LOCUS       NM_019916               1532 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus T cell leukemia, homeobox 3 (Tlx3), mRNA.
ACCESSION   NM_019916
VERSION     NM_019916.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1532)
  AUTHORS   Alvarez,S., Gupta,S., Mercado-Ayon,Y., Honeychurch,K.,
            Rodriguez,C., Kawaguchi,R. and Butler,S.J.
  TITLE     Netrin1 patterns the dorsal spinal cord through modulation of Bmp
            signaling
  JOURNAL   Cell Rep 43 (11), 114954 (2024)
   PUBMED   39547237
REFERENCE   2  (bases 1 to 1532)
  AUTHORS   Parvathy,S., Basu,B., Surya,S., Jose,R., Meera,V., Riya,P.A.,
            Jyothi,N.P., Sanalkumar,R., Praz,V., Riggi,N., Nair,B.S.,
            Gulia,K.K., Kumar,M., Binukumar,B.K. and James,J.
  TITLE     TLX3 regulates CGN progenitor proliferation during cerebellum
            development and its dysfunction can lead to autism
  JOURNAL   iScience 27 (12), 111260 (2024)
   PUBMED   39628587
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1532)
  AUTHORS   Lowenstein,E.D., Misios,A., Buchert,S. and Ruffault,P.L.
  TITLE     Molecular Characterization of Nodose Ganglia Development Reveals a
            Novel Population of Phox2b+ Glial Progenitors in Mice
  JOURNAL   J Neurosci 44 (28), e1441232024 (2024)
   PUBMED   38830761
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1532)
  AUTHORS   Vermeiren,S., Cabochette,P., Dannawi,M., Desiderio,S., San
            Jose,A.S., Achouri,Y., Kricha,S., Sitte,M., Salinas-Riester,G.,
            Vanhollebeke,B., Brunet,J.F. and Bellefroid,E.J.
  TITLE     Prdm12 represses the expression of the visceral neuron determinants
            Phox2a/b in developing somatosensory ganglia
  JOURNAL   iScience 26 (12), 108364 (2023)
   PUBMED   38025786
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1532)
  AUTHORS   Wang,H., Cao,Z., Jiang,X., Huang,C., Cao,C. and Liu,Z.
  TITLE     Tlx3 controls the development of C-low threshold mechanoreceptors
  JOURNAL   Neuroreport 33 (14), 617-622 (2022)
   PUBMED   36062515
  REMARK    GeneRIF: Tlx3 controls the development of C-low threshold
            mechanoreceptors.
REFERENCE   6  (bases 1 to 1532)
  AUTHORS   Qian,Y., Fritzsch,B., Shirasawa,S., Chen,C.L., Choi,Y. and Ma,Q.
  TITLE     Formation of brainstem (nor)adrenergic centers and first-order
            relay visceral sensory neurons is dependent on homeodomain protein
            Rnx/Tlx3
  JOURNAL   Genes Dev 15 (19), 2533-2545 (2001)
   PUBMED   11581159
REFERENCE   7  (bases 1 to 1532)
  AUTHORS   Bernard,O.A., Busson-LeConiat,M., Ballerini,P., Mauchauffe,M.,
            Della Valle,V., Monni,R., Nguyen Khac,F., Mercher,T.,
            Penard-Lacronique,V., Pasturaud,P., Gressin,L., Heilig,R.,
            Daniel,M.T., Lessard,M. and Berger,R.
  TITLE     A new recurrent and specific cryptic translocation,
            t(5;14)(q35;q32), is associated with expression of the Hox11L2 gene
            in T acute lymphoblastic leukemia
  JOURNAL   Leukemia 15 (10), 1495-1504 (2001)
   PUBMED   11587205
REFERENCE   8  (bases 1 to 1532)
  AUTHORS   Shirasawa,S., Arata,A., Onimaru,H., Roth,K.A., Brown,G.A.,
            Horning,S., Arata,S., Okumura,K., Sasazuki,T. and Korsmeyer,S.J.
  TITLE     Rnx deficiency results in congenital central hypoventilation
  JOURNAL   Nat Genet 24 (3), 287-290 (2000)
   PUBMED   10700185
REFERENCE   9  (bases 1 to 1532)
  AUTHORS   Roberts,C.W., Sonder,A.M., Lumsden,A. and Korsmeyer,S.J.
  TITLE     Development expression of Hox11 and specification of splenic cell
            fate
  JOURNAL   Am J Pathol 146 (5), 1089-1101 (1995)
   PUBMED   7747804
REFERENCE   10 (bases 1 to 1532)
  AUTHORS   Dear,T.N., Sanchez-Garcia,I. and Rabbitts,T.H.
  TITLE     The HOX11 gene encodes a DNA-binding nuclear transcription factor
            belonging to a distinct family of homeobox genes
  JOURNAL   Proc Natl Acad Sci U S A 90 (10), 4431-4435 (1993)
   PUBMED   8099440
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK141870.1 and AW493622.1.
