LOCUS       NM_205823               3174 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus toll-like receptor 12 (Tlr12), mRNA.
ACCESSION   NM_205823 XM_357393
VERSION     NM_205823.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3174)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3174)
  AUTHORS   Kawabe,T., Yi,J., Kawajiri,A., Hilligan,K., Fang,D., Ishii,N.,
            Yamane,H., Zhu,J., Jankovic,D., Kim,K.S., Trinchieri,G. and Sher,A.
  TITLE     Requirements for the differentiation of innate T-bethigh
            memory-phenotype CD4+ T lymphocytes under steady state
  JOURNAL   Nat Commun 11 (1), 3366 (2020)
   PUBMED   32632165
  REMARK    Erratum:[Nat Commun. 2020 Sep 10;11(1):4624. doi:
            10.1038/s41467-020-18568-5.. PMID: 32913264]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3174)
  AUTHORS   Mukhopadhyay,D., Arranz-Solis,D. and Saeij,J.P.J.
  TITLE     Toxoplasma GRA15 and GRA24 are important activators of the host
            innate immune response in the absence of TLR11
  JOURNAL   PLoS Pathog 16 (5), e1008586 (2020)
   PUBMED   32453782
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3174)
  AUTHORS   Koppes,E., Shaffer,B., Sadovsky,E., Himes,K., Barak,Y., Sadovsky,Y.
            and Chaillet,J.R.
  TITLE     Klf14 is an imprinted transcription factor that regulates placental
            growth
  JOURNAL   Placenta 88, 61-67 (2019)
   PUBMED   31675530
REFERENCE   5  (bases 1 to 3174)
  AUTHORS   Balounova,J., Splichalova,I., Dobesova,M., Kolar,M., Fiser,K.,
            Prochazka,J., Sedlacek,R., Jurisicova,A., Sung,H.K., Korinek,V.,
            Alberich-Jorda,M., Godin,I. and Filipp,D.
  TITLE     Toll-like receptor 2 expression on c-kit+ cells tracks the
            emergence of embryonic definitive hematopoietic progenitors
  JOURNAL   Nat Commun 10 (1), 5176 (2019)
   PUBMED   31729371
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3174)
  AUTHORS   Kumar,H., Kawai,T. and Akira,S.
  TITLE     Pathogen recognition in the innate immune response
  JOURNAL   Biochem J 420 (1), 1-16 (2009)
   PUBMED   19382893
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3174)
  AUTHORS   Mishra,B.B., Gundra,U.M. and Teale,J.M.
  TITLE     Expression and distribution of Toll-like receptors 11-13 in the
            brain during murine neurocysticercosis
  JOURNAL   J Neuroinflammation 5, 53 (2008)
   PUBMED   19077284
  REMARK    GeneRIF: TLRs 11-13 are expressed in normal and parasite infected
            mouse brains. This suggests a role for them in central nervous
            system infections.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 3174)
  AUTHORS   Yarovinsky,F., Zhang,D., Andersen,J.F., Bannenberg,G.L.,
            Serhan,C.N., Hayden,M.S., Hieny,S., Sutterwala,F.S., Flavell,R.A.,
            Ghosh,S. and Sher,A.
  TITLE     TLR11 activation of dendritic cells by a protozoan profilin-like
            protein
  JOURNAL   Science 308 (5728), 1626-1629 (2005)
   PUBMED   15860593
REFERENCE   9  (bases 1 to 3174)
  AUTHORS   Tabeta,K., Georgel,P., Janssen,E., Du,X., Hoebe,K., Crozat,K.,
            Mudd,S., Shamel,L., Sovath,S., Goode,J., Alexopoulou,L.,
            Flavell,R.A. and Beutler,B.
  TITLE     Toll-like receptors 9 and 3 as essential components of innate
            immune defense against mouse cytomegalovirus infection
  JOURNAL   Proc Natl Acad Sci U S A 101 (10), 3516-3521 (2004)
   PUBMED   14993594
REFERENCE   10 (bases 1 to 3174)
  AUTHORS   Zhang,D., Zhang,G., Hayden,M.S., Greenblatt,M.B., Bussey,C.,
            Flavell,R.A. and Ghosh,S.
  TITLE     A toll-like receptor that prevents infection by uropathogenic
            bacteria
  JOURNAL   Science 303 (5663), 1522-1526 (2004)
   PUBMED   15001781
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK137624.1.
