LOCUS       NM_145539               1417 bp    mRNA    linear   ROD 29-JUL-2024
DEFINITION  Mus musculus transmembrane 4 superfamily member 4 (Tm4sf4), mRNA.
ACCESSION   NM_145539
VERSION     NM_145539.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1417)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1417)
  AUTHORS   Roome,R.B., Bourojeni,F.B., Mona,B., Rastegar-Pouyani,S., Blain,R.,
            Dumouchel,A., Salesse,C., Thompson,W.S., Brookbank,M., Gitton,Y.,
            Tessarollo,L., Goulding,M., Johnson,J.E., Kmita,M., Chedotal,A. and
            Kania,A.
  TITLE     Phox2a Defines a Developmental Origin of the Anterolateral System
            in Mice and Humans
  JOURNAL   Cell Rep 33 (8), 108425 (2020)
   PUBMED   33238113
REFERENCE   3  (bases 1 to 1417)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643. PMID: 29144450]
REFERENCE   4  (bases 1 to 1417)
  AUTHORS   Liu,X., Jiao,Y., Cao,Y., Deng,N., Ma,Y., Hasty,K.A., Kang,A.,
            Chen,H., Stuart,J.M. and Gu,W.
  TITLE     Decreased expression levels of Ifi genes is associated to the
            increased resistance to spontaneous arthritis disease in mice
            deficiency of IL-1RA
  JOURNAL   BMC Immunol 17 (1), 25 (2016)
   PUBMED   27480124
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1417)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 1417)
  AUTHORS   Sherwood,R.I., Maehr,R., Mazzoni,E.O. and Melton,D.A.
  TITLE     Wnt signaling specifies and patterns intestinal endoderm
  JOURNAL   Mech Dev 128 (7-10), 387-400 (2011)
   PUBMED   21854845
REFERENCE   7  (bases 1 to 1417)
  AUTHORS   Anderson,K.R., Singer,R.A., Balderes,D.A., Hernandez-Lagunas,L.,
            Johnson,C.W., Artinger,K.B. and Sussel,L.
  TITLE     The L6 domain tetraspanin Tm4sf4 regulates endocrine pancreas
            differentiation and directed cell migration
  JOURNAL   Development 138 (15), 3213-3224 (2011)
   PUBMED   21750032
  REMARK    GeneRIF: Data show that Tm4sf4 is localized to the ductal
            epithelium and Ngn3(+) islet progenitor cells, and that pancreatic
            tm4sf4 expression and regulation by Nkx2.2 is conserved during
            development.
REFERENCE   8  (bases 1 to 1417)
  AUTHORS   Anderson,K.R., White,P., Kaestner,K.H. and Sussel,L.
  TITLE     Identification of known and novel pancreas genes expressed
            downstream of Nkx2.2 during development
  JOURNAL   BMC Dev Biol 9, 65 (2009)
   PUBMED   20003319
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 1417)
  AUTHORS   Nishimura,M., Yokoi,N., Miki,T., Horikawa,Y., Yoshioka,H.,
            Takeda,J., Ohara,O. and Seino,S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
REFERENCE   10 (bases 1 to 1417)
  AUTHORS   Neophytou,P.I., Muir,E.M. and Hutton,J.C.
  TITLE     A subtractive cloning approach to the identification of mRNAs
            specifically expressed in pancreatic beta-cells
  JOURNAL   Diabetes 45 (2), 127-133 (1996)
   PUBMED   8549854
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB840196.1, AK165731.1 and BP772386.1.
