LOCUS       NM_011905               2874 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus toll-like receptor 2 (Tlr2), mRNA.
ACCESSION   NM_011905
VERSION     NM_011905.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2874)
  AUTHORS   Wang,J., Gao,M., Wang,J., Zeng,Y., Wang,C. and Cao,X.
  TITLE     LGG promotes activation of intestinal ILC3 through TLR2 receptor
            and inhibits salmonella typhimurium infection in mice
  JOURNAL   Virulence 15 (1), 2384553 (2024)
   PUBMED   39080852
  REMARK    GeneRIF: LGG promotes activation of intestinal ILC3 through TLR2
            receptor and inhibits salmonella typhimurium infection in mice.
REFERENCE   2  (bases 1 to 2874)
  AUTHORS   Cui,H., Sun,F., Yu,N., Cao,Y., Wang,X., Zhang,D., Chen,Z., Wang,N.,
            Yuan,B., Liu,P., Duan,W., Qiu,W., Yin,X. and Ma,C.
  TITLE     TLR2/NF-kappaB signaling in macrophage/microglia mediated
            COVID-pain induced by SARS-CoV-2 envelope protein
  JOURNAL   iScience 27 (10), 111027 (2024)
   PUBMED   39435149
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2874)
  AUTHORS   Luo,X., Gong,H.B., Li,Z.C., Li,D.D., Li,Z.X., Sun,J., Yan,C.Y.,
            Huang,R.T., Feng,Y., Chen,S.R., Cao,Y.F., Liu,M., Wang,R.,
            Huang,F., Sun,W.Y., Kurihara,H., Duan,W.J., Liang,L., Jin,W.,
            Wu,Y.P., He,R.R. and Li,Y.F.
  TITLE     Phospholipid peroxidation in macrophage confers tumor resistance by
            suppressing phagocytic capability towards ferroptotic cells
  JOURNAL   Cell Death Differ 31 (9), 1184-1201 (2024)
   PUBMED   39103535
REFERENCE   4  (bases 1 to 2874)
  AUTHORS   Ko,J.H., Lee,H.J., Yoon,C.H., Choi,Y.R., Ryu,J.S. and Oh,J.Y.
  TITLE     Activation of Toll-like receptor 2 promotes mesenchymal
            stem/stromal cell-mediated immunoregulation and angiostasis through
            AKR1C1
  JOURNAL   Theranostics 14 (12), 4713-4729 (2024)
   PUBMED   39239520
  REMARK    GeneRIF: Activation of Toll-like receptor 2 promotes mesenchymal
            stem/stromal cell-mediated immunoregulation and angiostasis through
            AKR1C1.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2874)
  AUTHORS   Griesman,T., McMillen,C.M., Negatu,S.G., Hulahan,J.J., Whig,K.,
            Dohnalova,L., Dittmar,M., Thaiss,C.A., Jurado,K.A., Schultz,D.C.,
            Hartman,A.L. and Cherry,S.
  TITLE     The lipopeptide Pam3CSK4 inhibits Rift Valley fever virus infection
            and protects from encephalitis
  JOURNAL   PLoS Pathog 20 (6), e1012343 (2024)
   PUBMED   38935789
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2874)
  AUTHORS   Matsuguchi,T., Takagi,K., Musikacharoen,T. and Yoshikai,Y.
  TITLE     Gene expressions of lipopolysaccharide receptors, toll-like
            receptors 2 and 4, are differently regulated in mouse T lymphocytes
  JOURNAL   Blood 95 (4), 1378-1385 (2000)
   PUBMED   10666214
REFERENCE   7  (bases 1 to 2874)
  AUTHORS   Underhill,D.M., Ozinsky,A., Hajjar,A.M., Stevens,A., Wilson,C.B.,
            Bassetti,M. and Aderem,A.
  TITLE     The Toll-like receptor 2 is recruited to macrophage phagosomes and
            discriminates between pathogens
  JOURNAL   Nature 401 (6755), 811-815 (1999)
   PUBMED   10548109
REFERENCE   8  (bases 1 to 2874)
  AUTHORS   Takeuchi,O., Hoshino,K., Kawai,T., Sanjo,H., Takada,H., Ogawa,T.,
            Takeda,K. and Akira,S.
  TITLE     Differential roles of TLR2 and TLR4 in recognition of gram-negative
            and gram-positive bacterial cell wall components
  JOURNAL   Immunity 11 (4), 443-451 (1999)
   PUBMED   10549626
REFERENCE   9  (bases 1 to 2874)
  AUTHORS   Heine,H., Kirschning,C.J., Lien,E., Monks,B.G., Rothe,M. and
            Golenbock,D.T.
