LOCUS       NM_001410066            2691 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus transmembrane 4 superfamily member 1 (Tm4sf1),
            transcript variant 5, mRNA.
ACCESSION   NM_001410066
VERSION     NM_001410066.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2691)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2691)
  AUTHORS   Sabbagh,M.F., Heng,J.S., Luo,C., Castanon,R.G., Nery,J.R.,
            Rattner,A., Goff,L.A., Ecker,J.R. and Nathans,J.
  TITLE     Transcriptional and epigenomic landscapes of CNS and non-CNS
            vascular endothelial cells
  JOURNAL   Elife 7, e36187 (2018)
   PUBMED   30188322
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2691)
  AUTHORS   Cui,W., Dai,X., Marcho,C., Han,Z., Zhang,K., Tremblay,K.D. and
            Mager,J.
  TITLE     Towards Functional Annotation of the Preimplantation Transcriptome:
            An RNAi Screen in Mammalian Embryos
  JOURNAL   Sci Rep 6, 37396 (2016)
   PUBMED   27869233
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2691)
  AUTHORS   Lin,C.I., Merley,A., Sciuto,T.E., Li,D., Dvorak,A.M.,
            Melero-Martin,J.M., Dvorak,H.F. and Jaminet,S.C.
  TITLE     TM4SF1: a new vascular therapeutic target in cancer
  JOURNAL   Angiogenesis 17 (4), 897-907 (2014)
   PUBMED   24986520
REFERENCE   5  (bases 1 to 2691)
  AUTHORS   Anderson,K.R., Singer,R.A., Balderes,D.A., Hernandez-Lagunas,L.,
            Johnson,C.W., Artinger,K.B. and Sussel,L.
  TITLE     The L6 domain tetraspanin Tm4sf4 regulates endocrine pancreas
            differentiation and directed cell migration
  JOURNAL   Development 138 (15), 3213-3224 (2011)
   PUBMED   21750032
REFERENCE   6  (bases 1 to 2691)
  AUTHORS   Kao,Y.R., Shih,J.Y., Wen,W.C., Ko,Y.P., Chen,B.M., Chan,Y.L.,
            Chu,Y.W., Yang,P.C., Wu,C.W. and Roffler,S.R.
  TITLE     Tumor-associated antigen L6 and the invasion of human lung cancer
            cells
  JOURNAL   Clin Cancer Res 9 (7), 2807-2816 (2003)
   PUBMED   12855661
  REMARK    GeneRIF: TAL6 may play a role in cancer invasion and metastasis
REFERENCE   7  (bases 1 to 2691)
  AUTHORS   Liu,Z., Zhao,M., Yokoyama,K.K. and Li,T.
  TITLE     Molecular cloning of a cDNA for rat TM4SF4, a homolog of human
            il-TMP (TM4SF4), and enhanced expression of the corresponding gene
            in regenerating rat liver(1)
  JOURNAL   Biochim Biophys Acta 1518 (1-2), 183-189 (2001)
   PUBMED   11267677
REFERENCE   8  (bases 1 to 2691)
  AUTHORS   Maruyama,M., Kozuka-Hata,H., Sakaguchi-Sanai,A., Shioda,S.,
            Yamaguchi,N. and Maruyama,K.
  TITLE     The cDNA cloning of the hamster homologue of the human L6 gene
  JOURNAL   Gene 168 (2), 273-274 (1996)
   PUBMED   8654959
REFERENCE   9  (bases 1 to 2691)
  AUTHORS   Edwards,C.P., Farr,A.G., Marken,J.S., Nelson,A., Bajorath,J.,
            Hellstrom,K.E., Hellstrom,I. and Aruffo,A.
  TITLE     Cloning of the murine counterpart of the tumor-associated antigen
            H-L6: epitope mapping of the human and murine L6 antigens
  JOURNAL   Biochemistry 34 (39), 12653-12660 (1995)
   PUBMED   7548016
REFERENCE   10 (bases 1 to 2691)
  AUTHORS   Marken,J.S., Bajorath,J., Edwards,C.P., Farr,A.G., Schieven,G.L.,
            Hellstrom,I., Hellstrom,K.E. and Aruffo,A.
