LOCUS       NM_001276445            3021 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus toll-like receptor 1 (Tlr1), transcript variant 2,
            mRNA.
ACCESSION   NM_001276445
VERSION     NM_001276445.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3021)
  AUTHORS   Jia,D.J., Wang,Q.W., Hu,Y.Y., He,J.M., Ge,Q.W., Qi,Y.D., Chen,L.Y.,
            Zhang,Y., Fan,L.N., Lin,Y.F., Sun,Y., Jiang,Y., Wang,L., Fang,Y.F.,
            He,H.Q., Pi,X.E., Liu,W., Chen,S.J. and Wang,L.J.
  TITLE     Lactobacillus johnsonii alleviates colitis by TLR1/2-STAT3 mediated
            CD206+ macrophagesIL-10 activation
  JOURNAL   Gut Microbes 14 (1), 2145843 (2022)
   PUBMED   36398889
  REMARK    GeneRIF: Lactobacillus johnsonii alleviates colitis by TLR1/2-STAT3
            mediated CD206[+] macrophages[IL-10] activation.
REFERENCE   2  (bases 1 to 3021)
  AUTHORS   Baumann,A., Nier,A., Hernandez-Arriaga,A., Brandt,A., Lorenzo
            Pisarello,M.J., Jin,C.J., Pilar,E., Camarinha-Silva,A.,
            Schattenberg,J.M. and Bergheim,I.
  TITLE     Toll-like receptor 1 as a possible target in non-alcoholic fatty
            liver disease
  JOURNAL   Sci Rep 11 (1), 17815 (2021)
   PUBMED   34497333
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3021)
  AUTHORS   Yiu,J.H.C., Cheung,S.W.M., Cai,J., Chan,K.S., Chen,J., Cheong,L.Y.,
            Chau,H.T., Xu,A., Li,R.H.W. and Woo,C.W.
  TITLE     TLR5 Supports Development of Placental Labyrinthine Zone in Mice
  JOURNAL   Front Cell Dev Biol 9, 711253 (2021)
   PUBMED   34395439
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3021)
  AUTHORS   Gao,Y., Sun,Y., Ercan-Sencicek,A.G., King,J.S., Akerberg,B.N.,
            Ma,Q., Kontaridis,M.I., Pu,W.T. and Lin,Z.
  TITLE     YAP/TEAD1 Complex Is a Default Repressor of Cardiac Toll-Like
            Receptor Genes
  JOURNAL   Int J Mol Sci 22 (13), 6649 (2021)
   PUBMED   34206257
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3021)
  AUTHORS   Monlish,D.A., Greenberg,Z.J., Bhatt,S.T., Leonard,K.M.,
            Romine,M.P., Dong,Q., Bendesky,L., Duncavage,E.J., Magee,J.A. and
            Schuettpelz,L.G.
  TITLE     TLR2/6 signaling promotes the expansion of premalignant
            hematopoietic stem and progenitor cells in the NUP98-HOXD13 mouse
            model of MDS
  JOURNAL   Exp Hematol 88, 42-55 (2020)
   PUBMED   32652111
REFERENCE   6  (bases 1 to 3021)
  AUTHORS   Hajjar,A.M., O'Mahony,D.S., Ozinsky,A., Underhill,D.M., Aderem,A.,
            Klebanoff,S.J. and Wilson,C.B.
  TITLE     Cutting edge: functional interactions between toll-like receptor
            (TLR) 2 and TLR1 or TLR6 in response to phenol-soluble modulin
  JOURNAL   J Immunol 166 (1), 15-19 (2001)
   PUBMED   11123271
REFERENCE   7  (bases 1 to 3021)
  AUTHORS   Ozinsky,A., Underhill,D.M., Fontenot,J.D., Hajjar,A.M., Smith,K.D.,
            Wilson,C.B., Schroeder,L. and Aderem,A.
