LOCUS       NM_016928               3592 bp    mRNA    linear   ROD 31-DEC-2024
DEFINITION  Mus musculus toll-like receptor 5 (Tlr5), mRNA.
ACCESSION   NM_016928 XM_916118 XM_924115 XM_977935
VERSION     NM_016928.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3592)
  AUTHORS   Kim,T.S., Ikeuchi,T., Theofilou,V.I., Williams,D.W.,
            Greenwell-Wild,T., June,A., Adade,E.E., Li,L., Abusleme,L.,
            Dutzan,N., Yuan,Y., Brenchley,L., Bouladoux,N., Sakamachi,Y.,
            Palmer,R.J. Jr., Iglesias-Bartolome,R., Trinchieri,G.,
            Garantziotis,S., Belkaid,Y., Valm,A.M., Diaz,P.I., Holland,S.M. and
            Moutsopoulos,N.M.
  CONSRTM   NIDCD/NIDCR Genomics and Computational Biology Core
  TITLE     Epithelial-derived interleukin-23 promotes oral mucosal
            immunopathology
  JOURNAL   Immunity 57 (4), 859-875 (2024)
   PUBMED   38513665
REFERENCE   2  (bases 1 to 3592)
  AUTHORS   Pearson,J.A., Hu,Y., Peng,J., Wong,F.S. and Wen,L.
  TITLE     TLR5-deficiency controls dendritic cell subset development in an
            autoimmune diabetes-susceptible model
  JOURNAL   Front Immunol 15, 1333967 (2024)
   PUBMED   38482010
  REMARK    GeneRIF: TLR5-deficiency controls dendritic cell subset development
            in an autoimmune diabetes-susceptible model.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3592)
  AUTHORS   Lim,J.S., Jeon,E.J., Go,H.S., Kim,H.J., Kim,K.Y., Nguyen,T.Q.T.,
            Lee,D.Y., Kim,K.S., Pietrocola,F., Hong,S.H., Lee,S.E., Kim,K.S.,
            Park,T.S., Choi,D.H., Jeong,Y.J., Park,J.H., Kim,H.S., Min,J.J.,
            Kim,Y.S., Park,J.T., Cho,J.H., Lee,G.W., Lee,J.H., Choy,H.E.,
            Park,S.C., Lee,C.H., Rhee,J.H., Serrano,M. and Cho,K.A.
  TITLE     Mucosal TLR5 activation controls healthspan and longevity
  JOURNAL   Nat Commun 15 (1), 46 (2024)
   PUBMED   38167804
  REMARK    GeneRIF: Mucosal TLR5 activation controls healthspan and longevity.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3592)
  AUTHORS   Kemter,A.M., Patry,R.T., Arnold,J., Hesser,L.A., Campbell,E.,
            Ionescu,E., Mimee,M., Wang,S. and Nagler,C.R.
  TITLE     Commensal bacteria signal through TLR5 and AhR to improve barrier
            integrity and prevent allergic responses to food
  JOURNAL   Cell Rep 42 (10), 113153 (2023)
   PUBMED   37742185
  REMARK    GeneRIF: Commensal bacteria signal through TLR5 and AhR to improve
            barrier integrity and prevent allergic responses to food.
REFERENCE   5  (bases 1 to 3592)
  AUTHORS   Kamada,H., Emura,K., Yamamoto,R., Kawahara,K., Uto,S., Minami,T.,
            Ito,S., Matsumoto,K.I. and Okuda-Ashitaka,E.
  TITLE     Hypersensitivity of myelinated A-fibers via toll-like receptor 5
            promotes mechanical allodynia in tenascin-X-deficient mice
            associated with Ehlers-Danlos syndrome
  JOURNAL   Sci Rep 13 (1), 18490 (2023)
   PUBMED   37898719
  REMARK    GeneRIF: Hypersensitivity of myelinated A-fibers via toll-like
            receptor 5 promotes mechanical allodynia in tenascin-X-deficient
            mice associated with Ehlers-Danlos syndrome.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3592)
  AUTHORS   Rutitzky,L.I., Hernandez,H.J., Yim,Y.S., Ricklan,D.E., Finger,E.,
            Mohan,C., Peter,I., Wakeland,E.K. and Stadecker,M.J.
