LOCUS       NM_019725               2994 bp    mRNA    linear   ROD 06-FEB-2024
DEFINITION  Mus musculus transducin-like enhancer of split 2 (Tle2), transcript
            variant 1, mRNA.
ACCESSION   NM_019725
VERSION     NM_019725.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2994)
  AUTHORS   Theis,A., Singer,R.A., Garofalo,D., Paul,A., Narayana,A. and
            Sussel,L.
  TITLE     Groucho co-repressor proteins regulate beta cell development and
            proliferation by repressing Foxa1 in the developing mouse pancreas
  JOURNAL   Development 148 (6) (2021)
   PUBMED   33658226
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2994)
  AUTHORS   Jones,M.R., Dilai,S., Lingampally,A., Chao,C.M., Danopoulos,S.,
            Carraro,G., Mukhametshina,R., Wilhelm,J., Baumgart-Vogt,E., Al
            Alam,D., Chen,C., Minoo,P., Zhang,J.S. and Bellusci,S.
  TITLE     A Comprehensive Analysis of Fibroblast Growth Factor Receptor 2b
            Signaling on Epithelial Tip Progenitor Cells During Early Mouse
            Lung Branching Morphogenesis
  JOURNAL   Front Genet 9, 746 (2019)
   PUBMED   30728831
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2994)
  AUTHORS   Chytoudis-Peroudis,C.C., Siskos,N., Kalyviotis,K., Fysekis,I.,
            Ypsilantis,P., Simopoulos,C., Skavdis,G. and Grigoriou,M.E.
  TITLE     Spatial distribution of the full-length members of the Grg family
            during embryonic neurogenesis reveals a 'Grg-mediated repression
            map' in the mouse telencephalon
  JOURNAL   PLoS One 13 (12), e0209369 (2018)
   PUBMED   30571765
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2994)
  AUTHORS   Kaltenbrun,E., Greco,T.M., Slagle,C.E., Kennedy,L.M., Li,T.,
            Cristea,I.M. and Conlon,F.L.
  TITLE     A Gro/TLE-NuRD corepressor complex facilitates Tbx20-dependent
            transcriptional repression
  JOURNAL   J Proteome Res 12 (12), 5395-5409 (2013)
   PUBMED   24024827
REFERENCE   5  (bases 1 to 2994)
  AUTHORS   Kovach,C., Dixit,R., Li,S., Mattar,P., Wilkinson,G., Elsen,G.E.,
            Kurrasch,D.M., Hevner,R.F. and Schuurmans,C.
  TITLE     Neurog2 simultaneously activates and represses alternative gene
            expression programs in the developing neocortex
  JOURNAL   Cereb Cortex 23 (8), 1884-1900 (2013)
   PUBMED   22735158
REFERENCE   6  (bases 1 to 2994)
  AUTHORS   Dang,J., Inukai,T., Kurosawa,H., Goi,K., Inaba,T., Lenny,N.T.,
            Downing,J.R., Stifani,S. and Look,A.T.
  TITLE     The E2A-HLF oncoprotein activates Groucho-related genes and
            suppresses Runx1
  JOURNAL   Mol Cell Biol 21 (17), 5935-5945 (2001)
   PUBMED   11486032
REFERENCE   7  (bases 1 to 2994)
  AUTHORS   Grbavec,D., Lo,R., Liu,Y. and Stifani,S.
  TITLE     Transducin-like Enhancer of split 2, a mammalian homologue of
            Drosophila Groucho, acts as a transcriptional repressor, interacts
            with Hairy/Enhancer of split proteins, and is expressed during
            neuronal development
  JOURNAL   Eur J Biochem 258 (2), 339-349 (1998)
   PUBMED   9874198
REFERENCE   8  (bases 1 to 2994)
  AUTHORS   Nakayama,H., Liu,Y., Stifani,S. and Cross,J.C.
  TITLE     Developmental restriction of Mash-2 expression in trophoblast
            correlates with potential activation of the notch-2 pathway
  JOURNAL   Dev Genet 21 (1), 21-30 (1997)
   PUBMED   9291577
REFERENCE   9  (bases 1 to 2994)
  AUTHORS   Dehni,G., Liu,Y., Husain,J. and Stifani,S.
