LOCUS       NM_133211               3794 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus toll-like receptor 7 (Tlr7), transcript variant 3,
            mRNA.
ACCESSION   NM_133211 XM_913204
VERSION     NM_133211.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3794)
  AUTHORS   Wang,C., Khatun,M.S., Ellsworth,C.R., Chen,Z., Islamuddin,M.,
            Nisperuza Vidal,A.K., Afaque Alam,M., Liu,S., Mccombs,J.E.,
            Maness,N.J., Blair,R.V., Kolls,J.K. and Qin,X.
  TITLE     Deficiency of Tlr7 and Irf7 in mice increases the severity of
            COVID-19 through the reduced interferon production
  JOURNAL   Commun Biol 7 (1), 1162 (2024)
   PUBMED   39289468
  REMARK    GeneRIF: Deficiency of Tlr7 and Irf7 in mice increases the severity
            of COVID-19 through the reduced interferon production.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3794)
  AUTHORS   Padmanaban,V., Keller,I., Seltzer,E.S., Ostendorf,B.N., Kerner,Z.
            and Tavazoie,S.F.
  TITLE     Neuronal substance P drives metastasis through an extracellular
            RNA-TLR7 axis
  JOURNAL   Nature 633 (8028), 207-215 (2024)
   PUBMED   39112700
  REMARK    GeneRIF: Neuronal substance P drives metastasis through an
            extracellular RNA-TLR7 axis.
REFERENCE   3  (bases 1 to 3794)
  AUTHORS   Xie,Y., Chi,Y., Tao,X., Yu,P., Liu,Q., Zhang,M., Yang,N., Liu,S.
            and Zhu,W.
  TITLE     Rabies Virus Regulates Inflammatory Response in BV-2 Cells through
            Activation of Myd88 and NF-kappaB Signaling Pathways via TLR7
  JOURNAL   Int J Mol Sci 25 (17), 9144 (2024)
   PUBMED   39273091
  REMARK    GeneRIF: Rabies Virus Regulates Inflammatory Response in BV-2 Cells
            through Activation of Myd88 and NF-kappaB Signaling Pathways via
            TLR7.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3794)
  AUTHORS   Gordon,R.A., Cosgrove,H.A., Marinov,A., Gingras,S., Tilstra,J.S.,
            Campbell,A.M., Bastacky,S.I., Kashgarian,M., Perl,A.,
            Nickerson,K.M. and Shlomchik,M.J.
  TITLE     NADPH oxidase in B cells and macrophages protects against murine
            lupus by regulation of TLR7
  JOURNAL   JCI Insight 9 (16), e178563 (2024)
   PUBMED   39042716
  REMARK    GeneRIF: NADPH oxidase in B cells and macrophages protects against
            murine lupus by regulation of TLR7.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3794)
  AUTHORS   Suvieri,C., Mondanelli,G., Orabona,C., Pallotta,M.T., Panfili,E.,
            Rossini,S., Volpi,C. and Belladonna,M.L.
  TITLE     Sensing of an HIV-1-Derived Single-Stranded RNA-Oligonucleotide
            Induces Arginase 1-Mediated Tolerance
  JOURNAL   Cells 13 (13), 1088 (2024)
   PUBMED   38994942
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3794)
  AUTHORS   Heil,F., Hemmi,H., Hochrein,H., Ampenberger,F., Kirschning,C.,
            Akira,S., Lipford,G., Wagner,H. and Bauer,S.
  TITLE     Species-specific recognition of single-stranded RNA via toll-like
            receptor 7 and 8
  JOURNAL   Science 303 (5663), 1526-1529 (2004)
   PUBMED   14976262
  REMARK    GeneRIF: mediates species-specific recognition of GU-rich
            single-stranded RNA (ssRNA); data suggest that ssRNA represents a
            physiological ligand for TLR7
REFERENCE   7  (bases 1 to 3794)
  AUTHORS   Diebold,S.S., Kaisho,T., Hemmi,H., Akira,S. and Reis e Sousa,C.
  TITLE     Innate antiviral responses by means of TLR7-mediated recognition of
            single-stranded RNA
  JOURNAL   Science 303 (5663), 1529-1531 (2004)
   PUBMED   14976261
  REMARK    GeneRIF: results identify ssRNA as a ligand for TLR7 and suggest
            that cells of the innate immune system sense endosomal ssRNA to
            detect infection by RNA viruses
REFERENCE   8  (bases 1 to 3794)
  AUTHORS   Pinhal-Enfield,G., Ramanathan,M., Hasko,G., Vogel,S.N.,
            Salzman,A.L., Boons,G.J. and Leibovich,S.J.
