LOCUS       NM_011602               8560 bp    mRNA    linear   ROD 04-OCT-2024
DEFINITION  Mus musculus talin 1 (Tln1), mRNA.
ACCESSION   NM_011602
VERSION     NM_011602.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8560)
  AUTHORS   Terri,M., Sandoval,P., Bontempi,G., Montaldo,C., Tomero-Sanz,H., de
            Turris,V., Trionfetti,F., Pascual-Anton,L., Clares-Pedrero,I.,
            Battistelli,C., Valente,S., Zwergel,C., Mai,A., Rosano,L., Del
            Pozo,M.A., Sanchez-Alvarez,M., Cabanas,C., Tripodi,M.,
            Lopez-Cabrera,M. and Strippoli,R.
  TITLE     HDAC1/2 control mesothelium/ovarian cancer adhesive interactions
            impacting on Talin-1-alpha5beta1-integrin-mediated actin
            cytoskeleton and extracellular matrix protein remodeling
  JOURNAL   J Exp Clin Cancer Res 43 (1), 27 (2024)
   PUBMED   38254102
  REMARK    GeneRIF: HDAC1/2 control mesothelium/ovarian cancer adhesive
            interactions impacting on Talin-1-alpha5beta1-integrin-mediated
            actin cytoskeleton and extracellular matrix protein remodeling.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8560)
  AUTHORS   Latour,Y.L., McNamara,K.M., Allaman,M.M., Barry,D.P., Smith,T.M.,
            Asim,M., Williams,K.J., Hawkins,C.V., Jacobse,J., Goettel,J.A.,
            Delgado,A.G., Piazuelo,M.B., Washington,M.K., Gobert,A.P. and
            Wilson,K.T.
  TITLE     Myeloid deletion of talin-1 reduces mucosal macrophages and
            protects mice from colonic inflammation
  JOURNAL   Sci Rep 13 (1), 22368 (2023)
   PUBMED   38102166
  REMARK    GeneRIF: Myeloid deletion of talin-1 reduces mucosal macrophages
            and protects mice from colonic inflammation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8560)
  AUTHORS   Hou,X., Chen,Y., Zhou,B., Tang,W., Ding,Z., Chen,L., Wu,Y.,
            Yang,H., Du,C., Yang,D., Ma,G. and Cao,H.
  TITLE     Talin-1 inhibits Smurf1-mediated Stat3 degradation to modulate
            beta-cell proliferation and mass in mice
  JOURNAL   Cell Death Dis 14 (10), 709 (2023)
   PUBMED   37903776
  REMARK    GeneRIF: Talin-1 inhibits Smurf1-mediated Stat3 degradation to
            modulate beta-cell proliferation and mass in mice.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8560)
  AUTHORS   Sun,H., Lee,H.S., Kim,S.H., Fernandes de Lima,M., Gingras,A.R.,
            Du,Q., McLaughlin,W., Ablack,J., Lopez-Ramirez,M.A., Lagarrigue,F.,
            Fan,Z., Chang,J.T., VanDyke,D., Spangler,J.B. and Ginsberg,M.H.
  TITLE     IL-2 can signal via chemokine receptors to promote regulatory T
            cells' suppressive function
  JOURNAL   Cell Rep 42 (8), 112996 (2023)
   PUBMED   37598341
REFERENCE   5  (bases 1 to 8560)
  AUTHORS   Horitani,S., Ueda,Y., Kamioka,Y., Kondo,N., Ikeda,Y., Naganuma,M.
            and Kinashi,T.
  TITLE     The critical role of Rap1-GAPs Rasa3 and Sipa1 in T cells for
            pulmonary transit and egress from the lymph nodes
  JOURNAL   Front Immunol 14, 1234747 (2023)
   PUBMED   37545505
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 8560)
  AUTHORS   Menko,A.S., Kreidberg,J.A., Ryan,T.T., Van Bockstaele,E. and
            Kukuruzinska,M.A.
  TITLE     Loss of alpha3beta1 integrin function results in an altered
            differentiation program in the mouse submandibular gland
  JOURNAL   Dev Dyn 220 (4), 337-349 (2001)
   PUBMED   11307167
REFERENCE   7  (bases 1 to 8560)
  AUTHORS   Monkley,S.J., Zhou,X.H., Kinston,S.J., Giblett,S.M., Hemmings,L.,
            Priddle,H., Brown,J.E., Pritchard,C.A., Critchley,D.R. and
            Fassler,R.
