LOCUS       NM_008536               3413 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus transmembrane 4 superfamily member 1 (Tm4sf1),
            transcript variant 1, mRNA.
ACCESSION   NM_008536
VERSION     NM_008536.5
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3413)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3413)
  AUTHORS   Sabbagh,M.F., Heng,J.S., Luo,C., Castanon,R.G., Nery,J.R.,
            Rattner,A., Goff,L.A., Ecker,J.R. and Nathans,J.
  TITLE     Transcriptional and epigenomic landscapes of CNS and non-CNS
            vascular endothelial cells
  JOURNAL   Elife 7, e36187 (2018)
   PUBMED   30188322
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3413)
  AUTHORS   Cui,W., Dai,X., Marcho,C., Han,Z., Zhang,K., Tremblay,K.D. and
            Mager,J.
  TITLE     Towards Functional Annotation of the Preimplantation Transcriptome:
            An RNAi Screen in Mammalian Embryos
  JOURNAL   Sci Rep 6, 37396 (2016)
   PUBMED   27869233
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3413)
  AUTHORS   Lin,C.I., Merley,A., Sciuto,T.E., Li,D., Dvorak,A.M.,
            Melero-Martin,J.M., Dvorak,H.F. and Jaminet,S.C.
  TITLE     TM4SF1: a new vascular therapeutic target in cancer
  JOURNAL   Angiogenesis 17 (4), 897-907 (2014)
   PUBMED   24986520
REFERENCE   5  (bases 1 to 3413)
  AUTHORS   Anderson,K.R., Singer,R.A., Balderes,D.A., Hernandez-Lagunas,L.,
            Johnson,C.W., Artinger,K.B. and Sussel,L.
  TITLE     The L6 domain tetraspanin Tm4sf4 regulates endocrine pancreas
            differentiation and directed cell migration
  JOURNAL   Development 138 (15), 3213-3224 (2011)
   PUBMED   21750032
REFERENCE   6  (bases 1 to 3413)
  AUTHORS   Kao,Y.R., Shih,J.Y., Wen,W.C., Ko,Y.P., Chen,B.M., Chan,Y.L.,
            Chu,Y.W., Yang,P.C., Wu,C.W. and Roffler,S.R.
  TITLE     Tumor-associated antigen L6 and the invasion of human lung cancer
            cells
  JOURNAL   Clin Cancer Res 9 (7), 2807-2816 (2003)
   PUBMED   12855661
  REMARK    GeneRIF: TAL6 may play a role in cancer invasion and metastasis
REFERENCE   7  (bases 1 to 3413)
  AUTHORS   Liu,Z., Zhao,M., Yokoyama,K.K. and Li,T.
  TITLE     Molecular cloning of a cDNA for rat TM4SF4, a homolog of human
            il-TMP (TM4SF4), and enhanced expression of the corresponding gene
            in regenerating rat liver(1)
  JOURNAL   Biochim Biophys Acta 1518 (1-2), 183-189 (2001)
   PUBMED   11267677
REFERENCE   8  (bases 1 to 3413)
  AUTHORS   Maruyama,M., Kozuka-Hata,H., Sakaguchi-Sanai,A., Shioda,S.,
            Yamaguchi,N. and Maruyama,K.
  TITLE     The cDNA cloning of the hamster homologue of the human L6 gene
  JOURNAL   Gene 168 (2), 273-274 (1996)
   PUBMED   8654959
REFERENCE   9  (bases 1 to 3413)
  AUTHORS   Edwards,C.P., Farr,A.G., Marken,J.S., Nelson,A., Bajorath,J.,
            Hellstrom,K.E., Hellstrom,I. and Aruffo,A.
  TITLE     Cloning of the murine counterpart of the tumor-associated antigen
            H-L6: epitope mapping of the human and murine L6 antigens
  JOURNAL   Biochemistry 34 (39), 12653-12660 (1995)
   PUBMED   7548016
REFERENCE   10 (bases 1 to 3413)
  AUTHORS   Marken,J.S., Bajorath,J., Edwards,C.P., Farr,A.G., Schieven,G.L.,
            Hellstrom,I., Hellstrom,K.E. and Aruffo,A.
  TITLE     Membrane topology of the L6 antigen and identification of the
            protein epitope recognized by the L6 monoclonal antibody
  JOURNAL   J Biol Chem 269 (10), 7397-7401 (1994)
   PUBMED   7510285
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC119854.7.