  TITLE     An angiogenic switch in macrophages involving synergy between
            Toll-like receptors 2, 4, 7, and 9 and adenosine A(2A) receptors
  JOURNAL   Am J Pathol 163 (2), 711-721 (2003)
   PUBMED   12875990
  REMARK    GeneRIF: Results suggest novel signaling pathway in murine
            macrophages involving synergy between toll-like receptors 2, 4, 7,
            and 9 and adenosine A(2A)receptors, that up-regulates VEGF and
            down-regulates TNFalpha expression, thus acting as an angiogenic
            switch.
REFERENCE   9  (bases 1 to 3794)
  AUTHORS   Jurk,M., Heil,F., Vollmer,J., Schetter,C., Krieg,A.M., Wagner,H.,
            Lipford,G. and Bauer,S.
  TITLE     Human TLR7 or TLR8 independently confer responsiveness to the
            antiviral compound R-848
  JOURNAL   Nat Immunol 3 (6), 499 (2002)
   PUBMED   12032557
REFERENCE   10 (bases 1 to 3794)
  AUTHORS   Hemmi,H., Kaisho,T., Takeuchi,O., Sato,S., Sanjo,H., Hoshino,K.,
            Horiuchi,T., Tomizawa,H., Takeda,K. and Akira,S.
  TITLE     Small anti-viral compounds activate immune cells via the TLR7
            MyD88-dependent signaling pathway
  JOURNAL   Nat Immunol 3 (2), 196-200 (2002)
   PUBMED   11812998
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL731735.14, AK036549.1 and BY543663.1.
            
            On Mar 19, 2014 this sequence version replaced NM_133211.3.
            
            Transcript Variant: This variant (3) lacks two alternate exons in
            the 5' region and initiates translation from an alternate upstream
            start codon, compared to variant 1. Variants 1, 2, 3, and 4 encode
            the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK036549.1, AF334942.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                AL731735.14        150258-150300       c
            44-3789             AK036549.1         2-3747
            3790-3794           BY543663.1         446-450
FEATURES             Location/Qualifiers
     source          1..3794
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 78.31 cM"
     gene            1..3794
                     /gene="Tlr7"
                     /note="toll-like receptor 7"
                     /db_xref="GeneID:170743"
                     /db_xref="MGI:MGI:2176882"
     exon            1..135
                     /gene="Tlr7"
                     /inference="alignment:Splign:2.1.0"
     exon            136..234
                     /gene="Tlr7"
                     /inference="alignment:Splign:2.1.0"
     CDS             232..3384
                     /gene="Tlr7"
                     /note="isoform a precursor is encoded by transcript
                     variant 3; Toll like receptor 7"
                     /codon_start=1
                     /product="toll-like receptor 7 isoform a precursor"
                     /protein_id="NP_573474.1"
                     /db_xref="CCDS:CCDS30531.1"
                     /db_xref="GeneID:170743"
                     /db_xref="MGI:MGI:2176882"
                     /translation="MVFSMWTRKRQILIFLNMLLVSRVFGFRWFPKTLPCEVKVNIPE
                     AHVIVDCTDKHLTEIPEGIPTNTTNLTLTINHIPSISPDSFRRLNHLEEIDLRCNCVP