  TITLE     Disruption of the talin gene arrests mouse development at the
            gastrulation stage
  JOURNAL   Dev Dyn 219 (4), 560-574 (2000)
   PUBMED   11084655
REFERENCE   8  (bases 1 to 8560)
  AUTHORS   Adey,N.B. and Kay,B.K.
  TITLE     Isolation of peptides from phage-displayed random peptide libraries
            that interact with the talin-binding domain of vinculin
  JOURNAL   Biochem J 324 (Pt 2) (Pt 2), 523-528 (1997)
   PUBMED   9182713
REFERENCE   9  (bases 1 to 8560)
  AUTHORS   Gilmore,A.P., Ohanian,V., Spurr,N.K. and Critchley,D.R.
  TITLE     Localisation of the human gene encoding the cytoskeletal protein
            talin to chromosome 9p
  JOURNAL   Hum Genet 96 (2), 221-224 (1995)
   PUBMED   7635475
REFERENCE   10 (bases 1 to 8560)
  AUTHORS   Rees,D.J., Ades,S.E., Singer,S.J. and Hynes,R.O.
  TITLE     Sequence and domain structure of talin
  JOURNAL   Nature 347 (6294), 685-689 (1990)
   PUBMED   2120593
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL732506.10, AK147228.1, AK122420.2, BC121787.1 and CJ242702.1.
            
            On Apr 21, 2009 this sequence version replaced NM_011602.4.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK122420.2, AK147228.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-430               AL732506.10        176315-176744       c
            431-4822            AK147228.1         2-4393
            4823-8050           AK122420.2         4449-7676
            8051-8393           BC121787.1         3563-3905
            8394-8560           CJ242702.1         280-446
FEATURES             Location/Qualifiers
     source          1..8560
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 23.05 cM"
     gene            1..8560
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /note="talin 1"
                     /db_xref="GeneID:21894"
                     /db_xref="MGI:MGI:1099832"
     exon            1..454
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            455..617
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     CDS             488..8113
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /codon_start=1
                     /product="talin-1"
                     /protein_id="NP_035732.2"
                     /db_xref="CCDS:CCDS18101.1"
                     /db_xref="GeneID:21894"
                     /db_xref="MGI:MGI:1099832"
                     /translation="MVALSLKISIGNVVKTMQFEPSTMVYDACRMIRERIPEALAGPP
                     NDFGLFLSDDDPKKGIWLEAGKALDYYMLRNGDTMEYRKKQRPLKIRMLDGTVKTIMV
                     DDSKTVTDMLMTICARIGITNHDEYSLVRELMEEKKDEGTGTLRKDKTLLRDEKKMEK
                     LKQKLHTDDELNWLDHGRTLREQGVEEHETLLLRRKFFYSDQNVDSRDPVQLNLLYVQ
                     ARDDILNGSHPVSFDKACEFAGFQCQIQFGPHNEQKHKAGFLDLKDFLPKEYVKQKGE
                     RKIFQAHKNCGQMSEIEAKVRYVKLARSLKTYGVSFFLVKEKMKGKNKLVPRLLGITK
                     ECVMRVDEKTKEVIQEWSLTNIKRWAASPKSFTLDFGDYQDGYYSVQTTEGEQIAQLI
                     AGYIDIILKKKKSKDHFGLEGDEESTMLEDSVSPKKSTVLQQQYNRVGKVEHGSVALP
                     AIMRSGASGPENFQVGSMPPAQQQITSGQMHRGHMPPLTSAQQALTGTINSSMQAVQA
                     AQATLDDFETLPPLGQDAASKAWRKNKMDESKHEIHSQVDAITAGTASVVNLTAGDPA
                     ETDYTAVGCAVTTISSNLTEMSRGVKLLAALLEDEGGNGRPLLQAAKGLAGAVSELLR
                     SAQPASAEPRQNLLQAAGNVGQASGELLQQIGESDTDPHFQDVLMQLAKAVASAAAAL
                     VLKAKSVAQRTEDSGLQTQVIAAATQCALSTSQLVACTKVVAPTISSPVCQEQLVEAG
                     RLVAKAVEGCVSASQAATEDGQLLRGVGAAATAVTQALNELLQHVKAHATGAGPAGRY
