LOCUS       NM_001276288            1485 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus TLE family member 5, transcriptional modulator (Tle5),
            transcript variant 2, mRNA.
ACCESSION   NM_001276288
VERSION     NM_001276288.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1485)
  AUTHORS   Chung,I.C., Huang,W.C., Huang,Y.T., Chen,M.L., Tsai,A.W., Wu,P.Y.
            and Yuan,T.T.
  TITLE     Unrevealed roles of extracellular enolase-1 (ENO1) in promoting
            glycolysis and pro-cancer activities in multiple myeloma via
            hypoxia-inducible factor 1alpha
  JOURNAL   Oncol Rep 50 (5) (2023)
   PUBMED   37800625
  REMARK    GeneRIF: Unrevealed roles of extracellular enolase-1 (ENO1) in
            promoting glycolysis and pro-cancer activities in multiple myeloma
            via hypoxia-inducible factor 1alpha.
REFERENCE   2  (bases 1 to 1485)
  AUTHORS   Cheung,L.Y.M. and Camper,S.A.
  TITLE     PROP1-Dependent Retinoic Acid Signaling Regulates Developmental
            Pituitary Morphogenesis and Hormone Expression
  JOURNAL   Endocrinology 161 (2) (2020)
   PUBMED   31913463
REFERENCE   3  (bases 1 to 1485)
  AUTHORS   Chanoumidou,K., Hadjimichael,C., Athanasouli,P., Ahlenius,H.,
            Klonizakis,A., Nikolaou,C., Drakos,E., Kostouros,A., Stratidaki,I.,
            Grigoriou,M. and Kretsovali,A.
  TITLE     Groucho related gene 5 (GRG5) is involved in embryonic and neural
            stem cell state decisions
  JOURNAL   Sci Rep 8 (1), 13790 (2018)
   PUBMED   30214018
  REMARK    GeneRIF: The results demonstrate that GRG5 has pleiotropic roles in
            stem cell biology functioning as a stemness factor and a neural
            fate specifier.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1485)
  AUTHORS   Zhou,F., Liu,Y., Rohde,C., Pauli,C., Gerloff,D., Kohn,M.,
            Misiak,D., Baumer,N., Cui,C., Gollner,S., Oellerich,T., Serve,H.,
            Garcia-Cuellar,M.P., Slany,R., Maciejewski,J.P., Przychodzen,B.,
            Seliger,B., Klein,H.U., Bartenhagen,C., Berdel,W.E., Dugas,M.,
            Taketo,M.M., Farouq,D., Schwartz,S., Regev,A., Hebert,J.,
            Sauvageau,G., Pabst,C., Huttelmaier,S. and Muller-Tidow,C.
  TITLE     AML1-ETO requires enhanced C/D box snoRNA/RNP formation to induce
            self-renewal and leukaemia
  JOURNAL   Nat Cell Biol 19 (7), 844-855 (2017)
   PUBMED   28650479
REFERENCE   5  (bases 1 to 1485)
  AUTHORS   Okada,Y., Sonoshita,M., Kakizaki,F., Aoyama,N., Itatani,Y.,
            Uegaki,M., Sakamoto,H., Kobayashi,T., Inoue,T., Kamba,T.,
            Suzuki,A., Ogawa,O. and Taketo,M.M.
  TITLE     Amino-terminal enhancer of split gene AES encodes a tumor and
            metastasis suppressor of prostate cancer
  JOURNAL   Cancer Sci 108 (4), 744-752 (2017)
   PUBMED   28178391
REFERENCE   6  (bases 1 to 1485)
  AUTHORS   Mallo,M., Gendron-Maguire,M., Harbison,M.L. and Gridley,T.
  TITLE     Protein characterization and targeted disruption of Grg, a mouse
            gene related to the groucho transcript of the Drosophila Enhancer
            of split complex
  JOURNAL   Dev Dyn 204 (3), 338-347 (1995)
   PUBMED   8573724
REFERENCE   7  (bases 1 to 1485)
  AUTHORS   Mallo,M., Lieberman,P.M. and Gridley,T.