  TITLE     Membrane topology of the L6 antigen and identification of the
            protein epitope recognized by the L6 monoclonal antibody
  JOURNAL   J Biol Chem 269 (10), 7397-7401 (1994)
   PUBMED   7510285
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC119854.7.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17253011.5001529.1, BI455123.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-120               AC119854.7         131569-131688
            121-210             AC119854.7         133044-133133
            211-356             AC119854.7         133221-133366
            357-537             AC119854.7         136277-136457
            538-2691            AC119854.7         138376-140529
FEATURES             Location/Qualifiers
     source          1..2691
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 27.68 cM"
     gene            1..2691
                     /gene="Tm4sf1"
                     /gene_synonym="L6; M3s1"
                     /note="transmembrane 4 superfamily member 1"
                     /db_xref="GeneID:17112"
                     /db_xref="MGI:MGI:104678"
     exon            1..120
                     /gene="Tm4sf1"
                     /gene_synonym="L6; M3s1"
                     /inference="alignment:Splign:2.1.0"
     CDS             121..552
                     /gene="Tm4sf1"
                     /gene_synonym="L6; M3s1"
                     /note="isoform 3 is encoded by transcript variant 5;
                     transmembrane 4 L6 family member 1; tumor-associated
                     antigen L6; membrane component chromosome 3 surface marker
                     1 homolog; membrane component, surface marker 1; L6
                     antigen; 12A8 target antigen"
                     /codon_start=1
                     /product="transmembrane 4 L6 family member 1 isoform 3"
                     /protein_id="NP_001396995.1"
                     /db_xref="GeneID:17112"
                     /db_xref="MGI:MGI:104678"
                     /translation="MLLPAFVFIGMDEEDCCGCCGYENYGKRCSMLSSVLAALIGIVG
                     SAYCVIVASLGLAEGPKCSDAHGVWNYTFASTEGQYLLNSSMWSKCYEPKHIVEWHVT
                     LFSILLAFAAVEFILCLIQVINGMLGGLCGYCCSRQQQYNC"
     exon            121..210
                     /gene="Tm4sf1"
                     /gene_synonym="L6; M3s1"
                     /inference="alignment:Splign:2.1.0"
     exon            211..356
                     /gene="Tm4sf1"
                     /gene_synonym="L6; M3s1"
                     /inference="alignment:Splign:2.1.0"
     exon            357..537
                     /gene="Tm4sf1"
                     /gene_synonym="L6; M3s1"
                     /inference="alignment:Splign:2.1.0"
     exon            538..2691
                     /gene="Tm4sf1"
                     /gene_synonym="L6; M3s1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      810..815
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tm4sf1"
                     /gene_synonym="L6; M3s1"
                     /note="hexamer: GATAAA"
     polyA_site      827
                     /gene="Tm4sf1"
                     /gene_synonym="L6; M3s1"
                     /note="major polyA site"
     regulatory      856..861
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tm4sf1"
                     /gene_synonym="L6; M3s1"
                     /note="hexamer: AATAAA"
     polyA_site      889
                     /gene="Tm4sf1"
                     /gene_synonym="L6; M3s1"
     regulatory      900..905
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tm4sf1"
                     /gene_synonym="L6; M3s1"
                     /note="hexamer: AATAAA"
     polyA_site      925
                     /gene="Tm4sf1"
                     /gene_synonym="L6; M3s1"
     regulatory      1278..1283
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tm4sf1"
                     /gene_synonym="L6; M3s1"
                     /note="hexamer: CATAAA"
     polyA_site      1301
                     /gene="Tm4sf1"
