LOCUS       NM_126166               4407 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus toll-like receptor 3 (Tlr3), transcript variant 1,
            mRNA.
ACCESSION   NM_126166
VERSION     NM_126166.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4407)
  AUTHORS   Chung,K.Y., Kim,S., Yoon,H.T., Kwon,S.H., Park,H.S., Im,J.P.,
            Kim,J.S., Kim,J.W., Han,Y.M. and Koh,S.J.
  TITLE     Toll-like receptor 3 signaling attenuated colitis-associated cancer
            development in mice
  JOURNAL   Sci Rep 14 (1), 30308 (2024)
   PUBMED   39639064
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4407)
  AUTHORS   Zhang,R.R., Yang,X.Y., Yang,Y.L., Guo,T.K., Huang,J.S., Yang,Y.S.,
            Shi,C.W., Yang,G.L., Huang,H.B., Wang,J.Z., Jiang,Y.L., Cao,X.,
            Wang,N., Zeng,Y., Yang,W.T. and Wang,C.F.
  TITLE     TLR3/TRIF and MAVS Signaling Is Essential in Regulating Mucosal T
            Cell Responses during Rotavirus Infection
  JOURNAL   J Immunol 213 (7), 1008-1022 (2024)
   PUBMED   39194407
  REMARK    GeneRIF: TLR3/TRIF and MAVS Signaling Is Essential in Regulating
            Mucosal T Cell Responses during Rotavirus Infection.
REFERENCE   3  (bases 1 to 4407)
  AUTHORS   Li,N., Kumar,S.R.P., Cao,D., Munoz-Melero,M., Arisa,S., Brian,B.A.,
            Greenwood,C.M., Yamada,K., Duan,D. and Herzog,R.W.
  TITLE     Redundancy in Innate Immune Pathways That Promote CD8+ T-Cell
            Responses in AAV1 Muscle Gene Transfer
  JOURNAL   Viruses 16 (10), 1507 (2024)
   PUBMED   39459842
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4407)
  AUTHORS   Lopez,D.A., Griffin,A., Aguilar,L.M., Deering-Rice,C., Myers,E.J.,
            Warren,K.J., Welner,R.S. and Beaudin,A.E.
  TITLE     Prenatal inflammation remodels lung immunity and function by
            programming ILC2 hyperactivation
  JOURNAL   Cell Rep 43 (7), 114365 (2024)
   PUBMED   38909363
REFERENCE   5  (bases 1 to 4407)
  AUTHORS   Suvieri,C., Mondanelli,G., Orabona,C., Pallotta,M.T., Panfili,E.,
            Rossini,S., Volpi,C. and Belladonna,M.L.
  TITLE     Sensing of an HIV-1-Derived Single-Stranded RNA-Oligonucleotide
            Induces Arginase 1-Mediated Tolerance
  JOURNAL   Cells 13 (13), 1088 (2024)
   PUBMED   38994942
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4407)
  AUTHORS   Takami,M., Kim,N., Rho,J. and Choi,Y.
  TITLE     Stimulation by toll-like receptors inhibits osteoclast
            differentiation
  JOURNAL   J Immunol 169 (3), 1516-1523 (2002)
   PUBMED   12133979
REFERENCE   7  (bases 1 to 4407)
  AUTHORS   Matsumoto,M., Kikkawa,S., Kohase,M., Miyake,K. and Seya,T.
  TITLE     Establishment of a monoclonal antibody against human Toll-like
            receptor 3 that blocks double-stranded RNA-mediated signaling
  JOURNAL   Biochem Biophys Res Commun 293 (5), 1364-1369 (2002)
   PUBMED   12054664
REFERENCE   8  (bases 1 to 4407)
  AUTHORS   Suzuki,N., Suzuki,S., Duncan,G.S., Millar,D.G., Wada,T.,
            Mirtsos,C., Takada,H., Wakeham,A., Itie,A., Li,S., Penninger,J.M.,
            Wesche,H., Ohashi,P.S., Mak,T.W. and Yeh,W.C.
  TITLE     Severe impairment of interleukin-1 and Toll-like receptor
            signalling in mice lacking IRAK-4
  JOURNAL   Nature 416 (6882), 750-756 (2002)
   PUBMED   11923871
  REMARK    GeneRIF: Severe impairment of interleukin-1 and Toll-like receptor
            signalling in mice lacking IRAK-4.
