LOCUS       NM_172664               4050 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus tousled-like kinase 1 (Tlk1), transcript variant 1,
            mRNA.
ACCESSION   NM_172664 XM_001002185 XM_001002200 XM_001002208 XM_001002214
            XM_001002220 XM_982936 XM_982971 XM_983010 XM_983048 XM_983091
            XM_983131
VERSION     NM_172664.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4050)
  AUTHORS   Zhang,F., Xiang,X., Wen,C., Guo,X., Nie,L., Chen,J., Xia,Y., Hu,B.
            and Mao,L.
  TITLE     CircTLK1: A novel regulator involved in VSMC phenotypic switching
            and the developmental process of atherosclerosis
  JOURNAL   FASEB J 38 (6), e23557 (2024)
   PUBMED   38498343
  REMARK    GeneRIF: CircTLK1: A novel regulator involved in VSMC phenotypic
            switching and the developmental process of atherosclerosis.
REFERENCE   2  (bases 1 to 4050)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4050)
  AUTHORS   Kuang,L., Lu,A. and Yao,S.
  TITLE     CircTLK1 alleviates oxygen-glucose deprivation/reperfusion induced
            apoptosis in HK-2 cells through miR-136-5p/Bcl2 signal axis
  JOURNAL   Ren Fail 45 (1), 2236219 (2023)
   PUBMED   37462140
  REMARK    GeneRIF: CircTLK1 alleviates oxygen-glucose deprivation/reperfusion
            induced apoptosis in HK-2 cells through miR-136-5p/Bcl2 signal
            axis.
REFERENCE   4  (bases 1 to 4050)
  AUTHORS   Sun,R.C., Li,J., Li,Y.X., Wang,H.Z., Dal,E., Wang,M.L. and Li,Y.X.
  TITLE     Tousled-like kinase 1 promotes gastric cancer progression by
            regulating the tumor growth factor-beta signaling pathway
  JOURNAL   World J Gastroenterol 29 (44), 5919-5934 (2023)
   PUBMED   38111505
  REMARK    GeneRIF: Tousled-like kinase 1 promotes gastric cancer progression
            by regulating the tumor growth factor-beta signaling pathway.
REFERENCE   5  (bases 1 to 4050)
  AUTHORS   Song,Y.F., Zhao,L., Wang,B.C., Sun,J.J., Hu,J.L., Zhu,X.L.,
            Zhao,J., Zheng,D.K. and Ge,Z.W.
  TITLE     The circular RNA TLK1 exacerbates myocardial ischemia/reperfusion
            injury via targeting miR-214/RIPK1 through TNF signaling pathway
  JOURNAL   Free Radic Biol Med 155, 69-80 (2020)
   PUBMED   32445866
  REMARK    GeneRIF: The circular RNA TLK1 exacerbates myocardial
            ischemia/reperfusion injury via targeting miR-214/RIPK1 through TNF
            signaling pathway.
            Erratum:[Free Radic Biol Med. 2022 Feb 1;179:435-436. doi:
            10.1016/j.freeradbiomed.2021.03.012.. PMID: 33985875]
REFERENCE   6  (bases 1 to 4050)
  AUTHORS   Cobellis,G., Nicolaus,G., Iovino,M., Romito,A., Marra,E.,
            Barbarisi,M., Sardiello,M., Di Giorgio,F.P., Iovino,N., Zollo,M.,
            Ballabio,A. and Cortese,R.
  TITLE     Tagging genes with cassette-exchange sites
  JOURNAL   Nucleic Acids Res 33 (4), e44 (2005)
   PUBMED   15741177
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4050)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   8  (bases 1 to 4050)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 4050)
  AUTHORS   Sillje,H.H., Takahashi,K., Tanaka,K., Van Houwe,G. and Nigg,E.A.
  TITLE     Mammalian homologues of the plant Tousled gene code for
            cell-cycle-regulated kinases with maximal activities linked to
            ongoing DNA replication
  JOURNAL   EMBO J 18 (20), 5691-5702 (1999)
   PUBMED   10523312
REFERENCE   10 (bases 1 to 4050)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC051641.1.