            
            On Jun 2, 2007 this sequence version replaced NM_205823.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK137624.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3174              AK137624.1         2-3175
FEATURES             Location/Qualifiers
     source          1..3174
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 62.08 cM"
     gene            1..3174
                     /gene="Tlr12"
                     /gene_synonym="Gm1365; Tlr11"
                     /note="toll-like receptor 12"
                     /db_xref="GeneID:384059"
                     /db_xref="MGI:MGI:3045221"
     exon            1..3174
                     /gene="Tlr12"
                     /gene_synonym="Gm1365; Tlr11"
                     /inference="alignment:Splign:2.1.0"
     CDS             165..2885
                     /gene="Tlr12"
                     /gene_synonym="Gm1365; Tlr11"
                     /EC_number="3.2.2.6"
                     /note="toll-like receptor 11"
                     /codon_start=1
                     /product="toll-like receptor 12 precursor"
                     /protein_id="NP_991392.1"
                     /db_xref="CCDS:CCDS18673.1"
                     /db_xref="GeneID:384059"
                     /db_xref="MGI:MGI:3045221"
                     /translation="MGRYWLLPGLLLSLPLVTGWSTSNCLVTEGSRLPLVSRYFTFCR
                     HSKLSFLAACLSVSNLTQTLEVVPRTVEGLCLGGTVSTLLPDAFSAFPGLKVLALSLH
                     LTQLLPGALRGLGQLQSLSFFDSPLRRSLFLPPDAFSDLISLQRLHISGPCLDKKAGI
                     RLPPGLQWLGVTLSCIQDVGELAGMFPDLVQGSSSRVSWTLQKLDLSSNWKLKMASPG
                     SLQGLQVEILDLTRTPLDAVWLKGLGLQKLDVLYAQTATAELAAEAVAHFELQGLIVK
                     ESKIGSISQEALASCHSLKTLGLSSTGLTKLPPGFLTAMPRLQRLELSGNQLQSAVLC
                     MNETGDVSGLTTLDLSGNRLRILPPAAFSCLPHLRELLLRYNQLLSLEGYLFQELQQL
                     ETLKLDGNPLLHLGKNWLAALPALTTLSLLDTQIRMSPEPGFWGAKNLHTLSLKLPAL
                     PAPAVLFLPMYLTSLELHIASGTTEHWTLSPAIFPSLETLTISGGGLKLKLGSQNASG
                     VFPALQKLSLLKNSLDAFCSQGTSNLFLWQLPKLQSLRVWGAGNSSRPCLITGLPSLR
                     ELKLASLQSITQPRSVQLEELVGDLPQLQALVLSSTGLKSLSAAAFQRLHSLQVLVLE
                     YEKDLMLQDSLREYSPQMPHYIYILESNLACHCANAWMEPWVKRSTKTYIYIRDNRLC
                     PGQDRLSARGSLPSFLWDHCPQTLELKLFLASSALVFMLIALPLLQEARNSWIPYLQA
                     LFRVWLQGLRGKGDKGKRFLFDVFVSHCRQDQGWVIEELLPALEGFLPAGLGLRLCLP
                     ERDFEPGKDVVDNVVDSMLSSRTTLCVLSGQALCNPRCRLELRLATSLLLAAPSPPVL
                     LLVFLEPISRHQLPGYHRLARLLRRGDYCLWPEEEERKSGFWTWLRSRLG"
ORIGIN      
        1 agtgctaagt atctccaagt cggcctcctc acttcccggc ttccacagtg gccctttgac
       61 ggtgctcccg gaccttgcag gtactctgag gtggatgaga gtattggtaa cccggaggca
      121 taggagtcta aagtcctctc agctctgatt cctctggtgt agagatgggc aggtactggc
      181 tgctgccagg tctcctcctt tccctgcctc tggtaactgg gtggagcact tccaactgcc
      241 tggtgaccga aggctcccga ctgcccctgg tctcccgcta tttcacattc tgccgccatt
      301 ccaagctatc ctttcttgct gcatgcctct ccgtgagcaa cctgacacag accttggaag
      361 ttgtacctcg gactgtggag gggctctgcc tcggtggtac tgtgtctact ctgcttccag
      421 atgctttctc tgcttttcct ggtctcaagg tcctggcact gagtctgcac cttacccaac
      481 ttctgccagg agctctccgg ggtctgggac agttgcagag cctctctttt tttgactctc