REFERENCE   9  (bases 1 to 4407)
  AUTHORS   Alexopoulou,L., Holt,A.C., Medzhitov,R. and Flavell,R.A.
  TITLE     Recognition of double-stranded RNA and activation of NF-kappaB by
            Toll-like receptor 3
  JOURNAL   Nature 413 (6857), 732-738 (2001)
   PUBMED   11607032
REFERENCE   10 (bases 1 to 4407)
  AUTHORS   Bogerd,A.M., Franklin,A., Rice,D.A., Schimmer,B.P. and Parker,K.L.
  TITLE     Identification and characterization of two upstream elements that
            regulate adrenocortical expression of steroid 11 beta-hydroxylase
  JOURNAL   Mol Endocrinol 4 (6), 845-850 (1990)
   PUBMED   2233742
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY770706.1, AK083977.1 and BC099937.1.
            
            On Oct 25, 2017 this sequence version replaced NM_126166.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK083977.1, BC099937.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-80                BY770706.1         1-80
            81-3843             AK083977.1         2-3764
            3844-4202           BC099937.1         3802-4160
            4203-4407           AK083977.1         4124-4328
FEATURES             Location/Qualifiers
     source          1..4407
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 25.31 cM"
     gene            1..4407
                     /gene="Tlr3"
                     /note="toll-like receptor 3"
                     /db_xref="GeneID:142980"
                     /db_xref="MGI:MGI:2156367"
     exon            1..167
                     /gene="Tlr3"
                     /inference="alignment:Splign:2.1.0"
     exon            168..362
                     /gene="Tlr3"
                     /inference="alignment:Splign:2.1.0"
     exon            363..432
                     /gene="Tlr3"
                     /inference="alignment:Splign:2.1.0"
     exon            433..885
                     /gene="Tlr3"
                     /inference="alignment:Splign:2.1.0"
     CDS             442..3159
                     /gene="Tlr3"
                     /codon_start=1
                     /product="toll-like receptor 3 precursor"
                     /protein_id="NP_569054.2"
                     /db_xref="CCDS:CCDS22278.1"
                     /db_xref="GeneID:142980"
                     /db_xref="MGI:MGI:2156367"
                     /translation="MKGCSSYLMYSFGGLLSLWILLVSSTNQCTVRYNVADCSHLKLT
                     HIPDDLPSNITVLNLTHNQLRRLPPTNFTRYSQLAILDAGFNSISKLEPELCQILPLL
                     KVLNLQHNELSQISDQTFVFCTNLTELDLMSNSIHKIKSNPFKNQKNLIKLDLSHNGL
                     SSTKLGTGVQLENLQELLLAKNKILALRSEELEFLGNSSLRKLDLSSNPLKEFSPGCF
                     QTIGKLFALLLNNAQLNPHLTEKLCWELSNTSIQNLSLANNQLLATSESTFSGLKWTN
                     LTQLDLSYNNLHDVGNGSFSYLPSLRYLSLEYNNIQRLSPRSFYGLSNLRYLSLKRAF
                     TKQSVSLASHPNIDDFSFQWLKYLEYLNMDDNNIPSTKSNTFTGLVSLKYLSLSKTFT
                     SLQTLTNETFVSLAHSPLLTLNLTKNHISKIANGTFSWLGQLRILDLGLNEIEQKLSG
                     QEWRGLRNIFEIYLSYNKYLQLSTSSFALVPSLQRLMLRRVALKNVDISPSPFRPLRN
                     LTILDLSNNNIANINEDLLEGLENLEILDFQHNNLARLWKRANPGGPVNFLKGLSHLH
                     ILNLESNGLDEIPVGVFKNLFELKSINLGLNNLNKLEPFIFDDQTSLRSLNLQKNLIT
                     SVEKDVFGPPFQNLNSLDMRFNPFDCTCESISWFVNWINQTHTNISELSTHYLCNTPH
