LOCUS       NM_031178               3471 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus toll-like receptor 9 (Tlr9), mRNA.
ACCESSION   NM_031178
VERSION     NM_031178.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3471)
  AUTHORS   Fan,R., Li,Q., Jiang,N., Zhang,Y., Yu,L., Zheng,Y., Su,Z.,
            Zhang,N., Chen,R., Feng,Y., Sang,X. and Chen,Q.
  TITLE     Plasmodium berghei TatD-like DNase hijacks host innate immunity by
            inhibiting the TLR9-NF-kappaB pathway
  JOURNAL   Int Immunopharmacol 140, 112843 (2024)
   PUBMED   39098224
REFERENCE   2  (bases 1 to 3471)
  AUTHORS   Li,N., Kumar,S.R.P., Cao,D., Munoz-Melero,M., Arisa,S., Brian,B.A.,
            Greenwood,C.M., Yamada,K., Duan,D. and Herzog,R.W.
  TITLE     Redundancy in Innate Immune Pathways That Promote CD8+ T-Cell
            Responses in AAV1 Muscle Gene Transfer
  JOURNAL   Viruses 16 (10), 1507 (2024)
   PUBMED   39459842
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3471)
  AUTHORS   Chen,J., Wang,T., Li,X., Gao,L., Wang,K., Cheng,M., Zeng,Z.,
            Chen,L., Shen,Y. and Wen,F.
  TITLE     DNA of neutrophil extracellular traps promote NF-kappaB-dependent
            autoimmunity via cGAS/TLR9 in chronic obstructive pulmonary disease
  JOURNAL   Signal Transduct Target Ther 9 (1), 163 (2024)
   PUBMED   38880789
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3471)
  AUTHORS   Yang,X., Huang,J., Peng,J., Wang,P., Wong,F.S., Wang,R., Wang,D.
            and Wen,L.
  TITLE     Gut microbiota from B-cell-specific TLR9-deficient NOD mice promote
            IL-10+ Breg cells and protect against T1D
  JOURNAL   Front Immunol 15, 1413177 (2024)
   PUBMED   38903498
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3471)
  AUTHORS   Wang,C., Oishi,K., Kobayashi,T., Fujii,K., Horii,M., Fushida,N.,
            Kitano,T., Maeda,S., Ikawa,Y., Komuro,A., Hamaguchi,Y. and
            Matsushita,T.
  TITLE     The Role of TLR7 and TLR9 in the Pathogenesis of Systemic Sclerosis
  JOURNAL   Int J Mol Sci 25 (11), 6133 (2024)
   PUBMED   38892317
  REMARK    GeneRIF: The Role of TLR7 and TLR9 in the Pathogenesis of Systemic
            Sclerosis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3471)
  AUTHORS   Suzuki,N., Suzuki,S., Duncan,G.S., Millar,D.G., Wada,T.,
            Mirtsos,C., Takada,H., Wakeham,A., Itie,A., Li,S., Penninger,J.M.,
            Wesche,H., Ohashi,P.S., Mak,T.W. and Yeh,W.C.
  TITLE     Severe impairment of interleukin-1 and Toll-like receptor
            signalling in mice lacking IRAK-4
  JOURNAL   Nature 416 (6882), 750-756 (2002)
   PUBMED   11923871
  REMARK    GeneRIF: Severe impairment of interleukin-1 and Toll-like receptor
            signalling in mice lacking IRAK-4.
REFERENCE   7  (bases 1 to 3471)
  AUTHORS   Chuang,T.H., Lee,J., Kline,L., Mathison,J.C. and Ulevitch,R.J.
  TITLE     Toll-like receptor 9 mediates CpG-DNA signaling
  JOURNAL   J Leukoc Biol 71 (3), 538-544 (2002)
   PUBMED   11867692
  REMARK    GeneRIF: TLR9 acts at the cell surface and engages an intracellular
            signaling pathway that includes MyD88, IRAK, and TRAF6
REFERENCE   8  (bases 1 to 3471)
  AUTHORS   Hemmi,H., Kaisho,T., Takeuchi,O., Sato,S., Sanjo,H., Hoshino,K.,
            Horiuchi,T., Tomizawa,H., Takeda,K. and Akira,S.
