LOCUS       NM_011599              11550 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus transducin-like enhancer of split 1 (Tle1), transcript
            variant 1, mRNA.
ACCESSION   NM_011599 XM_984048 XM_984086 XM_984116 XM_984146 XM_984174
            XM_984202 XM_984240 XM_984277 XM_984316 XM_984359 XM_984397
            XM_984426 XM_984456 XM_984492 XM_984530
VERSION     NM_011599.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 11550)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 11550)
  AUTHORS   Simonson,L., Oldham,E. and Chang,H.
  TITLE     Overactive Wnt5a signaling disrupts hair follicle polarity during
            mouse skin development
  JOURNAL   Development 149 (22) (2022)
   PUBMED   36305473
REFERENCE   3  (bases 1 to 11550)
  AUTHORS   Ypsilanti,A.R., Pattabiraman,K., Catta-Preta,R., Golonzhka,O.,
            Lindtner,S., Tang,K., Jones,I.R., Abnousi,A., Juric,I., Hu,M.,
            Shen,Y., Dickel,D.E., Visel,A., Pennachio,L.A., Hawrylycz,M.,
            Thompson,C.L., Zeng,H., Barozzi,I., Nord,A.S. and Rubenstein,J.L.
  TITLE     Transcriptional network orchestrating regional patterning of
            cortical progenitors
  JOURNAL   Proc Natl Acad Sci U S A 118 (51) (2021)
   PUBMED   34921112
REFERENCE   4  (bases 1 to 11550)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 11550)
  AUTHORS   Li,J., Sun,L., Peng,X.L., Yu,X.M., Qi,S.J., Lu,Z.J., Han,J.J. and
            Shen,Q.
  TITLE     Integrative genomic analysis of early neurogenesis reveals a
            temporal genetic program for differentiation and specification of
            preplate and Cajal-Retzius neurons
  JOURNAL   PLoS Genet 17 (3), e1009355 (2021)
   PUBMED   33760820
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 11550)
  AUTHORS   Lepourcelet,M. and Shivdasani,R.A.
  TITLE     Characterization of a novel mammalian Groucho isoform and its role
            in transcriptional regulation
  JOURNAL   J Biol Chem 277 (49), 47732-47740 (2002)
   PUBMED   12359720
  REMARK    GeneRIF: Grg1-S may operate in conjunction with beta-catenin and
            Tcf factors to regulate vertebrate gut epithelial cell
            differentiation
REFERENCE   7  (bases 1 to 11550)
  AUTHORS   Husain,J., Lo,R., Grbavec,D. and Stifani,S.
  TITLE     Affinity for the nuclear compartment and expression during cell
            differentiation implicate phosphorylated Groucho/TLE1 forms of
            higher molecular mass in nuclear functions
  JOURNAL   Biochem J 317 (Pt 2) (Pt 2), 523-531 (1996)
   PUBMED   8713081
REFERENCE   8  (bases 1 to 11550)
  AUTHORS   Ishibashi,M., Ang,S.L., Shiota,K., Nakanishi,S., Kageyama,R. and
            Guillemot,F.
  TITLE     Targeted disruption of mammalian hairy and Enhancer of split
            homolog-1 (HES-1) leads to up-regulation of neural helix-loop-helix
            factors, premature neurogenesis, and severe neural tube defects
  JOURNAL   Genes Dev 9 (24), 3136-3148 (1995)
   PUBMED   8543157
REFERENCE   9  (bases 1 to 11550)
  AUTHORS   Dehni,G., Liu,Y., Husain,J. and Stifani,S.
  TITLE     TLE expression correlates with mouse embryonic segmentation,
            neurogenesis, and epithelial determination
  JOURNAL   Mech Dev 53 (3), 369-381 (1995)
   PUBMED   8645603
REFERENCE   10 (bases 1 to 11550)
  AUTHORS   Mallo,M., Gendron-Maguire,M., Harbison,M.L. and Gridley,T.