                     DQATDTILTVTENIFSSMGDAGEMVRQARILAQATSDLVNAIKADAEGESDLENSRKL
                     LSAAKILADATAKMVEAAKGAAAHPDSEEQQQRLREAAEGLRMATNAAAQNAIKKKLV
                     QRLEHAAKQAAASATQTIAAAQHAASAPKASAGPQPLLVQSCKAVAEQIPLLVQGVRG
                     SQAQPDSPSAQLALIAASQSFLQPGGKMVAAAKASVPTIQDQASAMQLSQCAKNLGTA
                     LAELRTAAQKAQEACGPLEMDSALSVVQNLEKDLQEIKAAARDGKLKPLPGETMEKCT
                     QDLGNSTKAVSSAIAKLLGEIAQGNENYAGIAARDVAGGLRSLAQAARGVAALTSDPA
                     VQAIVLDTASDVLDKASSLIEEAKKASGHPGDPESQQRLAQVAKAVTQALNRCVSCLP
                     GQRDVDNALRAVGDASKRLLSDSLPPSTGTFQEAQSRLNEAAAGLNQAATELVQASRG
                     TPQDLARASGRFGQDFSTFLEAGVEMAGQAPSQEDRAQVVSNLKGISMSSSKLLLAAK
                     ALSTDPASPNLKSQLAAAARAVTDSINQLITMCTQQAPGQKECDNALRQLETVRELLE
                     NPVQPINDMSYFGCLDSVMENSKVLGEAMTGISQNAKNGNLPEFGDAIATASKALCGF
                     TEAAAQAAYLVGVSDPNSQAGQQGLVEPTQFARANQAIQMACQSLGEPGCTQAQVLSA
                     ATIVAKHTSALCNSCRLASARTANPTAKRQFVQSAKEVANSTANLVKTIKALDGDFTE
                     ENRAQCRAATAPLLEAVDNLSAFASNPEFSSVPAQISPEGRAAMEPIVISAKTMLESA
                     GGLIQTARALAVNPRDPPRWSVLAGHSRTVSDSIKKLITSMRDKAPGQLECETAIAAL
                     NSCLRDLDQASLAAVSQQLAPREGISQEALHTQMLTAVQEISHLIEPLASAARAEASQ
                     LGHKVSQMAQYFEPLTLAAVGAASKTLSHPQQMALLDQTKTLAESALQLLYTAKEAGG
                     NPKQAAHTQEALEEAVQMMTEAVEDLTTTLNEAASAAGVVGGMVDSITQAINQLDEGP
                     MGDPEGSFVDYQTTMVRTAKAIAVTVQEMVTKSNTSPEELGPLANQLTSDYGRLASQA
                     KPAAVAAENEEIGAHIKHRVQELGHGCSALVTKAGALQCSPSDVYTKKELIECARRVS
                     EKVSHVLAALQAGNRGTQACITAASAVSGIIADLDTTIMFATAGTLNREGAETFADHR
                     EGILKTAKVLVEDTKVLVQNAAGSQEKLAQAAQSSVATITRLADVVKLGAASLGAEDP
                     ETQVVLINAVKDVAKALGDLISATKAAAGKVGDDPAVWQLKNSAKVMVTNVTSLLKTV
                     KAVEDEATKGTRALEATTEHIRQELAVFCSPEPPAKTSTPEDFIRMTKGITMATAKAV
                     AAGNSCRQEDVIATANLSRRAIADMLRACKEAAFHPEVAPDVRLRALHYGRECANGYL
                     ELLDHVLLTLQKPNPDLKQQLTGHSKRVAGSVTELIQAAEAMKGTEWVDPEDPTVIAE
                     NELLGAAAAIEAAAKKLEQLKPRAKPKEADESLNFEEQILEAAKSIAAATSALVKAAS
                     AAQRELVAQGKVGAIPANALDDGQWSQGLISAARMVAAATNNLCEAANAAVQGHASQE
                     KLISSAKQVAASTAQLLVACKVKADQDSEAMKRLQAAGNAVKRASDNLVKAAQKAAAF
                     EDQENETVVVKEKMVGGIAQIIAAQEEMLRKERELEEARKKLAQIRQQQYKFLPSELR
                     DEH"
     exon            618..715
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            716..845
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            846..998
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1141
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1269
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1330
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            1331..1435
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            1436..1591
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            1592..1693
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            1694..1770
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            1771..1951
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            1952..2065
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            2066..2174
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            2175..2383
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            2384..2482
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            2483..2650