  TITLE     Cutting edge: cells that carry A null allele for toll-like receptor
            2 are capable of responding to endotoxin
  JOURNAL   J Immunol 162 (12), 6971-6975 (1999)
   PUBMED   10358136
REFERENCE   10 (bases 1 to 2874)
  AUTHORS   Nishiguchi,S., Sakuma,R., Nomura,M., Zou,Z., Jearanaisilavong,J.,
            Joh,T., Yasunaga,T. and Shimada,K.
  TITLE     A catalogue of genes in mouse embryonal carcinoma F9 cells
            identified with expressed sequence tags
  JOURNAL   J Biochem 119 (4), 749-767 (1996)
   PUBMED   8743579
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK005043.1, BY743020.1 and BP771904.1.
            
            On Oct 27, 2007 this sequence version replaced NM_011905.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC014693.1, AK005043.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-527               AK005043.1         2-528
            528-585             BY743020.1         496-553
            586-2853            AK005043.1         587-2854
            2854-2874           BP771904.1         28-48               c
FEATURES             Location/Qualifiers
     source          1..2874
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 37.4 cM"
     gene            1..2874
                     /gene="Tlr2"
                     /gene_synonym="Ly105"
                     /note="toll-like receptor 2"
                     /db_xref="GeneID:24088"
                     /db_xref="MGI:MGI:1346060"
     exon            1..89
                     /gene="Tlr2"
                     /gene_synonym="Ly105"
                     /inference="alignment:Splign:2.1.0"
     exon            90..337
                     /gene="Tlr2"
                     /gene_synonym="Ly105"
                     /inference="alignment:Splign:2.1.0"
     exon            338..2855
                     /gene="Tlr2"
                     /gene_synonym="Ly105"
                     /inference="alignment:Splign:2.1.0"
     CDS             353..2707
                     /gene="Tlr2"
                     /gene_synonym="Ly105"
                     /EC_number="3.2.2.6"
                     /codon_start=1
                     /product="toll-like receptor 2 precursor"
                     /protein_id="NP_036035.3"
                     /db_xref="CCDS:CCDS17435.1"
                     /db_xref="GeneID:24088"
                     /db_xref="MGI:MGI:1346060"
                     /translation="MLRALWLFWILVAITVLFSKRCSAQESLSCDASGVCDGRSRSFT
                     SIPSGLTAAMKSLDLSFNKITYIGHGDLRACANLQVLMLKSSRINTIEGDAFYSLGSL
                     EHLDLSDNHLSSLSSSWFGPLSSLKYLNLMGNPYQTLGVTSLFPNLTNLQTLRIGNVE
                     TFSEIRRIDFAGLTSLNELEIKALSLRNYQSQSLKSIRDIHHLTLHLSESAFLLEIFA
                     DILSSVRYLELRDTNLARFQFSPLPVDEVSSPMKKLAFRGSVLTDESFNELLKLLRYI
                     LELSEVEFDDCTLNGLGDFNPSESDVVSELGKVETVTIRRLHIPQFYLFYDLSTVYSL
                     LEKVKRITVENSKVFLVPCSFSQHLKSLEFLDLSENLMVEEYLKNSACKGAWPSLQTL
                     VLSQNHLRSMQKTGEILLTLKNLTSLDISRNTFHPMPDSCQWPEKMRFLNLSSTGIRV
                     VKTCIPQTLEVLDVSNNNLDSFSLFLPRLQELYISRNKLKTLPDASLFPVLLVMKIRE
                     NAVSTFSKDQLGSFPKLETLEAGDNHFVCSCELLSFTMETPALAQILVDWPDSYLCDS
                     PPRLHGHRLQDARPSVLECHQAALVSGVCCALLLLILLVGALCHHFHGLWYLRMMWAW
                     LQAKRKPKKAPCRDVCYDAFVSYSEQDSHWVENLMVQQLENSDPPFKLCLHKRDFVPG
                     KWIIDNIIDSIEKSHKTVFVLSENFVRSEWCKYELDFSHFRLFDENNDAAILVLLEPI
                     ERKAIPQRFCKLRKIMNTKTYLEWPLDEGQQEVFWVNLRTAIKS"
     regulatory      2835..2840
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tlr2"
                     /gene_synonym="Ly105"
                     /note="hexamer: TATAAA"
     polyA_site      2855
                     /gene="Tlr2"
