LOCUS       NM_145375               2234 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus transmembrane 6 superfamily member 1 (Tm6sf1),
            transcript variant 1, mRNA.
ACCESSION   NM_145375
VERSION     NM_145375.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2234)
  AUTHORS   Tam,W.Y., Jiang,L. and Kwan,K.M.
  TITLE     Transmembrane 6 superfamily 1 (Tm6sf1) is a novel lysosomal
            transmembrane protein
  JOURNAL   Protoplasma 252 (4), 977-983 (2015)
   PUBMED   25422095
REFERENCE   2  (bases 1 to 2234)
  AUTHORS   Miller,J.A., Nathanson,J., Franjic,D., Shim,S., Dalley,R.A.,
            Shapouri,S., Smith,K.A., Sunkin,S.M., Bernard,A., Bennett,J.L.,
            Lee,C.K., Hawrylycz,M.J., Jones,A.R., Amaral,D.G., Sestan,N.,
            Gage,F.H. and Lein,E.S.
  TITLE     Conserved molecular signatures of neurogenesis in the hippocampal
            subgranular zone of rodents and primates
  JOURNAL   Development 140 (22), 4633-4644 (2013)
   PUBMED   24154525
REFERENCE   3  (bases 1 to 2234)
  AUTHORS   Abdallah,B.M., Ditzel,N., Mahmood,A., Isa,A., Traustadottir,G.A.,
            Schilling,A.F., Ruiz-Hidalgo,M.J., Laborda,J., Amling,M. and
            Kassem,M.
  TITLE     DLK1 is a novel regulator of bone mass that mediates estrogen
            deficiency-induced bone loss in mice
  JOURNAL   J Bone Miner Res 26 (7), 1457-1471 (2011)
   PUBMED   21308776
REFERENCE   4  (bases 1 to 2234)
  AUTHORS   Sharov,A.A., Piao,Y., Matoba,R., Dudekula,D.B., Qian,Y.,
            VanBuren,V., Falco,G., Martin,P.R., Stagg,C.A., Bassey,U.C.,
            Wang,Y., Carter,M.G., Hamatani,T., Aiba,K., Akutsu,H., Sharova,L.,
            Tanaka,T.S., Kimber,W.L., Yoshikawa,T., Jaradat,S.A., Pantano,S.,
            Nagaraja,R., Boheler,K.R., Taub,D., Hodes,R.J., Longo,D.L.,
            Schlessinger,D., Keller,J., Klotz,E., Kelsoe,G., Umezawa,A.,
            Vescovi,A.L., Rossant,J., Kunath,T., Hogan,B.L., Curci,A.,
            D'Urso,M., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Transcriptome analysis of mouse stem cells and early embryos
  JOURNAL   PLoS Biol 1 (3), E74 (2003)
   PUBMED   14691545
REFERENCE   5  (bases 1 to 2234)
  AUTHORS   Carim-Todd,L., Escarceller,M., Estivill,X. and Sumoy,L.
  TITLE     Cloning of the novel gene TM6SF1 reveals conservation of clusters
            of paralogous genes between human chromosomes 15q24-->q26 and
            19p13.3-->p12
  JOURNAL   Cytogenet Cell Genet 90 (3-4), 255-260 (2000)
   PUBMED   11124529
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB653227.1, AK083132.1 and AK162572.1.
            
            On Apr 1, 2014 this sequence version replaced NM_145375.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK083132.1, AK172109.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-618               BB653227.1         3-620
            619-2226            AK083132.1         622-2229
            2227-2234           AK162572.1         1891-1898
FEATURES             Location/Qualifiers
     source          1..2234
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 45.71 cM"
     gene            1..2234
                     /gene="Tm6sf1"
                     /gene_synonym="C630016D09Rik"
                     /note="transmembrane 6 superfamily member 1"
                     /db_xref="GeneID:107769"
                     /db_xref="MGI:MGI:1933209"
     exon            1..540
                     /gene="Tm6sf1"
                     /gene_synonym="C630016D09Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             449..1561
                     /gene="Tm6sf1"
                     /gene_synonym="C630016D09Rik"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="transmembrane 6 superfamily member 1 isoform 1"
                     /protein_id="NP_663350.2"
                     /db_xref="CCDS:CCDS21408.1"
                     /db_xref="GeneID:107769"
                     /db_xref="MGI:MGI:1933209"
                     /translation="MSASAATGVFVLSLSAIPVTYIFNHLAAQHDSWTIVGVAALILL
                     LVALLARVLVRRKPPRDPLFYVYAVFGFTSVVNLIIGLEQDGIIDGFMTHYLREGEPY
                     LNTAYGHMICYWDGSVHYLMYLVMVAAIAWEESYRTIGLYWVGSIIMSIVVFVPGNIV
                     GKYGTRICPAFFLSIPYTCLPVWAGFRIYNQPSENYNYPSKVLQEAQAKALLRRPFDL
                     VLVLCLFLATGFCLFRGLIALDCPAELCRLYTQFQEPYLKDPAAYPKIQMLAYMFYSV
                     PYFVIALYGLVVPGCSWMPDITLVHAGGLAQAQFSHIGASLHARTAYVYRVPEEAKIF
                     FLALNIAYGVLPQLLAYRCTYNPEFFLRTKADEKLE"
     exon            541..644
                     /gene="Tm6sf1"
                     /gene_synonym="C630016D09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            645..742
