LOCUS       NM_001293795            1446 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus transmembrane 6 superfamily member 2 (Tm6sf2),
            transcript variant 1, mRNA.
ACCESSION   NM_001293795 XM_006509533
VERSION     NM_001293795.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1446)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1446)
  AUTHORS   Zhu,W., Liang,W., Lu,H., Chang,L., Zhang,J., Chen,Y.E. and Guo,Y.
  TITLE     Myeloid TM6SF2 Deficiency Inhibits Atherosclerosis
  JOURNAL   Cells 11 (18), 2877 (2022)
   PUBMED   36139452
  REMARK    GeneRIF: Myeloid TM6SF2 Deficiency Inhibits Atherosclerosis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1446)
  AUTHORS   Fan,Y., Wolford,B.N., Lu,H., Liang,W., Sun,J., Zhou,W., Rom,O.,
            Mahajan,A., Surakka,I., Graham,S.E., Liu,Z., Kim,H., Ramdas,S.,
            Fritsche,L.G., Nielsen,J.B., Gabrielsen,M.E., Hveem,K., Yang,D.,
            Song,J., Garcia-Barrio,M.T., Zhang,J., Liu,W., Zhang,K.,
            Willer,C.J. and Chen,Y.E.
  TITLE     Type 2 diabetes sex-specific effects associated with E167K coding
            variant in TM6SF2
  JOURNAL   iScience 24 (11), 103196 (2021)
   PUBMED   34746691
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1446)
  AUTHORS   Newberry,E.P., Hall,Z., Xie,Y., Molitor,E.A., Bayguinov,P.O.,
            Strout,G.W., Fitzpatrick,J.A.J., Brunt,E.M., Griffin,J.L. and
            Davidson,N.O.
  TITLE     Liver-Specific Deletion of Mouse Tm6sf2 Promotes Steatosis,
            Fibrosis, and Hepatocellular Cancer
  JOURNAL   Hepatology 74 (3), 1203-1219 (2021)
   PUBMED   33638902
  REMARK    GeneRIF: Liver-Specific Deletion of Mouse Tm6sf2 Promotes
            Steatosis, Fibrosis, and Hepatocellular Cancer.
REFERENCE   5  (bases 1 to 1446)
  AUTHORS   Li,B.T., Sun,M., Li,Y.F., Wang,J.Q., Zhou,Z.M., Song,B.L. and
            Luo,J.
  TITLE     Disruption of the ERLIN-TM6SF2-APOB complex destabilizes APOB and
            contributes to non-alcoholic fatty liver disease
  JOURNAL   PLoS Genet 16 (8), e1008955 (2020)
   PUBMED   32776921
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1446)
  AUTHORS   Smagris,E., Gilyard,S., BasuRay,S., Cohen,J.C. and Hobbs,H.H.
  TITLE     Inactivation of Tm6sf2, a Gene Defective in Fatty Liver Disease,
            Impairs Lipidation but Not Secretion of Very Low Density
            Lipoproteins
  JOURNAL   J Biol Chem 291 (20), 10659-10676 (2016)
   PUBMED   27013658
  REMARK    GeneRIF: Despite TM6SF2 being located in the endoplasmic reticulum
            and Golgi complex, the lipids that accumulate in its absence reside
            in lipid droplets.
REFERENCE   7  (bases 1 to 1446)
  AUTHORS   Fan,Y., Lu,H., Guo,Y., Zhu,T., Garcia-Barrio,M.T., Jiang,Z.,
            Willer,C.J., Zhang,J. and Chen,Y.E.
  TITLE     Hepatic Transmembrane 6 Superfamily Member 2 Regulates Cholesterol
            Metabolism in Mice
  JOURNAL   Gastroenterology 150 (5), 1208-1218 (2016)
   PUBMED   26774178
  REMARK    GeneRIF: Expression of TM6SF2 promoted cholesterol biosynthesis in
            hepatocytes.
REFERENCE   8  (bases 1 to 1446)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   9  (bases 1 to 1446)
  AUTHORS   Carim-Todd,L., Escarceller,M., Estivill,X. and Sumoy,L.
  TITLE     Cloning of the novel gene TM6SF1 reveals conservation of clusters
            of paralogous genes between human chromosomes 15q24-->q26 and
            19p13.3-->p12
  JOURNAL   Cytogenet Cell Genet 90 (3-4), 255-260 (2000)
   PUBMED   11124529
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC167132.12.