                     /gene_synonym="Ly105"
                     /note="major polyA site"
ORIGIN      
        1 cccttccctc acttccaggt cttcagtctt cctaggctgg tgcccagatg gctagtgggc
       61 acggggagcg gcggctggag gactcctagg ctccgggcag gcggtcactg gcaggagatg
      121 tgtccgcaat catagtttct gatggtgaag gttggacggc agtctctgcg acctagaagt
      181 ggaaaagatg tcgttcaagg aggtgcggac tgtttccttc tgaccaggat cttgtttctg
      241 agtgtagggg cttcacttct ctgcttttcg ttcatctctg gagcatccga attgcatcac
      301 cggtcagaaa acaacttacc gaaacctcag acaaagcgtc aaatctcaga ggatgctacg
      361 agctctttgg ctcttctgga tcttggtggc cataacagtc ctcttcagca aacgctgttc
      421 tgctcaggag tctctgtcat gtgatgcttc tggggtgtgt gatggccgct ccaggtcttt
      481 cacctctatt ccctccggac tcacagcagc catgaaaagc cttgacctgt ctttcaacaa
      541 gatcacctac attggccatg gtgacctccg agcgtgtgcg aacctccagg ttctgatgtt
      601 gaagtccagc agaatcaata caatagaggg agacgccttt tattctctgg gcagtcttga
      661 acatttggat ttgtctgata atcacctatc tagtttatct tcctcctggt tcgggcccct
      721 ttcctctttg aaatacttaa acttaatggg aaatccttac cagacactgg gggtaacatc
      781 gctttttccc aatctcacaa atttacaaac cctcaggata ggaaatgtag agactttcag
      841 tgagataagg agaatagatt ttgctgggct gacttctctc aatgaacttg aaattaaggc
      901 attaagtctc cggaattatc agtcccaaag tctaaagtcg atccgcgaca tccatcacct
      961 gactcttcac ttaagcgagt ctgctttcct gctggagatt tttgcagata ttctgagttc
     1021 tgtgagatat ttagaactaa gagatactaa cttggccagg ttccagtttt caccactgcc
     1081 cgtagatgaa gtcagctcac cgatgaagaa gctggcattc cgaggctcgg ttctcactga
     1141 tgaaagcttt aacgagctcc tgaagctgtt gcgttacatc ttggaactgt cggaggtaga
     1201 gttcgacgac tgtaccctca atgggctcgg cgatttcaac ccctcggagt cagacgtagt
     1261 gagcgagctg ggtaaagtag aaacagtcac tatccggagg ttgcatatcc cccagttcta
     1321 tttgttttat gacctgagta ctgtctattc cctcctggag aaggtgaagc gaatcacagt
     1381 agagaacagc aaggtcttcc tggttccctg ctcgttctcc cagcatttaa aatcattaga
     1441 attcttagac ctcagcgaaa atctgatggt tgaagaatat ttgaagaact cagcctgtaa
     1501 gggagcctgg ccttctctac aaaccttagt tttgagccag aatcatttga gatcaatgca
     1561 aaaaacagga gagattttgc tgactctgaa aaacctgacc tctcttgaca tcagcaggaa
     1621 cacttttcat ccgatgcccg acagctgtca gtggccagaa aagatgcgct tcctgaattt
     1681 gtccagtaca gggatccggg tggtaaaaac gtgcattcct cagacgctgg aggtgttgga
     1741 tgttagtaac aacaatcttg actcattttc tttgttcttg cctcggctgc aagagctcta
     1801 tatttccaga aataagctga aaacactccc agatgcttcg ttgttccctg tgttgctggt
     1861 catgaaaatc agagagaatg cagtaagtac tttctctaaa gaccaacttg gttcttttcc
     1921 caaactggag actctggaag caggcgacaa ccactttgtt tgctcctgcg aactcctatc
     1981 ctttactatg gagacgccag ctctggctca aatcctggtt gactggccag acagctacct
     2041 gtgtgactct ccgcctcgcc tgcacggcca caggcttcag gatgcccggc cctccgtctt
     2101 ggaatgtcac caggctgcac tggtgtctgg agtctgctgt gcccttctcc tgttgatctt
     2161 gctcgtaggt gccctgtgcc accatttcca cggactgtgg tacctgagaa tgatgtgggc
     2221 gtggctccag gccaagagga agcccaagaa agctccctgc agggacgttt gctatgatgc
     2281 ctttgtttcc tacagtgagc aggattccca ttgggtggag aacctcatgg tccagcagct
     2341 ggagaactct gacccgccct ttaagctgtg tctccacaag cgggacttcg ttccgggcaa
     2401 atggatcatt gacaacatca tcgattccat cgaaaagagc cacaaaactg tgttcgtgct
     2461 ttctgagaac ttcgtacgga gcgagtggtg caagtacgaa ctggacttct cccacttcag
     2521 gctctttgac gagaacaacg acgcggccat ccttgttttg ctggagccca ttgagaggaa
     2581 agccattccc cagcgcttct gcaaactgcg caagataatg aacaccaaga cctacctgga
     2641 gtggcccttg gatgaaggcc agcaggaagt gttttgggta aatctgagaa ctgcaataaa
     2701 gtcctaggtt ctccacccag ttcctgactt ccttaactaa ggtctttgtg acacaaactg
     2761 taacaaagtt tataagtaac atagaattgt attattgagg atattaacta tgggttttgt
     2821 cttgaatact gttatataaa tatgtgacat caggaaaaaa aaaaaaaaaa aaaa
//
