LOCUS       NM_001302947            4628 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus transducin-like enhancer of split 4 (Tle4), transcript
            variant 1, mRNA.
ACCESSION   NM_001302947
VERSION     NM_001302947.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4628)
  AUTHORS   Clemot-Dupont,S., Lourenco Fernandes,J.A., Larrigan,S., Sun,X.,
            Medisetti,S., Stanley,R., El Hankouri,Z., Joshi,S.V.,
            Picketts,D.J., Shekhar,K. and Mattar,P.
  TITLE     The chromatin remodeler ADNP regulates neurodevelopmental disorder
            risk genes and neocortical neurogenesis
  JOURNAL   Proc Natl Acad Sci U S A 122 (3), e2405981122 (2025)
   PUBMED   39808658
REFERENCE   2  (bases 1 to 4628)
  AUTHORS   Barao,S., Xu,Y., Llongueras,J.P., Vistein,R., Goff,L.,
            Nielsen,K.J., Bae,B.I., Smith,R.S., Walsh,C.A., Stein-O'Brien,G.
            and Muller,U.
  TITLE     Conserved transcriptional regulation by BRN1 and BRN2 in
            neocortical progenitors drives mammalian neural specification and
            neocortical expansion
  JOURNAL   Nat Commun 15 (1), 8043 (2024)
   PUBMED   39271675
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4628)
  AUTHORS   Aberle,T., Walter,A., Piefke,S., Hillgartner,S., Wust,H.M.,
            Wegner,M. and Kuspert,M.
  TITLE     Sox10 Activity and the Timing of Schwann Cell Differentiation Are
            Controlled by a Tle4-Dependent Negative Feedback Loop
  JOURNAL   Int J Mol Sci 25 (10), 5234 (2024)
   PUBMED   38791273
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4628)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 4628)
  AUTHORS   Zheng,Y., Zhao,C., Song,Q., Xu,L., Zhang,B., Hu,G., Kong,X., Li,S.,
            Li,X., Shen,Y., Zhuang,L., Wu,M., Liu,Y. and Zhou,Y.
  TITLE     Histone methylation mediated by NSD1 is required for the
            establishment and maintenance of neuronal identities
  JOURNAL   Cell Rep 42 (12), 113496 (2023)
   PUBMED   37995181
REFERENCE   6  (bases 1 to 4628)
  AUTHORS   Tchernev,V.T., Barbosa,M.D., Detter,J.C., Patel,T.D., Achey,K.,
            Wakeland,E.K., Gueorguieva,R.V., Yang,M.C., Gossler,A. and
            Kingsmore,S.F.
  TITLE     Genetic mapping of 20 novel expressed sequence tags from
            midgestation mouse embryos suggests chromosomal clustering
  JOURNAL   Genomics 40 (1), 170-174 (1997)
   PUBMED   9070936
REFERENCE   7  (bases 1 to 4628)
  AUTHORS   Leon,C. and Lobe,C.G.
  TITLE     Grg3, a murine Groucho-related gene, is expressed in the developing
            nervous system and in mesenchyme-induced epithelial structures
  JOURNAL   Dev Dyn 208 (1), 11-24 (1997)
   PUBMED   8989517
REFERENCE   8  (bases 1 to 4628)
  AUTHORS   Koop,K.E., MacDonald,L.M. and Lobe,C.G.
  TITLE     Transcripts of Grg4, a murine groucho-related gene, are detected in
            adjacent tissues to other murine neurogenic gene homologues during
            embryonic development
  JOURNAL   Mech Dev 59 (1), 73-87 (1996)
   PUBMED   8892234
REFERENCE   9  (bases 1 to 4628)
  AUTHORS   Dehni,G., Liu,Y., Husain,J. and Stifani,S.
  TITLE     TLE expression correlates with mouse embryonic segmentation,
            neurogenesis, and epithelial determination
  JOURNAL   Mech Dev 53 (3), 369-381 (1995)
   PUBMED   8645603
REFERENCE   10 (bases 1 to 4628)
  AUTHORS   Mallo,M., Gendron-Maguire,M., Harbison,M.L. and Gridley,T.
  TITLE     Protein characterization and targeted disruption of Grg, a mouse
            gene related to the groucho transcript of the Drosophila Enhancer
            of split complex
  JOURNAL   Dev Dyn 204 (3), 338-347 (1995)
   PUBMED   8573724
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC125315.4 and AC122202.4.
