LOCUS       NP_033416               1013 aa            linear   ROD 14-JUN-2024
DEFINITION  tolloid-like protein 1 isoform 1 precursor [Mus musculus].
ACCESSION   NP_033416 XP_001475524 XP_001475902
VERSION     NP_033416.2
DBSOURCE    REFSEQ: accession NM_009390.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1013)
  AUTHORS   Eshed-Eisenbach,Y., Devaux,J., Vainshtein,A., Golani,O., Lee,S.J.,
            Feinberg,K., Sukhanov,N., Greenspan,D.S., Susuki,K., Rasband,M.N.
            and Peles,E.
  TITLE     Precise Spatiotemporal Control of Nodal Na+ Channel Clustering by
            Bone Morphogenetic Protein-1/Tolloid-like Proteinases
  JOURNAL   Neuron 106 (5), 806-815 (2020)
   PUBMED   32209430
  REMARK    GeneRIF: Precise Spatiotemporal Control of Nodal Na(+) Channel
            Clustering by Bone Morphogenetic Protein-1/Tolloid-like
            Proteinases.
REFERENCE   2  (residues 1 to 1013)
  AUTHORS   Wang,J., Massoudi,D., Ren,Y., Muir,A.M., Harris,S.E.,
            Greenspan,D.S. and Feng,J.Q.
  TITLE     BMP1 and TLL1 Are Required for Maintaining Periodontal Homeostasis
  JOURNAL   J Dent Res 96 (5), 578-585 (2017)
   PUBMED   28068493
REFERENCE   3  (residues 1 to 1013)
  AUTHORS   Zhang,H., Jani,P., Liang,T., Lu,Y. and Qin,C.
  TITLE     Inactivation of bone morphogenetic protein 1 (Bmp1) and
            tolloid-like 1 (Tll1) in cells expressing type I collagen leads to
            dental and periodontal defects in mice
  JOURNAL   J Mol Histol 48 (2), 83-98 (2017)
   PUBMED   28000152
  REMARK    GeneRIF: the proteinases encoded by Bmp1 and Tll1 genes play
            essential roles in the development and maintenance of mouse dentin
            and periodontal ligaments.
REFERENCE   4  (residues 1 to 1013)
  AUTHORS   Wang,J., Muir,A.M., Ren,Y., Massoudi,D., Greenspan,D.S. and
            Feng,J.Q.
  TITLE     Essential Roles of Bone Morphogenetic Protein-1 and Mammalian
            Tolloid-like 1 in Postnatal Root Dentin Formation
  JOURNAL   J Endod 43 (1), 109-115 (2017)
   PUBMED   27847137
  REMARK    GeneRIF: plays crucial role in maintaining extracellular matrix
            homeostasis essential to root formation and dentin mineralization
REFERENCE   5  (residues 1 to 1013)
  AUTHORS   Troilo,H., Bayley,C.P., Barrett,A.L., Lockhart-Cairns,M.P.,
            Jowitt,T.A. and Baldock,C.
  TITLE     Mammalian tolloid proteinases: role in growth factor signalling
  JOURNAL   FEBS Lett 590 (15), 2398-2407 (2016)
   PUBMED   27391803
  REMARK    Review article
REFERENCE   6  (residues 1 to 1013)
  AUTHORS   Scott,I.C., Blitz,I.L., Pappano,W.N., Imamura,Y., Clark,T.G.,
            Steiglitz,B.M., Thomas,C.L., Maas,S.A., Takahara,K., Cho,K.W. and
            Greenspan,D.S.
  TITLE     Mammalian BMP-1/Tolloid-related metalloproteinases, including novel
            family member mammalian Tolloid-like 2, have differential enzymatic
            activities and distributions of expression relevant to patterning
            and skeletogenesis
  JOURNAL   Dev Biol 213 (2), 283-300 (1999)
   PUBMED   10479448
REFERENCE   7  (residues 1 to 1013)
  AUTHORS   Clark,T.G., Conway,S.J., Scott,I.C., Labosky,P.A., Winnier,G.,
            Bundy,J., Hogan,B.L. and Greenspan,D.S.
  TITLE     The mammalian Tolloid-like 1 gene, Tll1, is necessary for normal
            septation and positioning of the heart
  JOURNAL   Development 126 (12), 2631-2642 (1999)
   PUBMED   10331975
REFERENCE   8  (residues 1 to 1013)
  AUTHORS   Scott,I.C., Clark,T.G., Takahara,K., Hoffman,G.G., Eddy,R.L.,
            Haley,L.L., Shows,T.B. and Greenspan,D.S.
  TITLE     Assignment of TLL1 and TLL2, which encode human
            BMP-1/Tolloid-related metalloproteases, to chromosomes 4q32-->q33
            and 10q23-->q24 and assignment of murine Tll2 to chromosome 19
  JOURNAL   Cytogenet Cell Genet 86 (1), 64-65 (1999)
   PUBMED   10516436
REFERENCE   9  (residues 1 to 1013)
  AUTHORS   Takahara,K., Brevard,R., Hoffman,G.G., Suzuki,N. and Greenspan,D.S.
  TITLE     Characterization of a novel gene product (mammalian tolloid-like)
            with high sequence similarity to mammalian tolloid/bone
            morphogenetic protein-1
  JOURNAL   Genomics 34 (2), 157-165 (1996)
   PUBMED   8661043
REFERENCE   10 (residues 1 to 1013)
  AUTHORS   Takahara,K., Lyons,G.E. and Greenspan,D.S.
  TITLE     Bone morphogenetic protein-1 and a mammalian tolloid homologue
            (mTld) are encoded by alternatively spliced transcripts which are
            differentially expressed in some tissues
  JOURNAL   J Biol Chem 269 (51), 32572-32578 (1994)
   PUBMED   7798260
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC147185.2, AC110622.6 and AC149051.4.