  TITLE     TLE expression correlates with mouse embryonic segmentation,
            neurogenesis, and epithelial determination
  JOURNAL   Mech Dev 53 (3), 369-381 (1995)
   PUBMED   8645603
REFERENCE   10 (bases 1 to 2994)
  AUTHORS   Mallo,M., Gendron-Maguire,M., Harbison,M.L. and Gridley,T.
  TITLE     Protein characterization and targeted disruption of Grg, a mouse
            gene related to the groucho transcript of the Drosophila Enhancer
            of split complex
  JOURNAL   Dev Dyn 204 (3), 338-347 (1995)
   PUBMED   8573724
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK144581.1 and AF145958.2.
            
            [WARNING] On Mar 31, 2024 this sequence was replaced by
            NM_019725.3.
            
            On Nov 14, 2011 this sequence version replaced NM_019725.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and it encodes the longer protein (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF145958.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164136, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-245               AK144581.1         2-246
            246-2994            AF145958.2         1-2749
FEATURES             Location/Qualifiers
     source          1..2994
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10"
     gene            1..2994
                     /gene="Tle2"
                     /gene_synonym="Gm32024; Grg2; mKIAA4188"
                     /note="transducin-like enhancer of split 2"
                     /db_xref="GeneID:21886"
                     /db_xref="MGI:MGI:104635"
     exon            1..405
                     /gene="Tle2"
                     /gene_synonym="Gm32024; Grg2; mKIAA4188"
                     /inference="alignment:Splign:2.1.0"
     CDS             382..2685
                     /gene="Tle2"
                     /gene_synonym="Gm32024; Grg2; mKIAA4188"
                     /note="isoform 1 is encoded by transcript variant 1;
                     groucho-related protein; transducin-like enhancer protein
                     2; transducin-like enhancer of split 2, homolog of
                     Drosophila E(spl)"
                     /codon_start=1
                     /product="transducin-like enhancer protein 2 isoform 1"
                     /protein_id="NP_062699.1"
                     /db_xref="CCDS:CCDS24063.1"
                     /db_xref="GeneID:21886"
                     /db_xref="MGI:MGI:104635"
                     /translation="MYPQGRHPTPLQSGQPFKFSVLEICDRIKEEFQFLQAQYHSLKL
                     ECEKLASEKTEMQRHYVMAAPHQCPQGGTSYPHWPRLSPLQYYEMSYGLNIEMHKQAE
                     IVKRLSAICAQMVPFLTQEHQQQVLQAVDRAKQVTVGELNSLLGQQNQLQPLSHAPPV
                     PLTPRPAGLVGAGATGLLALSGALAAQAQLVAAVKEDRVGVDAEGSRVDRAASRSSSP
                     SPPESLVEEDHPSSRGGSGKQQRAEDKDLSGPYDSEEDKSDYNLVVDEDQPSEPPSPV
                     TTPCGKAPLCIPARRDLTDSPASLASSLGSPLPRSKDIALNDLPTGTPASRSCGTSPP
                     QDSSTPGPSSASHLCQLAAQPAAPTDSIALRSPLTLSSPFTSSFSLGSHSTLNGDLSM
                     PGSYVGLHLSPQVSSSVVYGRSPLQMAFESHPHLRGSSVSLPGIPVAKPAYSFHVSAD
                     GQMQPVPFPSDALVGTGIPRHARQLHTLAHGEVVCAVTISSSTQHVYTGGKGCVKVWD
                     VGQPGSKTPVAQLDCLNRDNYIRSCKLLPDGQSLIVGGEASTLSIWDLAAPTPRIKAE
                     LTSSAPACYALAVSPDAKVCFSCCSDGNIVVWDLQNQAMVRQFQGHTDGASCIDISDY
                     GTRLWTGGLDNTVRCWDLREGRQLQQHDFSSQIFSLGHCPNQDWLAVGMESSHVEVLH
                     VRKPEKYQLRLHESCVLSLKFASCGRWFVSTGKDNLLNAWRTPYGASIFQSKESSSVL
                     SCDISRNNKYIVTGSGDKKATVYEVVY"
     exon            406..503
                     /gene="Tle2"