  TITLE     Small anti-viral compounds activate immune cells via the TLR7
            MyD88-dependent signaling pathway
  JOURNAL   Nat Immunol 3 (2), 196-200 (2002)
   PUBMED   11812998
REFERENCE   9  (bases 1 to 3471)
  AUTHORS   Bauer,S., Kirschning,C.J., Hacker,H., Redecke,V., Hausmann,S.,
            Akira,S., Wagner,H. and Lipford,G.B.
  TITLE     Human TLR9 confers responsiveness to bacterial DNA via
            species-specific CpG motif recognition
  JOURNAL   Proc Natl Acad Sci U S A 98 (16), 9237-9242 (2001)
   PUBMED   11470918
REFERENCE   10 (bases 1 to 3471)
  AUTHORS   Hemmi,H., Takeuchi,O., Kawai,T., Kaisho,T., Sato,S., Sanjo,H.,
            Matsumoto,M., Hoshino,K., Wagner,H., Takeda,K. and Akira,S.
  TITLE     A Toll-like receptor recognizes bacterial DNA
  JOURNAL   Nature 408 (6813), 740-745 (2000)
   PUBMED   11130078
  REMARK    Erratum:[Nature 2001 Feb 1;409(6820):646]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC164430.3.
            
            On Sep 7, 2007 this sequence version replaced NM_031178.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB045181.1, AF314224.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-109               AC164430.3         155121-155229
            110-3471            AC164430.3         156038-159399
FEATURES             Location/Qualifiers
     source          1..3471
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 57.46 cM"
     gene            1..3471
                     /gene="Tlr9"
                     /note="toll-like receptor 9"
                     /db_xref="GeneID:81897"
                     /db_xref="MGI:MGI:1932389"
     exon            1..109
                     /gene="Tlr9"
                     /inference="alignment:Splign:2.1.0"
     exon            110..3471
                     /gene="Tlr9"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgaaagtgtc acttcctcaa ttctctgaga gaccctggtg tggaacatca ttctctgccg
       61 cccagtttgt cagagggagc ctcgggagaa tcctccatct cccaacatgg ttctccgtcg
      121 aaggactctg caccccttgt ccctcctggt acaggctgca gtgctggctg agactctggc
      181 cctgggtacc ctgcctgcct tcctaccctg tgagctgaag cctcatggcc tggtggactg
      241 caattggctg ttcctgaagt ctgtaccccg tttctctgcg gcagcatcct gctccaacat
      301 cacccgcctc tccttgatct ccaaccgtat ccaccacctg cacaactctg acttcgtcca
      361 cctgtccaac ctgcggcagc tgaacctcaa gtggaactgt ccacccactg gccttagccc
      421 cctgcacttc tcttgccaca tgaccattga gcccagaacc ttcctggcta tgcgtacact
      481 ggaggagctg aacttgagct ataatggtat caccactgtg ccccgactgc ccagctccct
      541 ggtgaatctg agcctgagcc acaccaacat cctggttcta gatgctaaca gcctcgccgg
      601 cctatacagc ctgcgcgttc tcttcatgga cgggaactgc tactacaaga acccctgcac
      661 aggagcggtg aaggtgaccc caggcgccct cctgggcctg agcaatctca cccatctgtc
      721 tctgaagtat aacaacctca caaaggtgcc ccgccaactg ccccccagcc tggagtacct
      781 cctggtgtcc tataacctca ttgtcaagct ggggcctgaa gacctggcca atctgacctc
      841 ccttcgagta cttgatgtgg gtgggaattg ccgtcgctgt gaccatgccc ccaatccctg
      901 tatagaatgt ggccaaaagt ccctccacct gcaccctgag accttccatc acctgagcca
      961 tctggaaggc ctggtgctga aggacagctc tctccataca ctgaactctt cctggttcca