            
            On Jul 29, 2009 this sequence version replaced NM_019916.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK141870.1, BC141308.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164136
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-449               AK141870.1         2-450
            450-559             AW493622.1         1-110               c
            560-1532            AK141870.1         561-1533
FEATURES             Location/Qualifiers
     source          1..1532
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 19.21 cM"
     gene            1..1532
                     /gene="Tlx3"
                     /gene_synonym="Hox11l2; Rnx; Tlx1l2"
                     /note="T cell leukemia, homeobox 3"
                     /db_xref="GeneID:27140"
                     /db_xref="MGI:MGI:1351209"
     exon            1..550
                     /gene="Tlx3"
                     /gene_synonym="Hox11l2; Rnx; Tlx1l2"
                     /inference="alignment:Splign:2.1.0"
     CDS             130..1005
                     /gene="Tlx3"
                     /gene_synonym="Hox11l2; Rnx; Tlx1l2"
                     /note="homeobox TLX-3; homeobox protein Hox-11L2;
                     respiratory neuron homeobox protein; homeo box 11-like 2"
                     /codon_start=1
                     /product="T-cell leukemia homeobox protein 3"
                     /protein_id="NP_064300.2"
                     /db_xref="CCDS:CCDS24533.1"
                     /db_xref="GeneID:27140"
                     /db_xref="MGI:MGI:1351209"
                     /translation="MEAPASAQTPHPHEPISFGIDQILNSPDQDSAPAPRGPDGASYL
                     GGPPGGRPGAAYPSLPASFAGLGAPFEDAGSYSVNLSLAPAGVIRVPAHRPLPGAVPP
                     PLPSALPAMPSVPTVSSLGGLNFPWMESSRRFVKDRFTAAAALTPFTVTRRIGHPYQN
                     RTPPKRKKPRTSFSRVQICELEKRFHRQKYLASAERAALAKSLKMTDAQVKTWFQNRR
                     TKWRRQTAEEREAERQQASRLMLQLQHDAFQKSLNDSIQPDPLCLHNSSLFALQNLQP
                     WEEDSSKVPAVTSLV"
     exon            551..794
                     /gene="Tlx3"
                     /gene_synonym="Hox11l2; Rnx; Tlx1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            795..1532
                     /gene="Tlx3"
                     /gene_synonym="Hox11l2; Rnx; Tlx1l2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1511..1516
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tlx3"
                     /gene_synonym="Hox11l2; Rnx; Tlx1l2"
ORIGIN      
        1 ctgtcgggcc cgcgcactct tggcaaagtt tcagtgcgac tggaggcgcc gggcgctcca
       61 tggccgcgcc gtaacgggga cccagcagcc tccccgccca gcccagccca gcccttccgc
      121 ccgcccagga tggaggcgcc cgccagcgcg cagaccccac acccgcacga gcccatcagc
      181 ttcggcatcg accaaatcct caacagcccg gaccaggaca gcgcgcccgc cccgcggggc
      241 cccgacggcg ccagctacct gggagggccc cccgggggcc gtccgggcgc cgcgtacccg
      301 tctctgcccg cctcctttgc gggcctcggc gcgcccttcg aggacgcggg atcttacagt
      361 gtcaacctaa gcttggcccc cgccggcgtg atccgggtgc cagcgcacag gccgctccct
      421 ggggccgtgc cgccgcctct gcctagcgcg ctgcccgcta tgccctcggt gcccacggtc
      481 tccagcctag gcggcctcaa tttcccctgg atggagagca gtcgccgctt tgtaaaggac
      541 cgcttcacag cggcggccgc gctcacgccc ttcaccgtga cccggcgcat tggccacccc
      601 taccagaacc ggacgccacc caagcgtaag aagccgcgca cgtccttttc ccgggtgcag
      661 atctgtgagc tggaaaagcg cttccatcgc caaaagtacc tggcctcggc cgagagggcg
      721 gcgctcgcaa agtccctcaa aatgacggac gcgcaggtca agacctggtt ccaaaatcgg
      781 aggaccaagt ggcggcggca gacggcggag gagcgggagg cggagcggca gcaggcgagc
      841 cggctcatgc tacagctgca acacgacgcc ttccagaaga gcctcaacga ttccatccag
      901 cccgacccgc tctgtctgca caactcgtcg ctctttgctc tgcagaatct gcagccctgg
      961 gaggaggaca gttccaaggt ccccgctgtc acctctctgg tgtgagccac cggcgtgcaa
     1021 cgtagctacg gatcgctgcc cccaccaggc ggggcgtccg ggtcccccag ccgggctggg
     1081 aagggaagct gggccgagaa gggtagggcg gcccgactcg cgtgggtctt ggggcgcgcc
     1141 gcacagcgcc ggccgcggag aggggctggg cccaggtcct cgcggctgca caatccaagc
     1201 cccccgcccc gcgccccgtc ccgccccagg cccgggcctg acaaagaagc gccttacgtt
     1261 actccgcccc gcacccgcac ccccgggctg ggcgcctgta ttatactttg tacttttgcc
     1321 caaacgtgta aataataaaa gttttggctt ttttctttag aaaccggcca cctgcttccc
     1381 ctgcggggcc gctggaggag gggcaaccga cccggcgtct gggggaagcg tgtggggccg
     1441 ggggcaccca gcgtttaggc tgggtgcacg cctctccttt tccgttcctt ttatttaagt
     1501 cgttttattt aataaaaagt tagctatttc ac
//
