LOCUS       NM_053254               2015 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus transducin-like enhancer of split 6 (Tle6), transcript
            variant 1, mRNA.
ACCESSION   NM_053254
VERSION     NM_053254.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2015)
  AUTHORS   Kazama,K., Miyagoshi,Y. and Nishizono,H.
  TITLE     Tle6 deficiency in male mice led to abnormal sperm morphology and
            reduced sperm motility
  JOURNAL   Front Cell Dev Biol 12, 1481659 (2024)
   PUBMED   39512902
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2015)
  AUTHORS   Han,Z., Wang,R., Chi,P., Zhang,Z., Min,L., Jiao,H., Ou,G., Zhou,D.,
            Qin,D., Xu,C., Gao,Z., Qi,Q., Li,J., Lu,Y., Wang,X., Chen,J.,
            Yu,X., Hu,H., Li,L. and Deng,D.
  TITLE     The subcortical maternal complex modulates the cell cycle during
            early mammalian embryogenesis via 14-3-3
  JOURNAL   Nat Commun 15 (1), 8887 (2024)
   PUBMED   39406751
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2015)
  AUTHORS   Zhang,W., Zhang,R., Wu,L., Zhu,C., Zhang,C., Xu,C., Zhao,S.,
            Liu,X., Guo,T., Lu,Y., Gao,Z., Yu,X., Li,L., Chen,Z.J., Qin,Y. and
            Jiao,X.
  TITLE     NLRP14 deficiency causes female infertility with oocyte maturation
            defects and early embryonic arrest by impairing cytoplasmic UHRF1
            abundance
  JOURNAL   Cell Rep 42 (12), 113531 (2023)
   PUBMED   38060382
REFERENCE   4  (bases 1 to 2015)
  AUTHORS   Jentoft,I.M.A., Bauerlein,F.J.B., Welp,L.M., Cooper,B.H.,
            Petrovic,A., So,C., Penir,S.M., Politi,A.Z., Horokhovskyi,Y.,
            Takala,I., Eckel,H., Moltrecht,R., Lenart,P., Cavazza,T., Liepe,J.,
            Brose,N., Urlaub,H., Fernandez-Busnadiego,R. and Schuh,M.
  TITLE     Mammalian oocytes store proteins for the early embryo on
            cytoplasmic lattices
  JOURNAL   Cell 186 (24), 5308-5327 (2023)
   PUBMED   37922900
REFERENCE   5  (bases 1 to 2015)
  AUTHORS   Meng,T.G., Guo,J.N., Zhu,L., Yin,Y., Wang,F., Han,Z.M., Lei,L.,
            Ma,X.S., Xue,Y., Yue,W., Nie,X.Q., Zhao,Z.H., Zhang,H.Y., Sun,S.M.,
            Ouyang,Y.C., Hou,Y., Schatten,H., Ju,Z., Ou,X.H., Wang,Z.B.,
            Wong,C.C.L., Li,Z. and Sun,Q.Y.
  TITLE     NLRP14 Safeguards Calcium Homeostasis via Regulating the K27
            Ubiquitination of Nclx in Oocyte-to-Embryo Transition
  JOURNAL   Adv Sci (Weinh) 10 (27), e2301940 (2023)
   PUBMED   37493331
REFERENCE   6  (bases 1 to 2015)
  AUTHORS   Hoffman,B.G., Zavaglia,B., Beach,M. and Helgason,C.D.
  TITLE     Expression of Groucho/TLE proteins during pancreas development
  JOURNAL   BMC Dev Biol 8, 81 (2008)
   PUBMED   18778483
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2015)
  AUTHORS   Chen,P.C., Kuraguchi,M., Velasquez,J., Wang,Y., Yang,K.,
            Edwards,R., Gillen,D., Edelmann,W., Kucherlapati,R. and Lipkin,S.M.
  TITLE     Novel roles for MLH3 deficiency and TLE6-like amplification in DNA
            mismatch repair-deficient gastrointestinal tumorigenesis and
            progression
  JOURNAL   PLoS Genet 4 (6), e1000092 (2008)
   PUBMED   18551179
  REMARK    GeneRIF: Expression of Tle6-like in colon cancer cells increased
            cell proliferation, colony-formation, cell migration, and xenograft
            tumorgenicity.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2015)
  AUTHORS   Hoffman,B.G., Zavaglia,B., Witzsche,J., Ruiz de Algara,T.,
            Beach,M., Hoodless,P.A., Jones,S.J., Marra,M.A. and Helgason,C.D.
  TITLE     Identification of transcripts with enriched expression in the
            developing and adult pancreas
  JOURNAL   Genome Biol 9 (6), R99 (2008)
   PUBMED   18554416
REFERENCE   9  (bases 1 to 2015)
  AUTHORS   Marcal,N., Patel,H., Dong,Z., Belanger-Jasmin,S., Hoffman,B.,
            Helgason,C.D., Dang,J. and Stifani,S.
