LOCUS       NM_009390               4943 bp    mRNA    linear   ROD 24-DEC-2022
DEFINITION  Mus musculus tolloid-like (Tll1), mRNA.
ACCESSION   NM_009390 XM_001475474 XM_001475852
VERSION     NM_009390.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4943)
  AUTHORS   Eshed-Eisenbach Y, Devaux J, Vainshtein A, Golani O, Lee SJ,
            Feinberg K, Sukhanov N, Greenspan DS, Susuki K, Rasband MN and
            Peles E.
  TITLE     Precise Spatiotemporal Control of Nodal Na+ Channel Clustering by
            Bone Morphogenetic Protein-1/Tolloid-like Proteinases
  JOURNAL   Neuron 106 (5), 806-815 (2020)
   PUBMED   32209430
  REMARK    GeneRIF: Precise Spatiotemporal Control of Nodal Na(+) Channel
            Clustering by Bone Morphogenetic Protein-1/Tolloid-like
            Proteinases.
REFERENCE   2  (bases 1 to 4943)
  AUTHORS   Wang J, Massoudi D, Ren Y, Muir AM, Harris SE, Greenspan DS and
            Feng JQ.
  TITLE     BMP1 and TLL1 Are Required for Maintaining Periodontal Homeostasis
  JOURNAL   J Dent Res 96 (5), 578-585 (2017)
   PUBMED   28068493
REFERENCE   3  (bases 1 to 4943)
  AUTHORS   Zhang H, Jani P, Liang T, Lu Y and Qin C.
  TITLE     Inactivation of bone morphogenetic protein 1 (Bmp1) and
            tolloid-like 1 (Tll1) in cells expressing type I collagen leads to
            dental and periodontal defects in mice
  JOURNAL   J Mol Histol 48 (2), 83-98 (2017)
   PUBMED   28000152
  REMARK    GeneRIF: the proteinases encoded by Bmp1 and Tll1 genes play
            essential roles in the development and maintenance of mouse dentin
            and periodontal ligaments.
REFERENCE   4  (bases 1 to 4943)
  AUTHORS   Wang J, Muir AM, Ren Y, Massoudi D, Greenspan DS and Feng JQ.
  TITLE     Essential Roles of Bone Morphogenetic Protein-1 and Mammalian
            Tolloid-like 1 in Postnatal Root Dentin Formation
  JOURNAL   J Endod 43 (1), 109-115 (2017)
   PUBMED   27847137
  REMARK    GeneRIF: plays crucial role in maintaining extracellular matrix
            homeostasis essential to root formation and dentin mineralization
REFERENCE   5  (bases 1 to 4943)
  AUTHORS   Troilo H, Bayley CP, Barrett AL, Lockhart-Cairns MP, Jowitt TA and
            Baldock C.
  TITLE     Mammalian tolloid proteinases: role in growth factor signalling
  JOURNAL   FEBS Lett 590 (15), 2398-2407 (2016)
   PUBMED   27391803
  REMARK    Review article
REFERENCE   6  (bases 1 to 4943)
  AUTHORS   Scott IC, Blitz IL, Pappano WN, Imamura Y, Clark TG, Steiglitz BM,
            Thomas CL, Maas SA, Takahara K, Cho KW and Greenspan DS.
  TITLE     Mammalian BMP-1/Tolloid-related metalloproteinases, including novel
            family member mammalian Tolloid-like 2, have differential enzymatic
            activities and distributions of expression relevant to patterning
            and skeletogenesis
  JOURNAL   Dev Biol 213 (2), 283-300 (1999)
   PUBMED   10479448
REFERENCE   7  (bases 1 to 4943)
  AUTHORS   Clark TG, Conway SJ, Scott IC, Labosky PA, Winnier G, Bundy J,
            Hogan BL and Greenspan DS.
  TITLE     The mammalian Tolloid-like 1 gene, Tll1, is necessary for normal
            septation and positioning of the heart
  JOURNAL   Development 126 (12), 2631-2642 (1999)
   PUBMED   10331975
REFERENCE   8  (bases 1 to 4943)
  AUTHORS   Scott IC, Clark TG, Takahara K, Hoffman GG, Eddy RL, Haley LL,
            Shows TB and Greenspan DS.
