LOCUS       NM_133212               5047 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus toll-like receptor 8 (Tlr8), transcript variant 1,
            mRNA.
ACCESSION   NM_133212 XM_006528717
VERSION     NM_133212.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5047)
  AUTHORS   Georges,H.M., Cassin,C., Tong,M. and Abrahams,V.M.
  TITLE     TLR8-activating miR-146a-3p is an intermediate signal contributing
            to fetal membrane inflammation in response to bacterial LPS
  JOURNAL   Immunology 172 (4), 577-587 (2024)
   PUBMED   38631842
  REMARK    GeneRIF: TLR8-activating miR-146a-3p is an intermediate signal
            contributing to fetal membrane inflammation in response to
            bacterial LPS.
REFERENCE   2  (bases 1 to 5047)
  AUTHORS   Hou,Y., Peng,J., Hong,L., Wu,Z., Zheng,E. and Li,Z.
  TITLE     Gender Control of Mouse Embryos by Activation of TLR7/8 on X Sperm
            via Ligands dsRNA-40 and dsRNA-DR
  JOURNAL   Molecules 29 (1), 262 (2024)
   PUBMED   38202845
  REMARK    GeneRIF: Gender Control of Mouse Embryos by Activation of TLR7/8 on
            X Sperm via Ligands dsRNA-40 and dsRNA-DR.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5047)
  AUTHORS   Shibata,T., Sato,R., Taoka,M., Saitoh,S.I., Komine,M.,
            Yamaguchi,K., Goyama,S., Motoi,Y., Kitaura,J., Izawa,K.,
            Yamauchi,Y., Tsukamoto,Y., Ichinohe,T., Fujita,E., Hiranuma,R.,
            Fukui,R., Furukawa,Y., Kitamura,T., Takai,T., Tojo,A., Ohtsuki,M.,
            Ohto,U., Shimizu,T., Ozawa,M., Yoshida,N., Isobe,T., Latz,E.,
            Mukai,K., Taguchi,T., Hemmi,H., Akira,S. and Miyake,K.
  TITLE     TLR7/8 stress response drives histiocytosis in SLC29A3 disorders
  JOURNAL   J Exp Med 220 (9) (2023)
   PUBMED   37462944
  REMARK    GeneRIF: TLR7/8 stress response drives histiocytosis in SLC29A3
            disorders.
REFERENCE   4  (bases 1 to 5047)
  AUTHORS   Xu,X., Qu,S., Zhang,C., Zhang,M., Qin,W., Ren,G., Bao,H., Li,L.,
            Zen,K. and Liu,Z.
  TITLE     CD8 T Cell-Derived Exosomal miR-186-5p Elicits Renal Inflammation
            via Activating Tubular TLR7/8 Signal Axis
  JOURNAL   Adv Sci (Weinh) 10 (25), e2301492 (2023)
   PUBMED   37395441
  REMARK    GeneRIF: CD8 T Cell-Derived Exosomal miR-186-5p Elicits Renal
            Inflammation via Activating Tubular TLR7/8 Signal Axis.
REFERENCE   5  (bases 1 to 5047)
  AUTHORS   Seizer,L., Rahimi,S., Santos-Sierra,S. and Drexel,M.
  TITLE     Expression of toll like receptor 8 (TLR8) in specific groups of
            mouse hippocampal interneurons
  JOURNAL   PLoS One 17 (5), e0267860 (2022)
   PUBMED   35507634
  REMARK    GeneRIF: Expression of toll like receptor 8 (TLR8) in specific
            groups of mouse hippocampal interneurons.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5047)
  AUTHORS   Qin,J., Yao,J., Cui,G., Xiao,H., Kim,T.W., Fraczek,J., Wightman,P.,
            Sato,S., Akira,S., Puel,A., Casanova,J.L., Su,B. and Li,X.