            
            On Sep 30, 2009 this sequence version replaced NM_145539.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK148484.1, BC010814.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                BB840196.1         98-131
            35-1008             AK165731.1         3-976
            1009-1417           BP772386.1         27-435              c
FEATURES             Location/Qualifiers
     source          1..1417
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 27.72 cM"
     gene            1..1417
                     /gene="Tm4sf4"
                     /gene_synonym="Iltmp"
                     /note="transmembrane 4 superfamily member 4"
                     /db_xref="GeneID:229302"
                     /db_xref="MGI:MGI:2385173"
     exon            1..379
                     /gene="Tm4sf4"
                     /gene_synonym="Iltmp"
                     /inference="alignment:Splign:2.1.0"
     exon            380..469
                     /gene="Tm4sf4"
                     /gene_synonym="Iltmp"
                     /inference="alignment:Splign:2.1.0"
     exon            470..606
                     /gene="Tm4sf4"
                     /gene_synonym="Iltmp"
                     /inference="alignment:Splign:2.1.0"
     exon            607..796
                     /gene="Tm4sf4"
                     /gene_synonym="Iltmp"
                     /inference="alignment:Splign:2.1.0"
     exon            797..1400
                     /gene="Tm4sf4"
                     /gene_synonym="Iltmp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1011..1016
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tm4sf4"
                     /gene_synonym="Iltmp"
                     /note="hexamer: AATAAA"
     polyA_site      1036
                     /gene="Tm4sf4"
                     /gene_synonym="Iltmp"
     regulatory      1374..1379
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tm4sf4"
                     /gene_synonym="Iltmp"
                     /note="hexamer: ATTAAA"
     polyA_site      1395
                     /gene="Tm4sf4"
                     /gene_synonym="Iltmp"
                     /note="major polyA site"
ORIGIN      
        1 ggatataaat atccattgcc actgaaggcc tgccgtagtt gagaagtgaa gtgtctccaa
       61 ggttcaaaga actctgatat ttggtcccac ttttcttatt gaccccggta cagccactgg
      121 aacgtgctgc tgcaatccct gaggagaacc gtcaagctgg tggcgacgag cctttgatct
      181 ctgtgctttc ctgtgacccc ccagcatgtg tactgggggc tgtgccaggt gcctgggggg
      241 caccctcatt cccctggctg tgtttggcct cctggcaaat atcctgttgt tctttcctgg
      301 aggaaaagtg gtgaacgaca aaagccacct ttcggatgag gtctggtact tcggaggaat
      361 attgggaagt ggagtcttga tgatcttccc tgcgcttgtg ttcttgggcc tgcagaacaa
      421 cgactgctgc ggatgctgtg gcaatgaggg ctgtgggaag cgatttgcga tgttcacctc
      481 cacgttgttt gctgtgattg gattcttagg tgctggctac tcatttatcg tctcagctgt
      541 ttctatcaac aagggtccta aatgcttcat ggccaatggt acatggggat accccttcca
      601 cgatggtgat tatctaaaag accaagcctt gtggagcgag tgcaaagagc cccgtgatgt
      661 ggtcccctgg aacctcaccc tcttctccat tctgctggtc atcggaggga tccagatggt
      721 tctctgtgcc atccaggtga tcaatggcct cctgggaact ctctgtggag actgccagtg
      781 ctgtggctgc tgtgggggtg atggaccagt ctaacaggtt atgatgagct gctccacgtc
      841 tacagtccag tgcgtgggaa gacatgcccc aggcccagcc ctgaccacat gtgttgctaa
      901 ttcctgtctg gttcctctct ggcagagctt gggaggcaca agagatcctt ttctctttcc
      961 aaacagcttt gcacaatcta gaaattcagt gggttttttt ttttttttca aataaaaaac
     1021 tagttagata actttacaaa ttaggtcctt tcttgaattc cagaacgagt tcaaagtagt
     1081 tttttttttt tcattctttc ccataagaaa agacaaaata gacaaggtca cttatcctgc
     1141 catattgtct ctttgtatat aaagatgttc atattttagg aatatttgca taactcaagt
     1201 ggataaaaca ttaaaatgaa aaccagtttt tcaggatgca taggtaagga atgattgcta
     1261 tattatatat aatttttatg tgaagcctgt ttgactaatg tgtctggact acttgtaact
     1321 agttttatga gcctgtcata atttgccagg gttcccatat gtatattaag ttaattaaat
     1381 tcagaattaa aataataaaa aaaaaaaaaa aaaaaaa
//
