LOCUS       NM_011904               6400 bp    mRNA    linear   ROD 04-APR-2024
DEFINITION  Mus musculus tolloid-like 2 (Tll2), mRNA.
ACCESSION   NM_011904
VERSION     NM_011904.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6400)
  AUTHORS   Troilo,H., Bayley,C.P., Barrett,A.L., Lockhart-Cairns,M.P.,
            Jowitt,T.A. and Baldock,C.
  TITLE     Mammalian tolloid proteinases: role in growth factor signalling
  JOURNAL   FEBS Lett 590 (15), 2398-2407 (2016)
   PUBMED   27391803
  REMARK    Review article
REFERENCE   2  (bases 1 to 6400)
  AUTHORS   Hoch,R.V., Lindtner,S., Price,J.D. and Rubenstein,J.L.
  TITLE     OTX2 Transcription Factor Controls Regional Patterning within the
            Medial Ganglionic Eminence and Regional Identity of the Septum
  JOURNAL   Cell Rep 12 (3), 482-494 (2015)
   PUBMED   26166575
REFERENCE   3  (bases 1 to 6400)
  AUTHORS   Lee,S.J.
  TITLE     Genetic analysis of the role of proteolysis in the activation of
            latent myostatin
  JOURNAL   PLoS One 3 (2), e1628 (2008)
   PUBMED   18286185
  REMARK    GeneRIF: loss-of-function mutation in Tll2, has a small, but
            significant, effect on muscle mass
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6400)
  AUTHORS   Aruga,J., Yoshikawa,F., Nozaki,Y., Sakaki,Y., Toyoda,A. and
            Furuichi,T.
  TITLE     An oligodendrocyte enhancer in a phylogenetically conserved intron
            region of the mammalian myelin gene Opalin
  JOURNAL   J Neurochem 102 (5), 1533-1547 (2007)
   PUBMED   17442045
REFERENCE   5  (bases 1 to 6400)
  AUTHORS   Desai,J., Shannon,M.E., Johnson,M.D., Ruff,D.W., Hughes,L.A.,
            Kerley,M.K., Carpenter,D.A., Johnson,D.K., Rinchik,E.M. and
            Culiat,C.T.
  TITLE     Nell1-deficient mice have reduced expression of extracellular
            matrix proteins causing cranial and vertebral defects
  JOURNAL   Hum Mol Genet 15 (8), 1329-1341 (2006)
   PUBMED   16537572
REFERENCE   6  (bases 1 to 6400)
  AUTHORS   Uzel,M.I., Scott,I.C., Babakhanlou-Chase,H., Palamakumbura,A.H.,
            Pappano,W.N., Hong,H.H., Greenspan,D.S. and Trackman,P.C.
  TITLE     Multiple bone morphogenetic protein 1-related mammalian
            metalloproteinases process pro-lysyl oxidase at the correct
            physiological site and control lysyl oxidase activation in mouse
            embryo fibroblast cultures
  JOURNAL   J Biol Chem 276 (25), 22537-22543 (2001)
   PUBMED   11313359
REFERENCE   7  (bases 1 to 6400)
  AUTHORS   Scott,I.C., Blitz,I.L., Pappano,W.N., Imamura,Y., Clark,T.G.,
            Steiglitz,B.M., Thomas,C.L., Maas,S.A., Takahara,K., Cho,K.W. and
            Greenspan,D.S.
  TITLE     Mammalian BMP-1/Tolloid-related metalloproteinases, including novel
            family member mammalian Tolloid-like 2, have differential enzymatic
            activities and distributions of expression relevant to patterning
            and skeletogenesis
  JOURNAL   Dev Biol 213 (2), 283-300 (1999)
   PUBMED   10479448
REFERENCE   8  (bases 1 to 6400)
  AUTHORS   Scott,I.C., Clark,T.G., Takahara,K., Hoffman,G.G., Eddy,R.L.,
            Haley,L.L., Shows,T.B. and Greenspan,D.S.
  TITLE     Assignment of TLL1 and TLL2, which encode human
            BMP-1/Tolloid-related metalloproteases, to chromosomes 4q32-->q33
            and 10q23-->q24 and assignment of murine Tll2 to chromosome 19
  JOURNAL   Cytogenet Cell Genet 86 (1), 64-65 (1999)
   PUBMED   10516436
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC133099.3 and AC121873.3.
