LOCUS       NM_001160402            1257 bp    mRNA    linear   ROD 15-DEC-2024
DEFINITION  Mus musculus transmembrane 4 L six family member 19 (Tm4sf19),
            mRNA.
ACCESSION   NM_001160402 XM_205829
VERSION     NM_001160402.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1257)
  AUTHORS   Choi,C., Jeong,Y.L., Park,K.M., Kim,M., Kim,S., Jo,H., Lee,S.,
            Kim,H., Choi,G., Choi,Y.H., Seong,J.K., Namgoong,S., Chung,Y.,
            Jung,Y.S., Granneman,J.G., Hyun,Y.M., Kim,J.K. and Lee,Y.H.
  TITLE     TM4SF19-mediated control of lysosomal activity in macrophages
            contributes to obesity-induced inflammation and metabolic
            dysfunction
  JOURNAL   Nat Commun 15 (1), 2779 (2024)
   PUBMED   38555350
  REMARK    GeneRIF: TM4SF19-mediated control of lysosomal activity in
            macrophages contributes to obesity-induced inflammation and
            metabolic dysfunction.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1257)
  AUTHORS   Park,S., Heo,J.S., Mizuno,S., Kim,M., An,H., Hong,E., Kang,M.G.,
            Kim,J., Yun,R., Park,H., Noh,E.H., Lee,M.J., Yoon,K., Kim,P.,
            Son,M., Pang,K., Lee,J., Park,J., Ooshima,A., Kim,T.J., Park,J.Y.,
            Yang,K.M., Myung,S.J., Bae,H., Lee,K.M., Letterio,J., Park,S.H.,
            Takahashi,S. and Kim,S.J.
  TITLE     Tm4sf19 deficiency inhibits osteoclast multinucleation and prevents
            bone loss
  JOURNAL   Metabolism 151, 155746 (2024)
   PUBMED   38016540
  REMARK    GeneRIF: Tm4sf19 deficiency inhibits osteoclast multinucleation and
            prevents bone loss.
REFERENCE   3  (bases 1 to 1257)
  AUTHORS   Rutkowski,T.P., Purcell,R.H., Pollak,R.M., Grewenow,S.M.,
            Gafford,G.M., Malone,T., Khan,U.A., Schroeder,J.P., Epstein,M.P.,
            Bassell,G.J., Warren,S.T., Weinshenker,D., Caspary,T. and
            Mulle,J.G.
  TITLE     Behavioral changes and growth deficits in a CRISPR engineered mouse
            model of the schizophrenia-associated 3q29 deletion
  JOURNAL   Mol Psychiatry 26 (3), 772-783 (2021)
   PUBMED   30976085
REFERENCE   4  (bases 1 to 1257)
  AUTHORS   Anderson,K.R., Singer,R.A., Balderes,D.A., Hernandez-Lagunas,L.,
            Johnson,C.W., Artinger,K.B. and Sussel,L.
  TITLE     The L6 domain tetraspanin Tm4sf4 regulates endocrine pancreas
            differentiation and directed cell migration
  JOURNAL   Development 138 (15), 3213-3224 (2011)
   PUBMED   21750032
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC147727.1 and AC087556.30.
