LOCUS       NM_009389               5172 bp    mRNA    linear   ROD 21-AUG-2024
DEFINITION  Mus musculus transducin-like enhancer of split 3 (Tle3), transcript
            variant 2, mRNA.
ACCESSION   NM_009389 XM_001003585
VERSION     NM_009389.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5172)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5172)
  AUTHORS   Kalita,B., Sahu,S., Bharadwaj,A., Panneerselvam,L.,
            Martinez-Cebrian,G., Agarwal,M. and Mathew,S.J.
  TITLE     The Wnt-pathway corepressor TLE3 interacts with the histone
            methyltransferase KMT1A to inhibit differentiation in
            Rhabdomyosarcoma
  JOURNAL   Oncogene 43 (7), 524-538 (2024)
   PUBMED   38177411
  REMARK    GeneRIF: The Wnt-pathway corepressor TLE3 interacts with the
            histone methyltransferase KMT1A to inhibit differentiation in
            Rhabdomyosarcoma.
REFERENCE   3  (bases 1 to 5172)
  AUTHORS   Edwards,W., Bussey,O.K. and Conlon,F.L.
  TITLE     The Tbx20-TLE interaction is essential for the maintenance of the
            second heart field
  JOURNAL   Development 150 (21) (2023)
   PUBMED   37756602
REFERENCE   4  (bases 1 to 5172)
  AUTHORS   Kumar,P., Zehra,A., Saini,M. and Mathew,S.J.
  TITLE     Zeb1 and Tle3 are trans-factors that differentially regulate the
            expression of myosin heavy chain-embryonic and skeletal muscle
            differentiation
  JOURNAL   FASEB J 37 (8), e23074 (2023)
   PUBMED   37392376
  REMARK    GeneRIF: Zeb1 and Tle3 are trans-factors that differentially
            regulate the expression of myosin heavy chain-embryonic and
            skeletal muscle differentiation.
REFERENCE   5  (bases 1 to 5172)
  AUTHORS   Li,X., Zhang,B., Zhang,X., Yu,S., Xue,H.H. and Hu,X.
  TITLE     TLE3 and TLE4-coordinated colonic macrophage-CD4+ T cell crosstalk
            maintains intestinal immune homeostasis
  JOURNAL   Mucosal Immunol 16 (1), 50-60 (2023)
   PUBMED   36801171
  REMARK    GeneRIF: TLE3 and TLE4-coordinated colonic macrophage-CD4[+] T cell
            crosstalk maintains intestinal immune homeostasis.
REFERENCE   6  (bases 1 to 5172)
  AUTHORS   Leon,C. and Lobe,C.G.
  TITLE     Grg3, a murine Groucho-related gene, is expressed in the developing
            nervous system and in mesenchyme-induced epithelial structures
  JOURNAL   Dev Dyn 208 (1), 11-24 (1997)
   PUBMED   8989517
REFERENCE   7  (bases 1 to 5172)
  AUTHORS   Koop,K.E., MacDonald,L.M. and Lobe,C.G.
  TITLE     Transcripts of Grg4, a murine groucho-related gene, are detected in
            adjacent tissues to other murine neurogenic gene homologues during
            embryonic development
  JOURNAL   Mech Dev 59 (1), 73-87 (1996)
   PUBMED   8892234
REFERENCE   8  (bases 1 to 5172)
  AUTHORS   Dehni,G., Liu,Y., Husain,J. and Stifani,S.
  TITLE     TLE expression correlates with mouse embryonic segmentation,
            neurogenesis, and epithelial determination
  JOURNAL   Mech Dev 53 (3), 369-381 (1995)
   PUBMED   8645603
REFERENCE   9  (bases 1 to 5172)
  AUTHORS   Mallo,M., Gendron-Maguire,M., Harbison,M.L. and Gridley,T.
  TITLE     Protein characterization and targeted disruption of Grg, a mouse
            gene related to the groucho transcript of the Drosophila Enhancer
            of split complex
  JOURNAL   Dev Dyn 204 (3), 338-347 (1995)
   PUBMED   8573724
REFERENCE   10 (bases 1 to 5172)
  AUTHORS   Miyasaka,H., Choudhury,B.K., Hou,E.W. and Li,S.S.
  TITLE     Molecular cloning and expression of mouse and human cDNA encoding
            AES and ESG proteins with strong similarity to Drosophila enhancer
            of split groucho protein
  JOURNAL   Eur J Biochem 216 (1), 343-352 (1993)
   PUBMED   8365415
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB611599.1, BQ770333.1, AK122524.1, AK031322.1, AC126672.3 and
            BX630781.1.