            
            On Feb 8, 2019 this sequence version replaced NM_011904.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC132537.1, AF073526.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-298               AC133099.3         55573-55870         c
            299-409             AC133099.3         32297-32407         c
            410-484             AC121873.3         188668-188742       c
            485-640             AC121873.3         169230-169385       c
            641-758             AC121873.3         165067-165184       c
            759-937             AC121873.3         159601-159779       c
            938-1043            AC121873.3         157582-157687       c
            1044-1168           AC121873.3         149292-149416       c
            1169-1284           AC121873.3         146356-146471       c
            1285-1387           AC121873.3         142108-142210       c
            1388-1504           AC121873.3         134773-134889       c
            1505-1650           AC121873.3         134027-134172       c
            1651-1846           AC121873.3         132801-132996       c
            1847-1972           AC121873.3         127740-127865       c
            1973-2133           AC121873.3         126905-127065       c
            2134-2314           AC121873.3         124974-125154       c
            2315-2440           AC121873.3         121843-121968       c
            2441-2568           AC121873.3         120538-120665       c
            2569-2782           AC121873.3         117794-118007       c
            2783-3033           AC121873.3         115341-115591       c
            3034-6400           AC121873.3         110071-113437       c
FEATURES             Location/Qualifiers
     source          1..6400
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 34.39 cM"
     gene            1..6400
                     /gene="Tll2"
                     /note="tolloid-like 2"
                     /db_xref="GeneID:24087"
                     /db_xref="MGI:MGI:1346044"
     exon            1..298
                     /gene="Tll2"
                     /inference="alignment:Splign:2.1.0"
     CDS             130..3168
                     /gene="Tll2"
                     /note="tolloid-like protein 2"
                     /codon_start=1
                     /product="tolloid-like protein 2 precursor"
                     /protein_id="NP_036034.1"
                     /db_xref="CCDS:CCDS37986.1"
                     /db_xref="GeneID:24087"
                     /db_xref="MGI:MGI:1346044"
                     /translation="MPLATTLGTLVLLLLLPLPRGAEVTGDHSNVALDYGALEGEEGT
                     EQQLHYHDPCKAAVFWGDIALDEDDLKLFHIDKAEDWTKPSIDKPGHDTGGLEETSAR
                     WPNDTASNASIQAPRKDGKDATTFLPNPGTSNTTAKTFSARVRRATTSRTERIWPGGV
                     IPYVIGGNFTGTQRAIFKQAMRHWEKHTCVTFVERTDEESFIVFSYRTCGCCSYVGRR
                     GGGPQAISIGKNCDKFGIVAHELGHVVGFWHEHTRPDRDQHVTIIRENIQPGQEYNFL
                     KMEAGEVSSLGETYDFDSIMHYARNTFSRGVFLDTILPRRDDNGVRPTIGQRVRLSQG
                     DIAQARKLYKCPACGETLQDTTGNFSAPGFPNGYPSYSHCVWRISVTPGEKIILNFTS
                     MDLFKSRLCWYDYVEIRDGYWRKAPLLGRFCGDKIPESLVSSDSRLWVEFRSSSSSLG
                     KGFFAVYEAMCGGDITKDAGQIQSPNYPDDYRPSKECVWRITVPDGFHVGLTFQSFEI
                     ERHDSCAYDYLEIRDGPTEDSTLIGHFCGYEKPEAVKSSANRLWVKFVSDGSINKAGF
                     AANFFKEVDECSWPDHGGCEQRCVNTLGSYTCACDPGYELAADKKTCEVACGGFITKL
                     NGTITSPGWPKEYPTNKNCVWQVVAPVQYRISLQFEAFELEGNDVCKYDFVEVRSGLS
                     PDAKLHGKFCGSETPEVITSQSNNMRVEFKSDNTVSKRGFRAHFFSDKDECAKDNGGC