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            2651..2945
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            2946..3112
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            3113..3241
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            3242..3358
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            3359..3472
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            3473..3607
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            3608..3736
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            3737..3839
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            3840..4048
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            4049..4168
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            4169..4366
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            4367..4506
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            4507..4600
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            4601..4690
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            4691..4813
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            4814..4957
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            4958..5119
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            5120..5260
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            5261..5442
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            5443..5575
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            5576..5677
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            5678..5848
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            5849..5998
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            5999..6100
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            6101..6220
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            6221..6367
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            6368..6534
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            6535..6718
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            6719..6844
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            6845..6961
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            6962..7147
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            7148..7255
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            7256..7361
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            7362..7486
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            7487..7612
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            7613..7675
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            7676..7858
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            7859..7987
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            7988..8560
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8538..8543
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /note="hexamer: AATAAA"
     polyA_site      8555
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /note="major polyA site"
ORIGIN      
        1 aactcggaag tggctcctgg gctgcgccac gtcccggggg ctatgcaaat tatggggacg
       61 tcctttcaag cttcccacgc cccagggcgg ggattctgag gatccttgtc cgccttcgcc
      121 tcgagctatt aaaaaaaaaa acttaagcgt ttaaaaggga actccagctt agttcgggcg
      181 ttctctccag agctctgcac gctcgcttcc tgctggggag gggcggccag gcttcgcggg
