LOCUS       NM_205820               4014 bp    mRNA    linear   ROD 11-DEC-2024
DEFINITION  Mus musculus toll-like receptor 13 (Tlr13), mRNA.
ACCESSION   NM_205820 XM_205159
VERSION     NM_205820.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4014)
  AUTHORS   Rafique,A., Ali,I., Kim,S., Farooq,A., Manzoor,U., Moon,J.,
            Arooj,M., Ahn,M., Park,Y., Hyun,C.L. and Koh,Y.S.
  TITLE     Toll-like receptor 13-mediated signaling protects against the
            development of colon cancer
  JOURNAL   Int J Cancer 155 (10), 1858-1873 (2024)
   PUBMED   38989970
REFERENCE   2  (bases 1 to 4014)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4014)
  AUTHORS   Lentini,G., De Gaetano,G.V., Fama,A., Galbo,R., Coppolino,F.,
            Mancuso,G., Teti,G. and Beninati,C.
  TITLE     Neutrophils discriminate live from dead bacteria by integrating
            signals initiated by Fprs and TLRs
  JOURNAL   EMBO J 41 (5), e109386 (2022)
   PUBMED   35112724
REFERENCE   4  (bases 1 to 4014)
  AUTHORS   Gu,L., Wang,Z., Zhang,Y., Zhu,N., Li,J., Yang,M., Wang,L. and
            Rong,S.
  TITLE     TLR13 contributes to skeletal muscle atrophy by increasing insulin
            resistance in chronic kidney disease
  JOURNAL   Cell Prolif 55 (3), e13181 (2022)
   PUBMED   35088922
  REMARK    GeneRIF: TLR13 contributes to skeletal muscle atrophy by increasing
            insulin resistance in chronic kidney disease.
REFERENCE   5  (bases 1 to 4014)
  AUTHORS   Lentini,G., Fama,A., De Gaetano,G.V., Galbo,R., Coppolino,F.,
            Venza,M., Teti,G. and Beninati,C.
  TITLE     Role of Endosomal TLRs in Staphylococcus aureus Infection
  JOURNAL   J Immunol 207 (5), 1448-1455 (2021)
   PUBMED   34362834
REFERENCE   6  (bases 1 to 4014)
  AUTHORS   Shi,Z., Cai,Z., Sanchez,A., Zhang,T., Wen,S., Wang,J., Yang,J.,
            Fu,S. and Zhang,D.
  TITLE     A novel Toll-like receptor that recognizes vesicular stomatitis
            virus
  JOURNAL   J Biol Chem 286 (6), 4517-4524 (2011)
   PUBMED   21131352
  REMARK    GeneRIF: the potential role of the novel Toll-like receptor tlr13
            in the recognition of viral infection.
REFERENCE   7  (bases 1 to 4014)
  AUTHORS   Shi,Z., Cai,Z., Wen,S., Chen,C., Gendron,C., Sanchez,A.,
            Patterson,K., Fu,S., Yang,J., Wildman,D., Finnell,R.H. and Zhang,D.
  TITLE     Transcriptional regulation of the novel Toll-like receptor Tlr13
  JOURNAL   J Biol Chem 284 (31), 20540-20547 (2009)
   PUBMED   19487701
  REMARK    GeneRIF: These findings reveal the mechanism of Tlr13 gene
            regulation, thereby providing insight into the function of Tlr13 in
            the immune response to pathogen.
REFERENCE   8  (bases 1 to 4014)
  AUTHORS   Mishra,B.B., Gundra,U.M. and Teale,J.M.
  TITLE     Expression and distribution of Toll-like receptors 11-13 in the
            brain during murine neurocysticercosis
  JOURNAL   J Neuroinflammation 5, 53 (2008)
   PUBMED   19077284
  REMARK    GeneRIF: TLRs 11-13 are expressed in normal and parasite infected
            mouse brains. This suggests a role for them in central nervous
            system infections.
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 4014)
  AUTHORS   Brinkmann,M.M., Spooner,E., Hoebe,K., Beutler,B., Ploegh,H.L. and
            Kim,Y.M.
