LOCUS       NM_030705               3847 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus talin rod domain containing 1 (Tlnrd1), mRNA.
ACCESSION   NM_030705
VERSION     NM_030705.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3847)
  AUTHORS   Dali,O., D'Cruz,S., Legoff,L., Diba Lahmidi,M., Heitz,C.,
            Merret,P.E., Kernanec,P.Y., Pakdel,F. and Smagulova,F.
  TITLE     Transgenerational epigenetic effects imposed by neonicotinoid
            thiacloprid exposure
  JOURNAL   Life Sci Alliance 7 (2), e202302237 (2023)
   PUBMED   37973188
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3847)
  AUTHORS   Tang,F., Barbacioru,C., Nordman,E., Bao,S., Lee,C., Wang,X.,
            Tuch,B.B., Heard,E., Lao,K. and Surani,M.A.
  TITLE     Deterministic and stochastic allele specific gene expression in
            single mouse blastomeres
  JOURNAL   PLoS One 6 (6), e21208 (2011)
   PUBMED   21731673
REFERENCE   3  (bases 1 to 3847)
  AUTHORS   Gingras,A.R., Bate,N., Goult,B.T., Patel,B., Kopp,P.M., Emsley,J.,
            Barsukov,I.L., Roberts,G.C. and Critchley,D.R.
  TITLE     Central region of talin has a unique fold that binds vinculin and
            actin
  JOURNAL   J Biol Chem 285 (38), 29577-29587 (2010)
   PUBMED   20610383
  REMARK    GeneRIF: Study show that the MESDc1 protein, which is predicted to
            have a similar fold, is a novel actin-binding protein.
REFERENCE   4  (bases 1 to 3847)
  AUTHORS   Li,Y., Lu,W., He,X. and Bu,G.
  TITLE     Modulation of LRP6-mediated Wnt signaling by molecular chaperone
            Mesd
  JOURNAL   FEBS Lett 580 (22), 5423-5428 (2006)
   PUBMED   16989816
REFERENCE   5  (bases 1 to 3847)
  AUTHORS   Wines,M.E., Lee,L., Katari,M.S., Zhang,L., DeRossi,C., Shi,Y.,
            Perkins,S., Feldman,M., McCombie,W.R. and Holdener,B.C.
  TITLE     Identification of mesoderm development (mesd) candidate genes by
            comparative mapping and genome sequence analysis
  JOURNAL   Genomics 72 (1), 88-98 (2001)
   PUBMED   11247670
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB629761.1, AK162446.1 and AK084510.1.
            
            On May 25, 2007 this sequence version replaced NM_030705.3.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-308               BB629761.1         1-308
            309-2693            AK162446.1         196-2580
            2694-3847           AK084510.1         2640-3793
FEATURES             Location/Qualifiers
     source          1..3847
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 48.33 cM"
     gene            1..3847
                     /gene="Tlnrd1"
                     /gene_synonym="Mesdc1"
                     /note="talin rod domain containing 1"
                     /db_xref="GeneID:80889"
                     /db_xref="MGI:MGI:1891420"
     exon            1..3847
                     /gene="Tlnrd1"
                     /gene_synonym="Mesdc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             1121..2209
                     /gene="Tlnrd1"
                     /gene_synonym="Mesdc1"
                     /note="mesoderm development candidate 1"
                     /codon_start=1
                     /product="talin rod domain-containing protein 1"