                     HYYGFPLKLFDTSSCKDSAPFELLFIISTSMLLVFILVVLLIHIEGWRISFYWNVSVH
                     RILGFKEIDTQAEQFEYTAYIIHAHKDRDWVWEHFSPMEEQDQSLKFCLEERDFEAGV
                     LGLEAIVNSIKRSRKIIFVITHHLLKDPLCRRFKVHHAVQQAIEQNLDSIILIFLQNI
                     PDYKLNHALCLRRGMFKSHCILNWPVQKERINAFHHKLQVALGSRNSAH"
     exon            886..1077
                     /gene="Tlr3"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..2930
                     /gene="Tlr3"
                     /inference="alignment:Splign:2.1.0"
     exon            2931..4407
                     /gene="Tlr3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4178..4183
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tlr3"
                     /note="hexamer: ATTAAA"
     polyA_site      4202
                     /gene="Tlr3"
                     /note="major polyA site"
     regulatory      4280..4285
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tlr3"
                     /note="hexamer: AATAAA"
     polyA_site      4302
                     /gene="Tlr3"
ORIGIN      
        1 attgttattt cccggcctag ttgtttctgg gagtttcctg cttttgaggc aggacctcct
       61 cctgtgtccg agatgtcctc aacatttcct gctggaaaac tggatggcca tttttaccta
      121 agagattaag ttcgacttta ctcattttgc aaagaagata aagcgagttt cactttcagg
      181 ctgaaaggaa atgtgtgatt taaaaaaaaa agtctgaatg aaaactaagg ggatgcagga
      241 cctcaggctg agtaaaatca gaatgtactt ggcttttgag gttgacgcac ctgttctcta
      301 tctgggaagt taaactgcct gaatcacaat cgcgcaccaa aagaagatag aagatgatgc
      361 agtctttcca gagggataga tgttacctaa gcaaggagta gaatatgata cagggattgc
      421 acccataatc tgggctgaat catgaaaggg tgttcctctt atctaatgta ctcctttggg
      481 ggacttttgt ccctatggat tcttctggtg tcttccacaa accaatgcac tgtgagatac
      541 aacgtagctg actgcagcca tttgaagcta acacacatac ctgatgatct tccctctaac
      601 ataacagtgt tgaatcttac tcacaaccaa ctcagaagat taccacctac caactttaca
      661 agatacagcc aacttgctat cttggatgca ggatttaact ccatttcaaa actggagcca
      721 gaactgtgcc aaatactccc tttgttgaaa gtattgaacc tgcaacataa tgagctctct
      781 cagatttctg atcaaacctt tgtcttctgc acgaacctga cagaactcga tctaatgtct
      841 aactcaatac acaaaattaa aagcaaccct ttcaaaaacc agaagaatct aatcaaatta
      901 gatttgtctc ataatggttt atcatctaca aagttgggaa cgggggtcca actggagaac
      961 ctccaagaac tgctcttagc aaaaaataaa atccttgcgt tgcgaagtga agaacttgag
     1021 tttcttggca attcttcttt acgaaagttg gacttgtcat caaatccact taaagagttc
     1081 tccccggggt gtttccagac aattggcaag ttattcgccc tcctcttgaa caacgcccaa
     1141 ctgaaccccc acctcacaga gaagctttgc tgggaacttt caaacacaag catccagaat
     1201 ctctctctgg ctaacaacca gctgctggcc accagcgaga gcactttctc tgggctgaag
     1261 tggacaaatc tcacccagct cgatctttcc tacaacaacc tccatgatgt cggcaacggt
     1321 tccttctcct atctcccaag cctgaggtat ctgtctctgg agtacaacaa tatacagcgt
     1381 ctgtcccctc gctcttttta tggactctcc aacctgaggt acctgagttt gaagcgagca
     1441 tttactaagc aaagtgtttc acttgcttca catcccaaca ttgacgattt ttcctttcaa
     1501 tggttaaaat atttggaata tctcaacatg gatgacaata atattccaag taccaaaagc
     1561 aataccttca cgggattggt gagtctgaag tacctaagtc tttccaaaac tttcacaagt
     1621 ttgcaaactt taacaaatga aacatttgtg tcacttgctc attctccctt gctcactctc
     1681 aacttaacga aaaatcacat ctcaaaaata gcaaatggta ctttctcttg gttaggccaa
     1741 ctcaggatac ttgatctcgg ccttaatgaa attgaacaaa aactcagcgg ccaggaatgg