     1021 aggtctggtc aacctctcgg tgctggacct aagcgagaac tttctctatg aaagcatcac
     1081 ccacaccaat gcctttcaga acctaacccg cctgcgcaag ctcaacctgt ccttcaatta
     1141 ccgcaagaag gtatcctttg cccgcctcca cctggcaagt tcctttaaga acctggtgtc
     1201 actgcaggag ctgaacatga acggcatctt cttccgcttg ctcaacaagt acacgctcag
     1261 atggctggcc gatctgccca aactccacac tctgcatctt caaatgaact tcatcaacca
     1321 ggcacagctc agcatctttg gtaccttccg agcccttcgc tttgtggact tgtcagacaa
     1381 tcgcatcagt gggccttcaa cgctgtcaga agccacccct gaagaggcag atgatgcaga
     1441 gcaggaggag ctgttgtctg cggatcctca cccagctccg ctgagcaccc ctgcttctaa
     1501 gaacttcatg gacaggtgta agaacttcaa gttcaccatg gacctgtctc ggaacaacct
     1561 ggtgactatc aagccagaga tgtttgtcaa tctctcacgc ctccagtgtc ttagcctgag
     1621 ccacaactcc attgcacagg ctgtcaatgg ctctcagttc ctgccgctga ctaatctgca
     1681 ggtgctggac ctgtcccata acaaactgga cttgtaccac tggaaatcgt tcagtgagct
     1741 accacagttg caggccctgg acctgagcta caacagccag ccctttagca tgaagggtat
     1801 aggccacaat ttcagttttg tgacccatct gtccatgcta cagagcctta gcctggcaca
     1861 caatgacatt catacccgtg tgtcctcaca tctcaacagc aactcagtga ggtttcttga
     1921 cttcagcggc aacggtatgg gccgcatgtg ggatgagggg ggcctttatc tccatttctt
     1981 ccaaggcctg agtggcctgc tgaagctgga cctgtctcaa aataacctgc atatcctccg
     2041 gccccagaac cttgacaacc tccccaagag cctgaagctg ctgagcctcc gagacaacta
     2101 cctatctttc tttaactgga ccagtctgtc cttcctaccc aacctggaag tcctagacct
     2161 ggcaggcaac cagctaaagg ccctgaccaa tggcaccctg cctaatggca ccctcctcca
     2221 gaaactcgat gtcagtagca acagtatcgt ctctgtggtc ccagccttct tcgctctggc
     2281 ggtcgagctg aaagaggtca acctcagcca caacattctc aagacggtgg atcgctcctg
     2341 gtttgggccc attgtgatga acctgacagt tctagacgtg agaagcaacc ctctgcactg
     2401 tgcctgtggg gcagccttcg tagacttact gttggaggtg cagaccaagg tgcctggcct
     2461 ggctaatggt gtgaagtgtg gcagccccgg ccagctgcag ggccgtagca tcttcgcgca
     2521 ggacctgcgg ctgtgcctgg atgaggtcct ctcttgggac tgctttggcc tttcactctt
     2581 ggctgtggcc gtgggcatgg tggtgcctat actgcaccat ctctgcggct gggacgtctg
     2641 gtactgtttt catctgtgcc tggcatggct acctttgcta gcccgcagcc gacgcagcgc
     2701 ccaaactctc ccttatgatg ccttcgtggt gttcgataag gcacagagcg cagttgccga
     2761 ctgggtgtat aacgagctgc gggtgcggct ggaggagcgg cgcggccgcc gagccctacg
     2821 cttgtgtctg gaggaccgag attggctgcc tggccagacg ctcttcgaga acctctgggc
     2881 ttccatctat gggagccgca agactctatt tgtgctggcc cacacggacc gcgtcagtgg
     2941 cctcctgcgc accagcttcc tgctggctca gcagcgcctg ttggaagacc gcaaggacgt
     3001 ggtggtgttg gtgatcctgc gtccggatgc ccaccgctcc cgctatgtgc gactgcgcca
     3061 gcgtctctgc cgccagagtg tgctcttctg gccccagcag cccaacgggc aggggggctt
     3121 ctgggcccag ctgagtacag ccctgactag ggacaaccgc cacttctata accagaactt
     3181 ctgccgggga cctacagcag aatagctcag agcaacagct ggaaacagct gcatcttcat
     3241 gtctggttcc cgagttgctc tgcctgcctt gctctgtctt actacaccgc tatttggcaa
     3301 gtgcgcaata tatgctacca agccaccagg cccacggagc aaaggttggc tgtaaagggt
     3361 agttttcttc ccatgcatct ttcaggagag tgaagataga caccaaaccc acacagaaca
     3421 ggactggagt tcattctctg cccctccacc cccctttgtc tgtctctgta t
//