  TITLE     Assignment of TLL1 and TLL2, which encode human
            BMP-1/Tolloid-related metalloproteases, to chromosomes 4q32-->q33
            and 10q23-->q24 and assignment of murine Tll2 to chromosome 19
  JOURNAL   Cytogenet Cell Genet 86 (1), 64-65 (1999)
   PUBMED   10516436
REFERENCE   9  (bases 1 to 4943)
  AUTHORS   Takahara K, Brevard R, Hoffman GG, Suzuki N and Greenspan DS.
  TITLE     Characterization of a novel gene product (mammalian tolloid-like)
            with high sequence similarity to mammalian tolloid/bone
            morphogenetic protein-1
  JOURNAL   Genomics 34 (2), 157-165 (1996)
   PUBMED   8661043
REFERENCE   10 (bases 1 to 4943)
  AUTHORS   Takahara K, Lyons GE and Greenspan DS.
  TITLE     Bone morphogenetic protein-1 and a mammalian tolloid homologue
            (mTld) are encoded by alternatively spliced transcripts which are
            differentially expressed in some tissues
  JOURNAL   J Biol Chem 269 (51), 32572-32578 (1994)
   PUBMED   7798260
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK080919.1, AC110622.6, CF734525.1, AK139103.1 and AC149051.4.
            
            [WARNING] On Oct 16, 2023 this sequence was replaced by
            NM_009390.4.
            
            On Oct 21, 2017 this sequence version replaced NM_009390.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U34042.1, SRR9219382.190837.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1783              AK080919.1         2-1784
            1784-1830           AC110622.6         72937-72983         c
            1831-2342           CF734525.1         1-512
            2343-4779           AK139103.1         117-2553
            4780-4943           AC149051.4         175701-175864       c
FEATURES             Location/Qualifiers
     source          1..4943
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 32.19 cM"
     gene            1..4943
                     /gene="Tll1"
                     /gene_synonym="b2b2476Clo; Tll; Tll-1"
                     /note="tolloid-like"
                     /db_xref="GeneID:21892"
                     /db_xref="MGI:MGI:106923"
     exon            1..794
                     /gene="Tll1"
                     /gene_synonym="b2b2476Clo; Tll; Tll-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             626..3667
                     /gene="Tll1"
                     /gene_synonym="b2b2476Clo; Tll; Tll-1"
                     /note="tolloid-like protein 1"
                     /codon_start=1
                     /product="tolloid-like protein 1 precursor"
                     /protein_id="NP_033416.2"
                     /db_xref="CCDS:CCDS40352.1"
                     /db_xref="GeneID:21892"
                     /db_xref="MGI:MGI:106923"
                     /translation="MGLQALSPRMLLWLVVSGIVFSRVLWVCAGLDYDYTFDGNEEDK
                     TEPIDYKDPCKAAVFWGDIALDDEDLNIFQIDRTIDLTQSPFGKLGHITGGFGDHGMP
                     KKRGALYQLIERIRRIGSGLEQNNTMKGKAPPKLSEQSEKNRVPRAATSRTERIWPGG
                     VIPYVIGGNFTGSQRAMFKQAMRHWEKHTCVTFTERSDEESYIVFTYRPCGCCSYVGR
                     RGNGPQAISIGKNCDKFGIVVHELGHVIGFWHEHTRPDRDNHVTIIRENIQPGQEYNF
                     LKMEPGEVNSLGERYDFDSIMHYARNTFSRGMFLDTILPSRDDNGIRPAIGQRTRLSK
                     GDIAQARKLYRCPACGETLQESSGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFT
                     TMDLYKSSLCWYDYIEVRDGYWRKSPLLGRFCGDKVAGVLTSTDSRMWIEFRSSSNWV