  TITLE     Enhanced egg-induced immunopathology correlates with high IFN-gamma
            in murine schistosomiasis: identification of two epistatic genetic
            intervals
  JOURNAL   J Immunol 174 (1), 435-440 (2005)
   PUBMED   15611268
REFERENCE   7  (bases 1 to 3592)
  AUTHORS   Bambou,J.C., Giraud,A., Menard,S., Begue,B., Rakotobe,S.,
            Heyman,M., Taddei,F., Cerf-Bensussan,N. and Gaboriau-Routhiau,V.
  TITLE     In vitro and ex vivo activation of the TLR5 signaling pathway in
            intestinal epithelial cells by a commensal Escherichia coli strain
  JOURNAL   J Biol Chem 279 (41), 42984-42992 (2004)
   PUBMED   15302888
  REMARK    GeneRIF: TLR5 is activated in intestinal epithelial cells by a
            commensal Escherichia coli strain
REFERENCE   8  (bases 1 to 3592)
  AUTHORS   Mizel,S.B., Honko,A.N., Moors,M.A., Smith,P.S. and West,A.P.
  TITLE     Induction of macrophage nitric oxide production by Gram-negative
            flagellin involves signaling via heteromeric Toll-like receptor
            5/Toll-like receptor 4 complexes
  JOURNAL   J Immunol 170 (12), 6217-6223 (2003)
   PUBMED   12794153
  REMARK    GeneRIF: Gram-negative flagellin stimulates nitric oxide production
            in macrophages via a pathway that requires TLR5 in complex with
            TLR4.
REFERENCE   9  (bases 1 to 3592)
  AUTHORS   Rantanen,A., Gaspari,M., Falkenberg,M., Gustafsson,C.M. and
            Larsson,N.G.
  TITLE     Characterization of the mouse genes for mitochondrial transcription
            factors B1 and B2
  JOURNAL   Mamm Genome 14 (1), 1-6 (2003)
   PUBMED   12532263
REFERENCE   10 (bases 1 to 3592)
  AUTHORS   Sebastiani,G., Leveque,G., Lariviere,L., Laroche,L., Skamene,E.,
            Gros,P. and Malo,D.
  TITLE     Cloning and characterization of the murine toll-like receptor 5
            (Tlr5) gene: sequence and mRNA expression studies in
            Salmonella-susceptible MOLF/Ei mice
  JOURNAL   Genomics 64 (3), 230-240 (2000)
   PUBMED   10756091
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC170917.2 and FO082331.3.
            
            On Jul 30, 2020 this sequence version replaced NM_016928.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK036842.1, BB629857.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-87                AC170917.2         18808-18894         c
            88-215              AC170917.2         4549-4676           c
            216-317             AC170917.2         1218-1319           c
            318-836             AC170917.2         1-519               c
            837-3592            FO082331.3         26182-28937
FEATURES             Location/Qualifiers
     source          1..3592
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 86.12 cM"
     gene            1..3592
                     /gene="Tlr5"
                     /note="toll-like receptor 5"
                     /db_xref="GeneID:53791"
                     /db_xref="MGI:MGI:1858171"
     exon            1..87
                     /gene="Tlr5"
                     /inference="alignment:Splign:2.1.0"
     exon            88..215
                     /gene="Tlr5"
                     /inference="alignment:Splign:2.1.0"