  TITLE     TLR8-mediated NF-kappaB and JNK activation are TAK1-independent and
            MEKK3-dependent
  JOURNAL   J Biol Chem 281 (30), 21013-21021 (2006)
   PUBMED   16737960
  REMARK    GeneRIF: TLR8-mediated MEKK3-dependent IKKgamma phosphorylation
            might play an important role in the activation of IKK complex,
            leading to IkappaBalpha phosphorylation
REFERENCE   7  (bases 1 to 5047)
  AUTHORS   Cheverud,J.M., Ehrich,T.H., Hrbek,T., Kenney,J.P., Pletscher,L.S.
            and Semenkovich,C.F.
  TITLE     Quantitative trait loci for obesity- and diabetes-related traits
            and their dietary responses to high-fat feeding in LGXSM
            recombinant inbred mouse strains
  JOURNAL   Diabetes 53 (12), 3328-3336 (2004)
   PUBMED   15561968
REFERENCE   8  (bases 1 to 5047)
  AUTHORS   Heil,F., Hemmi,H., Hochrein,H., Ampenberger,F., Kirschning,C.,
            Akira,S., Lipford,G., Wagner,H. and Bauer,S.
  TITLE     Species-specific recognition of single-stranded RNA via toll-like
            receptor 7 and 8
  JOURNAL   Science 303 (5663), 1526-1529 (2004)
   PUBMED   14976262
REFERENCE   9  (bases 1 to 5047)
  AUTHORS   Valenzuela,D.M., Murphy,A.J., Frendewey,D., Gale,N.W.,
            Economides,A.N., Auerbach,W., Poueymirou,W.T., Adams,N.C.,
            Rojas,J., Yasenchak,J., Chernomorsky,R., Boucher,M., Elsasser,A.L.,
            Esau,L., Zheng,J., Griffiths,J.A., Wang,X., Su,H., Xue,Y.,
            Dominguez,M.G., Noguera,I., Torres,R., Macdonald,L.E.,
            Stewart,A.F., DeChiara,T.M. and Yancopoulos,G.D.
  TITLE     High-throughput engineering of the mouse genome coupled with
            high-resolution expression analysis
  JOURNAL   Nat Biotechnol 21 (6), 652-659 (2003)
   PUBMED   12730667
REFERENCE   10 (bases 1 to 5047)
  AUTHORS   Jurk,M., Heil,F., Vollmer,J., Schetter,C., Krieg,A.M., Wagner,H.,
            Lipford,G. and Bauer,S.
  TITLE     Human TLR7 or TLR8 independently confer responsiveness to the
            antiviral compound R-848
  JOURNAL   Nat Immunol 3 (6), 499 (2002)
   PUBMED   12032557
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL731735.14, BY203208.1 and BC132054.1.
            
            On or before Sep 1, 2015 this sequence version replaced
            XM_006528717.2, NM_133212.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BY748160.1, BB619967.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                AL731735.14        84014-84058         c
            46-404              BY203208.1         1-359
            405-3438            BC132054.1         125-3158
            3439-5047           AL731735.14        60852-62460         c
FEATURES             Location/Qualifiers
     source          1..5047
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 78.29 cM"
     gene            1..5047
                     /gene="Tlr8"
                     /note="toll-like receptor 8"
                     /db_xref="GeneID:170744"
                     /db_xref="MGI:MGI:2176887"