                     /gene_synonym="Gm32024; Grg2; mKIAA4188"
                     /inference="alignment:Splign:2.1.0"
     exon            504..567
                     /gene="Tle2"
                     /gene_synonym="Gm32024; Grg2; mKIAA4188"
                     /inference="alignment:Splign:2.1.0"
     exon            568..681
                     /gene="Tle2"
                     /gene_synonym="Gm32024; Grg2; mKIAA4188"
                     /inference="alignment:Splign:2.1.0"
     exon            682..744
                     /gene="Tle2"
                     /gene_synonym="Gm32024; Grg2; mKIAA4188"
                     /inference="alignment:Splign:2.1.0"
     exon            745..819
                     /gene="Tle2"
                     /gene_synonym="Gm32024; Grg2; mKIAA4188"
                     /inference="alignment:Splign:2.1.0"
     exon            820..1003
                     /gene="Tle2"
                     /gene_synonym="Gm32024; Grg2; mKIAA4188"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1023
                     /gene="Tle2"
                     /gene_synonym="Gm32024; Grg2; mKIAA4188"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1134
                     /gene="Tle2"
                     /gene_synonym="Gm32024; Grg2; mKIAA4188"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1179
                     /gene="Tle2"
                     /gene_synonym="Gm32024; Grg2; mKIAA4188"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1329
                     /gene="Tle2"
                     /gene_synonym="Gm32024; Grg2; mKIAA4188"
                     /inference="alignment:Splign:2.1.0"
     exon            1330..1468
                     /gene="Tle2"
                     /gene_synonym="Gm32024; Grg2; mKIAA4188"
                     /inference="alignment:Splign:2.1.0"
     exon            1469..1629
                     /gene="Tle2"
                     /gene_synonym="Gm32024; Grg2; mKIAA4188"
                     /inference="alignment:Splign:2.1.0"
     exon            1630..1703
                     /gene="Tle2"
                     /gene_synonym="Gm32024; Grg2; mKIAA4188"
                     /inference="alignment:Splign:2.1.0"
     exon            1704..1953
                     /gene="Tle2"
                     /gene_synonym="Gm32024; Grg2; mKIAA4188"
                     /inference="alignment:Splign:2.1.0"
     exon            1954..2201
                     /gene="Tle2"
                     /gene_synonym="Gm32024; Grg2; mKIAA4188"
                     /inference="alignment:Splign:2.1.0"
     exon            2202..2349
                     /gene="Tle2"
                     /gene_synonym="Gm32024; Grg2; mKIAA4188"
                     /inference="alignment:Splign:2.1.0"
     exon            2350..2500
                     /gene="Tle2"
                     /gene_synonym="Gm32024; Grg2; mKIAA4188"
                     /inference="alignment:Splign:2.1.0"
     exon            2501..2577
                     /gene="Tle2"
                     /gene_synonym="Gm32024; Grg2; mKIAA4188"
                     /inference="alignment:Splign:2.1.0"
     exon            2578..2705
                     /gene="Tle2"
                     /gene_synonym="Gm32024; Grg2; mKIAA4188"
                     /inference="alignment:Splign:2.1.0"
     exon            2706..2994
                     /gene="Tle2"
                     /gene_synonym="Gm32024; Grg2; mKIAA4188"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaggccacca gcgccgaccc cgggcggcgg ccacagacct gcggcgctga ctgcagctgc
       61 ccctgggttg tacaaccccg gacgcgctgg ctggaggggg ggcgcagcgc ggggtcctgg