  TITLE     The repertoire for pattern recognition of pathogens by the innate
            immune system is defined by cooperation between toll-like receptors
  JOURNAL   Proc Natl Acad Sci U S A 97 (25), 13766-13771 (2000)
   PUBMED   11095740
REFERENCE   8  (bases 1 to 3021)
  AUTHORS   Xu,Y., Tao,X., Shen,B., Horng,T., Medzhitov,R., Manley,J.L. and
            Tong,L.
  TITLE     Structural basis for signal transduction by the Toll/interleukin-1
            receptor domains
  JOURNAL   Nature 408 (6808), 111-115 (2000)
   PUBMED   11081518
REFERENCE   9  (bases 1 to 3021)
  AUTHORS   Qureshi,S.T., Gros,P. and Malo,D.
  TITLE     Host resistance to infection: genetic control of lipopolysaccharide
            responsiveness by TOLL-like receptor genes
  JOURNAL   Trends Genet 15 (8), 291-294 (1999)
   PUBMED   10431187
  REMARK    Review article
REFERENCE   10 (bases 1 to 3021)
  AUTHORS   Takeuchi,O., Kawai,T., Sanjo,H., Copeland,N.G., Gilbert,D.J.,
            Jenkins,N.A., Takeda,K. and Akira,S.
  TITLE     TLR6: A novel member of an expanding toll-like receptor family
  JOURNAL   Gene 231 (1-2), 59-65 (1999)
   PUBMED   10231569
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC161757.5.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 encode the same protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK143721.1, BY732520.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849388, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                AC161757.5         78104-78136
            34-333              AC161757.5         78562-78861
            334-402             AC161757.5         81439-81507
            403-3021            AC161757.5         84364-86982
FEATURES             Location/Qualifiers
     source          1..3021
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 33.53 cM"
     gene            1..3021
                     /gene="Tlr1"
                     /note="toll-like receptor 1"
                     /db_xref="GeneID:21897"
                     /db_xref="MGI:MGI:1341295"
     exon            1..33
                     /gene="Tlr1"
                     /inference="alignment:Splign:2.1.0"
     exon            34..333
                     /gene="Tlr1"
                     /inference="alignment:Splign:2.1.0"
     exon            334..402
                     /gene="Tlr1"
                     /inference="alignment:Splign:2.1.0"
     exon            403..3021
                     /gene="Tlr1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2998..3003
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tlr1"
                     /note="hexamer: AATAAA"
     polyA_site      3019
                     /gene="Tlr1"
                     /note="major polyA site"
ORIGIN      
        1 ttactgctct gccggacggg taaggttgtc ttgacggaac acgttgtgac ccacatacac
       61 ttgagtgtgt ttactaagag cccacgtgtt ggataccttc tctgaggcat gaagagagcg
      121 gaagctcagg ctgaccatgg catttggggg tggtcctttt cgaggaaact aggattggat
      181 tccatcagat caccagagta gctagcttca tcgaagcaga gatgcaaccg gaaggcatac
      241 acgtgtcccc atctctcgcc ggatgctgcg ctgggattct gctctcaggg tcatcgcagg
      301 atgtgactga ccccttgtcg gtagagcaga actagtgttt gtgaatgcag ttggtgaaga
      361 actcaggcga gcagaggcaa ttgtggacac ccctacagaa acgtcctata cccatgtggc