            
            On Nov 15, 2022 this sequence version replaced NM_001302947.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK134989.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-684               AC125315.4         86704-87387
            685-782             AC125315.4         87901-87998
            783-846             AC125315.4         89102-89165
            847-891             AC125315.4         90327-90371
            892-954             AC122202.4         6742-6804
            955-1029            AC122202.4         26331-26405
            1030-1234           AC122202.4         53217-53421
            1235-1251           AC122202.4         54818-54834
            1252-1371           AC122202.4         102922-103041
            1372-1425           AC122202.4         103960-104013
            1426-1578           AC122202.4         104492-104644
            1579-1711           AC122202.4         105775-105907
            1712-1905           AC122202.4         106256-106449
            1906-1982           AC122202.4         106808-106884
            1983-2232           AC122202.4         116203-116452
            2233-2480           AC122202.4         117367-117614
            2481-2628           AC122202.4         118626-118773
            2629-2779           AC122202.4         118979-119129
            2780-2856           AC122202.4         119474-119550
            2857-4628           AC122202.4         121352-123123
FEATURES             Location/Qualifiers
     source          1..4628
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 9.11 cM"
     gene            1..4628
                     /gene="Tle4"
                     /gene_synonym="5730411M05Rik; Bce-1; Bce1; ESTM13; ESTM14;
                     grg-4; Grg4"
                     /note="transducin-like enhancer of split 4"
                     /db_xref="GeneID:21888"
                     /db_xref="MGI:MGI:104633"
     exon            1..684
                     /gene="Tle4"
                     /gene_synonym="5730411M05Rik; Bce-1; Bce1; ESTM13; ESTM14;
                     grg-4; Grg4"
                     /inference="alignment:Splign:2.1.0"
     CDS             640..2964
                     /gene="Tle4"
                     /gene_synonym="5730411M05Rik; Bce-1; Bce1; ESTM13; ESTM14;
                     grg-4; Grg4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     groucho-related protein 4; transducin-like enhancer
                     protein 4; B lymphocyte gene 1; transducin-like enhancer
                     of split 4, homolog of Drosophila E(spl)"
                     /codon_start=1
                     /product="transducin-like enhancer protein 4 isoform 1"
                     /protein_id="NP_001289876.1"
                     /db_xref="GeneID:21888"
                     /db_xref="MGI:MGI:104633"
                     /translation="MIRDLSKMYPQTRHPAPHQPAQPFKFTISESCDRIKEEFQFLQA
                     QYHSLKLECEKLASEKTEMQRHYVMYYEMSYGLNIEMHKQAEIVKRLNAICAQVIPFL
                     SQEHQQQVVQAVERAKQVTMAELNAIIGQQQLQAQHLSHGHGLPVPLTPHPSGLQPPA
                     IPPIGSSAGLLALSSALGGQSHLPIKDEKKHHDNDHQRDRDSIKSSSVSPSASFRGSE
                     KHRNSTDYSSESKKQKTEEKEIAARYDSDGEKSDDNLVVDVSNEDPSSPRGSPAHSPR
                     ENGLDKTRLLKKDAPISPASVASSSSTPSSKSKELSLNEKSTTPVSKSNTPTPRTDAP
                     TPGSNSTPGLRPVPGKPPGVDPLASSLRTPMAVPCPYPTPFGIVPHAGMNGELTSPGA
                     AYAGLHNISPQMSAAAAAAAAAAAYGRSPVVGFDPHHHMRVPAIPPNLTGIPGGKPAY
                     SFHVSADGQMQPVPFPPDALIGPGIPRHARQINTLNHGEVVCAVTISNPTRHVYTGGK
                     GCVKVWDISHPGNKSPVSQLDCLNRDNYIRSCRLLPDGRTLIVGGEASTLSIWDLAAP
                     TPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGAS
                     CIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIFSLGYCPTGEWLAVGMEN
                     SNVEVLHVTKPDKYQLHLHESCVLSLKFAHCGKWFVSTGKDNLLNAWRTPYGASIFQS
