LOCUS       NM_001384171            2632 bp    mRNA    linear   ROD 29-DEC-2022
DEFINITION  Mus musculus toll-like receptor 6 (Tlr6), transcript variant 3,
            mRNA.
ACCESSION   NM_001384171 XM_006503859
VERSION     NM_001384171.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2632)
  AUTHORS   Simpson M, Frisbee A, Kumar P, Schwan C, Aktories K and Petri WA.
  TITLE     Clostridioides difficile Binary Toxin Is Recognized by the
            Toll-Like Receptor 2/6 Heterodimer to Induce a Nuclear
            Factor-kappaB Response
  JOURNAL   J Infect Dis 225 (7), 1296-1300 (2022)
   PUBMED   33011801
  REMARK    GeneRIF: Clostridioides difficile Binary Toxin Is Recognized by the
            Toll-Like Receptor 2/6 Heterodimer to Induce a Nuclear
            Factor-kappaB Response.
REFERENCE   2  (bases 1 to 2632)
  AUTHORS   Yiu JHC, Cheung SWM, Cai J, Chan KS, Chen J, Cheong LY, Chau HT, Xu
            A, Li RHW and Woo CW.
  TITLE     TLR5 Supports Development of Placental Labyrinthine Zone in Mice
  JOURNAL   Front Cell Dev Biol 9, 711253 (2021)
   PUBMED   34395439
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2632)
  AUTHORS   Gao Y, Sun Y, Ercan-Sencicek AG, King JS, Akerberg BN, Ma Q,
            Kontaridis MI, Pu WT and Lin Z.
  TITLE     YAP/TEAD1 Complex Is a Default Repressor of Cardiac Toll-Like
            Receptor Genes
  JOURNAL   Int J Mol Sci 22 (13), 6649 (2021)
   PUBMED   34206257
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2632)
  AUTHORS   Monlish DA, Greenberg ZJ, Bhatt ST, Leonard KM, Romine MP, Dong Q,
            Bendesky L, Duncavage EJ, Magee JA and Schuettpelz LG.
  TITLE     TLR2/6 signaling promotes the expansion of premalignant
            hematopoietic stem and progenitor cells in the NUP98-HOXD13 mouse
            model of MDS
  JOURNAL   Exp Hematol 88, 42-55 (2020)
   PUBMED   32652111
  REMARK    GeneRIF: TLR2/6 signaling promotes the expansion of premalignant
            hematopoietic stem and progenitor cells in the NUP98-HOXD13 mouse
            model of MDS.
REFERENCE   5  (bases 1 to 2632)
  AUTHORS   Kim JH, Kordahi MC, Chac D and DePaolo RW.
  TITLE     Toll-like Receptor-6 Signaling Prevents Inflammation and Impacts
            Composition of the Microbiota During Inflammation-Induced
            Colorectal Cancer
  JOURNAL   Cancer Prev Res (Phila) 13 (1), 25-40 (2020)
   PUBMED   31771941
  REMARK    GeneRIF: Toll-like Receptor-6 Signaling Prevents Inflammation and
            Impacts Composition of the Microbiota During Inflammation-Induced
            Colorectal Cancer.
REFERENCE   6  (bases 1 to 2632)
  AUTHORS   Takeuchi O, Kawai T, Muhlradt PF, Morr M, Radolf JD, Zychlinsky A,
            Takeda K and Akira S.
  TITLE     Discrimination of bacterial lipoproteins by Toll-like receptor 6
  JOURNAL   Int Immunol 13 (7), 933-940 (2001)
   PUBMED   11431423
REFERENCE   7  (bases 1 to 2632)
  AUTHORS   Hume DA, Underhill DM, Sweet MJ, Ozinsky AO, Liew FY and Aderem A.
  TITLE     Macrophages exposed continuously to lipopolysaccharide and other
            agonists that act via toll-like receptors exhibit a sustained and
            additive activation state
  JOURNAL   BMC Immunol 2, 11 (2001)
   PUBMED   11686851
REFERENCE   8  (bases 1 to 2632)
  AUTHORS   Ozinsky A, Underhill DM, Fontenot JD, Hajjar AM, Smith KD, Wilson
            CB, Schroeder L and Aderem A.
  TITLE     The repertoire for pattern recognition of pathogens by the innate
            immune system is defined by cooperation between toll-like receptors
  JOURNAL   Proc Natl Acad Sci U S A 97 (25), 13766-13771 (2000)
   PUBMED   11095740
REFERENCE   9  (bases 1 to 2632)
  AUTHORS   Takeuchi O, Kawai T, Sanjo H, Copeland NG, Gilbert DJ, Jenkins NA,
            Takeda K and Akira S.
  TITLE     TLR6: A novel member of an expanding toll-like receptor family
  JOURNAL   Gene 231 (1-2), 59-65 (1999)
   PUBMED   10231569
REFERENCE   10 (bases 1 to 2632)
  AUTHORS   Deckwerth TL, Easton RM, Knudson CM, Korsmeyer SJ and Johnson EM
            Jr.
  TITLE     Placement of the BCL2 family member BAX in the death pathway of
            sympathetic neurons activated by trophic factor deprivation
  JOURNAL   Exp Neurol 152 (1), 150-162 (1998)
   PUBMED   9682022
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC161757.5.
            
            [WARNING] On Sep 28, 2023 this sequence was replaced by
            NM_001384171.2.
            
            On Jun 2, 2020 this sequence version replaced XM_006503859.4.
            