                     QQECVNTFGSYLCRCRNGYRLHENGHDCKEAGCAYKISSAEGTLMSPNWPDKYPSRKE
                     CTWNISSTAGHRVKITFSEFEIEQHQECAYDHLELYDGTDSLAPILGRFCGSKKPDPV
                     VATGSSLFLRFYSDASVQRKGFQAVHSTECGGRLKAEVQTKELYSHAQFGDNNYPSQA
                     RCDWVIVAEDGYGVELIFRTFEVEEEADCGYDFMEAYDGYDSSAPRLGRFCGSGPLEE
                     IYSAGDSLMIRFHTDDTINKKGFHARYTSTKFQDALHMRK"
     exon            299..409
                     /gene="Tll2"
                     /inference="alignment:Splign:2.1.0"
     exon            410..484
                     /gene="Tll2"
                     /inference="alignment:Splign:2.1.0"
     exon            485..640
                     /gene="Tll2"
                     /inference="alignment:Splign:2.1.0"
     exon            641..758
                     /gene="Tll2"
                     /inference="alignment:Splign:2.1.0"
     exon            759..937
                     /gene="Tll2"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1043
                     /gene="Tll2"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1168
                     /gene="Tll2"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1284
                     /gene="Tll2"
                     /inference="alignment:Splign:2.1.0"
     exon            1285..1387
                     /gene="Tll2"
                     /inference="alignment:Splign:2.1.0"
     exon            1388..1504
                     /gene="Tll2"
                     /inference="alignment:Splign:2.1.0"
     exon            1505..1650
                     /gene="Tll2"
                     /inference="alignment:Splign:2.1.0"
     exon            1651..1846
                     /gene="Tll2"
                     /inference="alignment:Splign:2.1.0"
     exon            1847..1972
                     /gene="Tll2"
                     /inference="alignment:Splign:2.1.0"
     exon            1973..2133
                     /gene="Tll2"
                     /inference="alignment:Splign:2.1.0"
     exon            2134..2314
                     /gene="Tll2"
                     /inference="alignment:Splign:2.1.0"
     exon            2315..2440
                     /gene="Tll2"
                     /inference="alignment:Splign:2.1.0"
     exon            2441..2568
                     /gene="Tll2"
                     /inference="alignment:Splign:2.1.0"
     exon            2569..2782
                     /gene="Tll2"
                     /inference="alignment:Splign:2.1.0"
     exon            2783..3033
                     /gene="Tll2"
                     /inference="alignment:Splign:2.1.0"
     exon            3034..6400
                     /gene="Tll2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcttggtacc ctaccggtgc ctggcagcca agcagcagcc accacaaccg accctgtacg
       61 tggtgtctct ctggatccga gctttctgtg caggttaagt ccctcgggcc ccgccgaccc
      121 cttgccacta tgccccttgc gaccactctt ggcaccctgg tgctactgtt gctgctaccg
      181 ctgccccgcg gtgctgaagt gactggggac cattcgaatg tcgccttgga ctacggagcc
      241 ttggaaggcg aggagggcac ggagcagcag ctgcattacc acgacccctg caaagctgct
      301 gtcttctggg gagatattgc tctggatgaa gatgatctca agttatttca catcgacaag
      361 gctgaggact ggaccaagcc atccattgac aaaccaggac atgacactgg aggccttgag
      421 gagacatctg caaggtggcc aaacgataca gcctctaacg ccagcatcca ggcaccaaga
      481 aaggatggca aggatgccac cacatttctg cctaaccctg ggacctcaaa caccaccgct
      541 aagaccttct ctgctcgagt tcgaagagct acaacctcaa ggacagagcg gatttggcct
      601 ggaggggtca ttccttatgt cattggagga aactttactg gtacccagag ggccattttc
      661 aaacaggcca tgaggcactg ggagaagcac acctgtgtga ccttcgtaga gaggacagat