            
            On Apr 13, 2007 this sequence version replaced NM_009389.1.
            
            Transcript Variant: This variant (2) uses an alternate splice site
            in the 5' coding region compared to variant 1. The resulting
            protein (isoform 2) is shorter but has the same N- and C-termini
            compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849374,
                              SAMN00849375 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-178               BB611599.1         3-180
            179-492             BQ770333.1         169-482
            493-1197            AK122524.1         1-705
            1198-2746           AK031322.1         5-1553
            2747-2747           AC126672.3         99311-99311
            2748-4485           AK031322.1         1555-3292
            4486-4912           AC126672.3         104180-104606
            4913-5172           BX630781.1         5-264               c
FEATURES             Location/Qualifiers
     source          1..5172
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 33.27 cM"
     gene            1..5172
                     /gene="Tle3"
                     /gene_synonym="2610103N05Rik; ESG; Grg3a; Grg3b;
                     mKIAA1547"
                     /note="transducin-like enhancer of split 3"
                     /db_xref="GeneID:21887"
                     /db_xref="MGI:MGI:104634"
     exon            1..1096
                     /gene="Tle3"
                     /gene_synonym="2610103N05Rik; ESG; Grg3a; Grg3b;
                     mKIAA1547"
                     /inference="alignment:Splign:2.1.0"
     CDS             1073..3391
                     /gene="Tle3"
                     /gene_synonym="2610103N05Rik; ESG; Grg3a; Grg3b;
                     mKIAA1547"
                     /note="isoform 2 is encoded by transcript variant 2;
                     transducin-like enhancer protein 3; grg-3; transducin-like
                     enhancer of split 3, homolog of Drosophila E(spl)"
                     /codon_start=1
                     /product="transducin-like enhancer protein 3 isoform 2"
                     /protein_id="NP_033415.2"
                     /db_xref="CCDS:CCDS52825.1"
                     /db_xref="GeneID:21887"
                     /db_xref="MGI:MGI:104634"
                     /translation="MYPQGRHPAPHQPGQPGFKFTVAESCDRIKDEFQFLQAQYHSLK
                     VEYDKLANEKTEMQRHYVMYYEMSYGLNIEMHKQTEIAKRLNTILAQIMPFLSQEHQQ
                     QVAQAVERAKQVTMTELNAIIGQQQLQAQHLSHATHGPPVQLPPHPSGLQPPGIPPVT
                     GSSSGLLALGALGSQAHLAVKDEKNHHELDHRERESSTNNSVSPSESLRASEKHRGSA
                     DYSMEAKKRKAEEKDSLSRYDSDGDKSDDLVVDVSNEDPATPRVSPAHSPPENGLDKA
                     RGLKKDAPTSPASVASSSSTPSSKTKDLGHNDKSSTPGLKSNTPTPRNDAPTPGTSTT
                     PGLRSMPGKPPGMDPIGIMASALRTPITLTSSYPAPFAMMSHHEMNGSLTSPSAYAGL
                     HNIPSQMSAAAAAAAAAYGRSPMVSFGAVGFDPHPPMRATGLPSSLASIPGGKPAYSF
                     HVSADGQMQPVPFPHDALAGPGIPRHARQINTLSHGEVVCAVTISNPTRHVYTGGKGC
                     VKIWDISQPGSKSPISQLDCLNRDNYIRSCKLLPDGRTLIVGGEASTLTIWDLASPTP
                     RIKAELTSSAPACYALAISPDAKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCI
                     DISHDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIFSLGYCPTGEWLAVGMESSN
                     VEVLHHTKPDKYQLHLHESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGASIFQSKE
                     SSSVLSCDISADDKYIVTGSGDKKATVYEVIY"
     exon            1097..1197
                     /gene="Tle3"
                     /gene_synonym="2610103N05Rik; ESG; Grg3a; Grg3b;