                     /gene_synonym="L6; M3s1"
     regulatory      2666..2671
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tm4sf1"
                     /gene_synonym="L6; M3s1"
                     /note="hexamer: AATAAA"
     regulatory      2671..2676
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tm4sf1"
                     /gene_synonym="L6; M3s1"
                     /note="hexamer: AATAAA"
     polyA_site      2681
                     /gene="Tm4sf1"
                     /gene_synonym="L6; M3s1"
     polyA_site      2691
                     /gene="Tm4sf1"
                     /gene_synonym="L6; M3s1"
ORIGIN      
        1 ctctcctctc gaatggcaga gagtattctt ctcatgcgaa gttttctata atgcccatct
       61 gtaaaaactg gattttgtcg ttgttgctgc gctctctctt tgaaagcaga atattctaag
      121 atgctcctgc cagcgtttgt gttcattggg atggatgaag aggactgctg tggttgctgc
      181 ggctacgaaa actacggcaa gcgatgctcg atgctttctt ctgtactggc tgctctgatt
      241 ggaatcgtgg gatctgctta ctgtgtcatt gtggcatcac tgggtttggc agaaggacca
      301 aagtgcagcg atgcccatgg agtatggaac tacacctttg ccagcactga gggacagtac
      361 cttctgaatt cctctatgtg gtccaagtgc tatgagccca agcatattgt ggagtggcat
      421 gtgactctat tttctatcct cttggctttt gccgcagttg aattcatctt gtgtctcatt
      481 caagtaataa atggaatgct tggaggctta tgtggctatt gctgctctcg ccaacagcaa
      541 tataactgct aaaaaagaac acaagacaga agggcgtgct tcctgtattt cactgtaatt
      601 tgtatatttt ccctgtgttg tgagactttg caccttgtgc cacatcctac cctttctgct
      661 tttgtaagga aatgtgctga cgtcatcaca tgatgtcagt gtttacattc acaaaacaaa
      721 caaggcagca aactgcactc tctccgaagg gattttacag acttaaggac tgttctcagc
      781 atagctgaga taaactcttc agtgtttgag ataaaaatca gagctaacta ttgtgcatat
      841 gtgcattttt ttttaaataa aagatctccg atttcctttt taagaccaag aaggaccaaa
      901 ataaaaaaaa aagaaaaaca agaaagatat attttactgt tcatatgctg tttcccattt
      961 gtatgtgaat gagtctctaa gaaaccctct gaagtgagat tttctcttac ctggattcgg
     1021 aaatctcatt gagagcgtgc taacccaagt atgggagagg aaatatataa tactgacaat
     1081 gtctgtgaaa cactactcaa ggctgaagtt gtgcagcttg tagaaacctt tttgcctttc
     1141 aaagacaaag actgtttctg taaagaggaa ggtcaggata gttagacaag gaaaatgaga
     1201 aatggtggga aaacagaaga gaggtggggc agggtcagga agctcacagg ggaatgcttc
     1261 ccaagcttgc ttctgagcat aaaattaagt attcaatacc attcagctgt ggctttagtt
     1321 ttacgtctga agtgacaccc tctctcatca ggcaatttat cggagtcacg tagagaggac
     1381 ttcttcctaa cacatagaaa gatctattac ctttcctgga agacaaaaga cgttttcaga
     1441 gtacaggctt ctgggtctgg agatctggtt tctaacttaa tagaatttga tttgaaaggt
     1501 tacacacagt gaatacactc agtaggacaa gccaatgtca ttgttcacag cttctgtttt
     1561 tccctccctc tcagtgacct gtggtctaca ggttgggtag catctatgcc aaggtcttgc
     1621 tttcctctgg gtcctctctc ctgctttccc tgccttatcc cctcttctgc cttttctatc
     1681 aacagataac catggctatg ctatccctcg aggctctcaa atcagctaga tatctttctt
     1741 tctgctgggt gctccagtta tcaaagtcct gggtaaggta gtatgttttt ctctcttggt
     1801 gcacaaatta caccttgtta tttatttatt ttaatgtaaa aggatccctt aacccactgc
     1861 ttggcagaat tacttagagg gggatagaac tatgtatttg ctcatggttc cggagctttt
     1921 agtctggggt tacaggctgc actgtcatag gcctgtggga aagcagaacc tccttctggt
     1981 aggagcatgc ataacaggac acagatcact tcatggtaga taggaagcag atagagaaag
     2041 ggactggggg ccagatgtaa ccttcagatt cacgtcctcc aacaactcac ttcctccaac
     2101 aaggtcctac ttctaaagtc cctactatct cctaggacca tccaaggacc aactattaaa
     2161 gaaacacatt cagataatag caattgggat tttatacaga ggacttggct ttggttattc
     2221 attgtcctgc ataacagaca agagagttag tggagttttg tttgctatta gacaggtgca
     2281 cgcttccttt aggcaagata cctgctgtgg tagctgatcc aactaacatc tttgtgctat
     2341 gatccctctg acaatctagt gaaacttgga gactttttct aataatatct ataaacacat
     2401 aaaataaaat atatagacgt aagaagtaaa tcaatgcact agaatatttt atcaaataaa
     2461 ttagaagtgg gactagagag atggctcagt ggttaagagc actgattgct cttccagagg
     2521 acctagtttt gagtcccagc actcacactg caggttataa ctgtctgtaa ctccagtgtc
     2581 agtggatcca atattctctt ctggttccac aggtgcctac atgtggtgca cagacatgca
     2641 tgcaggtaaa acatttattt acataaataa aataaaaata agtcaaaatt a
//