                     GKGFAAVYEAICGGEIRKNEGQIQSPNYPDDYRPMKECVWKIMVSEGYHVGLTFQAFE
                     IERHDSCAYDHLEVRDGASENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAG
                     FAANFFKEEDECAKPDRGGCEQRCLNTLGSYQCACEPGYELGPDRRSCEAACGGLLTK
                     LNGTITTPGWPKEYPPNKNCVWQVIAPSQYRISVKFEFFELEGNEVCKYDYVEIWSGL
                     SSESKLHGKFCGADIPEVMTSHFNNMRIEFKSDNTVSKKGFKAHFFSDKDECSKDNGG
                     CQHECVNTMGSYTCQCRNGFVLHENKHDCKEAECEQKIHSPSGLITSPNWPDKYPSRK
                     ECTWVISAIPGHRITLAFNEFEVEQHQECAYDHLEIFDGETEKSPILGRLCGSKIPDP
                     LMATGNEMFIRFISDASVQRKGFQATHSTECGGRLKAESKPRDLYSHAQFGDNNYPGQ
                     LDCEWLLVSERGSRLELSFQTFEVEEEADCGYDYVEVFDGLSSKAVGLGRFCGSGPPE
                     EIYSIGDVALIHFHTDDTINKKGFYIRYKSIRYPETMHAKN"
     exon            795..905
                     /gene="Tll1"
                     /gene_synonym="b2b2476Clo; Tll; Tll-1"
                     /inference="alignment:Splign:2.1.0"
     exon            906..986
                     /gene="Tll1"
                     /gene_synonym="b2b2476Clo; Tll; Tll-1"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1139
                     /gene="Tll1"
                     /gene_synonym="b2b2476Clo; Tll; Tll-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1257
                     /gene="Tll1"
                     /gene_synonym="b2b2476Clo; Tll; Tll-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1436
                     /gene="Tll1"
                     /gene_synonym="b2b2476Clo; Tll; Tll-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1437..1542
                     /gene="Tll1"
                     /gene_synonym="b2b2476Clo; Tll; Tll-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1543..1667
                     /gene="Tll1"
                     /gene_synonym="b2b2476Clo; Tll; Tll-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1668..1783
                     /gene="Tll1"
                     /gene_synonym="b2b2476Clo; Tll; Tll-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1784..1886
                     /gene="Tll1"
                     /gene_synonym="b2b2476Clo; Tll; Tll-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1887..2003
                     /gene="Tll1"
                     /gene_synonym="b2b2476Clo; Tll; Tll-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2004..2149
                     /gene="Tll1"
                     /gene_synonym="b2b2476Clo; Tll; Tll-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2150..2345
                     /gene="Tll1"
                     /gene_synonym="b2b2476Clo; Tll; Tll-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2346..2471
                     /gene="Tll1"
                     /gene_synonym="b2b2476Clo; Tll; Tll-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2472..2632
                     /gene="Tll1"
                     /gene_synonym="b2b2476Clo; Tll; Tll-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2633..2813
                     /gene="Tll1"
                     /gene_synonym="b2b2476Clo; Tll; Tll-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2814..2939
                     /gene="Tll1"
                     /gene_synonym="b2b2476Clo; Tll; Tll-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2940..3067
                     /gene="Tll1"