            
            On Jul 27, 2022 this sequence version replaced NM_008536.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083073.1, SRR7652917.1030592.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-256               AC119854.7         124163-124418
            257-371             AC119854.7         124510-124624
            372-842             AC119854.7         131064-131534
            843-932             AC119854.7         133044-133133
            933-1078            AC119854.7         133221-133366
            1079-1259           AC119854.7         136277-136457
            1260-3413           AC119854.7         138376-140529
FEATURES             Location/Qualifiers
     source          1..3413
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 27.68 cM"
     gene            1..3413
                     /gene="Tm4sf1"
                     /gene_synonym="L6; M3s1"
                     /note="transmembrane 4 superfamily member 1"
                     /db_xref="GeneID:17112"
                     /db_xref="MGI:MGI:104678"
     exon            1..256
                     /gene="Tm4sf1"
                     /gene_synonym="L6; M3s1"
                     /inference="alignment:Splign:2.1.0"
     exon            257..371
                     /gene="Tm4sf1"
                     /gene_synonym="L6; M3s1"
                     /inference="alignment:Splign:2.1.0"
     exon            372..842
                     /gene="Tm4sf1"
                     /gene_synonym="L6; M3s1"
                     /inference="alignment:Splign:2.1.0"
     CDS             666..1274
                     /gene="Tm4sf1"
                     /gene_synonym="L6; M3s1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transmembrane 4 L6 family member 1; tumor-associated
                     antigen L6; membrane component chromosome 3 surface marker
                     1 homolog; membrane component, surface marker 1; L6
                     antigen; 12A8 target antigen"
                     /codon_start=1
                     /product="transmembrane 4 L6 family member 1 isoform 1"
                     /protein_id="NP_032562.1"
                     /db_xref="CCDS:CCDS38433.1"
                     /db_xref="GeneID:17112"
                     /db_xref="MGI:MGI:104678"
                     /translation="MCYVKCARYIGYSLVWAAVFCIVANALLYFPNGETKYATEDHLS
                     RFVWYFAGIVGGGLLMLLPAFVFIGMDEEDCCGCCGYENYGKRCSMLSSVLAALIGIV
                     GSAYCVIVASLGLAEGPKCSDAHGVWNYTFASTEGQYLLNSSMWSKCYEPKHIVEWHV
                     TLFSILLAFAAVEFILCLIQVINGMLGGLCGYCCSRQQQYNC"
     exon            843..932
                     /gene="Tm4sf1"
                     /gene_synonym="L6; M3s1"
                     /inference="alignment:Splign:2.1.0"
     exon            933..1078
                     /gene="Tm4sf1"
                     /gene_synonym="L6; M3s1"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1259
                     /gene="Tm4sf1"
                     /gene_synonym="L6; M3s1"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..3413
                     /gene="Tm4sf1"
                     /gene_synonym="L6; M3s1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1532..1537
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tm4sf1"
                     /gene_synonym="L6; M3s1"
                     /note="hexamer: GATAAA"
     polyA_site      1549
                     /gene="Tm4sf1"
                     /gene_synonym="L6; M3s1"
                     /note="major polyA site"
     regulatory      1578..1583
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tm4sf1"
                     /gene_synonym="L6; M3s1"
                     /note="hexamer: AATAAA"
     polyA_site      1611
                     /gene="Tm4sf1"
                     /gene_synonym="L6; M3s1"
     regulatory      1622..1627
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tm4sf1"
                     /gene_synonym="L6; M3s1"
                     /note="hexamer: AATAAA"
     polyA_site      1647
                     /gene="Tm4sf1"
                     /gene_synonym="L6; M3s1"
     regulatory      2000..2005
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tm4sf1"
                     /gene_synonym="L6; M3s1"
                     /note="hexamer: CATAAA"
     polyA_site      2023
                     /gene="Tm4sf1"
                     /gene_synonym="L6; M3s1"
     regulatory      3388..3393
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tm4sf1"
                     /gene_synonym="L6; M3s1"
                     /note="hexamer: AATAAA"
     regulatory      3393..3398
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tm4sf1"