            
            On May 24, 2009 this sequence version replaced XM_205829.7.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC147729.1, SRR5189673.215444.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN00849388
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-897               BC147727.1         1-897
            898-911             AC087556.30        74393-74406         c
            912-1132            BC147727.1         912-1132
            1133-1133           AC087556.30        74171-74171         c
            1134-1207           BC147727.1         1134-1207
            1208-1208           AC087556.30        74096-74096         c
            1209-1257           BC147727.1         1209-1257
FEATURES             Location/Qualifiers
     source          1..1257
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 22.66 cM"
     gene            1..1257
                     /gene="Tm4sf19"
                     /gene_synonym="EG277203"
                     /note="transmembrane 4 L six family member 19"
                     /db_xref="GeneID:277203"
                     /db_xref="MGI:MGI:3645933"
     exon            1..423
                     /gene="Tm4sf19"
                     /gene_synonym="EG277203"
                     /inference="alignment:Splign:2.1.0"
     exon            424..625
                     /gene="Tm4sf19"
                     /gene_synonym="EG277203"
                     /inference="alignment:Splign:2.1.0"
     CDS             425..1045
                     /gene="Tm4sf19"
                     /gene_synonym="EG277203"
                     /note="tetraspan membrane protein OCTM4; osteoclast
                     maturation-associated gene 4 protein"
                     /codon_start=1
                     /product="transmembrane 4 L6 family member 19"
                     /protein_id="NP_001153874.1"
                     /db_xref="CCDS:CCDS49827.1"
                     /db_xref="GeneID:277203"
                     /db_xref="MGI:MGI:3645933"
                     /translation="MLSFSRVVNCSRTCSRFLGLSLGTASLCAAGANIALLFPNWDVT
                     YLMRGLIGKHAMLGSGLWGGGLMVLLAATLISMTGSFSKSAPCLQVLIALLSSGLALL
                     GAVICFVTSGVALKDGPFCMFDVSSFNQTQAWKFGYPFKDLHNRNYLYDRSLWTSVCL
                     EPSKAVVWHVAFFSILLCISLLQLLLVAIHLVNSILGLFCSFCEKH"
     exon            626..691
                     /gene="Tm4sf19"
                     /gene_synonym="EG277203"
                     /inference="alignment:Splign:2.1.0"
     exon            692..861
                     /gene="Tm4sf19"
                     /gene_synonym="EG277203"
                     /inference="alignment:Splign:2.1.0"
     exon            862..1257
                     /gene="Tm4sf19"
                     /gene_synonym="EG277203"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagcccagat ggtacaagga aggatgacac agccggatgg agcagctgat gtggaaaggg
       61 cgctggtggc agaggaggct gagggactgc tcctgggtgc atcagtgact cactaagacc
      121 gttgagcttg tgagtccatg tgtccttcct tggaatcaca tgaaagtgag cagagaatga
      181 gtgggtcacg agcacaggct tcgcctggga cagaatgatt tttcagtgga ggcccgtggg
      241 cagctgtgga cacccacgcc cactcgagtt cacatgaata cccaggcaac cgctacatat
      301 gcaggacctt cccgaccctg caagcctagc cggctggggc tgcccgaggg gccaaggtcc
      361 attttgaaga gtgtctcctc cactttcttg ttctcctatc ctgattcttg ccatcacaaa
      421 caggatgctg tccttttccc gtgtggtgaa ctgctcacgg acctgttctc gcttcctggg
      481 actgagtctg gggaccgcat ccctgtgtgc tgctggtgcc aacatcgcgc tcctctttcc
      541 taactgggat gtgacctacc tgatgagggg cctcattggc aagcatgcca tgctgggctc
      601 tgggctctgg ggaggaggcc tcatggttct cctggcagcc accctcatct ccatgacagg
      661 cagcttcagt aagagtgcac cctgcctgca ggtgctcatt gctcttttgt caagtggcct
      721 ggctctgctt ggggctgtga tttgctttgt cacttctgga gtagccttga aagatggtcc
      781 cttttgcatg tttgatgtct catccttcaa tcagacacaa gcttggaaat tcggctatcc
      841 ctttaaagat ctacacaaca ggaattatct gtatgaccgt tcactttgga cctccgtttg
      901 cctggagccc tctaaggctg tggtttggca cgtggccttc ttctccatcc tcctgtgtat
      961 cagcctcctc cagcttctct tggtggccat ccatcttgtc aatagcatcc tcggcctgtt
     1021 ctgcagcttc tgtgagaagc actaggtaac ggatgccctc tcgtgaattg gcgcgctcag
     1081 gacaagcttc ccccaacctt ttctgcaaga ataggctgtg aatccccttt agaccttctt
     1141 ataggatgac agggctgcct tgctcacagc aacaaagtca tgctgctgta taaatgatct
     1201 cagttcaacc ccttaaaaac ctcataaaag ggctggagga atggctcaga ggttgag
//
