LOCUS       NM_029360                981 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus transmembrane 4 superfamily member 5 (Tm4sf5), mRNA.
ACCESSION   NM_029360 XM_001471756
VERSION     NM_029360.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 981)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 981)
  AUTHORS   Kim,J.E., Park,S.Y., Kwak,C., Lee,Y., Song,D.G., Jung,J.W., Lee,H.,
            Shin,E.A., Pinanga,Y., Pyo,K.H., Lee,E.H., Kim,W., Kim,S.,
            Jun,C.D., Yun,J., Choi,S., Rhee,H.W., Liu,K.H. and Lee,J.W.
  TITLE     Glucose-mediated mitochondrial reprogramming by cholesterol export
            at TM4SF5-enriched mitochondria-lysosome contact sites
  JOURNAL   Cancer Commun (Lond) 44 (1), 47-75 (2024)
   PUBMED   38133457
  REMARK    GeneRIF: Glucose-mediated mitochondrial reprogramming by
            cholesterol export at TM4SF5-enriched mitochondria-lysosome contact
            sites.
REFERENCE   3  (bases 1 to 981)
  AUTHORS   Pinanga,Y.D., Lee,H.A., Shin,E.A., Lee,H., Pyo,K.H., Kim,J.E.,
            Lee,E.H., Kim,W., Kim,S., Kim,H.Y. and Lee,J.W.
  TITLE     TM4SF5-mediated abnormal food-intake behavior and apelin expression
            facilitate non-alcoholic fatty liver disease features
  JOURNAL   iScience 26 (9), 107625 (2023)
   PUBMED   37670786
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 981)
  AUTHORS   Lee,J., Kim,E., Kang,M.K., Ryu,J., Kim,J.E., Shin,E.A., Pinanga,Y.,
            Pyo,K.H., Lee,H., Lee,E.H., Cho,H., Cheon,J., Kim,W., Jho,E.H.,
            Kim,S. and Lee,J.W.
  TITLE     Systemic TM4SF5 overexpression in ApcMin/+ mice promotes hepatic
            portal hypertension associated with fibrosis
  JOURNAL   BMB Rep 55 (12), 609-614 (2022)
   PUBMED   36104259
  REMARK    GeneRIF: Systemic TM4SF5 overexpression in Apc[Min/+] mice promotes
            hepatic portal hypertension associated with fibrosis.
REFERENCE   5  (bases 1 to 981)
  AUTHORS   Jung,J.W., Kim,J.E., Kim,E., Lee,H., Lee,H., Shin,E.A. and Lee,J.W.
  TITLE     Liver-originated small extracellular vesicles with TM4SF5 target
            brown adipose tissue for homeostatic glucose clearance
  JOURNAL   J Extracell Vesicles 11 (9), e12262 (2022)
   PUBMED   36063136
REFERENCE   6  (bases 1 to 981)
  AUTHORS   Kwon,S., Kim,Y.E., Kim,D., Park,B.K., Wu,G., Kim,T.H., Choi,S.H.,
            Kim,D.S., Kwon,H.J. and Lee,Y.
  TITLE     Prophylactic effect of a peptide vaccine targeting TM4SF5 against
            colon cancer in a mouse model
  JOURNAL   Biochem Biophys Res Commun 435 (1), 134-139 (2013)
   PUBMED   23624388
  REMARK    GeneRIF: Data indicate expression of TM4SF5 in the colon cancer
            cell line CT-26 and that anti-TM4SF5 antibody inhibits growth of
            CT-26 cells.
REFERENCE   7  (bases 1 to 981)
  AUTHORS   Bell,S.M., Zhang,L., Xu,Y., Besnard,V., Wert,S.E., Shroyer,N. and
            Whitsett,J.A.
  TITLE     Kruppel-like factor 5 controls villus formation and initiation of
            cytodifferentiation in the embryonic intestinal epithelium
  JOURNAL   Dev Biol 375 (2), 128-139 (2013)
   PUBMED   23266329
REFERENCE   8  (bases 1 to 981)
  AUTHORS   Kang,M., Jeong,S.J., Park,S.Y., Lee,H.J., Kim,H.J., Park,K.H.,
            Ye,S.K., Kim,S.H. and Lee,J.W.
  TITLE     Antagonistic regulation of transmembrane 4 L6 family member 5
            attenuates fibrotic phenotypes in CCl(4) -treated mice
  JOURNAL   FEBS J 279 (4), 625-635 (2012)
   PUBMED   22177033
  REMARK    GeneRIF: Data suggest that transmembrane 4 L6 family member 5
            (TM4SF5) is a candidate target for prevention of liver fibrosis
            following chronic liver injury.