      421 aatgctctga agaatagcag ggacctcagg aatgtctatg gccatacaat gactaaacca
      481 aattccctca tcttctactg tatcattgtt ttaggactga cacttatgaa aatccaatta
      541 tctgaggaat gtgagcttat cataaagagg ccaaacgcaa accttaccag agtgcccaag
      601 gacctaccct tgcaaacaac tactttagat ctatcacaaa acaatatatc tgagcttcag
      661 acttctgaca tcctctcatt gtccaagctg agggtcctga taatgtccta caacagactc
      721 cagtatctta atatcagtgt tttcaaattc aacacagagc tggaatattt ggatttgtcc
      781 cacaatgagc taaaggtgat cttgtgccac ccaacagtca gcctcaagca tttggacctc
      841 tcctttaatg cctttgatgc cctgcctata tgcaaagaat ttggcaacat gtcccaacta
      901 cagttcctgg ggttgagcgg ttctcgggta caaagttcaa gtgtgcagct gattgctcat
      961 ttgaacatca gtaaggtttt gctggtgtta ggagatgctt atggggaaaa agaagacccc
     1021 gaatctcttc ggcacgttag cactgagact ctgcatattg ttttcccgtc gaaaagagaa
     1081 ttccgttttc ttctggatgt gtccgtcagc actacgatcg gtttggaact gtctaacatc
     1141 aagtgtgtgc ttgaagacca gggctgctct tatttcttac gtgctttgtc aaagcttgga
     1201 aagaatctga agctctcaaa tcttaccctg aacaatgtgg aaacaacgtg gaattccttc
     1261 attaatatcc tccagatagt ttggcatacg ccagtcaaat atttctcaat ttcaaatgtg
     1321 aagctacaag gtcaacttgc cttcaggatg ttcaattatt ctgacacttc tctgaaggct
     1381 ttgtcgatac atcaagttgt cactgatgtc ttcagcttcc cccaaagtta catatacagt
     1441 atctttgcca atatgaacat ccaaaacttt acaatgtctg gaacacacat ggtccacatg
     1501 ctgtgcccgt cccaagttag cccatttctg catgtggact ttacagataa ccttttaaca
     1561 gacatggttt ttaaagactg tagaaactta gttagattga aaacacttag tttacaaaag
     1621 aatcagttaa aaaaccttga gaatataatc ctcacatctg caaagatgac atccctacaa
     1681 aaactagaca ttagccagaa ttctctaagg tacagcgatg ggggaatccc atgcgcctgg
     1741 acccagagtt tgttagtttt aaatttgtct tcgaatatgc ttacaggctc tgtcttcaga
     1801 tgcttacctc ccaaagtcaa ggtccttgac cttcacaaca acaggataat gagcatccct
     1861 aaagatgtca cccacctgca ggctttgcag gaactcaatg tagcatccaa ctccttaact
     1921 gaccttcctg ggtgcggggc cttcagcagc ctttctgtgc tggtcatcga ccataactca
     1981 gtttcccatc cctctgagga tttcttccag agctgtcaga atattagatc cctaacagcg
     2041 ggaaacaacc cattccaatg cacatgtgag ctgagggact ttgtcaagaa cataggctgg
     2101 gtagcaagag aagtggtgga gggctggcct gactcttaca ggtgtgacta cccagaaagc
     2161 tctaggggaa ctgcactgag ggacttccac atgtctccac tatcctgtga tactgttctg
     2221 ctgactgtca ccatcggggc cactatgctg gtgctggctg tcactggggc tttcctctgt
     2281 ctctactttg acctgccctg gtatgtgagg atgctgtgtc agtggacaca gaccaggcac
     2341 agggccaggc acatcccctt agaggaactc cagagaaacc tccagttcca tgcttttgtc
     2401 tcatacagtg ggcatgattc tgcctgggtg aagaacgaat tactacccaa cctagagaaa
     2461 gatgacatcc agatttgcct ccatgagagg aactttgtcc ctggcaagag cattgtggag
     2521 aacatcatca atttcattga gaagagttac aagtccatct ttgtgctgtc tccccacttc
     2581 atccagagtg agtggtgtca ttatgaactc tattttgccc atcacaatct cttccatgaa
     2641 ggctctgata acttaatcct catcttgctg gcacccattc cccagtactc catccctacc
     2701 aattaccaca agctcaaaac tctcatgtca cgaaggacct atctggaatg gcccacagag
     2761 aagaacaagc atggactttt ttgggcaaac ctaagagcat ccattaatgt taagctggtt
     2821 aaccaggcag aaggaacgtg ttacacacag caataagaat atccacctca atgatgttgc
     2881 tgctctgggg agttctaata atagtaccat tcatatcagc aagaacctaa aaatggttct
     2941 gactttacaa tgtgggaatt tgtgcttttt agcccaagtt taccgctagt gttttctaat
     3001 aaaaattagt gggatactat a
//