      541 ctcttaggag atctctcttt ctacctcctg atgccttcag tgacctgatt tccctccaga
      601 gactccatat ctctggccct tgcctggata agaaggcagg catccgcctg cctcccggtc
      661 tgcaatggct gggtgtcacg ctcagttgca ttcaggacgt gggagagctg gctggtatgt
      721 tcccagatct ggtgcaaggt tcctcctcca gggtttcgtg gaccctgcag aagttggatc
      781 tgtcatccaa ctggaagctg aagatggcta gtcctgggtc cctccagggt ctccaggtgg
      841 agattctgga cctgacaaga acaccactgg atgccgtgtg gctgaagggc ctgggacttc
      901 agaaactcga tgtcttgtat gcacagactg ccacggccga gctggctgct gaggctgttg
      961 cccactttga gctgcagggc ttgattgtga aagaaagcaa gataggatct atatctcagg
     1021 aggctctggc ttcctgccac agcctgaaga ccttgggtct ttcaagcact ggcctaacca
     1081 agcttccacc aggcttcctg actgccatgc ctaggcttca gcgactggag ctgtccggaa
     1141 accaactgca gagcgccgtg ctgtgcatga atgagacggg agatgtgtca ggactcacga
     1201 ctctggatct gtcaggcaac aggttgcgca tcctgcctcc agccgccttc tcctgcttac
     1261 cccacttgcg agagctgctg cttcggtaca accagctgct ttccctggag ggatacctat
     1321 tccaggagct ccagcaacta gagaccttga agctggatgg aaaccccctg cttcacctgg
     1381 gtaagaactg gttggcggct ctgcctgcat tgaccaccct tagcttgcta gatacccaaa
     1441 tacggatgag cccagagcct ggcttctggg gagcaaagaa tctgcatacc ttgagcctga
     1501 agcttcccgc tctccctgct ccggcagtat tgttcctgcc catgtatctg accagcttag
     1561 agcttcatat agcctcaggc acgacggagc actggacgct gtccccagcg atctttcctt
     1621 ccttggagac cttgactata agcggcgggg gactgaagct gaagctgggg tcccagaatg
     1681 cttctggggt cttccctgct ctccagaagc tctccctgct taagaacagc ttggatgcct
     1741 tctgctccca gggtacctcc aaccttttcc tctggcagct ccccaaactt cagtccttga
     1801 gggtatgggg tgctggaaac agctccagac cctgccttat cactgggctg cccagcctac
     1861 gggagctgaa gctggcgtcg cttcagtcca taacccagcc ccgttcggtg cagctggagg
     1921 agctggtggg tgaccttcca cagctccagg ccttagtgct atccagcaca ggcctcaagt
     1981 cactgtcggc tgctgctttc cagcgcctgc acagtctcca ggtcttagtg ctagaatacg
     2041 agaaggactt gatgctgcag gacagtctga gggagtacag ccctcagatg ccccactata
     2101 tatacattct ggagtcaaac ctggcctgcc actgtgccaa tgcgtggatg gagccatggg
     2161 ttaagcggtc cactaaaacg tacatataca taagagacaa tcgcttatgt ccaggacaag
     2221 acaggctctc tgctaggggt tcccttccct cctttctctg ggaccactgc ccccagacgt
     2281 tggagctgaa actctttttg gctagttctg ccttggtgtt catgctaatt gccttgcctc
     2341 tcctccaaga agccaggaac tcttggatcc cctacctgca ggccttgttc agggtttggc
     2401 tccagggtct gaggggtaag ggagacaagg ggaagaggtt cctttttgat gtattcgtgt
     2461 cccactgcag gcaagaccag ggctgggtga tagaggaact tctgcctgct ctggagggct
     2521 tccttccagc tggcctgggc ctgcgcctct gtctccccga gcgtgacttt gagcctggta
     2581 aggatgtagt tgataatgtg gtagatagca tgttgagcag ccgtaccaca ctctgcgtgt
     2641 tgagtgggca ggccctgtgt aacccccgat gccgcctgga gctccgcttg gccacctctc
     2701 tcctcctggc tgccccgtcc cctccagtgt tgctgctagt cttcttggaa cccatttctc
     2761 ggcaccagct tccgggttac cacagactgg ctcggctgct tcgaagagga gactactgtc
     2821 tgtggcccga ggaagaggag agaaagagtg ggttctggac ttggctgagg agcaggctag
     2881 ggtagccata gccagcactg gtgtggggtg gtgcatgtga attttggggt ggggttgggg
     2941 gaagggaagc aagcctgcct gtcaaggagt tggtgtgttt gtaggtgcag ggtcggggac
     3001 agtgggtcta agaggctgaa gtcagccttt tgcagcgcag gaatccacgt gctgtgaaca
     3061 caggttttgg ggggcctgga ggttgaatga ggaaaactga gagatggaag gtgtccgcgg
     3121 ggtatgtgac attcccaaga tcttcaaatc ctcagtaaac ttgctaaatt catg
//