                     mKIAA1547"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1261
                     /gene="Tle3"
                     /gene_synonym="2610103N05Rik; ESG; Grg3a; Grg3b;
                     mKIAA1547"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1306
                     /gene="Tle3"
                     /gene_synonym="2610103N05Rik; ESG; Grg3a; Grg3b;
                     mKIAA1547"
                     /inference="alignment:Splign:2.1.0"
     exon            1307..1369
                     /gene="Tle3"
                     /gene_synonym="2610103N05Rik; ESG; Grg3a; Grg3b;
                     mKIAA1547"
                     /inference="alignment:Splign:2.1.0"
     exon            1370..1444
                     /gene="Tle3"
                     /gene_synonym="2610103N05Rik; ESG; Grg3a; Grg3b;
                     mKIAA1547"
                     /inference="alignment:Splign:2.1.0"
     exon            1445..1649
                     /gene="Tle3"
                     /gene_synonym="2610103N05Rik; ESG; Grg3a; Grg3b;
                     mKIAA1547"
                     /inference="alignment:Splign:2.1.0"
     exon            1650..1666
                     /gene="Tle3"
                     /gene_synonym="2610103N05Rik; ESG; Grg3a; Grg3b;
                     mKIAA1547"
                     /inference="alignment:Splign:2.1.0"
     exon            1667..1786
                     /gene="Tle3"
                     /gene_synonym="2610103N05Rik; ESG; Grg3a; Grg3b;
                     mKIAA1547"
                     /inference="alignment:Splign:2.1.0"
     exon            1787..1837
                     /gene="Tle3"
                     /gene_synonym="2610103N05Rik; ESG; Grg3a; Grg3b;
                     mKIAA1547"
                     /inference="alignment:Splign:2.1.0"
     exon            1838..1990
                     /gene="Tle3"
                     /gene_synonym="2610103N05Rik; ESG; Grg3a; Grg3b;
                     mKIAA1547"
                     /inference="alignment:Splign:2.1.0"
     exon            1991..2132
                     /gene="Tle3"
                     /gene_synonym="2610103N05Rik; ESG; Grg3a; Grg3b;
                     mKIAA1547"
                     /inference="alignment:Splign:2.1.0"
     exon            2133..2332
                     /gene="Tle3"
                     /gene_synonym="2610103N05Rik; ESG; Grg3a; Grg3b;
                     mKIAA1547"
                     /inference="alignment:Splign:2.1.0"
     exon            2333..2409
                     /gene="Tle3"
                     /gene_synonym="2610103N05Rik; ESG; Grg3a; Grg3b;
                     mKIAA1547"
                     /inference="alignment:Splign:2.1.0"
     exon            2410..2659
                     /gene="Tle3"
                     /gene_synonym="2610103N05Rik; ESG; Grg3a; Grg3b;
                     mKIAA1547"
                     /inference="alignment:Splign:2.1.0"
     exon            2660..2907
                     /gene="Tle3"
                     /gene_synonym="2610103N05Rik; ESG; Grg3a; Grg3b;
                     mKIAA1547"
                     /inference="alignment:Splign:2.1.0"
     exon            2908..3055
                     /gene="Tle3"
                     /gene_synonym="2610103N05Rik; ESG; Grg3a; Grg3b;
                     mKIAA1547"
                     /inference="alignment:Splign:2.1.0"
     exon            3056..3206
                     /gene="Tle3"
                     /gene_synonym="2610103N05Rik; ESG; Grg3a; Grg3b;
                     mKIAA1547"
                     /inference="alignment:Splign:2.1.0"
     exon            3207..3283
                     /gene="Tle3"