                     /gene_synonym="L6; M3s1"
                     /note="hexamer: AATAAA"
     polyA_site      3403
                     /gene="Tm4sf1"
                     /gene_synonym="L6; M3s1"
     polyA_site      3413
                     /gene="Tm4sf1"
                     /gene_synonym="L6; M3s1"
ORIGIN      
        1 gctttatgag gtctaccagt aagtgtgagg atgtcaaggg ataagaaatc aacactggtt
       61 tcatcttgaa cctagaattt tattttaacc catgaacaaa gtgagctgca gtttaaagag
      121 ggggaaagcc gggtggctgt gcgttaagac cattttctac tgcttcttct caactgcccc
      181 ttcgcctgtg tgtcatgatt acagtttcaa ataaaggaaa ctacagacca cctacattag
      241 tagactccaa ctccagagct gcagttaact gtgcaggact caacaggtgt gatctctgat
      301 gcagtcgtat ctagtgacac tcagatcctt cagaacctgc tctgggcacc gtctcatgac
      361 tcaaagaaaa ggtgactgag gatgtttctc acatcctact actggtttcg ttgtcccaag
      421 gatttcattt gaagggcggg gcactccatt acttccctcc accccaaccg gagtctgaag
      481 tctggaccaa tgaaagctta gaacctcgtt tactggcact aagcactggc actatttaag
      541 tgttagcagg aatgggctgt gagcatcggc tttctccaca aaggggcacg ctaacatctg
      601 atctgtggaa ccgctgagct gaagaaaggg aacagaggaa agcctgcagg actcctggtg
      661 ccactatgtg ctacgtaaag tgtgcaagat acatcggata ctctctggtg tgggctgctg
      721 tcttctgcat cgtagctaat gctttgctct actttcctaa tggggagaca aagtatgcta
      781 cggaggacca cctcagccgt ttcgtgtggt attttgccgg cattgtaggc ggaggcctgc
      841 tgatgctcct gccagcgttt gtgttcattg ggatggatga agaggactgc tgtggttgct
      901 gcggctacga aaactacggc aagcgatgct cgatgctttc ttctgtactg gctgctctga
      961 ttggaatcgt gggatctgct tactgtgtca ttgtggcatc actgggtttg gcagaaggac
     1021 caaagtgcag cgatgcccat ggagtatgga actacacctt tgccagcact gagggacagt
     1081 accttctgaa ttcctctatg tggtccaagt gctatgagcc caagcatatt gtggagtggc
     1141 atgtgactct attttctatc ctcttggctt ttgccgcagt tgaattcatc ttgtgtctca
     1201 ttcaagtaat aaatggaatg cttggaggct tatgtggcta ttgctgctct cgccaacagc
     1261 aatataactg ctaaaaaaga acacaagaca gaagggcgtg cttcctgtat ttcactgtaa
     1321 tttgtatatt ttccctgtgt tgtgagactt tgcaccttgt gccacatcct accctttctg
     1381 cttttgtaag gaaatgtgct gacgtcatca catgatgtca gtgtttacat tcacaaaaca
     1441 aacaaggcag caaactgcac tctctccgaa gggattttac agacttaagg actgttctca
     1501 gcatagctga gataaactct tcagtgtttg agataaaaat cagagctaac tattgtgcat
     1561 atgtgcattt ttttttaaat aaaagatctc cgatttcctt tttaagacca agaaggacca
     1621 aaataaaaaa aaaagaaaaa caagaaagat atattttact gttcatatgc tgtttcccat
     1681 ttgtatgtga atgagtctct aagaaaccct ctgaagtgag attttctctt acctggattc
     1741 ggaaatctca ttgagagcgt gctaacccaa gtatgggaga ggaaatatat aatactgaca
     1801 atgtctgtga aacactactc aaggctgaag ttgtgcagct tgtagaaacc tttttgcctt
     1861 tcaaagacaa agactgtttc tgtaaagagg aaggtcagga tagttagaca aggaaaatga
     1921 gaaatggtgg gaaaacagaa gagaggtggg gcagggtcag gaagctcaca ggggaatgct
     1981 tcccaagctt gcttctgagc ataaaattaa gtattcaata ccattcagct gtggctttag
     2041 ttttacgtct gaagtgacac cctctctcat caggcaattt atcggagtca cgtagagagg
     2101 acttcttcct aacacataga aagatctatt acctttcctg gaagacaaaa gacgttttca
     2161 gagtacaggc ttctgggtct ggagatctgg tttctaactt aatagaattt gatttgaaag
     2221 gttacacaca gtgaatacac tcagtaggac aagccaatgt cattgttcac agcttctgtt
     2281 tttccctccc tctcagtgac ctgtggtcta caggttgggt agcatctatg ccaaggtctt
     2341 gctttcctct gggtcctctc tcctgctttc cctgccttat cccctcttct gccttttcta
     2401 tcaacagata accatggcta tgctatccct cgaggctctc aaatcagcta gatatctttc
     2461 tttctgctgg gtgctccagt tatcaaagtc ctgggtaagg tagtatgttt ttctctcttg
     2521 gtgcacaaat tacaccttgt tatttattta ttttaatgta aaaggatccc ttaacccact
     2581 gcttggcaga attacttaga gggggataga actatgtatt tgctcatggt tccggagctt
     2641 ttagtctggg gttacaggct gcactgtcat aggcctgtgg gaaagcagaa cctccttctg
     2701 gtaggagcat gcataacagg acacagatca cttcatggta gataggaagc agatagagaa
     2761 agggactggg ggccagatgt aaccttcaga ttcacgtcct ccaacaactc acttcctcca
     2821 acaaggtcct acttctaaag tccctactat ctcctaggac catccaagga ccaactatta
     2881 aagaaacaca ttcagataat agcaattggg attttataca gaggacttgg ctttggttat
     2941 tcattgtcct gcataacaga caagagagtt agtggagttt tgtttgctat tagacaggtg
     3001 cacgcttcct ttaggcaaga tacctgctgt ggtagctgat ccaactaaca tctttgtgct
     3061 atgatccctc tgacaatcta gtgaaacttg gagacttttt ctaataatat ctataaacac
     3121 ataaaataaa atatatagac gtaagaagta aatcaatgca ctagaatatt ttatcaaata
     3181 aattagaagt gggactagag agatggctca gtggttaaga gcactgattg ctcttccaga
     3241 ggacctagtt ttgagtccca gcactcacac tgcaggttat aactgtctgt aactccagtg
     3301 tcagtggatc caatattctc ttctggttcc acaggtgcct acatgtggtg cacagacatg
     3361 catgcaggta aaacatttat ttacataaat aaaataaaaa taagtcaaaa tta
//