      241 cgcccgagca tcgagaacta cggccagagc agcttcctgc agtctccgct accatagagc
      301 gcgggcccag ggcgccgccg gcgggtgggg gacgtttcca ggacggaagt ggccgagagt
      361 gtgtcgaagg gagggcgagg ccggagcccc aaaagcgacc gggagaagga gcgggtagcg
      421 ggcccagggc ggggcgcaga gccgggcagc gcaggtatcg ccaggccgaa gagcagaagc
      481 tgccaccatg gttgcgcttt cgctgaagat tagcattggg aatgtggtga agacgatgca
      541 atttgagcca tctaccatgg tgtacgacgc ctgccgcatg attcgtgagc ggatcccaga
      601 ggccctggct ggccctccca acgactttgg gctctttctg tcagatgatg accccaaaaa
      661 aggcatctgg ctagaggctg ggaaagcttt ggactactac atgctccgaa atggggacac
      721 catggagtac agaaaaaagc agagacccct gaagatccgg atgttagacg gaacggtgaa
      781 gactatcatg gtggatgact ccaagaccgt cacagacatg ctcatgacca tttgtgcccg
      841 aattggtatc accaaccatg atgagtattc actggttcga gagctgatgg aagaaaagaa
      901 agatgagggg acagggaccc tgagaaaaga caagacccta ctgcgagatg aaaagaagat
      961 ggagaagcta aagcagaagt tgcacacaga cgatgagttg aactggctgg accatgggcg
     1021 gacactgagg gaacagggag tggaagagca tgagacgttg ctgctgcgga gaaagttctt
     1081 ctactcagac cagaatgtgg attcccgaga ccctgtacag ctgaaccttc tctatgtgca
     1141 ggcacgagat gacatcctga atggctccca tcctgtctcc tttgacaagg cctgtgaatt
     1201 tgcaggcttc cagtgccaga tccagtttgg acctcacaat gaacagaagc acaaggctgg
     1261 cttccttgac ctgaaggact tcctgcccaa ggagtatgtg aagcagaagg gagagcgtaa
     1321 gatctttcag gcacacaaga attgtgggca gatgagtgaa attgaggcca aggtacgcta
     1381 cgtgaagctg gcccgttccc tcaagactta cggtgtctcc ttcttcctag tcaaggaaaa
     1441 gatgaagggg aagaataaac tggtgcccag gctgttgggc atcactaagg agtgtgtgat
     1501 gcgtgtggat gagaagacca aggaggtgat tcaggaatgg agcctcacca acatcaaacg
     1561 ctgggctgcc tctcccaaga gctttactct ggactttgga gactatcagg atggctacta
     1621 ctcagtacag acgacagaag gcgagcagat cgcacagctc attgctggct acatagatat
     1681 catccttaag aagaaaaaaa gcaaggacca ttttgggctg gagggagatg aagagtctac
     1741 tatgttggag gactcagtgt cacccaaaaa gtcaacagtc cttcagcagc agtacaaccg
     1801 agtggggaaa gtggagcacg gctctgtggc tctgccagcc atcatgcgct ctggagcctc
     1861 tggtcctgag aatttccagg tggggagcat gccacctgcc cagcagcaga tcaccagtgg
     1921 ccagatgcac cgaggacaca tgccacctct gacttcagcc cagcaggcgc tcactggaac
     1981 cattaactcc agcatgcagg ctgtgcaggc tgcccaggcc actctggatg actttgagac
     2041 tctaccccct cttggccagg atgctgcctc caaagcttgg cgtaagaaca agatggatga
     2101 atcaaagcat gagatccact cccaggtaga tgccatcaca gctggcactg cctctgtggt
     2161 aaacctgaca gcaggagatc ctgcagagac agactataca gcagtgggct gtgcagtcac
     2221 caccatctct tccaacctga cggagatgtc ccgtggggtg aagctattgg ctgccctgct
     2281 ggaggatgaa ggcggcaatg gccggcccct tctgcaagca gcaaagggcc ttgcaggggc
     2341 tgtgtcggaa ctgcttcgca gtgctcagcc cgccagcgct gagccccgtc agaacctgct
     2401 gcaggcagcc gggaacgtgg gccaggccag tggggagctg ttgcagcaaa ttggggaaag
     2461 tgacactgac ccccacttcc aggatgttct aatgcagcta gcaaaggcag tggcaagtgc
     2521 tgcagccgcc ctggtcctca aggccaagag tgtggcccag cgcacagagg attccgggct
     2581 tcagacccaa gtgattgctg cagctacgca atgtgctctg tccacttccc agctggtggc
     2641 ctgtaccaag gtggtagcac ctacaatcag ctcacctgtg tgccaagaac agctagtcga
     2701 ggctgggcga ctggtggcca aagctgtgga gggctgtgtg tctgcctcgc aagcagctac
     2761 agaagatgga cagctgcttc gaggggtagg agcagcagcc acggctgtca cccaggccct
     2821 caatgagctg ctgcagcacg tgaaggccca cgccaccgga gctgggcctg ccggtcggta
     2881 tgaccaagcc actgatacca tcctcaccgt cactgaaaac atcttcagct ccatgggtga
     2941 tgctggggag atggtgcgcc aggcccgcat cctggcccaa gccacctcag acctggtcaa