                     /gene_synonym="2610103N05Rik; ESG; Grg3a; Grg3b;
                     mKIAA1547"
                     /inference="alignment:Splign:2.1.0"
     exon            3284..5172
                     /gene="Tle3"
                     /gene_synonym="2610103N05Rik; ESG; Grg3a; Grg3b;
                     mKIAA1547"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5122..5127
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tle3"
                     /gene_synonym="2610103N05Rik; ESG; Grg3a; Grg3b;
                     mKIAA1547"
                     /note="hexamer: AATGAA"
     polyA_site      5161
                     /gene="Tle3"
                     /gene_synonym="2610103N05Rik; ESG; Grg3a; Grg3b;
                     mKIAA1547"
                     /note="major polyA site"
ORIGIN      
        1 agtccctatt tggaactgct ctcgcggcag ttcagacctc gtgctcggcc cccttcgcct
       61 gtctgtgtgt ggtatccgca ggtccgaggc actttttttt ttttttgagt gcgtgtacgt
      121 gtgtgtgttg agtgcgtgtg cttgtgtgtt ttgggggttt gtcggggcgc ggagaggaga
      181 gccaggctgg gaggaaggaa agaagccgca gagctcccgg gctcgggcta cgtctccccc
      241 tccggtgctc tccagcctgc gcgctcctag gcggcaggac gcagaccgct cctcgccaga
      301 gacgcggccg atccacttga aagcagagga ccccttcgcc gaggcttcct atgccggctg
      361 gagttaggat gccacggctc attatttgca ccgactgagc ccggagttcc tcctcgaccc
      421 tgggaagggc tggcggcggc ggcaggagca gacggaacag caggctctcc tctccgaggg
      481 gggtgggggg gcgtcgaagc gtcctcgctg ggctctagcc ctcacccacg gtcctcaagc
      541 cgtcacctcg gtggcctgct tcctttctct tctcgccgcg agctccgggc ccgaccgcct
      601 ctgggatctg acccgcgcgc cccggatgct ccgggctgcc cagacgcgcc cccctccagc
      661 ctcatcgtcc tgattgaccc gtgaggggac aggagaatcc cccttcccgc aaacccccgg
      721 cctcgggatt ccgcactgga gccgccaggg agccgatgat gtccacgcag acccggcttc
      781 tgacactgtt cacgcagccg ggggaaggcg gccggccgca gccggccgag ccctaggcgc
      841 acaaagcgcg agcccgccga cgactttgcc gctcgctccg ccgctctttg tctgcacttg
      901 gggcgcacgc ccgactctgg gatttcgctg cgagagcggg ctgggggggc cgggggcgag
      961 ctctcggttc cccggccgcc ccccgctcgg gctcgcctcc cccctccccc gcacgtcccc
     1021 ggctcgggct ctcagcgctt ccaagctctc ggaatcgcga cccctccctg ccatgtatcc
     1081 gcaaggcaga catccggcac cccatcaacc cgggcagccg ggatttaaat tcactgtggc
     1141 cgagtcctgt gacaggatca aagacgaatt ccagttcctg caagctcagt atcacagcct
     1201 caaagtggag tatgacaagc tggctaacga gaagacggag atgcagcgcc attatgtgat
     1261 gtactatgag atgtcctatg gcttgaatat tgaaatgcac aagcagacag agattgcgaa
     1321 gagactgaac acaatcctag cccagatcat gccttttttg tcacaggagc atcagcagca
     1381 agtggcgcag gctgtggaac gcgccaagca ggtcaccatg acggagttga acgccatcat
     1441 cgggcagcag caactccagg cccagcacct ctcccatgcc acgcatggtc ccccggtcca
     1501 gctgccaccc cacccgtcag gcctccagcc tcctgggatt cccccagtga caggaagcag
     1561 ctctgggttg ctggcacttg gtgccctggg aagtcaagct cacttggcgg tgaaggatga
     1621 gaagaaccac catgaactgg atcacagaga gagagagtcc agcacgaaca attccgtgtc
     1681 accctctgaa agcctccggg ccagtgagaa gcaccggggc tctgcagact acagcatgga
     1741 agccaagaag cggaaggcgg aagagaaaga cagcctcagc agatacgata gcgatgggga
     1801 caagagtgac gacctggtgg tggatgtctc taatgaggac ccagcaacac cccgggtgag
     1861 cccagcacac tcccctcctg aaaatgggct ggacaaagcc cgtggtctga agaaagatgc
     1921 ccccaccagc ccagcctccg tggcttcctc cagcagcaca ccttcctcca agaccaaaga
     1981 ccttggtcat aatgacaaat cttccacacc tgggctcaag tccaacacac caacgccaag
     2041 aaatgatgcc ccaactccag gcaccagcac caccccgggg ctccggtcaa tgccgggcaa
     2101 acctccaggc atggacccga taggtataat ggcctcggcc ctgcgaacac ccatcaccct
     2161 caccagctcc tatccagcac cctttgccat gatgagccac cacgagatga atggctccct
     2221 caccagccca agcgcctatg ctggcctaca caacatccca tcccagatga gcgccgccgc