                     VLLGSKANVCTKRLQIRPGSFSGLSDLKALYLDGNQLLEIPQDLPSSLHLLSLEANNI
                     FSITKENLTELVNIETLYLGQNCYYRNPCNVSYSIEKDAFLVMRNLKVLSLKDNNVTA
                     VPTTLPPNLLELYLYNNIIKKIQENDFNNLNELQVLDLSGNCPRCYNVPYPCTPCENN
                     SPLQIHDNAFNSLTELKVLRLHSNSLQHVPPTWFKNMRNLQELDLSQNYLAREIEEAK
                     FLHFLPNLVELDFSFNYELQVYHASITLPHSLSSLENLKILRVKGYVFKELKNSSLSV
                     LHKLPRLEVLDLGTNFIKIADLNIFKHFENLKLIDLSVNKISPSEESREVGFCPNAQT
                     SVDRHGPQVLEALHYFRYDEYARSCRFKNKEPPSFLPLNADCHIYGQTLDLSRNNIFF
                     IKPSDFQHLSFLKCLNLSGNTIGQTLNGSELWPLRELRYLDFSNNRLDLLYSTAFEEL
                     QSLEVLDLSSNSHYFQAEGITHMLNFTKKLRLLDKLMMNDNDISTSASRTMESDSLRI
                     LEFRGNHLDVLWRAGDNRYLDFFKNLFNLEVLDISRNSLNSLPPEVFEGMPPNLKNLS
                     LAKNGLKSFFWDRLQLLKHLEILDLSHNQLTKVPERLANCSKSLTTLILKHNQIRQLT
                     KYFLEDALQLRYLDISSNKIQVIQKTSFPENVLNNLEMLVLHHNRFLCNCDAVWFVWW
                     VNHTDVTIPYLATDVTCVGPGAHKGQSVISLDLYTCELDLTNLILFSVSISSVLFLMV
                     VMTTSHLFFWDMWYIYYFWKAKIKGYQHLQSMESCYDAFIVYDTKNSAVTEWVLQELV
                     AKLEDPREKHFNLCLEERDWLPGQPVLENLSQSIQLSKKTVFVMTQKYAKTESFKMAF
                     YLSHQRLLDEKVDVIILIFLEKPLQKSKFLQLRKRLCRSSVLEWPANPQAHPYFWQCL
                     KNALTTDNHVAYSQMFKETV"
     exon            235..3794
                     /gene="Tlr7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3769..3774
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tlr7"
                     /note="hexamer: AATAAA"
     polyA_site      3792
                     /gene="Tlr7"
                     /note="major polyA site"
ORIGIN      
        1 actacccagc ctcaattttg tatttggaaa gcccaaagca cgcagctcaa aggctctgcg
       61 agtctcggtt ttctgttgcc ttctctctgt ctcagaggac tccatctata gaaccactct
      121 atgccttcaa gaaagatgtc cttggctccc ttctcaggat gatcctggcc tatctctgac
      181 tctcttctcc tccaccagac ctcttgattc cattttgaaa gaaaactgaa aatggtgttt
      241 tcgatgtgga cacggaagag acaaattttg atctttttaa atatgctctt agtttctaga
      301 gtctttgggt ttcgatggtt tcctaaaact ctaccttgtg aagttaaagt aaatatccca
      361 gaggcccatg tgatcgtgga ctgcacagac aagcatttga cagaaatccc tgagggcatt
      421 cccactaaca ccaccaatct tacccttacc atcaaccaca taccaagcat ctctccagat
      481 tccttccgta ggctgaacca tctggaagaa atcgatttaa gatgcaattg tgtacctgtt
      541 ctactggggt ccaaagccaa tgtgtgtacc aagaggctgc agattagacc tggaagcttt
      601 agtggactct ctgacttaaa agccctttac ctggatggaa accaacttct ggagatacca
      661 caggatctgc catccagctt acatcttctg agccttgagg ctaacaacat cttctccatc
      721 acgaaggaga atctaacaga actggtcaac attgaaacac tctacctggg tcaaaactgt
      781 tattatcgaa atccttgcaa tgtttcctat tctattgaaa aagatgcttt cctagttatg
      841 agaaatttga aggttctctc actaaaagat aacaatgtca cagctgtccc caccactttg
      901 ccacctaatt tactagagct ctatctttat aacaatatca ttaagaaaat ccaagaaaat
      961 gattttaata acctcaatga gttgcaagtt cttgacctaa gtggaaattg ccctcgatgt
     1021 tataatgtcc catatccgtg tacaccgtgt gaaaataatt cccccttaca gatccatgac
     1081 aatgctttca attcattgac agaattaaaa gttttacgtt tacacagtaa ttctcttcag
     1141 catgtgcccc caacatggtt taaaaacatg agaaacctcc aggaactaga cctctcccaa
     1201 aactacttgg ccagagaaat tgaggaggcc aaatttttgc attttcttcc caaccttgtt
