LOCUS       NM_178056                953 bp    mRNA    linear   ROD 07-AUG-2024
DEFINITION  Mus musculus TM2 domain containing 3 (Tm2d3), transcript variant 2,
            mRNA.
ACCESSION   NM_178056
VERSION     NM_178056.4
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 953)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 953)
  AUTHORS   Masuda,W., Yamakawa,T., Ajima,R., Miyake,K., Umemiya,T., Azuma,K.,
            Tamaru,J.I., Kiso,M., Das,P., Saga,Y., Matsuno,K. and Kitagawa,M.
  TITLE     TM2D3, a mammalian homologue of Drosophila neurogenic gene product
            Almondex, regulates surface presentation of Notch receptors
  JOURNAL   Sci Rep 13 (1), 20913 (2023)
   PUBMED   38016980
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122184.4.
            
            On Mar 30, 2022 this sequence version replaced NM_178056.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784650.915865.1,
                                           SRR13948564.1219173.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-114               AC122184.4         75196-75309         c
            115-207             AC122184.4         74822-74914         c
            208-392             AC122184.4         73438-73622         c
            393-567             AC122184.4         70895-71069         c
            568-643             AC122184.4         69598-69673         c
            644-953             AC122184.4         66863-67172         c
FEATURES             Location/Qualifiers
     source          1..953
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 35.26 cM"
     gene            1..953
                     /gene="Tm2d3"
                     /gene_synonym="1110025I09Rik; 5930422O05Rik; Blp2"
                     /note="TM2 domain containing 3"
                     /db_xref="GeneID:68634"
                     /db_xref="MGI:MGI:1915884"
     exon            1..114
                     /gene="Tm2d3"
                     /gene_synonym="1110025I09Rik; 5930422O05Rik; Blp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..809
                     /gene="Tm2d3"
                     /gene_synonym="1110025I09Rik; 5930422O05Rik; Blp2"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; BBP-like protein 2; TM2 domain-containing
                     protein 3"
                     /codon_start=1
                     /product="TM2 domain-containing protein 3 isoform 2
                     precursor"
                     /protein_id="NP_835157.1"
                     /db_xref="CCDS:CCDS21341.1"
                     /db_xref="GeneID:68634"
                     /db_xref="MGI:MGI:1915884"
                     /translation="MEAAAEPLRSVRHLSRVLLFLSQCYILSGDGSLNLEHSQPLAQA
                     IKDPGPTRTFSVVPRAAENQLFSHLTESTEIPPYMTKCPSNGLCSRLPADCIECATNV
                     SCTYGKPVTFDCTVKPSVTCVDQDLKPQRNFVINMTCRFCWQLPETDYECSNSTTCMT
                     VACPRQRYFANCTVRDHIHCLGNRTFPKLLYCNWTGGYKWSTALALSITLGGFGADRF
                     YLGQWREGLGKLFSFGGLGIWTLIDVLLIGVGYVGPADGSLYI"
     exon            115..207
                     /gene="Tm2d3"
                     /gene_synonym="1110025I09Rik; 5930422O05Rik; Blp2"
                     /inference="alignment:Splign:2.1.0"
     exon            208..392
                     /gene="Tm2d3"
                     /gene_synonym="1110025I09Rik; 5930422O05Rik; Blp2"
                     /inference="alignment:Splign:2.1.0"
     exon            393..567
                     /gene="Tm2d3"
                     /gene_synonym="1110025I09Rik; 5930422O05Rik; Blp2"
                     /inference="alignment:Splign:2.1.0"
     exon            568..643
                     /gene="Tm2d3"
                     /gene_synonym="1110025I09Rik; 5930422O05Rik; Blp2"
                     /inference="alignment:Splign:2.1.0"
     exon            644..953
                     /gene="Tm2d3"
                     /gene_synonym="1110025I09Rik; 5930422O05Rik; Blp2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      936..941
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tm2d3"
                     /gene_synonym="1110025I09Rik; 5930422O05Rik; Blp2"
                     /note="hexamer: AAGAAA"
     polyA_site      953
                     /gene="Tm2d3"
                     /gene_synonym="1110025I09Rik; 5930422O05Rik; Blp2"
                     /note="major polyA site"
ORIGIN      
        1 agtgcgcacg cgcagcgaca aaaatggagg ctgcggccga gccgctgcgg tctgtccgcc
       61 acctgtcccg cgtgctgctt ttcctgtccc agtgctacat tctgtcggga gatggatcct
      121 taaatttaga gcattcgcag ccgctggctc aggcaataaa ggatccgggc ccaacacgta
      181 cattctctgt agttcccagg gcagcagaga atcagctgtt ctctcacctc acagaaagta
      241 ctgaaatccc tccttacatg acgaagtgtc caagcaatgg tttgtgtagc agacttcctg
      301 cagactgtat agaatgtgcg accaatgtct cctgcactta cgggaagcct gtcacgttcg
      361 actgcacagt gaagccctct gttacctgtg tcgatcaaga cctcaaaccc cagaggaact
      421 tcgtcatcaa catgacttgc aggttttgct ggcagcttcc tgaaacagac tacgagtgtt
      481 caaattccac cacctgcatg accgtggctt gccctcggca gcgctatttc gccaactgca
      541 ccgtgcgtga ccacattcac tgcctgggca accggacttt ccctaagctg ctgtactgca
      601 actggacagg tggctacaag tggtcgacag ccctggctct cagcatcacc cttggggggt
      661 ttggagccga tcgcttctac ctgggccagt ggcgagaagg cctcggcaag ctcttcagct
      721 ttggcggcct gggaatatgg accctaatcg atgtcttgct gattggagtt ggctatgtgg
      781 gaccagcgga tggctctttg tacatttagc cgaggttatg tgcttcagag agcagtgtag
      841 agtcctgtgt gtggagatgg atgcggtgtg agagggggat ttatgttttt aatgtacagc
      901 atctgtactt ggcttgcctt gatgaaggta aaataaagaa atcgaacact gaa
//