     2281 agccgctgca gccgccgcct atggccgatc gccaatggtg agctttggag ctgttggttt
     2341 tgaccctcac cccccaatga gggccacagg cctgccttcc agtctcgcct ccattcctgg
     2401 agggaaaccg gcatactcct tccatgtgag tgctgatggg cagatgcaac ctgtgccctt
     2461 cccccatgat gcactagcag gccctggcat tcccaggcat gcccggcaga tcaatacgct
     2521 cagccatgga gaggtggtat gtgctgtgac catcagcaac cccacacgac acgtctacac
     2581 aggcggcaag ggctgtgtga agatatggga catcagccag ccgggcagca agagtcccat
     2641 ctcccagctg gactgcctga acagggacaa ctacatccgc tcgtgcaagc ttctccccga
     2701 tgggcgcacg ctcattgtgg gtggtgaggc cagcacgctc accatctggg acctggcctc
     2761 acccacaccc cgcatcaagg ctgagctgac gtcctcggct ccagcctgtt atgccctggc
     2821 catcagtcct gatgccaaag tctgtttttc ctgctgcagc gacgggaaca ttgcggtttg
     2881 ggatctgcac aaccagaccc tggtcaggca gttccagggc cacacagatg gggccagctg
     2941 tatagacatc tctcatgatg gcactaagct gtggaccggg ggcctggaca acaccgtgcg
     3001 ctcctgggac ctacgtgaag gacggcagtt acagcaacac gatttcacct cccagatctt
     3061 ctccctgggt tactgcccca ctggggagtg gctggccgtg ggcatggaga gcagcaatgt
     3121 ggaggtcctg caccacacta agcccgacaa ataccagctg cacctgcacg agagctgcgt
     3181 gctgtccctc aagttcgcct attgtggcaa gtggtttgtg agcactggga aagacaacct
     3241 tctcaatgcc tggaggacgc cttatggagc cagcatcttc cagtcaaaag aatcctcatc
     3301 tgtcttgagc tgtgacattt cagcggatga caaatatatt gtaacaggct ctggtgacaa
     3361 gaaggccaca gtttacgagg tcatctactg aacaaggact ctaacaggcc tgtcaaactc
     3421 tgggagagac acccacgtgg ccctgacagg gagatgctgg ccaggccccg aggacggcag
     3481 aaggagggag cagcattgtg gggctgccct ccagaaggtg gagaggacgc acgccccttc
     3541 gtggattgat gtgtctgaca gacttgaagg actttctcct ctccccctaa ccagtgctgg
     3601 cagatgcttc aattagattt ctctggaggc ttctgcttcc gtttctccca cagacatcct
     3661 cataagtctc tgtctcttcc tcccttctct gacctgtccc cgccccactc tgggatgggg
     3721 ggcggggaga tgcaggagta gacattgttg tttctgggga ggggcgcctc gttctgattg
     3781 tgcagtgcac aaggtttgtg aacagtgtaa ataagagact ggttgctgac tggccagtga
     3841 gggaggaacc ccatcccacc attgctcgcc gtggattttg cctgctgtat ttgtaaccca
     3901 ctcatggtgg tggcttttct ttcttttctt ttcttttttt ttcctttctt aaattttttt
     3961 ttaccagctg ttctgtgggg aaaggaaaca gagataagag agttggggag ccgagtgagg
     4021 agcttcctgg ggatggacaa gccatcctgg cgcactggga ctgaagtata tctccacacg
     4081 ggttttagcg ccatgtttag atagaatgat aggcagatgg acagacaaga tgatggacag
     4141 tactgggatg ggccagcctg ggctattacc cacaggaaca gcgaggattt tctgtgggtt
     4201 gctctgcccc atctgtctct tgccttgccc acacacctga cctccatctc tttctgtccc
     4261 ctgccttccc caccccaccc caccccgccc ccatctttct ctttggtgca cactcaatca
     4321 ttgtgatgag gaatggaagt tctagggaac cccctctctg actctcctcc agcgcagcct
     4381 agaaaggatt ccatatgggg gtgggggtag gggggagatg aagcgactca gctcagggag
     4441 ctaccagaga aaaacagcaa ctggtgtggg tgcttttttt tttttaattt gaataaaaat
     4501 aattagaagt gatctccttt gataagatac cgtctcccct ttcctgctct cagccctttc
     4561 tgctccctga agcggggaaa tggtgacccc cccccccacc agtctgagaa gatgggcggg
     4621 acagcgggct gggggctggg gcagcagtca tctgcagata tcacccccta gagtaccaat
     4681 gtttgtggta ttaggtttgc cttgttttgt tttggtcttt tgttgtttta ttaaagaaaa
     4741 gctaaagacc gtgtgagccc tgctggtggg ctctccatgg atgtagcata tggaagagag
     4801 tttttatatt gcatttttat ggattatttt ataatgtggg actccgtctg ggaaggaaga
     4861 tgagggtgtc taaaaccttc ccatctccag agctccagct gagcggctgc ccggaacagg
     4921 atgtatgttg ggacatggaa agaccgtggc accctgcgcc ttcctgagag gcatgtcgtc
     4981 gtgcctgtct agagtctgtc catctgtctc tgggtttcag atggtcactg gccaccactt
     5041 gttaaggctc tagccagaag ggagggttag ggtggaagag agttattcct gaagaaaaaa
     5101 gaaaaattga aaagtcattg taatgaagct ttttatattt ttaaaagtta ctatttaaaa
     5161 aggttggttt ga
//