     1261 gagttggatt tttctttcaa ttatgagctg caggtctacc atgcatctat aactttacca
     1321 cattcactct cttcattgga aaacttgaaa attctgcgtg tcaaggggta tgtctttaaa
     1381 gagctgaaaa actccagtct ttctgtattg cacaagcttc ccaggctgga agttcttgac
     1441 cttggcacta acttcataaa aattgctgac ctcaacatat tcaaacattt tgaaaacctc
     1501 aaactcatag acctttcagt gaataagata tctccttcag aagagtcaag agaagttggc
     1561 ttttgtccta atgctcaaac ttctgtagac cgtcatgggc cccaggtcct tgaggcctta
     1621 cactatttcc gatacgatga atatgcacgg agctgcaggt tcaaaaacaa agagccacct
     1681 tctttcttgc ctttgaatgc agactgccac atatatgggc agaccttaga cttaagtaga
     1741 aataacatat tttttattaa accttctgat tttcagcatc tttcattcct caaatgcctc
     1801 aacttatcag gaaacaccat tggccaaact cttaatggca gtgaactctg gccgttgaga
     1861 gagttgcggt acttagactt ctccaacaac cggcttgatt tactctactc aacagccttt
     1921 gaagagctcc agagtcttga agttctggat ctaagtagta acagccacta ttttcaagca
     1981 gaaggaatta ctcacatgct aaactttacc aagaaattac ggcttctgga caaactcatg
     2041 atgaatgata atgacatctc tacttcggcc agcaggacca tggaaagtga ctctcttcga
     2101 attctggagt tcagaggcaa ccatttagat gttctatgga gagccggtga taacagatac
     2161 ttggacttct tcaagaattt gttcaattta gaggtattag atatctccag aaattccctg
     2221 aattccttgc ctcctgaggt ttttgagggt atgccgccaa atctaaagaa tctctccttg
     2281 gccaaaaatg ggctcaaatc tttcttttgg gacagactcc agttactgaa gcatttggaa
     2341 attttggacc tcagccataa ccagctgaca aaagtacctg agagattggc caactgttcc
     2401 aaaagtctca caacactgat tcttaagcat aatcaaatca ggcaattgac aaaatatttt
     2461 ctagaagatg ctttgcaatt gcgctatcta gacatcagtt caaataaaat ccaggtcatt
     2521 cagaagacta gcttcccaga aaatgtcctc aacaatctgg agatgttggt tttacatcac
     2581 aatcgctttc tttgcaactg tgatgctgtg tggtttgtct ggtgggttaa ccatacagat
     2641 gttactattc catacctggc cactgatgtg acttgtgtag gtccaggagc acacaaaggt
     2701 caaagtgtca tatcccttga tctgtatacg tgtgagttag atctcacaaa cctgattctg
     2761 ttctcagttt ccatatcatc agtcctcttt cttatggtag ttatgacaac aagtcacctc
     2821 tttttctggg atatgtggta catttattat ttttggaaag caaagataaa ggggtatcag
     2881 catctgcaat ccatggagtc ttgttatgat gcttttattg tgtatgacac taaaaactca
     2941 gctgtgacag aatgggtttt gcaggagctg gtggcaaaat tggaagatcc aagagaaaaa
     3001 cacttcaatt tgtgtctaga agaaagagac tggctaccag gacagccagt tctagaaaac
     3061 ctttcccaga gcatacagct cagcaaaaag acagtgtttg tgatgacaca gaaatatgct
     3121 aagactgaga gttttaagat ggcattttat ttgtctcatc agaggctcct ggatgaaaaa
     3181 gtggatgtga ttatcttgat attcttggaa aagcctcttc agaagtctaa gtttcttcag
     3241 ctcaggaaga gactctgcag gagctctgtc cttgagtggc ctgcaaatcc acaggctcac
     3301 ccatacttct ggcagtgcct gaaaaatgcc ctgaccacag acaatcatgt ggcttatagt
     3361 caaatgttca aggaaacagt ctagctctct gaagaatgtc accacctagg acatgccttg
     3421 gtacctgaag ttttcataaa ggtttccata aatgaaggtc tgaatttttc ctaacagttg
     3481 tcatggctca gattggtggg aaatcatcaa tatatggcta agaaattaag aaggggagac
     3541 tgatagaaga taatttcttt cttcatgtgc catgctcagt taaatatttc ccctagctca
     3601 aatctgaaaa actgtgccta ggagacaaca caaggctttg atttatctgc atacaattga
     3661 taagagccac acatctgccc tgaagaagta ctagtagttt tagtagtagg gtaaaaatta
     3721 cacaagcttt ctctctctct gatactgaac tgtaccagag ttcaatgaaa taaaagccca
     3781 gagaacttct cagt
//
