct gctgaccctt ctttcttagg ttgcattaga
     2581 cggtgactgg accgtatttt gtcagagaga catcaatgag accttcctag cacctgtgaa
     2641 gttgtgctaa tgattgctct gtataatcaa agcccctgtg ctctgaagct cagagggatt
     2701 gatcacttag ccaccaccat gggttctgta aggagggaca tgctcttgac tcctctgaac
     2761 ggcagggctg agaactggct tccctgacgt gtgtggccca cagtgcgctg gtttgtcagt
     2821 ggtgtgcttc ttagtctctt cacagcaatg actatagcct tgacatttca gggagtgggt
     2881 ggagtcttca gttgtggctt tgaaaaaagg ttctgaagtt aaaacataat gaaaaattat
     2941 aaaatgaacc ccttttggtt tatttctgaa aatcctattc tgttattact acctagcttc
     3001 agcaatatat atatatattt taattgctat agggtttctg gcttgtcaca tgcttgcatt
     3061 ttagttgtac agattgttgg agaactattc tttgtactgt cggaacacac tgccagtcag
     3121 agctaaaaaa ggcagagtat gctttctcgg agggaaatac aaaatatttg taaattttca
     3181 taatttttaa taccatttgt ataatttttg taataaatac ctactttgaa aaaaatgctt
     3241 aatgtcctcc ttattaggat gtctccagga gtttatacca gtcttgtatg tacttatata
     3301 aatttaatct gg
//