            
            On Jun 21, 2014 this sequence version replaced XM_006509533.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC024498.1, SRR5189682.93297.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-166               AC167132.12        132999-133164
            167-270             AC167132.12        134353-134456
            271-368             AC167132.12        135407-135504
            369-472             AC167132.12        135575-135678
            473-555             AC167132.12        136076-136158
            556-680             AC167132.12        137465-137589
            681-782             AC167132.12        137956-138057
            783-875             AC167132.12        138385-138477
            876-995             AC167132.12        138880-138999
            996-1446            AC167132.12        139691-140141
FEATURES             Location/Qualifiers
     source          1..1446
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 34.15 cM"
     gene            1..1446
                     /gene="Tm6sf2"
                     /note="transmembrane 6 superfamily member 2"
                     /db_xref="GeneID:107770"
                     /db_xref="MGI:MGI:1933210"
     exon            1..166
                     /gene="Tm6sf2"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..1208
                     /gene="Tm6sf2"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="transmembrane 6 superfamily member 2 isoform 1"
                     /protein_id="NP_001280724.1"
                     /db_xref="CCDS:CCDS80889.1"
                     /db_xref="GeneID:107770"
                     /db_xref="MGI:MGI:1933210"
                     /translation="MDIPPLAGRTVAMSFCALPVSYLLNQVSAFSQPLFVVLTSALIL
                     GLLFLAVYSLSHGEITYDPLYAVFVIFSFTSVVDLVIALQEDGYMMGFMDFYTKEGEP
                     YLRTAHGIFICYWDGTVHYLLYLTMAGAIRKRKRYRNLGLYWLGSFAMSILVFLPGNI
                     LGKYSSEMRPTFFLAILYMLVPCWAGVRIFNQSRAPTSYTPDMVQEEQKKSLFQRPAD
                     LALIVYLIFAALFTVFRGLVVLDCPTDACFIYIYQYEPYLRDPVAYPKLQMLMYLFYA
                     LPFYCLAAYALAFPGCSWLPDWALVFAGAIGQAQFSHMGASMHMRTPFTYRVPEDTWA
                     TFFLSNLLLALGPHLLAFRCLWRPAFFLHAALPSSPQDQDKKQQ"
     exon            167..270
                     /gene="Tm6sf2"
                     /inference="alignment:Splign:2.1.0"
     exon            271..368
                     /gene="Tm6sf2"
                     /inference="alignment:Splign:2.1.0"
     exon            369..472
                     /gene="Tm6sf2"
                     /inference="alignment:Splign:2.1.0"
     exon            473..555
                     /gene="Tm6sf2"
                     /inference="alignment:Splign:2.1.0"
     exon            556..680
                     /gene="Tm6sf2"
                     /inference="alignment:Splign:2.1.0"
     exon            681..782
                     /gene="Tm6sf2"
                     /inference="alignment:Splign:2.1.0"
     exon            783..875
                     /gene="Tm6sf2"
                     /inference="alignment:Splign:2.1.0"
     exon            876..995
                     /gene="Tm6sf2"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1446
                     /gene="Tm6sf2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1413..1418
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tm6sf2"
                     /note="hexamer: AATAAA"
     polyA_site      1436
                     /gene="Tm6sf2"
                     /note="major polyA site"
ORIGIN      
        1 agagctctga cgcgctgcgg tcacggagcc aagcgtcctg gaggcctcgc cggggtcggg
       61 gtgccgctgc catggacatc ccgcccctag ccggcaggac tgtggcaatg tcattctgcg
      121 ccctgccagt gtcctaccta ctcaatcaag tttcggcgtt ctcacagccc ctgtttgtgg
      181 tgctgacgag tgctctgata ctgggtctgc tcttcctggc agtctatagc ctatctcatg
      241 gggagatcac ctacgaccct ctctatgctg tctttgtgat cttctccttc acctcggtgg
      301 tggaccttgt cattgcactc caagaagatg gctacatgat gggcttcatg gatttctaca
      361 ccaaggaggg tgagccctac ctacgcacag cacatggcat cttcatctgc tactgggatg
      421 gtactgtgca ctacctgctc tatctgacaa tggctggtgc catccgcaaa aggaaaaggt
      481 accggaacct tgggctctac tggctgggat ccttcgccat gagcatcctg gtgtttctcc
      541 cgggaaacat ccttggtaaa tacagttcag agatgaggcc taccttcttc ctcgccatcc
      601 tgtacatgct ggtcccatgc tgggccggtg tgaggatctt caaccagtcc cgggcaccaa
      661 cctcctatac ccctgacatg gtacaggaag aacagaagaa aagtctcttc cagcgtccgg
      721 ctgacctggc actcatagta tacctcatct ttgcagcgct cttcactgtc ttccggggtc
      781 tggtggtact tgactgcccc acagatgcct gcttcatcta tatttaccaa tatgagccat
      841 accttcggga ccctgtggcc tacccaaagt tgcagatgct gatgtatttg ttctatgctc
      901 taccattcta ctgcctggct gcctacgccc ttgccttccc tggctgctcc tggctgccgg
      961 actgggcctt ggtatttgct ggagccattg gccaggcgca gttctcacac atgggtgcct
     1021 ccatgcacat gcgcacaccc ttcacctacc gcgtgccaga ggacacctgg gctaccttct
     1081 ttctgagcaa cctgctattg gcactgggtc cccacctgct ggctttccgc tgcctgtggc
     1141 ggcccgcctt cttcttgcat gcagcgctgc catcttcgcc acaggaccaa gacaagaagc
     1201 agcagtgagc atgcgcatct ctctgctaag tcatctaccc gtgcagccat cattggcctt
     1261 cgagggtggg ttagccacac ggacattcgg agaaactgca atccaggcca gaaaggagca
     1321 taggtgttct tgctgcgtca ctgtacctca aaagtcaccc agactctaat gccccctcct
     1381 ggaatctagc catcacctct tcccatacat ttaataaaac cttctgatgt ctagaacatc
     1441 accacc
//