      721 gaggaaagct tcattgtatt cagttacagg acctgtggtt gttgttccta cgtgggacgc
      781 cgaggaggtg gcccgcaggc catatccatc gggaaaaact gtgacaagtt cggcattgtg
      841 gctcacgagc tgggccatgt ggttgggttc tggcatgaac acactcggcc agaccgagac
      901 caacatgtca ccatcatcag agaaaacatc cagccaggtc aggagtataa tttcttaaaa
      961 atggaagccg gcgaggtgag ctctctggga gagacctacg acttcgacag catcatgcac
     1021 tatgcccgga acaccttctc aagaggagtt ttcttagaca ccatcctccc ccgtcgagac
     1081 gacaatggcg tcaggccaac cattggccaa cgcgtgcggc tcagtcaggg agatatagct
     1141 caagccagga agctgtacaa atgcccagca tgtggggaga cactacagga cacgacagga
     1201 aacttttcgg cacctggttt cccaaatggc tacccctcct attcccactg cgtctggagg
     1261 atctccgtca ccccagggga aaagatcatc ctaaatttca cctccatgga tttgtttaag
     1321 agccgcctgt gctggtacga ttacgtggag atccgggatg gttactggag aaaggccccc
     1381 ctgttgggga ggttctgtgg cgataagata cctgagtccc ttgtctcctc ggacagccgg
     1441 ctctgggtgg aattccgtag cagcagcagc agcctgggca aaggcttctt tgctgtatat
     1501 gaagccatgt gtgggggaga cataaccaaa gatgcaggcc agattcagtc tcccaactac
     1561 cctgacgact acagaccttc caaggaatgt gtgtggagga tcacagtgcc cgacgggttc
     1621 catgtgggac ttaccttcca gtccttcgag atcgaaaggc atgacagttg tgcatatgac
     1681 tatctggaaa tccgagacgg tcccacagag gacagcaccc tgattggcca cttctgtggc
     1741 tacgagaagc cggaggccgt gaaatccagc gctaaccgac tgtgggtgaa gtttgtgtcc
     1801 gacggctcca tcaataaagc gggctttgca gccaatttct tcaaggaggt ggatgagtgc
     1861 tcctggccag accatggtgg atgtgagcag cgctgtgtaa acacactcgg cagctacacg
     1921 tgtgcctgtg accctggcta cgaactggct gccgacaaga agacatgtga agtggcctgt
     1981 ggtggcttca ttaccaagct aaacggcacc atcaccagcc ctggatggcc gaaggagtat
     2041 cccaccaaca agaactgtgt ctggcaggtg gtggctcccg tgcagtaccg catctcactg
     2101 cagttcgaag cctttgagct ggaaggcaat gacgtctgta agtatgactt cgtagaggtg
     2161 cgcagtggcc tgtccccaga tgccaagctt cacggcaaat tctgtggctc cgagaccccg
     2221 gaggtcatca catcgcagag caacaacatg cgagtggaat tcaagtctga caacaccgtc
     2281 tccaagcgag gcttcagggc tcacttcttc tcagacaaag acgagtgtgc caaagacaat
     2341 ggcggctgcc agcaggagtg tgtcaacacg ttcgggagtt acctgtgcag atgcaggaac
     2401 gggtaccgac tgcatgagaa cggacacgac tgcaaagagg ctggctgcgc ctacaagatc
     2461 agcagtgcag aggggaccct gatgagtcct aactggccag acaaataccc cagccggaag
     2521 gaatgtacct ggaacatttc atcaaccgca ggccacaggg tgaaaattac attcagtgag
     2581 ttcgagattg agcagcacca ggaatgtgcc tatgaccacc tggaactgta cgatgggaca
     2641 gacagcttgg cccccatcct tggccgcttc tgcggcagca agaagccgga tcccgtggtg
     2701 gcgacaggca gcagcctatt cctcaggttt tactcggacg cctcagtgca gcggaaaggc
     2761 ttccaggctg tgcacagcac agagtgtggg ggcaggctga aggctgaagt acagaccaaa
     2821 gagctctatt cccatgccca gtttggggac aacaactacc cgagccaggc ccgctgtgac
     2881 tgggtgatag tggcagaaga cggttatggc gtggagctga tattccggac ctttgaagtt
     2941 gaggaggaag ctgactgtgg ctacgacttc atggaggctt atgatgggta cgacagctcg
     3001 gcacccaggc tcggccgctt ctgtggctca gggccattag aggaaatcta ctccgccgga
     3061 gactcgctaa tgatccgctt ccacacggac gacaccatca acaagaaagg ctttcacgcc
     3121 cggtacacta gcaccaagtt ccaagacgcc ttgcacatga ggaagtagcg cctcagttct
     3181 ggaaaggcag agagactgag ggtgttttaa acacttgcga gtgagcagcc tcccatgtac
     3241 agtgtttttt ctccacaaca aaaacccaaa ctatgttctt gaaactctat atctgggtga
     3301 cagtacatgc ctttggccaa cgggaggaga gagaggggcc gttggttctg gctgtggcgt
     3361 tatcagtcgc agcttctgga ggaggtcaaa gtttgatgtt agcgaccaaa caggatgact
     3421 tcttcacatt tgtctctaag ctttgctcct gtggctccga aggccagcct ggggcaaaag
     3481 gacagcttag ggcaaaagac tgcctctctc tcaactctgg cccggcttcc atagatggca