  TITLE     Antagonistic effects of Grg6 and Groucho/TLE on the transcription
            repression activity of brain factor 1/FoxG1 and cortical neuron
            differentiation
  JOURNAL   Mol Cell Biol 25 (24), 10916-10929 (2005)
   PUBMED   16314515
  REMARK    GeneRIF: Grg6 is expressed in cortical neural progenitor cells,
            interacts with BF-1, and plays a role in in cortical neuron
            development.
REFERENCE   10 (bases 1 to 2015)
  AUTHORS   Dang,J., Inukai,T., Kurosawa,H., Goi,K., Inaba,T., Lenny,N.T.,
            Downing,J.R., Stifani,S. and Look,A.T.
  TITLE     The E2A-HLF oncoprotein activates Groucho-related genes and
            suppresses Runx1
  JOURNAL   Mol Cell Biol 21 (17), 5935-5945 (2001)
   PUBMED   11486032
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC153919.8.
            
            On Nov 17, 2006 this sequence version replaced NM_053254.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF145957.2, SRR13422592.106053.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-103               AC153919.8         55828-55930
            104-184             AC153919.8         56613-56693
            185-246             AC153919.8         57590-57651
            247-292             AC153919.8         58072-58117
            293-703             AC153919.8         60473-60883
            704-779             AC153919.8         61173-61248
            780-862             AC153919.8         61323-61405
            863-900             AC153919.8         61483-61520
            901-1159            AC153919.8         62143-62401
            1160-1407           AC153919.8         62486-62733
            1408-1549           AC153919.8         63874-64015
            1550-1703           AC153919.8         64689-64842
            1704-1780           AC153919.8         65392-65468
            1781-2015           AC153919.8         65589-65823
FEATURES             Location/Qualifiers
     source          1..2015
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 39.72 cM"
     gene            1..2015
                     /gene="Tle6"
                     /gene_synonym="1810057E06Rik; Grg6"
                     /note="transducin-like enhancer of split 6"
                     /db_xref="GeneID:114606"
                     /db_xref="MGI:MGI:2149593"
     exon            1..103
                     /gene="Tle6"
                     /gene_synonym="1810057E06Rik; Grg6"
                     /inference="alignment:Splign:2.1.0"
     exon            104..184
                     /gene="Tle6"
                     /gene_synonym="1810057E06Rik; Grg6"
                     /inference="alignment:Splign:2.1.0"
     CDS             140..1885
                     /gene="Tle6"
                     /gene_synonym="1810057E06Rik; Grg6"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transducin-like enhancer protein 6; Groucho-related
                     protein 6; transducin-like enhancer of split 6, homolog of
                     Drosophila E(spl)"
                     /codon_start=1
                     /product="transducin-like enhancer protein 6 isoform 1"
                     /protein_id="NP_444484.1"
                     /db_xref="CCDS:CCDS24064.1"
                     /db_xref="GeneID:114606"
                     /db_xref="MGI:MGI:2149593"
                     /translation="MTSHRQSSDTFGGILPSTLSSRYLSIVNQLPEEFSSVVSEMMVH
                     LENIFSLAENFFQAIERFSRTPDLLERNKMSIGVGAEGDSWPCHVSHEAPMGSAQTTE
                     NSAKEEDKQVPESAALQHPKFKSTPGPQLPTRRRFLSESDELQDPQPVWDAEPQFCQG
                     FLIQGLWELFMDSRQKNQQEHGGEDSSQESKDSGLCDFKPEPQPRHRNSLSDSADPFL
                     IKSPSALLDYYQEDVSRPQPETQESSGRADKFLKPLSWGSEVLESSCNQPSTALWQLE
                     RFTVPQALQKVRVLKHQELLLVVAVSSFTRHVFTCSQSGIKVWNLVNQVAEDRDPESH
                     LKCSVQDNKVYLRTCLLSSNSRTLFAGGYNLPGVIVWDLAAPSLYEKCQLPCEGLSCQ
                     ALANTKENMALAGFTDGTVRIWDLRTQEIVRNLKGPTNSARNLVVKDDNIWTGGLDAC
                     LRCWDLRMAKVSLEHLFQSQIMSLAHSPTEDWLLLGLANGQHCLFNSRKRDQVLTVDT
                     KDNTILGLKFSPNGKWWASVGMGNFITVHSMPTGAKLFQVPEVGPVRCFDMTENGRLI
                     ITGSRDCASVYHIKY"
     exon            185..246
                     /gene="Tle6"
                     /gene_synonym="1810057E06Rik; Grg6"
                     /inference="alignment:Splign:2.1.0"
     exon            247..292
                     /gene="Tle6"