                     KESSSVLSCDISVDDKYIVTGSGDKKATVYEVIY"
     exon            685..782
                     /gene="Tle4"
                     /gene_synonym="5730411M05Rik; Bce-1; Bce1; ESTM13; ESTM14;
                     grg-4; Grg4"
                     /inference="alignment:Splign:2.1.0"
     exon            783..846
                     /gene="Tle4"
                     /gene_synonym="5730411M05Rik; Bce-1; Bce1; ESTM13; ESTM14;
                     grg-4; Grg4"
                     /inference="alignment:Splign:2.1.0"
     exon            847..891
                     /gene="Tle4"
                     /gene_synonym="5730411M05Rik; Bce-1; Bce1; ESTM13; ESTM14;
                     grg-4; Grg4"
                     /inference="alignment:Splign:2.1.0"
     exon            892..954
                     /gene="Tle4"
                     /gene_synonym="5730411M05Rik; Bce-1; Bce1; ESTM13; ESTM14;
                     grg-4; Grg4"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1029
                     /gene="Tle4"
                     /gene_synonym="5730411M05Rik; Bce-1; Bce1; ESTM13; ESTM14;
                     grg-4; Grg4"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1234
                     /gene="Tle4"
                     /gene_synonym="5730411M05Rik; Bce-1; Bce1; ESTM13; ESTM14;
                     grg-4; Grg4"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..1251
                     /gene="Tle4"
                     /gene_synonym="5730411M05Rik; Bce-1; Bce1; ESTM13; ESTM14;
                     grg-4; Grg4"
                     /inference="alignment:Splign:2.1.0"
     exon            1252..1371
                     /gene="Tle4"
                     /gene_synonym="5730411M05Rik; Bce-1; Bce1; ESTM13; ESTM14;
                     grg-4; Grg4"
                     /inference="alignment:Splign:2.1.0"
     exon            1372..1425
                     /gene="Tle4"
                     /gene_synonym="5730411M05Rik; Bce-1; Bce1; ESTM13; ESTM14;
                     grg-4; Grg4"
                     /inference="alignment:Splign:2.1.0"
     exon            1426..1578
                     /gene="Tle4"
                     /gene_synonym="5730411M05Rik; Bce-1; Bce1; ESTM13; ESTM14;
                     grg-4; Grg4"
                     /inference="alignment:Splign:2.1.0"
     exon            1579..1711
                     /gene="Tle4"
                     /gene_synonym="5730411M05Rik; Bce-1; Bce1; ESTM13; ESTM14;
                     grg-4; Grg4"
                     /inference="alignment:Splign:2.1.0"
     exon            1712..1905
                     /gene="Tle4"
                     /gene_synonym="5730411M05Rik; Bce-1; Bce1; ESTM13; ESTM14;
                     grg-4; Grg4"
                     /inference="alignment:Splign:2.1.0"
     exon            1906..1982
                     /gene="Tle4"
                     /gene_synonym="5730411M05Rik; Bce-1; Bce1; ESTM13; ESTM14;
                     grg-4; Grg4"
                     /inference="alignment:Splign:2.1.0"
     exon            1983..2232
                     /gene="Tle4"
                     /gene_synonym="5730411M05Rik; Bce-1; Bce1; ESTM13; ESTM14;
                     grg-4; Grg4"
                     /inference="alignment:Splign:2.1.0"
     exon            2233..2480
                     /gene="Tle4"
                     /gene_synonym="5730411M05Rik; Bce-1; Bce1; ESTM13; ESTM14;
                     grg-4; Grg4"
                     /inference="alignment:Splign:2.1.0"
     exon            2481..2628
                     /gene="Tle4"
                     /gene_synonym="5730411M05Rik; Bce-1; Bce1; ESTM13; ESTM14;
                     grg-4; Grg4"
                     /inference="alignment:Splign:2.1.0"
     exon            2629..2779
                     /gene="Tle4"
                     /gene_synonym="5730411M05Rik; Bce-1; Bce1; ESTM13; ESTM14;