     exon            1..178
                     /gene="Tlr8"
                     /inference="alignment:Splign:2.1.0"
     exon            179..320
                     /gene="Tlr8"
                     /inference="alignment:Splign:2.1.0"
     CDS             318..3416
                     /gene="Tlr8"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /codon_start=1
                     /product="toll-like receptor 8 isoform 1 precursor"
                     /protein_id="NP_573475.2"
                     /db_xref="CCDS:CCDS41209.1"
                     /db_xref="GeneID:170744"
                     /db_xref="MGI:MGI:2176887"
                     /translation="MENMPPQSWILTCFCLLSSGTSAIFHKANYSRSYPCDEIRHNSL
                     VIAECNHRQLHEVPQTIGKYVTNIDLSDNAITHITKESFQKLQNLTKIDLNHNAKQQH
                     PNENKNGMNITEGALLSLRNLTVLLLEDNQLYTIPAGLPESLKELSLIQNNIFQVTKN
                     NTFGLRNLERLYLGWNCYFKCNQTFKVEDGAFKNLIHLKVLSLSFNNLFYVPPKLPSS
                     LRKLFLSNAKIMNITQEDFKGLENLTLLDLSGNCPRCYNAPFPCTPCKENSSIHIHPL
                     AFQSLTQLLYLNLSSTSLRTIPSTWFENLSNLKELHLEFNYLVQEIASGAFLTKLPSL
                     QILDLSFNFQYKEYLQFINISSNFSKLRSLKKLHLRGYVFRELKKKHFEHLQSLPNLA
                     TINLGINFIEKIDFKAFQNFSKLDVIYLSGNRIASVLDGTDYSSWRNRLRKPLSTDDD
                     EFDPHVNFYHSTKPLIKPQCTAYGKALDLSLNNIFIIGKSQFEGFQDIACLNLSFNAN
                     TQVFNGTEFSSMPHIKYLDLTNNRLDFDDNNAFSDLHDLEVLDLSHNAHYFSIAGVTH
                     RLGFIQNLINLRVLNLSHNGIYTLTEESELKSISLKELVFSGNRLDRLWNANDGKYWS
                     IFKSLQNLIRLDLSYNNLQQIPNGAFLNLPQSLQELLISGNKLRFFNWTLLQYFPHLH
                     LLDLSRNELYFLPNCLSKFAHSLETLLLSHNHFSHLPSGFLSEARNLVHLDLSFNTIK
                     MINKSSLQTKMKTNLSILELHGNYFDCTCDISDFRSWLDENLNITIPKLVNVICSNPG
                     DQKSKSIMSLDLTTCVSDTTAAVLFFLTFLTTSMVMLAALVHHLFYWDVWFIYHMCSA
                     KLKGYRTSSTSQTFYDAYISYDTKDASVTDWVINELRYHLEESEDKSVLLCLEERDWD
                     PGLPIIDNLMQSINQSKKTIFVLTKKYAKSWNFKTAFYLALQRLMDENMDVIIFILLE
                     PVLQYSQYLRLRQRICKSSILQWPNNPKAENLFWQSLKNVVLTENDSRYDDLYIDSIR
                     QY"
     exon            321..5047
                     /gene="Tlr8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4959..4964
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tlr8"
                     /note="hexamer: ATTAAA"
     polyA_site      4983
                     /gene="Tlr8"
                     /note="major polyA site"
     regulatory      5024..5029
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tlr8"
                     /note="hexamer: TATAAA"
     polyA_site      5047
                     /gene="Tlr8"
ORIGIN      
        1 ctgtcttcca acataaactt ctgcaaatcc attgctagat tttgctgatg ctaaagcgac
       61 cagatttcag aagtttgcca aagtctgctc tctgcacagc tactgtacac agaggaccac
      121 tgcactgcta ctacaagcta ttgaaagaga accttgaagg gatcccagcc agaaagggga
      181 aagcaagagc cttccaagaa agaatttggg ctgttctatt attttctggt ccagctatag
      241 agcacatctt cttccagaaa aacagagttg gatgttaaga gagaaacaaa cgttttacct