            
            On Mar 14, 2009 this sequence version replaced NM_172664.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC051641.1, SRR1660819.62914.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4050              BC051641.1         1-4050
FEATURES             Location/Qualifiers
     source          1..4050
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 41.9 cM"
     gene            1..4050
                     /gene="Tlk1"
                     /gene_synonym="4930545J15Rik"
                     /note="tousled-like kinase 1"
                     /db_xref="GeneID:228012"
                     /db_xref="MGI:MGI:2441683"
     exon            1..288
                     /gene="Tlk1"
                     /gene_synonym="4930545J15Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             150..2450
                     /gene="Tlk1"
                     /gene_synonym="4930545J15Rik"
                     /EC_number="2.7.11.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     serine/threonine-protein kinase tousled-like 1"
                     /codon_start=1
                     /product="serine/threonine-protein kinase tousled-like 1
                     isoform 1"
                     /protein_id="NP_766252.2"
                     /db_xref="CCDS:CCDS50599.1"
                     /db_xref="GeneID:228012"
                     /db_xref="MGI:MGI:2441683"
                     /translation="MSVQSSSGSLEGPPSWSRLSTSPTPGSAAAARSLLNHTPPSGRP
                     REGAMDELHSLDPRRQELLEARFTGVATGSTGSTGSCSVGAKASTNNESSNHSFGSLG
                     SLSDKESETPEKKQSESSRGRKRKAESQNESSQGKSIGGRGHKISDYFEYQGGNGSSP
                     VRGIPPAIRSPQNSHSHSTPSSSVRPNSPSPTALAFGDHPVVQPKQLSFKITQTDLTM
                     LKLAALESTKNQDLEKKEGRIDDLLRANCDLRRQIDDQQKLLEKYKERLNKCISMSKK
                     LLIEKSTQEKLSSREKSMQDRLRLGHFTTVRHGASFTEQWTDGFAFQNLVKQQEWVNQ
                     QREDIERQRKLLGKRKPPTANNSQAPATNSEAKQRKTKAVNGAENDPFVRPNLPQLLT
                     LAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRINNEDNSQFKDHP
                     TLNERYLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACRE
                     YRIHKELDHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVM
                     QIVNALRYLNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGM
                     DLTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQD
                     ILQENTILKATEVQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYLLPHMRR
                     SNSSGNLHMSGLTATPTPPSSSIITY"
     exon            289..407
                     /gene="Tlk1"
                     /gene_synonym="4930545J15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            408..479
                     /gene="Tlk1"
                     /gene_synonym="4930545J15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            480..555
                     /gene="Tlk1"
                     /gene_synonym="4930545J15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            556..602
                     /gene="Tlk1"
                     /gene_synonym="4930545J15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            603..698
                     /gene="Tlk1"
                     /gene_synonym="4930545J15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            699..788
                     /gene="Tlk1"
                     /gene_synonym="4930545J15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            789..881
                     /gene="Tlk1"
                     /gene_synonym="4930545J15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            882..992