  TITLE     The interaction between the ER membrane protein UNC93B and TLR3, 7,
            and 9 is crucial for TLR signaling
  JOURNAL   J Cell Biol 177 (2), 265-275 (2007)
   PUBMED   17452530
REFERENCE   10 (bases 1 to 4014)
  AUTHORS   Tabeta,K., Georgel,P., Janssen,E., Du,X., Hoebe,K., Crozat,K.,
            Mudd,S., Shamel,L., Sovath,S., Goode,J., Alexopoulou,L.,
            Flavell,R.A. and Beutler,B.
  TITLE     Toll-like receptors 9 and 3 as essential components of innate
            immune defense against mouse cytomegalovirus infection
  JOURNAL   Proc Natl Acad Sci U S A 101 (10), 3516-3521 (2004)
   PUBMED   14993594
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY510706.1.
            
            On Mar 22, 2004 this sequence version replaced XM_205159.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY510706.1, SRR1660815.252928.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4014
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 47.36 cM"
     gene            1..4014
                     /gene="Tlr13"
                     /gene_synonym="Gm713"
                     /note="toll-like receptor 13"
                     /db_xref="GeneID:279572"
                     /db_xref="MGI:MGI:3045213"
     exon            1..47
                     /gene="Tlr13"
                     /gene_synonym="Gm713"
                     /inference="alignment:Splign:2.1.0"
     exon            48..215
                     /gene="Tlr13"
                     /gene_synonym="Gm713"
                     /inference="alignment:Splign:2.1.0"
     CDS             180..3155
                     /gene="Tlr13"
                     /gene_synonym="Gm713"
                     /EC_number="3.2.2.6"
                     /codon_start=1
                     /product="toll-like receptor 13 precursor"
                     /protein_id="NP_991389.1"
                     /db_xref="CCDS:CCDS30338.1"
                     /db_xref="GeneID:279572"
                     /db_xref="MGI:MGI:3045213"
                     /translation="MSGLYRILVQLEQSPYVKTVPLNMRRDFFFLVVTWMPKTVKMNG
                     SSFVPSLQLLLMLVGFSLPPVAETYGFNKCTQYEFDIHHVLCIRKKITNLTEAISDIP
                     RYTTHLNLTHNEIQVLPPWSFTNLSALVDLRLEWNSIWKIDEGAFRGLENLTLLNLVE
                     NKIQSVNNSFEGLSSLKTLLLSHNQITHIHKDAFTPLIKLKYLSLSRNNISDFSGILE
                     AVQHLPCLERLDLTNNSIMYLDHSPRSLVSLTHLSFEGNKLRELNFSALSLPNLTNLS
                     ASRNGNKVIQNVYLKTLPQLKSLNLSGTVIKLENLSAKHLQNLRAMDLSNWELRHGHL
                     DMKTVCHLLGNLPKLETLVFQKNVTNAEGIKQLAKCTRLLFLDLGQNSDLIYLNDSEF
                     NALPSLQKLNLNKCQLSFINNRTWSSLQNLTSLDLSHNKFKSFPDFAFSPLKHLEFLS
                     LSRNPITELNNLAFSGLFALKELNLAACWIVTIDRYSFTQFPNLEVLDLGDNNIRTLN
                     HGTFRPLKKLQSLILSHNCLKILEPNSFSGLTNLRSLDLMYNSLSYFHEHLFSGLEKL
                     LILKLGFNKITYETTRTLQYPPFIKLKSLKQLNLEGQRHGIQVVPSNFFQGLGSLQEL
                     LLGKNPSVFLDHHQFDPLINLTKLDISGTKDGDRSLYLNASLFQNLKRLKILRLENNN