      301 tcctttgtct atagaacatg gaaaacatgc cccctcagtc atggattctg acgtgctttt
      361 gtctgctgtc ctctggaacc agtgccatct tccataaagc gaactattcc agaagctatc
      421 cttgtgacga gataaggcac aactcccttg tgattgcaga atgcaaccat cgtcaactgc
      481 atgaagttcc ccaaactata ggcaagtatg tgacaaacat agacttgtca gacaatgcca
      541 ttacacatat aacgaaagag tcctttcaaa agctgcaaaa cctcactaaa atcgatctga
      601 accacaatgc caaacaacag cacccaaatg aaaataaaaa tggtatgaat attacagaag
      661 gggcacttct cagcctaaga aatctaacag ttttactgct ggaagacaac cagttatata
      721 ctatacctgc tgggttgcct gagtctttga aagaacttag cctaattcaa aacaatatat
      781 ttcaggtaac taaaaacaac acttttgggc ttaggaactt ggaaagactc tatttgggct
      841 ggaactgcta ttttaaatgt aatcaaacct ttaaggtaga agatggggca tttaaaaatc
      901 ttatacactt gaaggtactc tcattatctt tcaataacct tttctatgtg ccccccaaac
      961 taccaagttc tctaaggaaa ctttttctga gtaatgccaa aatcatgaac atcactcagg
     1021 aagacttcaa aggactggaa aatttaacat tactagatct gagtggaaac tgtccaaggt
     1081 gttacaatgc tccatttcct tgcacacctt gcaaggaaaa ctcatccatc cacatacatc
     1141 ctctggcttt tcaaagtctc acccaacttc tctatctaaa cctttccagc acttccctca
     1201 ggacgattcc ttctacctgg tttgaaaatc tgtcaaatct gaaggaactc catcttgaat
     1261 tcaactattt agttcaagaa attgcctcgg gggcattttt aacaaaacta cccagtttac
     1321 aaatccttga tttgtccttc aactttcaat ataaggaata tttacaattt attaatattt
     1381 cctcaaattt ctctaagctt cgttctctca agaagttgca cttaagaggc tatgtgttcc
     1441 gagaacttaa aaagaagcat ttcgagcatc tccagagtct tccaaacttg gcaaccatca
     1501 acttgggcat taactttatt gagaaaattg atttcaaagc tttccagaat ttttccaaac
     1561 tcgacgttat ctatttatca ggaaatcgca tagcatctgt attagatggt acagattatt
     1621 cctcttggcg aaatcgtctt cggaaacctc tctcaacaga cgatgatgag tttgatccac
     1681 acgtgaattt ttaccatagc accaaacctt taataaagcc acagtgtact gcttatggca
     1741 aggccttgga tttaagtttg aacaatattt tcattattgg gaaaagccaa tttgaaggtt
     1801 ttcaggatat cgcctgctta aatctgtcct tcaatgccaa tactcaagtg tttaatggca
     1861 cagaattctc ctccatgccc cacattaaat atttggattt aaccaacaac agactagact
     1921 ttgatgataa caatgctttc agtgatcttc acgatctaga agtgctggac ctgagccaca
     1981 atgcacacta tttcagtata gcaggggtaa cgcaccgtct aggatttatc cagaacttaa
     2041 taaacctcag ggtgttaaac ctgagccaca atggcattta caccctcaca gaggaaagtg
     2101 agctgaaaag catctcactg aaagaattgg ttttcagtgg aaatcgtctt gaccgtttgt
     2161 ggaatgcaaa tgatggcaaa tactggtcca tttttaaaag tctccagaat ttgatacgcc
     2221 tggacttatc atacaataac cttcaacaaa tcccaaatgg agcattcctc aatttgcctc
     2281 agagcctcca agagttactt atcagtggta acaaattacg tttctttaat tggacattac
     2341 tccagtattt tcctcacctt cacttgctgg atttatcgag aaatgagctg tattttctac
     2401 ccaattgcct atctaagttt gcacattccc tggagacact gctactgagc cataatcatt
     2461 tctctcacct accctctggc ttcctctccg aagccaggaa tctggtgcac ctggatctaa
     2521 gtttcaacac aataaagatg atcaataaat cctccctgca aaccaagatg aaaacgaact
     2581 tgtctattct ggagctacat gggaactatt ttgactgcac gtgtgacata agtgattttc
     2641 gaagctggct agatgaaaat ctgaatatca caattcctaa attggtaaat gttatatgtt