            Transcript Variant: This variant (3) represents the longest
            transcript. Variants 1-3 all encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11927933.2309752.1,
                                           SRR13422601.454493.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164132, SAMN01164133
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-133               AC161757.5         52496-52628
            134-2632            AC161757.5         56069-58567
FEATURES             Location/Qualifiers
     source          1..2632
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 33.54 cM"
     gene            1..2632
                     /gene="Tlr6"
                     /note="toll-like receptor 6"
                     /db_xref="GeneID:21899"
                     /db_xref="MGI:MGI:1341296"
     exon            1..133
                     /gene="Tlr6"
                     /inference="alignment:Splign:2.1.0"
     exon            134..2632
                     /gene="Tlr6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attaaagtct ggggctgttt gccagaatgt gcaccctagg aacatctcga ggttctgagc
       61 atcttccagg acgcgcatat ccatgtgggg gacatggcag ctgaatgaat gacagtccct
      121 tgaacataga cacagcttgg atccaagtaa aaatgctgtg aagaatggta aagtccctct
      181 gggatagcct ctgcaacatg agccaagaca gaaaacccat cgtggggagt ttccactttg
      241 tttgcgccct ggccttaata gtcggaagca tgaccccgtt ctctaatgaa cttgagtcta
      301 tggtagacta ttcaaacagg aaccttactc atgtccccaa agacctgcca ccaagaacaa
      361 aagccctgag tctgtctcaa aactctatat ctgagcttcg gatgcctgat atcagctttc
      421 tgtcagagct gagagttctg agactctccc acaacaggat acggagcctt gatttccatg
      481 tattcttgtt caatcaggac ttagaatacc tggatgtctc acacaatcgg ttgcaaaaca
      541 tctcttgctg ccctatggcg agcctgaggc atctagacct ctcattcaat gactttgatg
      601 tactgcctgt gtgtaaggaa tttggcaacc tgacgaagct gactttcctg ggattaagtg
      661 ctgcaaagtt ccgacaactg gatctgctcc cagttgctca cttgcatcta agctgcattc
      721 ttctggactt agtgagttat catataaaag gcggggaaac agaaagtctt cagattccca
      781 ataccaccgt tctccatttg gtctttcatc caaatagctt gttctctgtt caagtgaaca
      841 tgtctgtaaa cgctttagga catttacaac tgagtaatat taaattgaat gatgaaaact
      901 gtcaaaggtt aatgacattt ttatcagaac tcaccagagg tccaacctta ttgaatgtga
      961 ccctccagca catagaaaca acctggaagt gctcggttaa acttttccaa ttcttttggc
     1021 cccgaccggt ggagtacctc aatatttaca acttaacgat aactgagaga atcgacaggg
     1081 aagaatttac ttactcggag acagcactga agtcactgat gatagagcac gtcaaaaacc
     1141 aagtgttcct cttttcaaag gaggcgctat actcggtgtt tgctgagatg aacatcaaga
     1201 tgctctctat ctcagacacc cctttcatcc acatggtgtg cccgccatcc ccaagctcat
     1261 ttacatttct gaactttacc cagaatgttt ttactgacag tgtttttcaa ggctgttcca
     1321 ccttaaagag attgcagaca cttatcttac aaaggaatgg tttgaagaac ttttttaaag
     1381 tagctctcat gactaagaat atgtcctctc tggaaacttt ggatgttagt ttgaattctt
     1441 tgaactctca tgcatatgac aggacatgcg cctgggctga gagcatattg gtgttgaatt
     1501 tgtcttcgaa tatgcttaca ggctctgtct tcagatgctt acctcccaag gtcaaggtcc
     1561 ttgaccttca caacaacagg ataatgagca tccctaaaga tgtcacccac ctgcaggctt
     1621 tgcaggaact caatgtagca tccaactcct taactgacct tcctgggtgt ggggccttca
     1681 gcagcctttc tgtgctggtc atcgaccata actcagtttc ccatccctct gaggatttct
     1741 tccagagctg tcagaatatt agatccctaa cagcgggaaa caacccattc caatgcacat
     1801 gtgagctgag ggactttgtc aagaacatag gctgggtagc aagagaagtg gtggagggct
     1861 ggcctgactc ttacaggtgt gactacccag aaagctctaa gggaactgca ctgagggact
     1921 tccacatgtc tccactgtcc tgtgatactg ttctgctgac tgtcaccatc ggggccacta
     1981 tgctggtgct ggctgtcact ggggctttcc tctgtctcta ctttgacctg ccctggtatg
     2041 tgaggatgct gtgtcagtgg acacagacca ggcacagggc caggcacatc cccttagagg
     2101 aactccagag aaacctccag ttccatgctt ttgtctcata cagtgagcat gattctgcct
     2161 gggtgaagaa cgaattacta cccaacctag agaaagatga catccgggtt tgcctccatg
     2221 agaggaactt tgtccctggc aagagcattg tggagaacat catcaatttc attgagaaga
     2281 gttacaaggc catctttgtg ctgtctcccc acttcatcca gagtgagtgg tgccattatg
     2341 aactctattt tgcccatcat aatctcttcc atgaaggctc tgataactta atcctcatct
     2401 tgctggaacc cattctacag aacaacattc ccagtagata ccacaagctg cgggctctca
     2461 tggcacagcg gacttacttg gaatggccta ctgagaaggg caaacgtggg ctgttttggg
     2521 ccaaccttag agcttcattt attatgaagt tagccttagt caatgaggat gatgtgaaaa
     2581 cttgaaactt gggtttctaa cttaataaac tgtcaacctg ggctctcatg aa
//