                     /gene="Tlk1"
                     /gene_synonym="4930545J15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1129
                     /gene="Tlk1"
                     /gene_synonym="4930545J15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1318
                     /gene="Tlk1"
                     /gene_synonym="4930545J15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1319..1385
                     /gene="Tlk1"
                     /gene_synonym="4930545J15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1483
                     /gene="Tlk1"
                     /gene_synonym="4930545J15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1484..1565
                     /gene="Tlk1"
                     /gene_synonym="4930545J15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1566..1747
                     /gene="Tlk1"
                     /gene_synonym="4930545J15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1748..1917
                     /gene="Tlk1"
                     /gene_synonym="4930545J15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1918..2053
                     /gene="Tlk1"
                     /gene_synonym="4930545J15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2054..2165
                     /gene="Tlk1"
                     /gene_synonym="4930545J15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2166..2273
                     /gene="Tlk1"
                     /gene_synonym="4930545J15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2274..4032
                     /gene="Tlk1"
                     /gene_synonym="4930545J15Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4006..4011
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tlk1"
                     /gene_synonym="4930545J15Rik"
                     /note="hexamer: AATAAA"
     polyA_site      4032
                     /gene="Tlk1"
                     /gene_synonym="4930545J15Rik"
                     /note="major polyA site"
ORIGIN      
        1 ccgcccggcg cgctccctcg gcggcgcggc gctcccctcc cagccctcgc gcccgcgctc
       61 gccctcagcg cggcccccgc catgacggag gcgggtgccg gtgccgccgc cgtcgcaggg
      121 ggggagtcgg gctcccagaa agtagcttga tgagtgtcca aagtagcagt ggaagtttgg
      181 aggggccgcc atcttggtcc cggctctcca cgtctccaac cccgggctcg gcggcggcgg
      241 ccaggtccct gctgaatcac acgccgccat ccgggaggcc cagggaaggt gcaatggatg
      301 agcttcacag tctggaccca agaaggcaag aattattgga agcaagattt actggagttg
      361 ctactgggag tactgggagt actgggagtt gcagtgttgg agcaaaagct tcaacaaata
      421 atgaaagttc taatcacagt tttggaagct taggatctct aagtgacaaa gaatcagaga
      481 caccagagaa gaaacaatca gagtcatcca ggggaagaaa gagaaaagca gaaagtcaga
      541 atgaaagtag tcagggaaaa agtatcgggg gacgtggcca taagatcagc gactattttg
      601 aataccaagg tggaaatggc tcgagtccag taagaggcat ccctccagca atccgttctc
      661 cgcagaactc acactcacat tccactcctt cctcatctgt tcgaccgaat agcccttctc
      721 ctactgcatt agctttcggg gaccaccctg ttgtacaacc aaagcagtta tcctttaaga
      781 tcactcaaac tgatcttaca atgctgaaat tggcagcatt agaaagtact aaaaatcaag
      841 acctggagaa gaaggaaggc cggattgatg atctgctcag ggccaactgt gatctcaggc
      901 ggcaaataga tgatcaacag aaattacttg aaaaatacaa agaacgatta aataagtgca
      961 tatctatgag caagaaacta cttattgaaa agagtacaca agaaaaattg tctagcagag
     1021 aaaagagtat gcaagatcgg ttgcgccttg ggcactttac cacagttaga cacggcgctt
     1081 cctttacaga acagtggaca gatggttttg catttcagaa tcttgtgaag caacaagaat
     1141 gggtgaatca acaaagggaa gacattgaac ggcaaagaaa acttctaggc aaacgcaaac