                     grg-4; Grg4"
                     /inference="alignment:Splign:2.1.0"
     exon            2780..2856
                     /gene="Tle4"
                     /gene_synonym="5730411M05Rik; Bce-1; Bce1; ESTM13; ESTM14;
                     grg-4; Grg4"
                     /inference="alignment:Splign:2.1.0"
     exon            2857..4628
                     /gene="Tle4"
                     /gene_synonym="5730411M05Rik; Bce-1; Bce1; ESTM13; ESTM14;
                     grg-4; Grg4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4529..4534
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tle4"
                     /gene_synonym="5730411M05Rik; Bce-1; Bce1; ESTM13; ESTM14;
                     grg-4; Grg4"
                     /note="hexamer: ATTAAA"
     regulatory      4535..4540
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tle4"
                     /gene_synonym="5730411M05Rik; Bce-1; Bce1; ESTM13; ESTM14;
                     grg-4; Grg4"
                     /note="hexamer: CATAAA"
     polyA_site      4549
                     /gene="Tle4"
                     /gene_synonym="5730411M05Rik; Bce-1; Bce1; ESTM13; ESTM14;
                     grg-4; Grg4"
                     /note="major polyA site"
     polyA_site      4555
                     /gene="Tle4"
                     /gene_synonym="5730411M05Rik; Bce-1; Bce1; ESTM13; ESTM14;
                     grg-4; Grg4"
     regulatory      4605..4610
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tle4"
                     /gene_synonym="5730411M05Rik; Bce-1; Bce1; ESTM13; ESTM14;
                     grg-4; Grg4"
                     /note="hexamer: ATTAAA"
     polyA_site      4628
                     /gene="Tle4"
                     /gene_synonym="5730411M05Rik; Bce-1; Bce1; ESTM13; ESTM14;
                     grg-4; Grg4"
ORIGIN      
        1 agagcgcgtt gttagagctg ttccgagcgg gcgttcggct gttggctgcc ttcttccccc
       61 tcttacacac tcgtgtatta ttttgaggtg gtgttcgcag agtttgaaag agaattttaa
      121 aaagccgcaa gcgtttcgct cttttatttt tataatcccc ttcaatttgg ggctaaaaaa
      181 acaggaagga agaaaaggaa atgaaatgtg gtaaaagaag ctaaaaggtg ccttttaaaa
      241 gatcgttgct gtgaagtgaa aaaaaatctc cagagaaccc ccaagcgccg cgagacctct
      301 tccgaaccaa aggagtttgc gctcgctctc agggaagaag cgaccattca ttccgaggaa
      361 tagcagccaa ttaaaagaca aataaaaaaa gtttggagtg gggcgcgagc aggcgggcgg
      421 cgctcggcgg gcgcggggct cggcgggcgc aggacggacg gtgcccgccg ccctcagtga
      481 cgcccgcggg gaatgcggag ccggccgccc gcgcccagcc gccgcgcctg cctgccgccc
      541 gcgtcacgcg agacccgcag gcccgggacg ccgccgcggg gccctcgaag cggatgagcc
      601 gcgcgcctct gcctggcgca gccaactaaa gcggcgtgga tgattcgcga cctgagcaag
      661 atgtacccgc agacgcgcca cccggcaccg catcagcctg ctcaaccctt caaatttaca
      721 atttcagaat cctgtgatcg gattaaggaa gagtttcagt ttttacaggc tcaataccac
      781 agtctgaagc tggaatgtga gaagctcgcc agcgagaaga cagagatgca gcggcattat
      841 gtcatgtatt atgaaatgtc ctatgggttg aacatagaaa tgcacaagca ggcagagatt
      901 gttaaacgac taaatgctat ctgtgcacag gtcattcctt tcctgtccca agagcaccag
      961 caacaagtgg tgcaggctgt ggaacgggcc aagcaggtga ccatggcaga actgaacgcc
     1021 atcattgggc agcaacaact ccaagctcag catttatcac atggacatgg tctgcctgtg
     1081 cctctgacac cacacccttc agggcttcag cccccagcca tcccacctat cggtagcagt
     1141 gcaggacttc tggccctctc cagtgcacta ggaggtcagt ctcacctccc aattaaggat
     1201 gagaagaagc accatgacaa tgatcaccaa agagacagag actccatcaa gagctcttcc
     1261 gtatccccat cagccagttt ccggggttct gagaaacata ggaactctac agactattcc
     1321 tcagagagca aaaagcagaa aacagaagaa aaagaaattg cagctcgcta tgacagtgat
     1381 ggtgagaaga gtgatgacaa cttggtagtt gatgtgtcca atgaggatcc atcttccccc
     1441 cgaggaagcc cagcacattc cccaagggag aatggcctgg acaagacacg actcctcaag
     1501 aaagatgccc ccatcagccc cgcttctgtt gcatcttcca gcagtactcc ttcctccaaa
