LOCUS       NM_010347               1488 bp    mRNA    linear   ROD 06-JUN-2024
DEFINITION  Mus musculus TLE family member 5, transcriptional modulator (Tle5),
            transcript variant 1, mRNA.
ACCESSION   NM_010347
VERSION     NM_010347.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1488)
  AUTHORS   Chung,I.C., Huang,W.C., Huang,Y.T., Chen,M.L., Tsai,A.W., Wu,P.Y.
            and Yuan,T.T.
  TITLE     Unrevealed roles of extracellular enolase-1 (ENO1) in promoting
            glycolysis and pro-cancer activities in multiple myeloma via
            hypoxia-inducible factor 1alpha
  JOURNAL   Oncol Rep 50 (5) (2023)
   PUBMED   37800625
  REMARK    GeneRIF: Unrevealed roles of extracellular enolase-1 (ENO1) in
            promoting glycolysis and pro-cancer activities in multiple myeloma
            via hypoxia-inducible factor 1alpha.
REFERENCE   2  (bases 1 to 1488)
  AUTHORS   Cheung,L.Y.M. and Camper,S.A.
  TITLE     PROP1-Dependent Retinoic Acid Signaling Regulates Developmental
            Pituitary Morphogenesis and Hormone Expression
  JOURNAL   Endocrinology 161 (2) (2020)
   PUBMED   31913463
REFERENCE   3  (bases 1 to 1488)
  AUTHORS   Chanoumidou,K., Hadjimichael,C., Athanasouli,P., Ahlenius,H.,
            Klonizakis,A., Nikolaou,C., Drakos,E., Kostouros,A., Stratidaki,I.,
            Grigoriou,M. and Kretsovali,A.
  TITLE     Groucho related gene 5 (GRG5) is involved in embryonic and neural
            stem cell state decisions
  JOURNAL   Sci Rep 8 (1), 13790 (2018)
   PUBMED   30214018
  REMARK    GeneRIF: The results demonstrate that GRG5 has pleiotropic roles in
            stem cell biology functioning as a stemness factor and a neural
            fate specifier.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1488)
  AUTHORS   Zhou,F., Liu,Y., Rohde,C., Pauli,C., Gerloff,D., Kohn,M.,
            Misiak,D., Baumer,N., Cui,C., Gollner,S., Oellerich,T., Serve,H.,
            Garcia-Cuellar,M.P., Slany,R., Maciejewski,J.P., Przychodzen,B.,
            Seliger,B., Klein,H.U., Bartenhagen,C., Berdel,W.E., Dugas,M.,
            Taketo,M.M., Farouq,D., Schwartz,S., Regev,A., Hebert,J.,
            Sauvageau,G., Pabst,C., Huttelmaier,S. and Muller-Tidow,C.
  TITLE     AML1-ETO requires enhanced C/D box snoRNA/RNP formation to induce
            self-renewal and leukaemia
  JOURNAL   Nat Cell Biol 19 (7), 844-855 (2017)
   PUBMED   28650479
REFERENCE   5  (bases 1 to 1488)
  AUTHORS   Okada,Y., Sonoshita,M., Kakizaki,F., Aoyama,N., Itatani,Y.,
            Uegaki,M., Sakamoto,H., Kobayashi,T., Inoue,T., Kamba,T.,
            Suzuki,A., Ogawa,O. and Taketo,M.M.
  TITLE     Amino-terminal enhancer of split gene AES encodes a tumor and
            metastasis suppressor of prostate cancer
  JOURNAL   Cancer Sci 108 (4), 744-752 (2017)
   PUBMED   28178391
REFERENCE   6  (bases 1 to 1488)
  AUTHORS   Mallo,M., Gendron-Maguire,M., Harbison,M.L. and Gridley,T.
  TITLE     Protein characterization and targeted disruption of Grg, a mouse
            gene related to the groucho transcript of the Drosophila Enhancer
            of split complex
  JOURNAL   Dev Dyn 204 (3), 338-347 (1995)
   PUBMED   8573724
REFERENCE   7  (bases 1 to 1488)
  AUTHORS   Mallo,M., Lieberman,P.M. and Gridley,T.
  TITLE     Possible involvement of the mouse Grg protein in transcription
  JOURNAL   Cell Mol Biol Res 41 (5), 435-440 (1995)
   PUBMED   8867791
REFERENCE   8  (bases 1 to 1488)
  AUTHORS   Mallo,M., Steingrimsson,E., Copeland,N.G., Jenkins,N.A. and
            Gridley,T.
  TITLE     Genomic organization, alternative polyadenylation, and chromosomal
            localization of Grg, a mouse gene related to the groucho transcript
            of the Drosophila Enhancer of split complex
  JOURNAL   Genomics 21 (1), 194-201 (1994)
   PUBMED   7916324
REFERENCE   9  (bases 1 to 1488)
  AUTHORS   Miyasaka,H., Choudhury,B.K., Hou,E.W. and Li,S.S.
  TITLE     Molecular cloning and expression of mouse and human cDNA encoding
            AES and ESG proteins with strong similarity to Drosophila enhancer
            of split groucho protein
  JOURNAL   Eur J Biochem 216 (1), 343-352 (1993)
   PUBMED   8365415
REFERENCE   10 (bases 1 to 1488)
  AUTHORS   Mallo,M., Franco del Amo,F. and Gridley,T.
  TITLE     Cloning and developmental expression of Grg, a mouse gene related
            to the groucho transcript of the Drosophila Enhancer of split
            complex
  JOURNAL   Mech Dev 42 (1-2), 67-76 (1993)
   PUBMED   8369224
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY713872.1, AK158714.1 and
            BQ174071.1.
            
            On Jan 25, 2013 this sequence version replaced NM_010347.3.