REFERENCE   9  (bases 1 to 981)
  AUTHORS   Anderson,K.R., Singer,R.A., Balderes,D.A., Hernandez-Lagunas,L.,
            Johnson,C.W., Artinger,K.B. and Sussel,L.
  TITLE     The L6 domain tetraspanin Tm4sf4 regulates endocrine pancreas
            differentiation and directed cell migration
  JOURNAL   Development 138 (15), 3213-3224 (2011)
   PUBMED   21750032
REFERENCE   10 (bases 1 to 981)
  AUTHORS   Lee,S.A., Kim,T.Y., Kwak,T.K., Kim,H., Kim,S., Lee,H.J., Kim,S.H.,
            Park,K.H., Kim,H.J., Cho,M. and Lee,J.W.
  TITLE     Transmembrane 4 L six family member 5 (TM4SF5) enhances migration
            and invasion of hepatocytes for effective metastasis
  JOURNAL   J Cell Biochem 111 (1), 59-66 (2010)
   PUBMED   20506553
  REMARK    GeneRIF: Data show that TM4SF5 expression facilitated migration,
            invadopodia formation, MMP activation, invasion, and eventually
            lung metastasis in vitro and in nude mice, but suppression of
            TM4SF5 with its shRNA blocked the effects.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB869909.1, AK008064.1, BB798656.1 and AI323987.1.
            
            On May 28, 2009 this sequence version replaced NM_029360.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK008064.1, BC010782.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-135               BB869909.1         2-136
            136-636             AK008064.1         134-634
            637-964             BB798656.1         56-383
            965-981             AI323987.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..981
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 42.99 cM"
     gene            1..981
                     /gene="Tm4sf5"
                     /gene_synonym="2010003F10Rik"
                     /note="transmembrane 4 superfamily member 5"
                     /db_xref="GeneID:75604"
                     /db_xref="MGI:MGI:1922854"
     exon            1..231
                     /gene="Tm4sf5"
                     /gene_synonym="2010003F10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            232..312
                     /gene="Tm4sf5"
                     /gene_synonym="2010003F10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            313..449
                     /gene="Tm4sf5"
                     /gene_synonym="2010003F10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            450..633
                     /gene="Tm4sf5"
                     /gene_synonym="2010003F10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            634..975
                     /gene="Tm4sf5"
                     /gene_synonym="2010003F10Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      946..951
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tm4sf5"
                     /gene_synonym="2010003F10Rik"
                     /note="hexamer: AATAAA"
     polyA_site      970
                     /gene="Tm4sf5"
                     /gene_synonym="2010003F10Rik"
                     /note="major polyA site"
ORIGIN      
        1 ggcacttcct tccctgctca cgttcactcc gctcctgcct gtttggaagc ctcagacatg
       61 tgtactggaa agtgtgcgcg ctgcctgggg ctctccctca tccctctctc cctggtctgc
      121 atcgtggcca acgccctcct gctggtacct gatgggaaga ccacctggac ggacggcaac
      181 ctcagcttgc aagtttggct catgggtggc ttcattggag ggggcctgat ggtgctgtgt
      241 ccaggaattg cagcggtccg ggcaggggga aagggctgct gcggtgcagg ttgctgtggc
      301 aaccgctgca ggatgctgcg ctccgtcttc tcctccgcct ttggggtgct tggcgccatc
      361 tactgcctgt cagtggcggg agctgggctc cgaattggac ccaaatgctt aatagacaac
      421 aagtgggact accacttcca agaaacagaa ggcgcttact tgcgaaatga cactctttgg
      481 aatttgtgtg aggcgccacc tcacgtggta ccctggaatg tgacactctt ctcaatcctg
      541 gtggtcgcat caagtctgga acttgtgctg tgtggaattc agctggtgaa tgcgaccttt
      601 ggtgtgttgt gtggcgattg caggaaaaag gagggtgcag ctcactgagt cccataggcc
      661 acccctaata cctcatttct ggaagtctga gtggtcaccc actccctggt tggctaggga
      721 aaaaaaaaaa catgcacact tttatcgttc aggctcttcc ttagtggaat aaaccaccct
      781 gagccccttc ccccagttct ggtttagcct ttggaaagag tgtacgtggg ccttcagaga
      841 tatgtgtcta gacttggggc ttctatatgt acctcccact ctacccacaa cccccacccc
      901 ctcttgttat tctcttaaca acaacaacat agttattgtt ctggaaataa aaatctgtgc
      961 tctcaaggaa gctaaaaaaa a
//