  TITLE     Protein characterization and targeted disruption of Grg, a mouse
            gene related to the groucho transcript of the Drosophila Enhancer
            of split complex
  JOURNAL   Dev Dyn 204 (3), 338-347 (1995)
   PUBMED   8573724
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK044642.1, AK082499.1, AK048515.1, BX640475.3, AL845340.11 and
            BM939470.1.
            
            On Oct 22, 2013 this sequence version replaced NM_011599.4.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a, also known as
            Grg1-L).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK082499.1, AY155195.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-395               AK044642.1         2-396
            396-884             AK044642.1         398-886
            885-1473            AK082499.1         851-1439
            1474-1674           AK048515.1         1461-1661
            1675-4343           AK082499.1         1641-4309
            4344-7820           BX640475.3         2001-5477           c
            7821-10923          AL845340.11        190141-193243       c
            10924-11550         BM939470.1         1-627               c
FEATURES             Location/Qualifiers
     source          1..11550
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 36.06 cM"
     gene            1..11550
                     /gene="Tle1"
                     /gene_synonym="C230057C06Rik; Estm14; Grg-1; Grg1; Tle4l"
                     /note="transducin-like enhancer of split 1"
                     /db_xref="GeneID:21885"
                     /db_xref="MGI:MGI:104636"
     exon            1..912
                     /gene="Tle1"
                     /gene_synonym="C230057C06Rik; Estm14; Grg-1; Grg1; Tle4l"
                     /inference="alignment:Splign:2.1.0"
     CDS             889..3201
                     /gene="Tle1"
                     /gene_synonym="C230057C06Rik; Estm14; Grg-1; Grg1; Tle4l"
                     /note="isoform a is encoded by transcript variant 1;
                     transducin-like enhancer of split 1, homolog of Drosophila
                     E(spl); transducin-like enhancer protein 1;
                     groucho-related protein 1; transducin-like enhancer of
                     split 4 (homolog of Drosophila E(spl)) - like"
                     /codon_start=1
                     /product="transducin-like enhancer protein 1 isoform a"
                     /protein_id="NP_035729.3"
                     /db_xref="CCDS:CCDS18274.1"
                     /db_xref="GeneID:21885"
                     /db_xref="MGI:MGI:104636"
                     /translation="MFPQSRHPTPHQAAGQPFKFTIPESLDRIKEEFQFLQAQYHSLK
                     LECEKLASEKTEMQRHYVMYYEMSYGLNIEMHKQTEIAKRLNTICAQVIPFLSQEHQQ
                     QVAQAVERAKQVTMAELNAIIGQQQLQAQHLSHGHGPPVPLTPHPSGLQPPGIPPLGG
                     SASLLALSSALSGQSHLAIKDDKKHHDAERHRDREPGTSNSLLVPDSLRGTDKRRNGP
                     EFSSDIKKRKVDDKDNYDSDGDKSDDNLVVDVSNEDPSSPHASPTHSPRENGIDKNRL
                     LKKDASGSPASTASSGSSSSLKSKEVSLHEKANTPVLKSSTPTPRSDMPTPGTSATPG
                     LRPGLGKPPAMEPLVNQAAAGLRTPLAVPGPYPAPFGMVPHAGMNGELTSPGAAYAGL
                     HSMSPQMSAAAAAAAAAVVAYGRSPMVGFDPPPHMRVPSIPPNLAGIPGGKPAYSFHV
                     TADGQMQPVPFPPDALIGPGIPRHARQINTLNHGEVVCAVTISNPTRHVYTGGKGCVK
                     VWDISHPGNKSPVSQLDCLNRDNYIRSCKLLPDGCTLIVGGEASTLSIWDLAAPTPRI
                     KAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDI
                     SNDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIFSLGYCPTGEWLAVGMESSNVE
                     VLHVNKPDKYQLHLHESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGASIFQSKESS
                     SVLSCDISVDDKYIVTGSGDKKATVYEVIY"
     exon            913..1013
                     /gene="Tle1"