     exon            216..317
                     /gene="Tlr5"
                     /inference="alignment:Splign:2.1.0"
     exon            318..3592
                     /gene="Tlr5"
                     /inference="alignment:Splign:2.1.0"
     CDS             322..2901
                     /gene="Tlr5"
                     /codon_start=1
                     /product="toll-like receptor 5 precursor"
                     /protein_id="NP_058624.3"
                     /db_xref="CCDS:CCDS35815.1"
                     /db_xref="GeneID:53791"
                     /db_xref="MGI:MGI:1858171"
                     /translation="MACQLDLLIGVIFMASPVLVISPCSSDGRIAFFRGCNLTQIPWI
                     LNTTTERLLLSFNYISMVVATSFPLLERLQLLELGTQYANLTIGPGAFRNLPNLRILD
                     LGQSQIEVLNRDAFQGLPHLLELRLFSCGLSSAVLSDGYFRNLYSLARLDLSGNQIHS
                     LRLHSSFRELNSLSDVNFAFNQIFTICEDELEPLQGKTLSFFGLKLTKLFSRVSVGWE
                     TCRNPFRGVRLETLDLSENGWTVDITRNFSNIIQGSQISSLILKHHIMGPGFGFQNIR
                     DPDQSTFASLARSSVLQLDLSHGFIFSLNPRLFGTLKDLKMLNLAFNKINKIGENAFY
                     GLDSLQVLNLSYNLLGELYNSNFYGLPRVAYVDLQRNHIGIIQDQTFRLLKTLQTLDL
                     RDNALKAIGFIPSIQMVLLGGNKLVHLPHIHFTANFLELSENRLENLSDLYFLLRVPQ
                     LQFLILNQNRLSSCKAAHTPSENPSLEQLFLTENMLQLAWETGLCWDVFQGLSRLQIL
                     YLSNNYLNFLPPGIFNDLVALRMLSLSANKLTVLSPGSLPANLEILDISRNQLFSPDP
                     ALFSSLRVLDITHNEFVCNCELSTFISWLNQTNVTLFGSPADVYCMYPNSLLGGSLYN
                     ISTEDCDEEEAMRSLKFSLFILCTVTLTLFLVITLVVIKFRGICFLCYKTIQKLVFKD
                     KVWSLEPGAYRYDAYFCFSSKDFEWAQNALLKHLDAHYSSRNRLRLCFEERDFIPGEN
                     HISNIQAAVWGSRKTVCLVSRHFLKDGWCLEAFRYAQSRSLSDLKSILIVVVVGSLSQ
                     YQLMRHETIRGFLQKQQYLRWPEDLQDVGWFLDKLSGCILKEEKGKKRSSSIQLRTIA
                     TIS"
     polyA_site      3592
                     /gene="Tlr5"
                     /note="major polyA site"
ORIGIN      
        1 gctttcccga gcccagcggc agctttggtg cctggagccg agtgaggtca gtcctggagc
       61 ctgtgttgtg ggaatcccgc ttgggagaac aatgcttgcc gggtcccctc ccacaccctt
      121 agcatgagcc tctccagacg cctcatctca ctgcatacct ggttcccctg ctcgccggtc
      181 ccgccagcca tttcaaccag agatctgcct cagagcacct acgcttggaa catatgccag
      241 acacatctgt gagacacccc ttgccgctgc agctcatgga tggatgctga gttcccccac
      301 gcaccacact tcagcaggat catggcatgt caacttgact tgctcatagg tgtgatcttc
      361 atggccagcc ccgtgttggt aatatctccc tgttcttcag acggcaggat agcctttttc
      421 cgaggctgta acctcaccca gattccctgg atcctcaata ctaccactga gaggctcctg
      481 ctcagcttca actatatcag tatggtggtt gccacatcat ttccactcct ggagcggctc
      541 cagttgctgg agctggggac ccagtatgct aacttgacca ttggtccagg ggctttcaga
      601 aacctgccca atcttaggat cttggacttg ggccaaagcc agatcgaagt cttgaatcga
      661 gatgcctttc aaggtctgcc ccatctcttg gaacttcggc tgttttcctg tggactctcc
      721 agtgctgtgt taagtgacgg ttacttcaga aatctatatt cattagctcg cttagaccta
      781 tctggcaacc agattcacag cctccgcctc cattcttcat tccgggaact gaattcctta
      841 agcgacgtaa attttgcttt caaccaaata ttcactatat gtgaagatga actcgagcct
      901 ctgcagggca aaacactgtc tttctttggc ctcaaattaa ctaagctgtt cagcagagtc
      961 tctgtgggct gggagacatg caggaacccc ttcagaggcg tgaggctaga aactctagat