                     /gene_synonym="b2b2476Clo; Tll; Tll-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3068..3281
                     /gene="Tll1"
                     /gene_synonym="b2b2476Clo; Tll; Tll-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3282..3532
                     /gene="Tll1"
                     /gene_synonym="b2b2476Clo; Tll; Tll-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3533..4943
                     /gene="Tll1"
                     /gene_synonym="b2b2476Clo; Tll; Tll-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcactccaa atcctcacac ccctttgctc tccgggcagt cgggagcttc cctagcttcg
       61 gcaggctttt aaggtctggc ggcgtagaaa tgcctatccc ccaccccctt cctcggtctc
      121 ccctttcagt tcagatgtgc tgatgtgcag accggattca tcttccccga gcagcggcgg
      181 tggcagcggc gggcgcaggc ggctgcagct cgctctcggc cgcggggtcc tgacagcggc
      241 gggggcgcgg cgcgggagcc ggagctccgg tggcagctga gcccgccgtg cgcctctcgc
      301 cgcggccggt cgtgatcgcg ggaagttcga ccgctggaag gacgacctag accgagccgg
      361 gttggctgcg gctgccctgc gccgagctcc tcacctgcct tccgcccacc cgcgggcccc
      421 cggccaagtt ccccagcatc cgggggagac agggagacat ttgccctctc tagcgtcctg
      481 aagacatccg catgtctccg gacacctgaa cattcaggtc tttccgagga gcttcccagt
      541 cgggataaga acactgtccc tagagccccg catatccacg cggccctccg ggtctggtcc
      601 cctccttttc ctctagggga ggaggatggg tttgcaagcg ctctccccga ggatgctcct
      661 gtggttggtg gtctcgggta ttgttttctc ccgggtgctg tgggtctgcg ctggcctcga
      721 ttatgattac acttttgatg ggaacgaaga ggacaaaacg gagcctatag attacaagga
      781 cccgtgcaaa gctgctgtgt tttggggtga catcgcctta gatgatgaag acttaaatat
      841 cttccaaata gacaggacaa ttgacctgac ccagagcccc tttggaaaac ttggacatat
      901 tacaggtggc tttggagacc atggcatgcc aaagaagcga ggggcactct accaacttat
      961 agagaggatc agaagaattg gctctggctt ggagcaaaat aacacgatga agggaaaagc
     1021 acctccaaaa ttgtcagagc aaagtgagaa aaatcgagtt cccagagctg ctacctcaag
     1081 aacggaaagg atatggcctg ggggtgtcat tccttatgtc ataggaggaa actttactgg
     1141 cagccagaga gccatgttca agcaggccat gagacactgg gaaaagcaca cctgtgtgac
     1201 gttcactgag agaagtgatg aagaaagtta tattgtgttc acctacaggc cttgtggatg
     1261 ctgctcctat gttggtcggc ggggaaatgg ccctcaggcc atctctattg gcaagaactg
     1321 tgacaagttt ggaattgttg ttcatgaact gggccacgtg ataggcttct ggcatgaaca
     1381 tacccgccca gaccgagaca accatgtcac catcattaga gagaacatcc agccaggtca
     1441 agagtacaat tttctaaaga tggagcctgg agaagtgaac tctcttgggg aaagatatga
     1501 ttttgacagt atcatgcact acgccaggaa caccttctca agagggatgt ttttagacac
     1561 aatactcccc tcccgtgatg ataatggcat tcgtcctgca attggtcaac ggacccggtt
     1621 aagcaaagga gacattgcac aagcaagaaa gctgtatcga tgcccagcat gtggagaaac
     1681 cctgcaagaa tccagtggca acctttcttc cccaggattc ccaaatggct acccttccta
     1741 cacacactgc atctggagag tgtctgtgac cccgggagaa aagattgtct tgaattttac
     1801 cacaatggac ctttacaaaa gtagtttgtg ctggtatgat tacattgaag taagagatgg
     1861 ttactggagg aagtcacctc tccttggtag attctgtggg gacaaagtgg ctggagttct
     1921 tacatctacg gacagcagaa tgtggattga gtttcgtagc agcagtaact gggtaggaaa
     1981 agggtttgca gctgtctatg aagcgatttg tggaggggag ataaggaaaa acgaagggca
     2041 gattcagtct cccaattacc ccgatgacta ccgaccaatg aaggagtgtg tatggaaaat
     2101 aatggtgtcc gagggctacc atgttggact gacctttcag gcctttgaga tcgaaagaca
     2161 tgacagctgt gcctatgacc acctagaagt tcgagatgga gccagtgaga acagcccttt
     2221 gataggacgg ttctgtggtt atgacaaacc tgaagatata aggtctactt ccaacaccct