                     /protein_id="NP_109630.1"
                     /db_xref="CCDS:CCDS21414.1"
                     /db_xref="GeneID:80889"
                     /db_xref="MGI:MGI:1891420"
                     /translation="MASGSAGKPTGEAASPAPGSAVGGASSQPRKRLVSICDHCKGKM
                     QLVADLLLLSSEARPVLFEGPASPGAGAESFEQCRDTIIARTKGLSILTHDVQSQLNM
                     GRFGEAGDSLVELGDLVVSLTECSAHAAYLAAVATPGAQPAQPGLVDRYRVTRCRHEV
                     EQGCAVLRATPLADMTPQLLLEVSQGLSRNLKFLTDACALASDKSRDRFSREQFKLGV
                     KCMSTSASALLACVREVKAAPSELARSRCALFSGPLVQAVSALVGFATEPQFLGRAAA
                     VSTEGKAVQTAILGGAMSVVSACVLLTQCLRDLAQHPDGSAKMSDHRERLRNSACAVS
                     EGCTLLSQALRERSSPRTLPPVNSNSVN"
     regulatory      2802..2807
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tlnrd1"
                     /gene_synonym="Mesdc1"
                     /note="hexamer: ATTAAA"
     polyA_site      2824
                     /gene="Tlnrd1"
                     /gene_synonym="Mesdc1"
                     /note="major polyA site"
     regulatory      3272..3277
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tlnrd1"
                     /gene_synonym="Mesdc1"
                     /note="hexamer: ATTAAA"
     polyA_site      3293
                     /gene="Tlnrd1"
                     /gene_synonym="Mesdc1"
     regulatory      3590..3595
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tlnrd1"
                     /gene_synonym="Mesdc1"
                     /note="hexamer: AATAAA"
     polyA_site      3614
                     /gene="Tlnrd1"
                     /gene_synonym="Mesdc1"
ORIGIN      
        1 aagcgggatt taaacgaaag gcggtgacgc cacacaaaag attcctatag gctccgggga
       61 ggttacggcc gaggtggcgg cggcgagccg ggggcgaggc ggacgccagg aggcgaaaac
      121 tgcaaccgtg cgcgggcagg cgggtgtccc ctggcctgcg gtctcctccc ttcctttcag
      181 ttgctcggag gtcgctcgga agttgctggt tgacaaacat ggcaggagtc cgggcccggg
      241 tcggcctccg cgacgccgcg ctcaccttct gagccgacca ccctggggcg tcggatgcgc
      301 ggggcccgcg ggctctgcgg ggaaacacag atggaatctc cacgacagcc ggtcgccggc
      361 cgcaggccat tcaggagggg agggcgtgcc gccgcggcgc cgggccgcgc actctgaacc
      421 gccaggcggg aaggcgcggc cgcccagcac cctgcgttgc agcctcccgc ccgactgact
      481 ccgcgcggcc gccacagagc cagccacgcc ctcggcccag tggccgccca gcgccctaag
      541 agccggagca ggagatgcgg ccgcgcgccc ccgggcgtca gctccggccg ccgtcgccag
      601 cctgtaccgt ctggcggggt cgccgcccct gaagcccacg tgcgctgctg agccggatag
      661 ccgcagcgca gcggctgaca gcaaagcctg ccggggccgc cgcccgcgct cctctaggag
      721 cagaggattt tgatttcaaa ggaaggaagg aaggaaggac aactcccagc ctccccgtcc
      781 cgccctctcc gctccggcgg cccggccggc catgcccagg aaggtggcga cagcccggca
      841 gcggggactt ttctggtagg ctagtgaaga ggggcgcgga ctaggagtct gccgtgcccc
      901 ggctcacggt tcccgcgagc tacacagcgc cccgaagagc ttgccgcggg cttgggcccg
      961 ccctgcgacg cccggccacc ggccgccgcc acccggatct ctgtgcccgc cgcggtgggt
     1021 ggcatgatgg tgcgcggaag gcagcgcggc cctggccagc tgagtcgcgg cggcggtggt
     1081 agcgggctcc ccagcggcat gccagtgccc cctgggcgcg atggctagcg gcagcgccgg
     1141 gaagcccact ggcgaggcgg cttctccggc tcctgggagc gccgtcggcg gggccagctc
     1201 gcagccgcgg aagaggctgg tatctatctg tgatcactgc aagggcaaga tgcagctggt