     1021 ctttctgaaa atggctggac ggtggacatc acaaggaact tcagcaacat catccaggga
     1081 agccagattt cctctttgat tcttaaacac cacatcatgg gtcctggctt tggcttccag
     1141 aacatcagag atcctgacca gagcacattt gccagcctgg ccagaagttc ggtgctgcaa
     1201 ctggaccttt cgcacggctt tatcttctcc ttgaatcctc gactgtttgg gacactgaag
     1261 gatttgaaga tgctgaacct tgccttcaac aagataaaca agattggaga gaatgccttt
     1321 tatgggcttg acagcctcca ggttctcaat ctatcctata atcttttggg ggaactctat
     1381 aattccaact tctatgggct tcctagagta gcctacgttg accttcaaag gaaccacatt
     1441 gggatcattc aagaccaaac attcagatta ttaaaaacgt tacaaacctt agatctccgt
     1501 gacaatgctc ttaaggccat tggttttatt ccaagcatac agatggtcct cctgggaggc
     1561 aataagctgg tccatttgcc acacatccac tttactgcca acttcctaga gttatctgaa
     1621 aacaggctag aaaacctgtc cgacctctac ttcctcctgc gagtccccca gctccagttt
     1681 ctcatcttga atcagaatcg cctttcgtca tgcaaggcag cccacactcc ctcggagaac
     1741 ccaagcttag aacagctttt ccttacagag aatatgctgc agctggcctg ggagaccggc
     1801 ctctgttggg atgtttttca aggcctttcc cgcctccaga ttctttacct gagtaataac
     1861 taccttaatt tccttccacc tgggatattt aacgacctgg ttgcattacg gatgcttagt
     1921 cttagtgcta acaagctgac cgtgctctct ccgggcagtt tacctgctaa tttagagatt
     1981 ctcgacatat ctagaaatca gcttttctct cctgaccctg ctttgttttc ttcgcttcgt
     2041 gttttggaca taactcataa cgagttcgtc tgcaactgtg aacttagcac ttttatctcc
     2101 tggctcaacc aaaccaacgt caccctgttc ggctctcctg cagacgtgta ttgcatgtac
     2161 cctaactcac tgctaggggg ctccctctac aacatatcca ccgaagactg cgatgaagag
     2221 gaagccatgc ggtccctaaa gttttccctt ttcatcctgt gcacggtcac tttgactcta
     2281 ttcctcgtca tcacccttgt agtcataaag ttccggggaa tctgtttcct gtgctataag
     2341 accatccaga agctggtgtt caaggacaag gtctggagtt tggaacctgg tgcatataga
     2401 tatgatgcct acttctgctt cagcagcaaa gactttgaat gggcacagaa tgctttgctc
     2461 aaacacctgg atgctcacta cagttcccga aacaggctca ggctatgctt tgaagaaaga
     2521 gacttcattc cgggggaaaa ccatatctcc aacatccagg cggctgtctg gggcagcagg
     2581 aagacggtgt gtctagtgag cagacacttc ctgaaggatg gttggtgcct ggaggccttc
     2641 aggtatgccc agagccggag tctgtctgac ctcaagagca ttctcatcgt ggtggtggtg
     2701 ggatcgctgt cccagtatca gctgatgaga catgagacca tcagagggtt tctgcaaaag
     2761 caacagtact tgaggtggcc tgaagacctc caggatgttg gctggtttct cgataaactc
     2821 tccggatgca ttctaaagga agaaaaagga aagaaaagaa gcagttccat ccagttgcga
     2881 accatagcaa ccatttccta gcaggagcgc ctcctagcag aagtgcaagc atcgtagata
     2941 actctccacg ctttatccgc acagccgctg ggggtccttc cctggagtca tttttctgac
     3001 aatgaaaaca acaccaatct cttgattttc atgtcaacag ggagctttgt ctcactgttt
     3061 tccaaatgga aagtaagagg tccagaaagc tgcctctaag ggctctcacc tgccattgat
     3121 gtcctttcag gcccaatgac atggtttccc tccatcctat tgcgtactgt ctgctaccca
     3181 ggtggcaaga gcaccttggg agaagttaca ggcagcttca tgctttctgt gctgttcagt
     3241 tcaaaagcag gtgccttgag aatcctgaat tcaagcactc tgtagaacat ggacagacaa
     3301 gatgggtcct tctctggcca taggcatgag gccagttgct gaggactgct ctcactacac
     3361 ctaagtgcac aagtgataag aagttggaca gatagacaga tagcagcagt cccattgctg
     3421 tagccagaat gcacttattt cctgttctga ccctgcaggc ccagcttttg gggaccacag
     3481 ccatgttctg cacgggacct ctcaacctgg cattcatgcc ctttcacgac ttagcaccgg
     3541 cctgcccttc tttcttcccc acaactatac aagagctgtt gcaaccactg aa
//