  TITLE     Possible involvement of the mouse Grg protein in transcription
  JOURNAL   Cell Mol Biol Res 41 (5), 435-440 (1995)
   PUBMED   8867791
REFERENCE   8  (bases 1 to 1485)
  AUTHORS   Mallo,M., Steingrimsson,E., Copeland,N.G., Jenkins,N.A. and
            Gridley,T.
  TITLE     Genomic organization, alternative polyadenylation, and chromosomal
            localization of Grg, a mouse gene related to the groucho transcript
            of the Drosophila Enhancer of split complex
  JOURNAL   Genomics 21 (1), 194-201 (1994)
   PUBMED   7916324
REFERENCE   9  (bases 1 to 1485)
  AUTHORS   Miyasaka,H., Choudhury,B.K., Hou,E.W. and Li,S.S.
  TITLE     Molecular cloning and expression of mouse and human cDNA encoding
            AES and ESG proteins with strong similarity to Drosophila enhancer
            of split groucho protein
  JOURNAL   Eur J Biochem 216 (1), 343-352 (1993)
   PUBMED   8365415
REFERENCE   10 (bases 1 to 1485)
  AUTHORS   Mallo,M., Franco del Amo,F. and Gridley,T.
  TITLE     Cloning and developmental expression of Grg, a mouse gene related
            to the groucho transcript of the Drosophila Enhancer of split
            complex
  JOURNAL   Mech Dev 42 (1-2), 67-76 (1993)
   PUBMED   8369224
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY713872.1, BC145299.1,
            AK158714.1 and BQ174071.1.
            
            Summary: This gene encodes a protein that belongs to the Aes
            (amino-terminal enhancer of split) subgroup of the
            Groucho/transducin-like Enhancer of split (TLE) family of proteins
            that function as transcriptional corepressors. The encoded protein
            plays a role in neurological development and cell-fate
            determination. Alternatively spliced transcript variants have been
            observed for this gene. [provided by RefSeq, Jan 2013].
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the 3' coding region compared to variant 1. It
            encodes isoform 2 which is shorter than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BI653522.1, BC145299.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-112               BY713872.1         2-113
            113-829             BC145299.1         1-717
            830-951             AK158714.1         718-839
            952-1485            BQ174071.1         1-534               c
FEATURES             Location/Qualifiers
     source          1..1485
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 39.72 cM"
     gene            1..1485
                     /gene="Tle5"
                     /gene_synonym="Aes; Esp1; Grg; Grg-5; Grg5"
                     /note="TLE family member 5, transcriptional modulator"
                     /db_xref="GeneID:14797"
                     /db_xref="MGI:MGI:95806"
     exon            1..225
                     /gene="Tle5"
                     /gene_synonym="Aes; Esp1; Grg; Grg-5; Grg5"
                     /inference="alignment:Splign:2.1.0"
     CDS             199..789
                     /gene="Tle5"
                     /gene_synonym="Aes; Esp1; Grg; Grg-5; Grg5"
                     /note="isoform 2 is encoded by transcript variant 2;
                     related to Drosophila groucho; groucho-related protein 5;
                     amino-terminal enhancer of split"
                     /codon_start=1
                     /product="TLE family member 5 isoform 2"
                     /protein_id="NP_001263217.1"
                     /db_xref="GeneID:14797"
                     /db_xref="MGI:MGI:95806"
                     /translation="MMFPQSRHSGSSHLPQQLKFTTSDSCDRIKDEFQLLQAQYHSLK
                     LECDKLASEKSEMQRHYVMYYEMSYGLNIEMHKQAEIVKRLNGICAQVLPYLSQEHQQ
                     QVLGAIERAKQVTAPELNSIIRQLQAHQLSQLQALALPLTPLPVGLQPPSLPAVSAGT