     1801 agaggtctga gaaatatatt tgagatctac ctatcctata acaaatacct ccaactgtct
     1861 accagttcct ttgcattggt ccccagcctt caaagactga tgctcaggag ggtggccctt
     1921 aaaaatgtgg atatctcccc ttcacctttc cgccctcttc gtaacttgac cattctggac
     1981 ttaagcaaca acaacatagc caacataaat gaggacttgc tggagggtct tgagaatcta
     2041 gaaatcctgg attttcagca caataactta gccaggctct ggaaacgcgc aaaccccggt
     2101 ggtcccgtta atttcctgaa ggggctgtct cacctccaca tcttgaattt agagtccaac
     2161 ggcttagatg aaatcccagt cggggttttc aagaacttat tcgaactaaa gagcatcaat
     2221 ctaggactga ataacttaaa caaacttgaa ccattcattt ttgatgacca gacatctcta
     2281 aggtcactga acctccagaa gaacctcata acatctgttg agaaggatgt tttcgggccg
     2341 ccttttcaaa acctgaacag tttagatatg cgcttcaatc cgttcgactg cacgtgtgaa
     2401 agtatttcct ggtttgttaa ctggatcaac cagacccaca ctaatatctc tgagctgtcc
     2461 actcactacc tctgtaacac tccacatcat tattatggct tccccctgaa gcttttcgat
     2521 acatcatcct gtaaagacag cgcccccttt gaactcctct tcataatcag caccagtatg
     2581 ctcctggttt ttatacttgt ggtactgctc attcacatcg agggctggag gatctctttt
     2641 tactggaatg tttcagtgca tcggattctt ggtttcaagg aaatagacac acaggctgag
     2701 cagtttgaat atacagccta cataattcat gcccataaag acagagactg ggtctgggaa
     2761 catttctccc caatggaaga acaagaccaa tctctcaaat tttgcctaga agaaagggac
     2821 tttgaagcag gcgtccttgg acttgaagca attgttaata gcatcaaaag aagccgaaaa
     2881 atcattttcg ttatcacaca ccatttatta aaagaccctc tgtgcagaag attcaaggta
     2941 catcacgcag ttcagcaagc tattgagcaa aatctggatt caattatact gatttttctc
     3001 cagaatattc cagattataa actaaaccat gcactctgtt tgcgaagagg aatgtttaaa
     3061 tctcattgca tcttgaactg gccagttcag aaagaacgga taaatgcctt tcatcataaa
     3121 ttgcaagtag cacttggatc tcggaattca gcacattaaa ctcatttgaa gatttggagt
     3181 cggtaaaggg atagatccaa tttataaagg tccatcatga atctaagttt tacttgaaag
     3241 ttttgtatat ttatttatat gtatagatga tgatattaca tcacaatcca atctcagttt
     3301 tgaaatattt cggcttattt cattgacatc tggtttattc actccaaata aacacatggg
     3361 cagttaaaaa catcctctat taatagatta cccattaatt cttgaggtgt atcacagctt
     3421 taaagggttt taaatatttt tatataaata agactgagag ttttataaat gtaatttttt
     3481 aaaactcgag tcttactgtg tagctcagaa aggcctggaa attaatatat tagagagtca
     3541 tgtcttgaac ttatttatct ctgcctccct ctgtctccag agtgttgctt ttaagggcat
     3601 gtagcaccac acccagctat gtacgtgtgg gattttataa tgctcatttt tgagacgttt
     3661 atagaataaa agataattgc ttttatggta taaggctact tgaggtaaca agaataaaat
     3721 atttagaaag aggagttttg ctttttcagt tgaaaagttt tgtattttat tttggtgttg
     3781 gttttgatag ctgttgagta gggtttaaac ctgcataccc aggagcagaa tatcttctta
     3841 atcttcatag tgtcacagga ccccagacct agcacaactg actccatgat ggaagtaaca
     3901 cctaggtcat aaatcttaga acatagactg catcgcctgc taagatgaaa acaaagacgt
     3961 aatcatcaaa gtctaaagtt ctgggaaagt ctctaaatgt actaactttg ctttttggct
     4021 tctgtagttc tgcttctggc tgcttttgtt aactgaatta tgtcaatgca gattatggtt
     4081 tttgttgttg ttgttgttgt tgtcttggtt ttgtgcctca aagttcggtt ggggctacct
     4141 tgggatccca aacagctaat atggtcacca actggctatt aaagactttc tgttaacata
     4201 aacccatgcc tgagtagtct tctctgagaa gagccacagt gatagatggc attttattac
     4261 ttgataaaat agatattgga ataaatactt gtattgtgct aattgttgtg tctcttctgc
     4321 tggagagtta aatgactttc ttacccatat tatagaaagc cttgcttcca gaacactagt
     4381 caataaagtg tctttgtgga aaacagc
//