     3001 tgctatcaag gccgatgctg agggggagag tgatctggag aactctagaa agctcctgag
     3061 tgctgccaag atcctcgctg atgccaccgc caagatggtg gaggcggcca agggagcagc
     3121 cgcccaccct gacagtgagg aacagcagca gcgactgcgt gaagcagctg aggggcttcg
     3181 catggccacc aatgcagctg cgcagaacgc catcaagaag aagttggtgc agcgcctgga
     3241 gcatgcagcc aagcaagctg cagcctctgc aacacagacc attgctgcag cccaacatgc
     3301 agcctctgcc cccaaggcct ctgcgggccc ccagccccta ctggtgcaga gctgtaaggc
     3361 cgtggcagag cagattccgt tgctggtgca gggtgtccga ggaagtcaag ctcagcctga
     3421 cagccctagt gctcagctcg ccctcattgc tgccagccag agcttcctgc agccaggtgg
     3481 gaagatggtg gcagcggcaa aagcctcagt gccaacaatt caggaccagg cttcagcaat
     3541 gcagctgagt cagtgcgcaa agaacctagg cactgccctg gccgagctgc gcactgctgc
     3601 tcagaaggct caggaggcat gtggaccttt ggagatggat tctgcactga gtgttgtaca
     3661 aaatctagag aaagacctac aggaaataaa agcagcagct cgagatggca agcttaagcc
     3721 cttacccggg gaaacaatgg agaagtgtac ccaagatctt ggcaacagca ccaaagcggt
     3781 gagctctgcc atcgccaagc tgctggggga gattgcccag ggcaatgaga actatgcagg
     3841 tattgcagct cgggatgtag ctggtggact aaggtcacta gcccaggctg cgcggggtgt
     3901 ggctgcgctg acatcagatc ctgcagtgca ggccattgtg cttgacacag ccagcgacgt
     3961 tctggacaag gccagcagcc tcattgaaga ggcaaaaaaa gcatctggac acccagggga
     4021 cccagaaagc cagcaaaggc ttgctcaggt agctaaagca gtgacccaag ccctgaaccg
     4081 ctgtgtcagc tgcctgcctg gccaaagaga cgtggataat gccctacgag ccgttggaga
     4141 tgccagcaag cgactcctga gtgactcgct tcctccaagc acggggacat ttcaagaagc
     4201 acagagccga ttgaatgaag ctgcagctgg gttaaatcag gccgccacag aactggtgca
     4261 agcctcccga ggaactcctc aggacctggc tcgggcctcc ggccgatttg gacaggactt
     4321 cagcaccttc ctggaagctg gtgtggagat ggccggacag gccccgagcc aggaggaccg
     4381 agcccaggtg gtgtccaacc tgaagggcat atccatgtct tcaagcaaac ttctccttgc
     4441 cgctaaggcc ttgtccacag accctgcttc tcccaacctc aagagtcagc tggctgcggc
     4501 tgcccgggca gtgacggaca gcatcaacca gctcatcacc atgtgcaccc agcaggcacc
     4561 tggccagaag gagtgtgaca atgcacttcg gcagctagag acagtccgag aactcctgga
     4621 gaatccagtc cagcccatca acgacatgtc ctacttcggt tgcttggaca gtgtcatgga
     4681 gaactccaag gtcctaggtg aggccatgac tggcatctcc caaaatgcca agaatggaaa
     4741 tctgccggag tttggagatg ccattgccac agcctccaag gctctctgtg gcttcacgga
     4801 ggcagccgca caggcagcat atctagttgg tgtctctgac cccaacagcc aagctggaca
     4861 gcaaggactg gtggaaccca cacagtttgc ccgtgcaaac caggcaattc agatggcctg
     4921 tcagagtctg ggggagcctg gctgtaccca ggcccaggtg ttatctgcag ccactattgt
     4981 agccaaacac acatctgcat tgtgtaacag ctgtcgcctg gcttccgcta ggactgccaa
     5041 tcccactgcc aagcgccagt ttgtacagtc agccaaggag gtggccaaca gtacagccaa
     5101 tcttgtcaag accatcaagg cactagatgg ggacttcaca gaagagaacc gtgcccagtg
     5161 ccgagcagcc acagcccctc tgctggaagc tgtggataac ctgagtgcct ttgcctccaa
     5221 ccctgagttc tccagcgtcc ctgcccagat cagccctgag ggcagagcag ccatggagcc
     5281 cattgtaatc tctgctaaga caatgttgga gagtgctgga gggctcatcc agacagctcg
     5341 ggcgttagca gtcaatcccc gagacccccc acgttggtct gtgctagctg gccactctcg
     5401 gactgtctca gattccatca agaaacttat tacaagcatg agggacaaag ccccagggca
     5461 gctggagtgt gagacagcca ttgcggctct gaacagctgc ttgcgggacc tagatcaggc
     5521 ttcgcttgcc gctgtcagcc agcagcttgc tccccgtgaa ggaatctctc aagaggcttt
     5581 gcacacccag atgctcactg cagtgcaaga aatttctcat ctcattgagc cgctggccag
     5641 cgctgctcgg gctgaagcct cccagctggg acacaaggtg tcccaaatgg cccagtactt
     5701 tgaaccactc accctggctg cagtgggtgc tgcgtctaag accctgagcc acccacagca