            
            On or before Jun 14, 2009 this sequence version replaced
            XP_001475524.1, XP_001475902.1, NP_033416.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U34042.1, SRR9219382.190837.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1013
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 32.19 cM"
     Protein         1..1013
                     /product="tolloid-like protein 1 isoform 1 precursor"
                     /note="tolloid-like protein 1"
                     /calculated_mol_wt=111264
     sig_peptide     1..30
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q62381.1)"
                     /calculated_mol_wt=3303
     Region          124..150
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q62381.1)"
     mat_peptide     148..1013
                     /product="Tolloid-like protein 1. /id=PRO_0000046026"
                     /note="propagated from UniProtKB/Swiss-Prot (Q62381.1)"
                     /calculated_mol_wt=98025
     Region          148..347
                     /region_name="ZnMc_BMP1_TLD"
                     /note="Zinc-dependent metalloprotease; BMP1/TLD-like
                     subfamily. BMP1 (Bone morphogenetic protein 1) and TLD
                     (tolloid)-like metalloproteases play vital roles in
                     extracellular matrix formation, by cleaving precursor
                     proteins such as enzymes, structural proteins; cd04281"
                     /db_xref="CDD:239808"
     Site            169
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q62381.1)"
     Site            order(240..241,244,250)
                     /site_type="active"
                     /db_xref="CDD:239808"
     Region          349..458
                     /region_name="CUB"
                     /note="CUB domain; pfam00431"
                     /db_xref="CDD:395345"
     Site            order(357,359,361,388,393,431,455,457,459..460)
                     /site_type="other"
                     /note="heterodimerization interface [polypeptide binding]"
                     /db_xref="CDD:238001"
     Site            359
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q62381.1)"
     Site            390
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q62381.1)"
     Region          462..571
                     /region_name="CUB"
                     /note="CUB domain; pfam00431"
                     /db_xref="CDD:395345"
     Site            order(470,472,474,501,506,544,568,570,572)
                     /site_type="other"
                     /note="heterodimerization interface [polypeptide binding]"
                     /db_xref="CDD:238001"
     Region          582..614
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          618..727
                     /region_name="CUB"
                     /note="CUB domain; pfam00431"
                     /db_xref="CDD:395345"
     Site            order(626,628,630,657,662,700,724,726,728..729)
                     /site_type="other"
                     /note="heterodimerization interface [polypeptide binding]"
                     /db_xref="CDD:238001"
     Site            626
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q62381.1)"
     Region          734..769
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          774..883
                     /region_name="CUB"
                     /note="CUB domain; pfam00431"
                     /db_xref="CDD:395345"
     Site            order(782,784,786,813,818,856,880,882,884..885)
                     /site_type="other"
                     /note="heterodimerization interface [polypeptide binding]"
                     /db_xref="CDD:238001"
     Region          887..1000
                     /region_name="CUB"
                     /note="CUB domain; pfam00431"
                     /db_xref="CDD:395345"
     Site            order(897,899,901,930,935,973,997,999,1001..1002)
                     /site_type="other"
                     /note="heterodimerization interface [polypeptide binding]"
                     /db_xref="CDD:238001"
     CDS             1..1013
                     /gene="Tll1"
                     /gene_synonym="b2b2476Clo; Tll; Tll-1"
                     /coded_by="NM_009390.4:627..3668"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS40352.1"
                     /db_xref="GeneID:21892"
                     /db_xref="MGI:MGI:106923"
ORIGIN      
        1 mglqalsprm llwlvvsgiv fsrvlwvcag ldydytfdgn eedktepidy kdpckaavfw
       61 gdialddedl nifqidrtid ltqspfgklg hitggfgdhg mpkkrgalyq lierirrigs
      121 gleqnntmkg kappklseqs eknrvpraat srteriwpgg vipyviggnf tgsqramfkq
      181 amrhwekhtc vtftersdee syivftyrpc gccsyvgrrg ngpqaisigk ncdkfgivvh
      241 elghvigfwh ehtrpdrdnh vtiireniqp gqeynflkme pgevnslger ydfdsimhya
      301 rntfsrgmfl dtilpsrddn girpaigqrt rlskgdiaqa rklyrcpacg etlqessgnl
      361 sspgfpngyp sythciwrvs vtpgekivln fttmdlykss lcwydyievr dgywrkspll
      421 grfcgdkvag vltstdsrmw iefrsssnwv gkgfaavyea icggeirkne gqiqspnypd
      481 dyrpmkecvw kimvsegyhv gltfqafeie rhdscaydhl evrdgasens pligrfcgyd
      541 kpedirstsn tlwmkfvsdg tvnkagfaan ffkeedecak pdrggceqrc lntlgsyqca
      601 cepgyelgpd rrsceaacgg lltklngtit tpgwpkeypp nkncvwqvia psqyrisvkf
      661 effelegnev ckydyveiws glssesklhg kfcgadipev mtshfnnmri efksdntvsk
      721 kgfkahffsd kdecskdngg cqhecvntmg sytcqcrngf vlhenkhdck eaeceqkihs
      781 psglitspnw pdkypsrkec twvisaipgh ritlafnefe veqhqecayd hleifdgete
      841 kspilgrlcg skipdplmat gnemfirfis dasvqrkgfq athstecggr lkaeskprdl
      901 yshaqfgdnn ypgqldcewl lvsergsrle lsfqtfevee eadcgydyve vfdglsskav
      961 glgrfcgsgp peeiysigdv alihfhtddt inkkgfyiry ksirypetmh akn
//