     2701 ccaatcctgg ggatcaaaaa tcaaagagta tcatgagcct agatctcacg acttgtgtat
     2761 cggataccac tgcagctgtc ctgtttttcc tcacattcct taccacctcc atggttatgt
     2821 tggctgctct ggttcaccac ctgttttact gggatgtttg gtttatctat cacatgtgct
     2881 ctgctaagtt aaaaggctac aggacttcat ccacatccca aactttctat gatgcttata
     2941 tttcttatga caccaaagat gcatctgtta ctgactgggt aatcaatgaa ctgcgctacc
     3001 accttgaaga gagtgaagac aaaagtgtcc tcctttgttt agaggagagg gattgggatc
     3061 caggattacc catcattgat aacctcatgc agagcataaa ccagagcaag aaaacaatct
     3121 ttgttttaac caagaaatat gccaagagct ggaactttaa aacagctttc tacttggcct
     3181 tgcagaggct aatggatgag aacatggatg tgattatttt catcctcctg gaaccagtgt
     3241 tacagtactc acagtacctg aggcttcggc agaggatctg taagagctcc atcctccagt
     3301 ggcccaacaa tcccaaagca gaaaacttgt tttggcaaag tctgaaaaat gtggtcttga
     3361 ctgaaaatga ttcacggtat gacgatttgt acattgattc cattaggcaa tactagtgat
     3421 gggaagtcac gactctgcca tcataaaaac acacagcttc tccttacaat gaactgtggc
     3481 aaatgaaagg gcatgtggct gcttgacgtg ctgagaataa gtgataattg ggtgcacagc
     3541 cctaaacagg acaattatac cagcctctct aaggctaggg taactttgtg caagagggag
     3601 ccagaaaaat gtatgagcta ggaaacagga agaagggctg gaaaatgctg tcttctgggc
     3661 ataacagcca ttgcaactgt aatcacacag cagctacggt tgcctgtcgt gagcctgcac
     3721 aagactgggc ctcttatcag tcaattacag atgggggcag gtgtataaaa ctatacttca
     3781 tctttctagg gggcaggtcc cctgtactcc atccttctgc actatcaact attagtggat
     3841 ccaggaaaga gactatcgtt atctttagct ttgaacccat tgatgagcct agattcaata
     3901 gacggttcaa aactcatggt cacacagaaa gagttggtaa agtcagtggc cagaagacaa
     3961 aacaaaaggg cctgaacatg agaaatggtt ttttaaggcg gtgggtaggt tgtccgcagt
     4021 gagagaggag ataggaaaag gtgggcatga gagtaaccag aatgcatggg tctctctcag
     4081 agatttcact ctgggatcca ctaccaagct cacccccatg cagttgtcct caagattcag
     4141 cttctcttgt gtgttagcca aaatagaaaa gctcatctcc ctgctatgtg aactttcccc
     4201 aaggcagctt gtttcatcaa ggccagcgag aggggacgca gtcagtcttt tggtagtgaa
     4261 tcagaaagtg acagcctacc actgcagttg tattctattt ggtaaaagtc aaccacagat
     4321 cctaccagct ccaggcacca agtatctcag gttcagggaa agctattgaa aaccagggta
     4381 atagatctag gggcctctca gctaagagga aagagttcga gataagtgat ctgatcgtct
     4441 gagttaatcg ttatccattt ctttggactg aaattaagag acggcttgcc atcttggtca
     4501 cagatcatca atactgggaa agtcaaatca catgggcagt cttagcaggc agcttattat
     4561 gcctactttt caatccctaa gaacatttgc cactgtatct aatgatcttg atattaagat
     4621 gctggtgaag ttgatacatc tatgactgtg gggttatatt acattgtgat tgcattaatt
     4681 tttcctttac aatgacattt taaaatctta agttttgaga ctataactac atcattccct
     4741 cttttatcct ctctccaaaa cttctcacat gccccactat gacttttata aatgctgcct
     4801 gcaatatttg ctttttaagc ttttgatgtt gcttaaacac tgaaaaggat atttttaaaa
     4861 agccttttaa tcctaaatca ttttaaaggt attcgtttaa atgaaaagct tttgggggta
     4921 tttgttattt cccattggtg tatattttca aatgaatgat taaaacgtct tcattttaca
     4981 tgacaaatgt gtgataaatc tgtagtagaa aacagaactc tgatataaaa gttgtcattt
     5041 gcactga
//