                     LESLVPDMFSSLQSLQVFSLRFNNLKVINQSHLKNLKSLMFFDVYGNKLQCTCDNLWF
                     KNWSMNTEEVHIPFLRSYPCQQPGSQSLLIDFDDAMCNFDLGKVYFLCSFSMVLSTMV
                     FSWFSTKMIASLWYGLYICRAWYLTKWHKTEKKFLYDAFVSFSATDEAWVYKELVPAL
                     EQGSQTTFKLCLHQRDFEPGIDIFENIQNAINTSRKTLCVVSNHYLHSEWCRLEVQLA
                     SMKMFYEHKDVIILIFLEEIPNYKLSSYHRLRKLINKQTFITWPDSVHQQPLFWARIR
                     NALGKETVEKENTHLIVVE"
     exon            216..4014
                     /gene="Tlr13"
                     /gene_synonym="Gm713"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3992..3997
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tlr13"
                     /gene_synonym="Gm713"
                     /note="hexamer: AATAAA"
     polyA_site      4014
                     /gene="Tlr13"
                     /gene_synonym="Gm713"
                     /note="major polyA site"
ORIGIN      
        1 tttagcaaag atgaacaatt gtactatgtg ctaggagctt ctgagagaac cttttccttg
       61 caagatacct gtggtatgtg tcttggggcc cagcaatgat tcctggttct ctgcttcctc
      121 tgttgcatga tgtcgagaca ctgatacact gatgcttgaa ggatgaagca gagttcagaa
      181 tgagtgggct ctacaggatc ctggtccagc tggaacaaag tccatatgtg aagaccgtgc
      241 ctttgaacat gagaagggat ttttttttcc tggttgtaac ctggatgcct aagacagtca
      301 agatgaatgg gagcagcttt gtgccatctc tacagctcct gctcatgtta gtaggatttt
      361 ctctgccgcc tgtggcagag acatatgggt tcaacaagtg cacacagtat gaatttgata
      421 ttcaccatgt gctctgcatt aggaagaaga tcaccaactt gacagaggcc attagtgaca
      481 tacctagata tactactcac cttaacctca cacacaacga aattcaagtc ctccctccct
      541 ggagttttac caatctgtct gctctggtgg acttgagact agagtggaac tcaatttgga
      601 agatcgacga aggtgccttt aggggacttg aaaatttgac tctgctgaat ttagtggaaa
      661 ataagattca aagtgtgaat aactcctttg agggcctgtc cagcctgaag accctgctcc
      721 tgagccataa tcagattacc catattcaca aagacgcctt cactcctcta atcaaattga
      781 aatatttgag cctatctcga aacaacatta gcgatttttc tggtattctt gaagcagtcc
      841 agcatcttcc atgcctggag cgccttgatc taactaacaa cagcatcatg tacttggacc
      901 acagccctag gtcactggtt tctctgaccc acctgagttt tgaggggaac aaactaaggg
      961 agttaaactt ctctgctttg tcattaccta acttaaccaa tctaagtgct tcccggaatg
     1021 gcaataaagt cattcagaat gtgtatctta aaactctgcc ccaacttaaa agcttgaatc
     1081 tgagtggaac ggtgataaaa ttggaaaatc tttcggccaa acacctgcag aatctaagag
     1141 ctatggatct cagtaattgg gagcttagac atggtcactt agatatgaaa actgtttgtc
     1201 acctgctcgg aaacctaccc aagttagaga cactggtttt tcagaaaaat gtcaccaatg
     1261 cagagggcat taagcagctg gcaaagtgca ccaggctctt gttccttgac ctgggtcaaa
     1321 acagtgactt gatttatctc aatgacagcg agttcaatgc tctgcccagt ctccaaaaac
     1381 tgaatttgaa caagtgccag ctctccttca tcaacaacag gacctggagt tccttgcaga
     1441 acttgaccag cctagatctg agccacaaca agtttaaaag ctttccagat tttgcatttt
     1501 cccccttgaa gcacttggag tttctctctc tttcaagaaa ccccatcaca gaactcaata
     1561 atctggcctt tagtgggcta tttgcactga aggagctcaa cttggctgca tgttggattg
     1621 taacaattga caggtattcc tttactcagt ttccaaactt agaggtctta gatcttggag