                     /gene="Tm6sf1"
                     /gene_synonym="C630016D09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            743..846
                     /gene="Tm6sf1"
                     /gene_synonym="C630016D09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            847..929
                     /gene="Tm6sf1"
                     /gene_synonym="C630016D09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1051
                     /gene="Tm6sf1"
                     /gene_synonym="C630016D09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1156
                     /gene="Tm6sf1"
                     /gene_synonym="C630016D09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1157..1249
                     /gene="Tm6sf1"
                     /gene_synonym="C630016D09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1369
                     /gene="Tm6sf1"
                     /gene_synonym="C630016D09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1370..2234
                     /gene="Tm6sf1"
                     /gene_synonym="C630016D09Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1557..1562
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tm6sf1"
                     /gene_synonym="C630016D09Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1577
                     /gene="Tm6sf1"
                     /gene_synonym="C630016D09Rik"
     regulatory      2197..2202
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tm6sf1"
                     /gene_synonym="C630016D09Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2223
                     /gene="Tm6sf1"
                     /gene_synonym="C630016D09Rik"
                     /note="major polyA site"
ORIGIN      
        1 aggtctctga gccgatctcg cgggcctgcg ggctctgaca ccctcagatc tggctccacc
       61 ctctgctggc ccttggctca gcccagctcc gttccagctc gaggatgccc agctcccatc
      121 tgtgacccgc gtccttcgcc gggcccttcc ttttcccatt aaagcaagcg tcctggggcg
      181 cttgtctcct cgcggtggct gctgagccct tgcgttcgtt agcaggagcc tggtggggac
      241 gcctctgggg atcgtacagc ggccctagag cacccgggtg gtgcctctct ctgtgcgcgc
      301 cgggcagcta cgggcgacgg ggacgcgcag aggagacgcg gccgggggcc gcctggaagg
      361 gcagcggcga ggggcgcggc gccgccggaa gctgagccag gggacccccg gcgcgatgcg
      421 gtgaaagaag agcgacccgg aggtggcaat gagtgcctct gcggccacgg gggtttttgt
      481 gctgtccctc tcagccatcc cggtcaccta catcttcaac cacctggcgg cccagcacga
      541 ttcctggacc attgttgggg ttgctgccct catcctgctc ctggtggccc ttttggcccg
      601 ggtccttgtc agaagaaaac caccgaggga ccctctgttc tacgtgtatg cagtgtttgg
      661 atttaccagt gtggtgaacc ttatcatagg cttggagcaa gatggcatca ttgatggatt
      721 catgacgcac tacttgagag agggtgaacc gtatctgaac acggcctatg ggcacatgat
      781 ctgctactgg gatggctctg ttcattacct gatgtaccta gtgatggtgg ccgccatagc
      841 ctgggaggaa agctacagaa ccattggcct atactgggtc ggatccatta taatgagcat
      901 cgtggttttt gtgcctggaa acatcgtagg aaagtatggg acacggattt gccctgcatt
      961 tttcttaagc ataccatata catgtcttcc ggtctgggct ggcttcagaa tctataatca
     1021 accatcagaa aactataatt atccctcaaa ggttcttcaa gaagcccaag caaaggccct
     1081 gctgagaaga ccgtttgact tagtgttggt tttgtgtctt ttcttggcaa ctggattttg
     1141 cctgttcaga ggcttgattg ctttggattg cccagctgag ctctgccgac tctacacgca
     1201 gtttcaagag ccctacctaa aggaccctgc tgcttatcct aagattcaga tgctggcata
     1261 catgttctat tccgtccctt actttgtgat tgccctttat ggcttagtgg tccctggatg
     1321 ctcatggatg cctgatataa cgctggtcca tgctggaggt ctagctcagg ctcagttttc
     1381 tcacattggt gcgtcccttc atgctagaac tgcttatgtc tacagagtcc ccgaagaagc
     1441 gaaaatcttt tttctagcac taaacatagc atatggagtt cttcctcagc tcttggccta
     1501 ccgttgtacc tacaatcccg agttcttcct aagaactaag gcagatgaga agttggaata
     1561 aacaaacata cctcacagtt ctctctgacc tgttaatggg actggcgctc tcctttatcc
     1621 cctccataca ggaatactca caagaacaca cttgttctgc agcatacatg tgagtgaaac
     1681 taagggtagt atctgggtat attctcagtt ttgaaagaaa attaaagttg agaaacagct
     1741 tttttaagga aatatatcac catttgtcta tgaatgtgac cattgatttt agcattgttt
     1801 gcacatagta tgtgtgaaaa ttacaactct agtgcctaca aaaagcataa aaatgaaact
     1861 attcagaagt aactaaccat actatgcata agaaataatt caaaacagca attgcaggtt
     1921 ggagaaatgg cttcatatga aatgtatgag ttgttgacaa tcttaatata aatgccagat
     1981 catcacaata tttttaaatt gattcaagtg ttttcacaag gaaagcatat tatttattgc
     2041 cattttaaaa attgctgtca aaacttctat tgtgaatttg aatagctaag atgacacaaa
     2101 tcaactttat tagttgcctt aatgaacact tgttttattg gttgataata tttctcttgt
     2161 gtttctgtgt ataccttcaa tactgtgtat accttcaata aaattatttt tggtgtttat
     2221 gaagataaac ttta
//