            
            Summary: This gene encodes a protein that belongs to the Aes
            (amino-terminal enhancer of split) subgroup of the
            Groucho/transducin-like Enhancer of split (TLE) family of proteins
            that function as transcriptional corepressors. The encoded protein
            plays a role in neurological development and cell-fate
            determination. Alternatively spliced transcript variants have been
            observed for this gene. [provided by RefSeq, Jan 2013].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK131994.1, AK158714.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-116               BY713872.1         2-117
            117-1463            AK158714.1         2-1348
            1464-1488           BQ174071.1         1-25                c
FEATURES             Location/Qualifiers
     source          1..1488
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 39.72 cM"
     gene            1..1488
                     /gene="Tle5"
                     /gene_synonym="Aes; Esp1; Grg; Grg-5; Grg5"
                     /note="TLE family member 5, transcriptional modulator"
                     /db_xref="GeneID:14797"
                     /db_xref="MGI:MGI:95806"
     exon            1..225
                     /gene="Tle5"
                     /gene_synonym="Aes; Esp1; Grg; Grg-5; Grg5"
                     /inference="alignment:Splign:2.1.0"
     exon            226..323
                     /gene="Tle5"
                     /gene_synonym="Aes; Esp1; Grg; Grg-5; Grg5"
                     /inference="alignment:Splign:2.1.0"
     exon            324..387
                     /gene="Tle5"
                     /gene_synonym="Aes; Esp1; Grg; Grg-5; Grg5"
                     /inference="alignment:Splign:2.1.0"
     exon            388..432
                     /gene="Tle5"
                     /gene_synonym="Aes; Esp1; Grg; Grg-5; Grg5"
                     /inference="alignment:Splign:2.1.0"
     exon            433..495
                     /gene="Tle5"
                     /gene_synonym="Aes; Esp1; Grg; Grg-5; Grg5"
                     /inference="alignment:Splign:2.1.0"
     exon            496..570
                     /gene="Tle5"
                     /gene_synonym="Aes; Esp1; Grg; Grg-5; Grg5"
                     /inference="alignment:Splign:2.1.0"
     exon            571..1470
                     /gene="Tle5"
                     /gene_synonym="Aes; Esp1; Grg; Grg-5; Grg5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1241..1246
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tle5"
                     /gene_synonym="Aes; Esp1; Grg; Grg-5; Grg5"
                     /note="hexamer: AATAAA"
     polyA_site      1263
                     /gene="Tle5"
                     /gene_synonym="Aes; Esp1; Grg; Grg-5; Grg5"
                     /note="major polyA site"
     regulatory      1441..1446
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tle5"
                     /gene_synonym="Aes; Esp1; Grg; Grg-5; Grg5"
                     /note="hexamer: AATAAA"
     polyA_site      1461
                     /gene="Tle5"
                     /gene_synonym="Aes; Esp1; Grg; Grg-5; Grg5"
ORIGIN      
        1 gggcgcggca ggtggagcgg gagcccgggc ggcaccgcgt cgccattaca caatagcgcg
       61 ggcggcgcgg gcgggcggcg ggcggcgcag gaggcgggac gcggggcccc ggagctgtcg
      121 atcggggaca aagcgcggcc gcccggcgcc ccccgagccg cccgagccgg ggcgcagccc
      181 gcgccccccg cgactgacat gatgtttccg caaagccggc actcgggctc ctcccacctc
      241 cctcagcagc tcaagttcac cacctccgac tcctgtgacc gcatcaaaga tgagttccag
      301 ctgctgcaag cgcagtatca cagcctgaag ctggagtgcg acaagctggc cagcgagaag
      361 tcagagatgc agaggcatta cgtcatgtac tatgagatgt cctacggatt gaacatcgag
      421 atgcacaaac aggcggaaat tgtgaagagg ctgaatggga tttgcgccca ggttctgccc
      481 tatttgtcac aggagcatca gcagcaggtc ctgggagcca tcgagagagc caagcaggtc
      541 acggctcctg agctgaactc catcatccga cagcagctcc aggctcacca gctgtcccag
      601 ctgcaggcgc tggccctgcc cctgacaccg ctgcctgtcg ggctccagcc accgtccctc
      661 cctgcagtca gtgcaggcac aggcctgctg tcactctctg ctctgggttc tcagacccac
      721 ctctccaagg aggacaagaa cggacacgat ggggacaccc accaggagga tgacggagag
      781 aagtcggatt agctcttggg gaagggggag gggggagacc aggggagaca ggcacagaga
      841 gcgcagtgtt ctaagggcca cacagcacac agctctgtca ctacccaagc ttacacctcc
      901 agtcctggtt ctggctgtgc accctgggcc taggggacgc cagagggaca ccccaggcta
      961 agggttcttc cccaccttca acatttccct gggccacagc caccaatctc ggcccagaat
     1021 gtacacaacg ctagctgccc ctttccaccc tgtgcacccc gaatctgccc ctatcccctt
     1081 ctctgcttcc tgcactgcac acctgctagt cccagacccc tccccccagc tcccccagct
     1141 ccggttccct caaccacaaa agaaggggac agagagaaag cattggctcg ggactgcagt
     1201 gggggtgggc accccacaaa cttccctccc ctcttcccca aataaacgtg agggttaaaa
     1261 gttggtttgt ttatgatttc tttcttgtgc cagtattcta tagctatcat ctcagaaagg
     1321 aaaagaagga agccccagga gtgtctgtca tagggttagc tttgttggtc gccttggtct
     1381 ctgtccagag gtcaaaggcc aagccgctgt actgaggatg gggtctagct gtgccttcaa
     1441 aataaaaaca tgaaaaggtt ggccactgtg aaaaaaaaaa aaaaaaaa
//