     2281 gtggatgaag tttgtctctg acgggactgt gaacaaggca gggtttgctg cgaacttttt
     2341 taaagaggaa gatgagtgtg ccaaacctga ccgaggaggc tgtgaacaga ggtgtcttaa
     2401 cacactaggc agctaccagt gtgcctgtga gcctggctat gaactggggc cagacagaag
     2461 aagctgtgaa gctgcttgcg gaggacttct gacgaagctc aatggcacca taaccacccc
     2521 cggctggccc aaagagtacc ctccaaacaa aaactgtgtg tggcaagtga tcgcgccaag
     2581 ccagtacaga atctctgtga agtttgagtt ttttgaattg gaaggcaatg aagtttgcaa
     2641 atacgattac gtggagatct ggagcggcct ttcctctgag tctaaactgc atggcaagtt
     2701 ctgtggcgct gacatacctg aagtgatgac ttcccatttc aacaacatga ggattgaatt
     2761 caagtcagac aacactgtat ccaagaaggg cttcaaagca cattttttct cagataagga
     2821 tgagtgttca aaggataatg gtggctgtca gcatgagtgt gtcaacacga tgggaagtta
     2881 cacgtgtcag tgccggaatg gattcgtgtt gcatgagaac aagcatgatt gcaaggaagc
     2941 cgagtgtgaa cagaagatac acagcccaag tggtctcatc accagtccca actggccaga
     3001 caagtatcca agcaggaaag agtgcacgtg ggtgatcagt gccattcctg gccaccgcat
     3061 cacattagcc ttcaatgagt ttgaggttga acaacatcaa gaatgtgctt atgatcactt
     3121 ggaaattttt gatggagaaa cggagaagtc accaatactt ggccgactat gtggcagcaa
     3181 gataccagat cccctcatgg ctactgggaa tgaaatgttt attcggttta tttctgatgc
     3241 ctctgttcaa agaaaaggct ttcaagctac acattccaca gagtgtggtg gtcgattgaa
     3301 agcagagtca aagcctagag acctgtactc ccatgctcag tttggtgata ataactaccc
     3361 aggacaactg gactgtgaat ggttgttggt gtcagaacga ggatctcgac ttgaattgtc
     3421 cttccagaca ttcgaagtag aagaagaagc tgactgtggc tatgactatg ttgaagtctt
     3481 tgatggtctc agttcaaaag ctgtgggtct tggtagattc tgtgggtcag ggccaccaga
     3541 agaaatctat tcaattggag atgtggcttt gattcatttc cacacagatg acactatcaa
     3601 caagaaagga ttttatataa gatataaaag tataagatac ccggaaacga tgcatgccaa
     3661 gaactaatgc cgaccctccc tcagaacaga aaggaatgtg catatggaaa gaagacattt
     3721 ttaaaataga caatattaat acaattgttt tatataatga atttgagcaa aagaaacctg
     3781 caagattaga gttatctctg aagtgaaaga gaactttcca gaaaacctga ttggcattgc
     3841 aaggatgttt gaaagtcatg cttgttcaag gaagattaac agcttgaaat agatgcttca
     3901 cattttggac agttcattta atgagctgtg attctctgga gtgatttctt gactactttt
     3961 ccaagatctg gggacgtaga aatgatggga cggatcatag cttggaaacc cacttcttgg
     4021 gtcttagcat gtttgcttag actctgtagg tcagacacag tgtaaaccaa attcatgtaa
     4081 ggtgatgtgg aatagtggtc tttggaaggt ggttcatcat ttaaatgtag gtttgtgctt
     4141 gtgtgtatgt tcacatatgc aagtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt
     4201 gcgtgtgtgt gtgtgtgcgt gtgtgtgtgt gtgcatgtgt gtgcatgtgt gtttggaaac
     4261 tggaatattt catcttcatt attttcaaat gcaggccagc ttaacctgtt cacacaaatg
     4321 attttgtgac cacttcattg tatctgtatc ttgagaagtt tgaaatatct atagtgtcta
     4381 caatgcagtt aatccctaga tatcatattt aattactgga taatacccag ttcactagta
     4441 aactcatttc tctctgggga agtgctgaat agtcacacca aattcaagaa actcaccatg
     4501 tcttataaac ctttaagata aaattccaac gaggtgtgtg cagccatctt ccaaatgact
     4561 gcctggatgt ttcttagtcc agttactact gctgctgcta ttggtctttc ttttattgtt
     4621 aatgtgttga tatgttgtta ttattatggt tattattatt gatgttgtta ctatatttaa
     4681 aaatgatgag atgaagtgga agtagagttt gggagaaatg aaatctctct tttttgttct
     4741 cttcttgaaa ttcagtttca aaaaatacaa tattgggtgg caaatgattt gtttctgaca
     4801 tatttcctat ggtgctattc cataaatatc aaaacagcag caacaacaag tttctaacct
     4861 ttgaaccaaa tgcctgtgta ctatgaatgc ctctttctat gtggctcgca aaggagactt
     4921 gagacttttt agatatttca aga
//