     1561 tccaaagagc ttagccttaa tgaaaagtct actactcctg tttcaaagtc caatacccct
     1621 actccacgaa ctgatgcacc tacccctggc agtaattcta ctcctggact gaggcctgta
     1681 cctggaaagc caccaggtgt ggacccctta gcatcaagcc tgaggacccc gatggctgta
     1741 ccttgtccat atccaacccc ctttgggatc gtgccccatg ctgggatgaa cggagagctg
     1801 accagccccg gagccgccta tgctgggcta cacaacatct ccccccagat gagtgcagct
     1861 gctgctgcag ctgcggcagc agcagcctat ggaagatcac ctgtggtggg atttgatcca
     1921 caccatcaca tgcgagtgcc agcaatacct ccaaatctaa caggcattcc aggaggaaaa
     1981 ccagcatact cctttcacgt cagtgccgat ggccagatgc agcctgtccc tttcccccct
     2041 gatgccctca ttggaccagg gatcccccga cacgctcgac agatcaacac cctcaaccat
     2101 ggggaggtgg tgtgtgcagt gaccatcagc aaccccacaa ggcacgtgta cacaggtggc
     2161 aagggctgtg ttaaggtctg ggacatcagc caccctggca acaagagccc agtctctcag
     2221 ctggactgtc tgaacaggga taactacatc cgttcctgca gattgctccc tgatggtcgc
     2281 accttaattg ttggagggga agccagcaca ctgtccatct gggacctggc agctccaact
     2341 ccacgcatca aggcagagct gacatcctca gcccctgcct gctatgctct ggccatcagc
     2401 cccgactcca aggtctgctt ctcatgctgc agcgacggta acatcgcagt gtgggatctg
     2461 cacaaccaga ctctggtgag gcaattccag gggcacacag atggagccag ctgtattgac
     2521 atttctaatg atggcaccaa gctctggaca ggtggtttgg acaacactgt gaggtcctgg
     2581 gacctgcgtg aagggcggca gctgcagcaa catgacttca cctctcagat cttttcattg
     2641 ggctattgcc caactggaga gtggcttgca gtggggatgg agaatagcaa tgtggaagta
     2701 ttgcatgtca ccaaaccaga caaataccag ttgcatcttc atgagagctg tgtgctgtca
     2761 ctcaagtttg cccactgtgg caaatggttt gtaagcactg gaaaggacaa ccttctgaat
     2821 gcttggagga cgccttatgg ggccagcata ttccagtcca aagaatcctc atcggtgctt
     2881 agctgtgaca tctctgtgga tgacaagtac attgtcactg gctctgggga caagaaagct
     2941 acggtttatg aagttattta ttaaggacaa atcttcgtgc aaactggact cctcctcata
     3001 gcactttgcg ctgttgtact tttctgttca cccctctccc attctaaaac caaggatttc
     3061 caatactcat tgcagttgtg gagtttaatc ccttcccata gccccacttc ctccttgcta
     3121 ttgaattgtg aatactcatt aagaacctgt gataccaaat cttcagctat cgtcttggaa
     3181 gaacatggaa tacctaacag tgaatggaat ctttaattat gtattatatc tgtaatatat
     3241 ttattttgtt taaagaaggc tttctaacaa tgactgacta aataaagctg tccgctcctg
     3301 cattgataat gaaggtgcat tgtatttgat gctccacccc tcccttttgg tgagggaggg
     3361 gaaaggaagg tttaaaataa ctgatttaaa tgtcactaaa tgtagactat tgactgtata
     3421 gagatgtgaa atgtataatt acacacggaa gcaatatgtt gctgtgttgt tatgaggttg
     3481 ttttgtttta ttttctactt atattaaaaa catttggaaa tttggctgtt tgaacaagta
     3541 gaatataaca ggccaagtac tattcctttg agtctatttg ggcaacttta accaatatgt
     3601 ctataacttt agattacatt caacaaaaat aattagatgt ttttcttttt tattttttac
     3661 ttgttgacaa gtatctttgt aatatttttt aattcctttt tttattgtat tatagacaga
     3721 tcaaaaatta aattgggcct caaagagaga acttaatttc ttctaaatat ttttgccaaa
     3781 tttcctggca gaggaagctg tgtgtctctg ggcagttgtg atgctgtgag acatggcagg
     3841 ctgttttgtg tcatgctctt taggagctgt aggtacagga ggactgcttg cctaccgctg
     3901 tgcaaagcaa gtctttccca cacaaaggcc agcagaggag ggtttgcaga gcccaccctc
     3961 tgaaagccac aaagaagagc ctctcccggg atggtggctt gctttattta cctctggttc
     4021 tttccatgtc ttagttggat gtccctgaaa tggacacagg ctgtgccatt gtgccagaaa
     4081 cattgtgtta tcttttatgt tgttgttgtt gttgctgtta aaactataac atgtgactcc
     4141 ttttttatta ttattttttg tttgaatgct ttaaaaagat cttttaagtc tgtggatctg
     4201 ctgatgtaca gtgcctttgc tgctatggat caaaatcaag aactgtgtag ataaacttta
     4261 ttgtataagt agaaaaatca cttaatttca tactagaaat ggatggatgc tgcaagctga
     4321 aatggactgt cattgacgtt ctttgtgtgg tagcaaaaaa aatggtgtct taagtgctta
     4381 gtgtttgatg tcattaacag tttcataaaa ctctacagtg tagaaagatt ttgatactaa
     4441 actgtgcatt gtacatagtt ctaacgcatt gtgttggcca ccagtacttc tatgatggta
     4501 gattgtttgt gcattcagac ttttaagcat taaacataaa taacttctag aatgattatt
     4561 ttctaattat ttttgctaat tgctttgtct atgccactcc ctatattaaa atcactagtt
     4621 atattcaa
//