      121 tcccctgccc cgacaggctc tccctggctg ctctttcttt gcgtaaaaat ccctccccca
      181 gctccggctt ctctcctagc ttttccaggc tcagtctcct tgcaccccag ctctagctta
      241 gcaccccaaa ttctactgcc tgctcctccc cgcacccaat tctctcccca gcgccacctc
      301 tgcacctcag cgtccctttg ccacatcctc aagcctccaa gaagctgggg gggtccattc
      361 tctcacccat ccatcagcag gatgtaccct cagggaaggc acccgacccc gctgcagtct
      421 ggccagcctt tcaagttctc agtactggaa atctgtgacc ggatcaaaga ggaattccag
      481 tttcttcaag ctcagtacca cagcctcaag ctagaatgtg agaagctggc cagcgagaag
      541 acagaaatgc aaaggcatta tgtgatggct gcaccccatc agtgtcccca gggtggcacc
      601 agctatccac actggccaag actgtctcct ttgcagtact acgagatgtc ctacggactc
      661 aacattgaga tgcataaaca ggctgagatt gtgaaacgcc tcagtgcgat ctgtgcccag
      721 atggtcccgt tcctcactca ggagcatcag cagcaggtgc tccaggctgt ggaccgagcc
      781 aagcaggtga ccgtggggga actgaacagc ctcctggggc agcagaatca gctccagccg
      841 ctgtcccacg caccccccgt gcctctcacc ccgcgcccag ccggcctggt gggtgccggg
      901 gccactgggc tgctggccct atctggggca ctggctgcgc aggcccagct ggtggctgcc
      961 gtaaaggaag accgtgtggg tgtggacgcc gaggggtcca gagtggacag agctgccagc
     1021 aggagttctt ccccgtctcc ccctgagagt ctggtggaag aggaccatcc cagcagccga
     1081 ggcggcagtg ggaaacagca gagagctgaa gacaaggatc tgtcagggcc ttatgacagt
     1141 gaggaagaca agagtgacta taacctggta gtggatgagg accaaccgtc agagcccccc
     1201 agccctgtga ccaccccttg tgggaaggcg cccctctgca ttcctgcccg cagggacctc
     1261 acagacagtc cagcctcctt ggcctccagt ttgggctcac cactccccag aagcaaagac
     1321 atagccctga acgatcttcc cacaggcact cctgcctcca ggtcatgtgg tacctctcca
     1381 ccccaggact cgtccacccc ggggcccagc tcagccagtc acctctgcca gctggcggct
     1441 cagccggcag cacccacaga cagcatcgcc ctgaggagtc ccctgacctt gtccagccct
     1501 ttcacctcat ccttcagcct gggctcccac agcaccctca atggggacct ctccatgcct
     1561 ggctcctatg tcggcctcca cctgtccccc caggtcagca gctctgtcgt gtatggacgc
     1621 tcacctctgc agatggcatt tgaatcgcac ccccatctcc gaggctcgtc tgtctccttg
     1681 cctggcatcc ctgtggctaa gccggcttac tccttccacg tgtctgcgga tggccagatg
     1741 cagcctgtgc ccttcccgtc tgatgctctg gtaggcacag gcatccctcg ccacgcaagg
     1801 cagctacaca cgctggccca cggtgaggtg gtgtgtgccg tcaccatcag cagctccaca
     1861 cagcacgtgt acacaggcgg caaaggatgc gtgaaggtgt gggacgtggg ccagccgggt
     1921 agcaagaccc ctgtggcaca gctggattgc ctgaaccgag acaactacat ccgctcctgc
     1981 aagctgctgc ccgacgggca gagcctgatt gtaggtggcg aggccagtac cctgtccatt
     2041 tgggacctgg cagcacccac accacggatc aaagcagagc tgacttcgtc tgccccggcc
     2101 tgctatgctc tggccgtcag tccggacgcc aaggtctgct tctcctgctg cagcgacggt
     2161 aacatcgtgg tctgggacct gcagaaccag gccatggtca gacagttcca gggccacacg
     2221 gacggggcca gctgcatcga catatcagac tacgggaccc ggctgtggac tgggggcctg
     2281 gacaacactg tgcgctgctg ggacctgcgc gagggccgcc agcttcagca gcatgacttc
     2341 agttcccaga ttttctcatt gggccactgt cccaatcagg actggttggc tgtggggatg
     2401 gagagcagcc acgtggaggt cctgcatgtg cgcaagcctg agaagtacca gctccgcctc
     2461 catgagagct gcgtgctgtc actcaagttc gcttcctgtg gacgctggtt tgtgagcaca
     2521 ggcaaggaca acctgctcaa tgcctggagg acaccctatg gggccagcat ttttcagtcc
     2581 aaagaatcat cttctgtact gagctgcgac atctccagga ataataagta catcgtgaca
     2641 ggctcagggg acaagaaggc cactgtgtat gaggtggtgt actgagccat ctgctgcctt
     2701 ttcagagtgt ggatctcact aatgagcctc acagacaggt caacatgccc caggaatcct
     2761 cctgtctcta cctacagagc tggatcaggg atttacactc actccttatc ctgcctggtg
     2821 tgggctttac caactgaacc atcttcctgg ctctctttaa aacaaaaact gggtggggct
     2881 agtttcttag tgtagcactg gctgtcctga aactatgtaa accaggctgg tctggaactc
     2941 agaaatccgc ctgcctctgt ctcctgagtg ctgggattaa aggcaaacac tcag
//