     5761 gatggcactt ctggaccaga ctaaaacgtt ggcagagtct gccttgcagt tgctatatac
     5821 tgccaaggag gctggtggta accccaagca agcagcacac acccaggaag ccctggagga
     5881 ggctgtgcag atgatgacag aggccgtaga agacctgacg acgaccctca acgaagcagc
     5941 cagtgctgca ggagtcgttg gcggcatggt ggactctatc actcaggcca tcaaccagct
     6001 agatgaagga cctatgggtg acccagaagg ctcattcgta gattaccaga caaccatggt
     6061 gaggacagcc aaggccattg ctgtcactgt tcaggagatg gtaaccaagt caaacaccag
     6121 ccctgaagag ctaggccctc ttgccaacca gctgaccagt gactatggcc gactggcctc
     6181 acaagccaag cctgcagctg tggctgctga aaatgaagag ataggcgctc acatcaaaca
     6241 ccgagtacag gagctgggcc atggctgctc tgctctggtc accaaggcag gtgccttgca
     6301 gtgtagcccc agtgatgtct acaccaagaa ggagctcata gagtgtgccc gcagagtgtc
     6361 agagaaggtc tcccatgttc tggctgcact ccaggctggg aatcgtggta cccaggcctg
     6421 cattacagca gccagtgctg tgtctggtat cattgctgac ctcgacacca ccatcatgtt
     6481 cgctactgct ggcacactta accgtgaggg tgctgaaact tttgctgacc accgggaggg
     6541 tatcttaaag acagcaaagg ttcttgtgga ggacaccaag gtcctagtgc agaatgcagc
     6601 tgggagccag gagaagttgg cacaagccgc ccagtcctcc gtggccacca ttacccgcct
     6661 cgctgatgtg gtcaagctcg gtgcagccag cctaggagcc gaagaccctg aaactcaggt
     6721 ggtgctgatc aatgcagtaa aggacgtagc caaggccctg ggtgacctca tcagcgctac
     6781 gaaggctgca gcgggcaaag ttggggatga ccctgcagtg tggcagctca agaactctgc
     6841 caaggtgatg gtgaccaatg tgacatcatt gctcaagaca gtgaaggctg tggaagatga
     6901 ggccaccaaa ggcacacggg ccctagaggc aaccacagag cacatacgtc aggaactggc
     6961 ggtcttctgt tccccagagc cacctgccaa gacctctacc cctgaagact tcatccgaat
     7021 gaccaagggt attactatgg caacagccaa agccgttgct gctggcaatt cctgtcgaca
     7081 ggaagatgtc attgccacag ccaatctgag ccgacgggct attgcggaca tgcttcgggc
     7141 ttgcaaggaa gcagctttcc acccagaagt ggcgcctgat gtacggctcc gagccctgca
     7201 ctatggccgg gagtgtgcca atggttacct ggaactgctg gaccacgtgc tgctgaccct
     7261 tcagaagcca aacccagacc tgaagcagca gctaactgga cactcaaagc gggttgctgg
     7321 ctctgtgact gagctcatcc aggctgctga agccatgaaa ggaacagagt gggtggaccc
     7381 agaggaccct actgtcattg ctgagaatga actcttggga gccgcagccg ccatcgaggc
     7441 tgcagccaag aagctggagc agctgaagcc cagggccaaa cccaaggagg cggatgagtc
     7501 cttgaacttt gaggaacaaa tcctagaagc tgccaagtcc atcgctgcag ccaccagtgc
     7561 actggtaaag gctgcgtcag cagcccagag ggagctggtg gctcaaggaa aggtgggcgc
     7621 cattccagcc aatgcactgg atgatgggca gtggtcgcag ggcctcattt ccgctgcccg
     7681 tatggtggct gcggccacca acaatctgtg tgaagcagct aacgcagctg tccagggcca
     7741 tgctagccag gagaaactca tttcctcagc caagcaagta gctgcctcca cagctcagct
     7801 cctggtagct tgcaaggtca aagcagatca ggactctgag gcaatgaaac ggctccaggc
     7861 tgctggcaat gcagtgaaga gggcctcaga taacctggta aaggcggccc agaaagctgc
     7921 agccttcgaa gaccaggaga atgagacggt ggtggtgaag gagaaaatgg ttgggggcat
     7981 tgcccagatt atcgcagcac aggaagagat gcttcggaag gaacgagagc tggaagaggc
     8041 tcggaaaaag ctcgcccaga tccggcagca gcagtacaag ttcttgcctt cagagcttcg
     8101 agacgagcac taaaaaagcc ctgtgtattt aatgcagacc cagcccagag actgtgcctg
     8161 ccactaccaa agccttctgg gctgctcagg acccaagctg cccaacccca gcactccccc
     8221 aaagtgcctg ccaaaccctg ggcctggccc tgcccagtcc cactgcaagc cgtgtcctct
     8281 ccctgactcc caagtgcctt tgcaccctag ggcccctaag tgcctgcccc cctccagagt
     8341 attaacgctc caagagtatt attaatgctg ccgtacctca gtttgaacct gccagggccc
     8401 cagctgctcc agcctgccag cagcttccag ccagtcccca cggccacgtc agctcaactc
     8461 atcccttttt gatactatat cccctaccca gctacctatg gggcttgagg gttgtaaacc
     8521 caaacaggtc agactccaat aaaggtgatt ctacagctgc
//