                     /gene_synonym="1810057E06Rik; Grg6"
                     /inference="alignment:Splign:2.1.0"
     exon            293..703
                     /gene="Tle6"
                     /gene_synonym="1810057E06Rik; Grg6"
                     /inference="alignment:Splign:2.1.0"
     exon            704..779
                     /gene="Tle6"
                     /gene_synonym="1810057E06Rik; Grg6"
                     /inference="alignment:Splign:2.1.0"
     exon            780..862
                     /gene="Tle6"
                     /gene_synonym="1810057E06Rik; Grg6"
                     /inference="alignment:Splign:2.1.0"
     exon            863..900
                     /gene="Tle6"
                     /gene_synonym="1810057E06Rik; Grg6"
                     /inference="alignment:Splign:2.1.0"
     exon            901..1159
                     /gene="Tle6"
                     /gene_synonym="1810057E06Rik; Grg6"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..1407
                     /gene="Tle6"
                     /gene_synonym="1810057E06Rik; Grg6"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..1549
                     /gene="Tle6"
                     /gene_synonym="1810057E06Rik; Grg6"
                     /inference="alignment:Splign:2.1.0"
     exon            1550..1703
                     /gene="Tle6"
                     /gene_synonym="1810057E06Rik; Grg6"
                     /inference="alignment:Splign:2.1.0"
     exon            1704..1780
                     /gene="Tle6"
                     /gene_synonym="1810057E06Rik; Grg6"
                     /inference="alignment:Splign:2.1.0"
     exon            1781..2015
                     /gene="Tle6"
                     /gene_synonym="1810057E06Rik; Grg6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaatggcccg gggcccagca ggaggggctt cctcctggcc tgaccctggc tgacctcaga
       61 ggcttcctct gggatccctg gggcctccct aacctcagag gtggacttaa tcagatttgt
      121 gacctcaaga atcttctaga tgacttccca cagacagagc agtgacacct ttggtggaat
      181 tttgccttcc accttatcca gtcggtattt gtccatcgtg aaccagcttc cggaggagtt
      241 cagcagcgtc gtctctgaaa tgatggttca cctagagaac atcttcagcc tggcagaaaa
      301 cttcttccag gcgatagagc gcttcagtag aaccccagac ctcctggaga ggaacaagat
      361 gagtattggt gttggggctg aaggggacag ttggccatgt catgtgtctc atgaggcccc
      421 aatgggctct gcccagacca cagagaactc agctaaggaa gaagacaaac aggtcccaga
      481 gtctgcagcc ctccagcacc ccaagttcaa aagcaccccg gggcctcagc tgcccaccag
      541 acgtcggttc ctctcagaga gtgatgagct ccaggaccca cagccggtct gggacgcgga
      601 gccccagttc tgtcaaggct tcctgatcca gggactctgg gaacttttca tggacagccg
      661 ccaaaagaac caacaggaac acgggggtga ggattcctca caggaaagca aagattcagg
      721 cctgtgtgac tttaaaccag aacctcagcc caggcacaga aacagcctga gtgactctgc
      781 cgaccccttc ctgatcaagt ctccctcagc tcttctagat tattaccaag aagacgtcag
      841 tcggccccaa cctgagacgc aggaatcttc tggaagagct gataaatttc tgaagccctt
      901 gtcctggggc tctgaagtct tagagagcag ctgtaatcag cctagcacag cactctggca
      961 attagagagg ttcactgtcc cccaagcact gcagaaggtg cgtgtgctga agcaccagga
     1021 actgctattg gtggtagctg tgagctcctt cacgcggcac gtcttcacct gcagccagag
     1081 cggcatcaag gtgtggaacc tcgtgaacca ggtggccgag gacagagacc cagaaagcca
     1141 cttgaaatgc agcgtccagg acaacaaggt gtacctgcgc acctgcctgc tgtcctccaa
     1201 cagcaggacc ctgttcgcgg gtggatacaa cttacctggc gtgatcgtgt gggacctggc
     1261 agccccatcc ctgtatgaga agtgccagct gccctgcgag ggcctgtcct gccaggcact
     1321 ggccaacaca aaggaaaaca tggcccttgc cggcttcaca gatggcacgg tcaggatatg
     1381 ggacctacgg actcaggaaa tagtcaggaa cctcaaaggc cctaccaatt cggccaggaa
     1441 ccttgtggtc aaagatgaca acatctggac agggggtctg gacgcctgcc tgcgatgctg
     1501 ggacctgcgg atggccaagg tgtcactgga gcatctgttc cagtcccaga tcatgagcct
     1561 ggctcacagt ccgaccgaag actggctgct gctgggcctg gccaatggcc agcactgcct
     1621 gttcaacagc aggaagaggg accaggtgct cactgtggac accaaggaca acaccatctt
     1681 aggcctcaag ttctccccaa atggcaagtg gtgggcgagc gtcggtatgg gcaacttcat
     1741 cacggtccac agcatgccca ccggagcaaa actgttccag gtccccgagg ttggccctgt
     1801 cagatgcttc gacatgactg agaacggcag gctcatcatc acaggatcca gggactgtgc
     1861 ctcggtgtac cacatcaagt actgacaact tcaactcccc tcccctaact gcacagtggt
     1921 ggatggcaat gggtgtgatg ggtctgcagt gcttctagag gcttccatgg ggtgtgcaga
     1981 tcccgagttg cgtgtaataa aacaattgaa atggc
//