     3541 tgagcccagt gtgctggtga cttggctgcc ctctgactac tgggcatgga ggattataga
     3601 ttggcagcgg cttcgctgat actcgcaggt gtggctgaac gcttctgtgc agttctacca
     3661 gagtcaagcc aatcaagaaa ccggagaccg tggacacgag agttaaggtg gcatcccagg
     3721 gcacagggag ggggctcaac ctgggaacca cataatggcg ctggaagacc ttgagcatct
     3781 tcctctggcc ctgcttgtcc ttgtcacctc tggggagccc ctgtcatcag tctccattca
     3841 gaaaggagaa cccacggtca ctcctagcag aacattcgct ggcgagcacc cccaggttgc
     3901 tgagaggacg cctagcttca cccaatattt ctcctctgct cagaggctta gaagatgatg
     3961 tcacctgcgc tggggttccc agatgtcacc tgggctgggg ttcccatggg cttccaggaa
     4021 cctcccagct gaaggcacct gctctggcga acctcagccg ctggacagcc agttcaaaca
     4081 gcatctgcga gacgtgtcaa gtcatctcag gaccaatcca cgtctcactg ggagaaaact
     4141 agtaattcca cattatctaa gagccaccgt ctctggaaca aggtggtctg tggtacgact
     4201 catgtaacca gacaggttag agtgcgtgga cggctttgct gggattaacc gggacccagc
     4261 cgccctcttg cactcagaat tctcagcacc cctgcacttg ctctagcggc gtgttaaggg
     4321 tgatgtttac ataattttag cacctcaagg tataatcgaa atagtgaggt agttttgaat
     4381 ggcatttcgt taaggcatct ctgggcatta tgagcttaaa agctgtggta cgttagcttt
     4441 ctaagagcat ttatgttgga atacttttaa aataatgttt acattaacta actgcaagtc
     4501 ctgttggttg ggttggtggc aaacgcaggg cggcggcaca ggagactgtt gctgttagag
     4561 atggcgtagc tcccaagcac cagaatccct atgtgatgga ctgtcacttt aaacaaagca
     4621 tatatgaagg ctaaaggttc tacttaaaaa aaaaatcaca gtatccccat cagaggatga
     4681 cgtccaactg aaataagtgc tgggagtaag aactaggaga caaagaaagg agagaaaaat
     4741 acatccaagt attattatta ttaataatat atgtctgtat atatgtatct atgtctgtat
     4801 gtaagggtca gctatcaatg ccttaatcaa ggcattgtga cagtgccaac ccactgactg
     4861 tggcttatca tcagactctg gtgctggccc cacaccttat tcctctccct tcaaaaccaa
     4921 gacctcttct ctcttctctt ggctctgaac tgtaagcttc agcctccatc ctgtcctgat
     4981 cgctggcttc atatggcaaa agagacagct tatgccatgg ttcttgtcca ctcagcccca
     5041 ctggggtaga ttccacatct ctggtgtgtg tgcatgtgtg tgtgtacgtg tgtgtgtatg
     5101 tgtgtgtgca tgcgtgtgtg tgggtgtggg tgtacgtgtg tgtgtgtgtg tgtgtgtgtg
     5161 tgtacgtgtg cgtgtgcgtg tgtgtatgtg tgattagctt ttattttttg cctcatcttg
     5221 tctggcaagg gtggaatgaa aatcaggatt cataaggtat ctgtcaccct ctcgctccac
     5281 acacataaaa attctgtatt tttaaccttt agaaatgtaa ctaagattgg caaattccat
     5341 ggaaaatagg agctggggag aatcagggtt ggtttcagca tttgtcaccc tggtgacaca
     5401 ctgataattc tttttagtgt gaatgttttc agaggcacac agctttagcg gaggccagct
     5461 tacaacaata gggctcttat gaaagctctt atttaagcct gtgaatgaca tattcccaga
     5521 agacaggctc agattcaaca aaggctgctt gagccccccc cccaccccct ctggaagcca
     5581 acacccacag ggattcacac atgacacagg ccctgcaatg aaccacaggc tggcttccaa
     5641 gaatagaata ccactccaca gacagaccca ggggcccgct tcggcccttc cagttgctca
     5701 gtggcctctc tggaaatgtc atatgtggat ggatagaggg gctcaagggt agcccttagg
     5761 tttacccttt atgtgggacc aggcctgggg gtgtcatgga gctctaagac ctaaaaactg
     5821 cctctgggac aaatgacgta aggaagagtt tggagccggg gtctcctgcc tgatgtaatt
     5881 ctattctact ctgagtcagc agaaactaga acctgtcccc caggatggaa aacttctcca
     5941 aacagctgaa gccaggccat gtattgattc actattttct ctaaaggatc tttctcagaa
     6001 tttccctcta cacagccatg gcattcataa attgcccagt ctgtttaaaa taattctcta
     6061 aacacagttc accagcaaat ctacgtagga tcacgctgta agtcttgccc cgttgctctg
     6121 cacggttctt ggtgttgctc acgcagtctg ggaagagatg gccccttagc atccacagat
     6181 gttttttaaa gtttgctttg cagattgtga tcaaagttcc aatcgccaac cccaaatatc
     6241 taaaaatgtt cttaaaaaaa aagaaaagtg ttatctataa atataaaggt atttttattt
     6301 tgagtaattt tacatttcgt gttaaatgtc agttggcaag aacatgggga gatggtaacc
     6361 ttgtttgaaa attgatggct tcattaaaga atgtggcttt
//