                     GLLSLSALGSQTHLSKEDKNGHDGDTHQEDDGEKSD"
     exon            226..323
                     /gene="Tle5"
                     /gene_synonym="Aes; Esp1; Grg; Grg-5; Grg5"
                     /inference="alignment:Splign:2.1.0"
     exon            324..387
                     /gene="Tle5"
                     /gene_synonym="Aes; Esp1; Grg; Grg-5; Grg5"
                     /inference="alignment:Splign:2.1.0"
     exon            388..432
                     /gene="Tle5"
                     /gene_synonym="Aes; Esp1; Grg; Grg-5; Grg5"
                     /inference="alignment:Splign:2.1.0"
     exon            433..495
                     /gene="Tle5"
                     /gene_synonym="Aes; Esp1; Grg; Grg-5; Grg5"
                     /inference="alignment:Splign:2.1.0"
     exon            496..570
                     /gene="Tle5"
                     /gene_synonym="Aes; Esp1; Grg; Grg-5; Grg5"
                     /inference="alignment:Splign:2.1.0"
     exon            571..1467
                     /gene="Tle5"
                     /gene_synonym="Aes; Esp1; Grg; Grg-5; Grg5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1238..1243
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tle5"
                     /gene_synonym="Aes; Esp1; Grg; Grg-5; Grg5"
                     /note="hexamer: AATAAA"
     polyA_site      1260
                     /gene="Tle5"
                     /gene_synonym="Aes; Esp1; Grg; Grg-5; Grg5"
                     /note="major polyA site"
     regulatory      1438..1443
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tle5"
                     /gene_synonym="Aes; Esp1; Grg; Grg-5; Grg5"
                     /note="hexamer: AATAAA"
     polyA_site      1458
                     /gene="Tle5"
                     /gene_synonym="Aes; Esp1; Grg; Grg-5; Grg5"
ORIGIN      
        1 gggcgcggca ggtggagcgg gagcccgggc ggcaccgcgt cgccattaca caatagcgcg
       61 ggcggcgcgg gcgggcggcg ggcggcgcag gaggcgggac gcggggcccc ggagctgtcg
      121 atcggggaca aagcgcggcc gcccggcgcc ccccgagccg cccgagccgg ggcgcagccc
      181 gcgccccccg cgactgacat gatgtttccg caaagccggc actcgggctc ctcccacctc
      241 cctcagcagc tcaagttcac cacctccgac tcctgtgacc gcatcaaaga tgagttccag
      301 ctgctgcaag cgcagtatca cagcctgaag ctggagtgcg acaagctggc cagcgagaag
      361 tcagagatgc agaggcatta cgtcatgtac tatgagatgt cctacggatt gaacatcgag
      421 atgcacaaac aggcggaaat tgtgaagagg ctgaatggga tttgcgccca ggttctgccc
      481 tatttgtcac aggagcatca gcagcaggtc ctgggagcca tcgagagagc caagcaggtc
      541 acggctcctg agctgaactc catcatccga cagctccagg ctcaccagct gtcccagctg
      601 caggcgctgg ccctgcccct gacaccgctg cctgtcgggc tccagccacc gtccctccct
      661 gcagtcagtg caggcacagg cctgctgtca ctctctgctc tgggttctca gacccacctc
      721 tccaaggagg acaagaacgg acacgatggg gacacccacc aggaggatga cggagagaag
      781 tcggattagc tcttggggaa gggggagggg ggagaccagg ggagacaggc acagagagcg
      841 cagtgttcta agggccacac agcacacagc tctgtcacta cccaagctta cacctccagt
      901 cctggttctg gctgtgcacc ctgggcctag gggacgccag agggacaccc caggctaagg
      961 gttcttcccc accttcaaca tttccctggg ccacagccac caatctcggc ccagaatgta
     1021 cacaacgcta gctgcccctt tccaccctgt gcaccccgaa tctgccccta tccccttctc
     1081 tgcttcctgc actgcacacc tgctagtccc agacccctcc ccccagctcc cccagctccg
     1141 gttccctcaa ccacaaaaga aggggacaga gagaaagcat tggctcggga ctgcagtggg
     1201 ggtgggcacc ccacaaactt ccctcccctc ttccccaaat aaacgtgagg gttaaaagtt
     1261 ggtttgttta tgatttcttt cttgtgccag tattctatag ctatcatctc agaaaggaaa
     1321 agaaggaagc cccaggagtg tctgtcatag ggttagcttt gttggtcgcc ttggtctctg
     1381 tccagaggtc aaaggccaag ccgctgtact gaggatgggg tctagctgtg ccttcaaaat
     1441 aaaaacatga aaaggttggc cactgtgaaa aaaaaaaaaa aaaaa
//