     1201 ctcccacagc taataattct caggcacctg ctaccaattc tgaagccaag caaagaaaga
     1261 ccaaggcagt caatggagcg gaaaacgatc cctttgttag gccaaattta ccacaactgc
     1321 tgactctggc agagtatcat gaacaagagg aaatttttaa acttagacta ggacatctca
     1381 aaaaggaaga ggctgaaatc caggcggaac tggagcgttt ggagagggtc cggaaccttc
     1441 acatccgaga gctgaagaga ataaacaatg aggataattc acagttcaaa gatcatccaa
     1501 cgttaaatga aagatattta ttacttcatc tgcttgggag aggcggcttt agtgaggtct
     1561 ataaggcatt cgacttgtat gagcaaagat acgctgctgt gaagatccac cagcttaata
     1621 agagctggag agacgagaag aaagaaaact accacaaaca cgcttgccga gagtatcgaa
     1681 tacacaagga actggaccac cccagaatag ttaaactcta tgattacttc tccttggata
     1741 cagatacgtt ttgtacagtg ctagagtact gtgaaggcaa tgacttggac ttctacctga
     1801 agcagcacaa gttgatgtct gagaaagaag ctcggtctat tgtgatgcag attgtgaatg
     1861 ccttacgcta tctcaatgaa atcaaacctc ctattataca ttatgacctt aagccaggaa
     1921 atatccttct ggtagatgga acagcatgtg gagaaatcaa aatcactgat tttggtctgt
     1981 ccaagattat ggatgacgat agttacggtg ttgatgggat ggatctgact tcccaggggg
     2041 caggcactta ctggtattta cctcctgagt gctttgtagt tggaaaagag ccaccgaaga
     2101 tctccaacaa ggttgacgtg tggtcagttg gggtcatctt cttccagtgc ctctatggta
     2161 gaaaaccatt tggtcacaat caatctcaac aagacattct acaggaaaac acaatactga
     2221 aagccacaga agtccagttc cctgtaaaac ctgttgtaag cagtgaagcc aaggccttca
     2281 taagacgctg tttggcttac cgaaaagaag atcgatttga tgtgcaccag ctggcaaatg
     2341 acccatacct tctgccacac atgagaagat caaattcttc aggaaactta catatgtctg
     2401 ggctgacagc aactcccaca cctccttctt caagcataat tacttactga ctcctctaag
     2461 attggcatga cctcttctct ttgattggct tccagatgca cacttgaatt tgactgcatt
     2521 ggactgtttg tggtattttt acatggacat ggttaagaag tgtttgtgaa ctaagctctc
     2581 caaggagtcc ttgtgtgaga gtggatcatg gacagtgact aagtacacac tcactcctca
     2641 ctgccctgga gcagcacgaa acaggaatac catgttacag tagaacaagg ggactctgta
     2701 aataacgttt ataatactta aatatatttg attgttacca gagagttgta atatgaaggg
     2761 tagtttttca ttatttaaga acacatggaa aaatgaggag acatttgtaa cccgggagct
     2821 acagtgcctg gtacagcgtc agcactcggc agctgatcta cagaaaccaa agcaagaact
     2881 gagtgacagc agccgctgtg tttataacag aatgtgagag ttagggtctt tggacagttg
     2941 gagactttgt catttgccta ttctgacttt taccaagttg tacctcgaga tcacgtgtca
     3001 gtggtccgcc gccctacccc cgacccctta accggttatg ttaaaggcaa gctgtcgttt
     3061 ctggacactt tacaccttta acacaaagag ctgcctattt caaatcagtt gaagttacta
     3121 aatgatagta tttccagggc tttcagtggg ttagattaac aggcgttttt cttttgtttt
     3181 caggcctggt tcattaaaac agaagacagt gtgtaaccaa aagcaggcca gttgtatgca
     3241 ggataatgat gaattccctt ctggctctat tgtaaactac tgtacagatg tcggattaca
     3301 attactgagt ttcagcagct tattcttgta caaatgttta aaaatacggc ttttctaatt
     3361 ggatattgta ttttttttaa gtcttcttga aggcgcttta attgctgcta aatgatattg
     3421 cttttttgct ataaaaaatt gaatgacctt gaaggcacaa gttgactgta catcatagag
     3481 agatattaaa agcaggcact cgttaacaat caaggcatgt gcagtgatcc atgctgggca
     3541 tattgagttc ttcaaatcag ttttttaggt tctggagctg tggaacacat agaaactaga
     3601 tttataaatt gttcatggtt attctacatt tctagaaagt tcttagcatc aaggtgggat
     3661 gatagtccca tagaatgttt ctcgtggttt gtacagattt gttaaaatgt gaacattttc
     3721 taactacctt gtgtggtaga aaccaatatt tttttgggga tgctgtattt cattcttgaa
     3781 aggatttttt tttctttatt gtcaaattca taatgccgag acttacatgt aagttgtcca
     3841 tggtgcagac aacaggctat ccctgccagc cgcccctaac atgtacagtt acactgtggc
     3901 tcttacctgg tgttgcaagc catttcgttt gtttgttttc attgtacata gacacactgt
     3961 ctgtttaaga tgctgctgga attatagaga atgtagccaa acagtaataa acaatgacag
     4021 taaaaatgta aaaaaaaaaa aaaaaaaaaa
//