     1261 ggccgacctg ctgctgctgt ctagcgaggc gcggccggtg ctcttcgaag gccccgcctc
     1321 ccctggcgct ggtgcggagt ccttcgagca gtgccgggac accatcatcg cgcgcactaa
     1381 ggggctgtcc atcctcaccc acgacgtgca gagccagctc aacatgggcc gcttcggaga
     1441 ggcgggagac agtcttgtgg aactgggcga cttggtggtg tcgctgaccg agtgttctgc
     1501 acatgcggcc tacctggcag ccgtggccac accgggcgct caacctgcac agccaggcct
     1561 tgtggaccgc taccgtgtga cacgctgccg ccacgaggta gaacaaggct gtgctgtgct
     1621 gcgagccacc ccactggcgg acatgacccc acagctgttg ctggaggtgt cgcagggcct
     1681 gtctcgaaac ctcaagttcc tgacggatgc gtgcgccctg gccagtgaca agtcacggga
     1741 ccgcttctct cgcgaacagt tcaagctggg cgtcaagtgc atgagcacaa gtgcatccgc
     1801 gctgttagca tgcgtacgcg aagtgaaggc ggcacccagc gagctggccc gcagtcgttg
     1861 cgcgctcttc agtgggccct tggtgcaggc ggtgagcgct ttggtgggct ttgccaccga
     1921 gcctcaattc ctgggtcgcg cagctgccgt gagcactgag ggcaaggcgg tgcagaccgc
     1981 catcctggga ggtgccatga gtgtggtgtc ggcctgcgtg ctcttgaccc agtgcctcag
     2041 ggatctggcg cagcacccag atgggagcgc caagatgtcg gaccacaggg agaggctgag
     2101 gaactcggcc tgcgccgtgt ctgaaggctg caccctgcta tctcaggctt taagggaaag
     2161 gtcttcaccc aggactttac cgccagtgaa ttccaattct gtgaattagc actccccacg
     2221 ctccaccccc accccagccc ctatacctgt tttccacccc aggctaaagg aagacactta
     2281 acccctcccc tctccattta taccaaagaa tccataggtg atcccctccc tcatgttaaa
     2341 tgctcaagag gaattttcca gaaggcaggg ccatgcaatc atcaagtact cagagggcct
     2401 gggtgtccac cagcccacta tagggactca gacacagaga agatgggtag tctgctggct
     2461 gcagggttaa ccctacacac tcgagcccct caactcagtt atcaattggg caggaaagag
     2521 gtcatgggct catttcttcc ttctttttaa ttaatgaaag gttacctcag ttttccctcc
     2581 tttagacatg gatgtagcta cctttttgta tgtcgttatt tttgttgaat tagagtatac
     2641 atggtgtgaa aaagagtatg actttgccat atgatttgca agtggggggg aaagctactg
     2701 tgagcgtgtg ttttattttt taaattacac tatagagtga tttccccccc cccccaatgt
     2761 caagttttta ccctgcatgt actggagtat ttatttcatc tattaaattg ttatgtttct
     2821 cagatggctt ttcgcagtta ctgtcttttc actaactgtg catgccgcct gccatctgtg
     2881 ggaaggagct gtggggggaa aaaggtttac atccattggc aagtgaatcc ccagtgccta
     2941 accatttcca ctctaaaatt ccattttccc tctggtatta ttcctctgag catccttgca
     3001 ccctagaaag acaaatgtat gtgatctatt tttaaaggca atcgaatgtg attggactat
     3061 gcagtgcgtg ggggaggact gttagtgggg aggactgtta gtggggagga ctgttagtgg
     3121 ggaggactgt tagtggggat tttgtcttct tccctctagt ttttctggaa agtaacctag
     3181 ctctctttgt cctccactca tttctctatt ataatgagcc ataggttcag gcttactgaa
     3241 atctgatttg tattcggcct gtcattttca gattaaagta cttcctaata ctgtgtgggg
     3301 tgctgccttg ccagctcaca gaattttgca tgggacttaa cagcactgta tcaactgatc
     3361 ctttagcatc ttcagtgagg ctaggcctaa cccagaaatc tctatgactt tatagaaggt
     3421 tctaggcagt ttgataaaag agtctatcct ctggacttag aactttctag agcatgcttg
     3481 tcagtggagg gcttgttttt atgaccttga ttcaagtggc tggttgggta ttgaaagagt
     3541 attttgttga ttgaaatcat gtcgaggtag tttggctttt ctgtagataa ataaatttgg
     3601 gatggacttt ttaaggggga gtttatggct tgttgaagac actgttgaat agtttcttac
     3661 taaatagagt gacaaactta tctatagcct tgaaacctgg atgagccaca tgcgcaaaaa
     3721 actcctgtag gctttcagtg tatcatttac tttttcaggg ggttttattg tgcttaaacc
     3781 tttccagtgc ccacagatct gaaaagttgt caccataaaa tgttagcagc aaaatgaaat
     3841 ttaactt
//