     1681 acaacaatat tcggactctc aaccacggaa ccttccgacc tctgaaaaaa ctccagtctt
     1741 tgattctttc ccacaactgc ctaaaaatcc tggagccaaa ttcgttttct ggtctcacta
     1801 acctacgttc ccttgacctg atgtacaaca gcttgtcata ttttcatgaa caccttttct
     1861 cgggccttga aaagcttctg attttgaaac ttggttttaa taagatcaca tatgaaacta
     1921 ctaggaccct tcagtatcct ccatttataa agctcaagtc tttgaaacag cttaacctag
     1981 aaggacaaag acacgggatt caggttgttc cgagcaactt tttccaagga ttgggtagtt
     2041 tgcaggagtt actcttagga aaaaatccct ctgtattcct ggaccaccac caatttgacc
     2101 ctctgattaa cctcacaaag ttggatatct caggaacaaa agatggagat cgaagcctct
     2161 atttaaatgc ttccttattc caaaacctca aaaggctaaa gatcctccgc cttgaaaata
     2221 acaacttaga gtcactggtt cctgacatgt tctccagctt acagagcctc caggtctttt
     2281 ctttaagatt caacaacttg aaggtcatta atcaaagtca tctgaagaat ctgaaatcac
     2341 tgatgttttt tgatgtctat gggaacaaac ttcagtgcac ctgtgacaat ttgtggttca
     2401 agaactggtc aatgaacaca gaggaggtcc acatcccctt cctccggagc tatccctgtc
     2461 agcagccagg cagccagagt ttacttatag attttgatga tgccatgtgt aattttgact
     2521 tgggaaaggt ctacttctta tgttccttca gtatggtcct cagcaccatg gtcttctctt
     2581 ggttcagtac caagatgatt gcatctctgt ggtatggttt gtacatatgt agggcctggt
     2641 acctcactaa atggcacaaa acggagaaga agttcttata tgatgcgttt gtctctttct
     2701 cggccactga tgaggcatgg gtatacaaag agcttgttcc agccctagaa caaggcagcc
     2761 agaccacctt taaactctgt cttcaccaac gggattttga accaggcatt gatatcttcg
     2821 agaacatcca gaatgctatt aacacaagca ggaaaacctt gtgcgtagtc agtaaccact
     2881 acctacacag tgaatggtgc cgacttgaag tccagctggc tagcatgaag atgttttatg
     2941 agcacaagga tgtcattatc ttgatcttcc ttgaagagat tccgaactat aagctgtcca
     3001 gctaccaccg actcaggaaa ctcataaaca aacagacgtt tatcacttgg ccggacagtg
     3061 ttcaccagca gccacttttc tgggctcgca tcagaaatgc gttgggcaag gagactgtgg
     3121 agaaagaaaa tacacatcta attgttgttg agtgactcga gtcttaacaa tcccaaaccc
     3181 ggctgcatga atgttgccca aaataaatgt aagctgtttg actaaatgaa ctctctctct
     3241 ctctccagag acaaacatga ttgcttagat agtgttcatc agaagagtag ggaggactgc
     3301 ttggaaaact ttcaggagca gggtcccact atgatgggat tggatatgca gaaggaattc
     3361 ctattttatt aaggagagga cttagaacaa cagtcatctg aacactgagg aacaggaagg
     3421 tcttcgcata tattcgatat ctttgctcat gttgtttctc caaatcagtt gtggtcatgg
     3481 gagactgcac ttgtgtatcc aaattgcccc aagattgaaa ctttccatct tgaaaggaaa
     3541 cttcctatga cagaggttta cagggagaga gaacaacagg atgttctaag gggagattga
     3601 aatattccac cctgcatgga agcttgttaa gacaggaggt aaatgactca aaatagtttc
     3661 atgaagtctc tgaaactgac cagggactag gccctttcct tccccaagtg tatataaaac
     3721 aatagagact gctgagacaa tcagacaagc ctagctgcct ggaagaagca gagagcagcc
     3781 ttggtgcctg gaagaggctc agaccagctg agccaccagg aaaggacact ctccatcctg
     3841 ttgagctgcc tgcagcctgt gcagtatgct ccaggttccc agcatttttg agctgtcacc
     3901 catgctgggg tgggctttag tgatgcagct gtctttgaaa catttctgct cctgtgagta
     3961 acccttcacc tatgttcttg taagtaaccc caataaaact cattggttca ccaa
//