                     /gene_synonym="C230057C06Rik; Estm14; Grg-1; Grg1; Tle4l"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1077
                     /gene="Tle1"
                     /gene_synonym="C230057C06Rik; Estm14; Grg-1; Grg1; Tle4l"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1122
                     /gene="Tle1"
                     /gene_synonym="C230057C06Rik; Estm14; Grg-1; Grg1; Tle4l"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1185
                     /gene="Tle1"
                     /gene_synonym="C230057C06Rik; Estm14; Grg-1; Grg1; Tle4l"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1260
                     /gene="Tle1"
                     /gene_synonym="C230057C06Rik; Estm14; Grg-1; Grg1; Tle4l"
                     /inference="alignment:Splign:2.1.0"
     exon            1261..1465
                     /gene="Tle1"
                     /gene_synonym="C230057C06Rik; Estm14; Grg-1; Grg1; Tle4l"
                     /inference="alignment:Splign:2.1.0"
     exon            1466..1482
                     /gene="Tle1"
                     /gene_synonym="C230057C06Rik; Estm14; Grg-1; Grg1; Tle4l"
                     /inference="alignment:Splign:2.1.0"
     exon            1483..1593
                     /gene="Tle1"
                     /gene_synonym="C230057C06Rik; Estm14; Grg-1; Grg1; Tle4l"
                     /inference="alignment:Splign:2.1.0"
     exon            1594..1647
                     /gene="Tle1"
                     /gene_synonym="C230057C06Rik; Estm14; Grg-1; Grg1; Tle4l"
                     /inference="alignment:Splign:2.1.0"
     exon            1648..1800
                     /gene="Tle1"
                     /gene_synonym="C230057C06Rik; Estm14; Grg-1; Grg1; Tle4l"
                     /inference="alignment:Splign:2.1.0"
     exon            1801..1945
                     /gene="Tle1"
                     /gene_synonym="C230057C06Rik; Estm14; Grg-1; Grg1; Tle4l"
                     /inference="alignment:Splign:2.1.0"
     exon            1946..2142
                     /gene="Tle1"
                     /gene_synonym="C230057C06Rik; Estm14; Grg-1; Grg1; Tle4l"
                     /inference="alignment:Splign:2.1.0"
     exon            2143..2219
                     /gene="Tle1"
                     /gene_synonym="C230057C06Rik; Estm14; Grg-1; Grg1; Tle4l"
                     /inference="alignment:Splign:2.1.0"
     exon            2220..2469
                     /gene="Tle1"
                     /gene_synonym="C230057C06Rik; Estm14; Grg-1; Grg1; Tle4l"
                     /inference="alignment:Splign:2.1.0"
     exon            2470..2717
                     /gene="Tle1"
                     /gene_synonym="C230057C06Rik; Estm14; Grg-1; Grg1; Tle4l"
                     /inference="alignment:Splign:2.1.0"
     exon            2718..2865
                     /gene="Tle1"
                     /gene_synonym="C230057C06Rik; Estm14; Grg-1; Grg1; Tle4l"
                     /inference="alignment:Splign:2.1.0"
     exon            2866..3016
                     /gene="Tle1"
                     /gene_synonym="C230057C06Rik; Estm14; Grg-1; Grg1; Tle4l"
                     /inference="alignment:Splign:2.1.0"
     exon            3017..3093
                     /gene="Tle1"
                     /gene_synonym="C230057C06Rik; Estm14; Grg-1; Grg1; Tle4l"
                     /inference="alignment:Splign:2.1.0"
     exon            3094..11540
                     /gene="Tle1"
                     /gene_synonym="C230057C06Rik; Estm14; Grg-1; Grg1; Tle4l"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3658..3663
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tle1"
                     /gene_synonym="C230057C06Rik; Estm14; Grg-1; Grg1; Tle4l"
                     /note="hexamer: AGTAAA"
     polyA_site      3680
                     /gene="Tle1"
                     /gene_synonym="C230057C06Rik; Estm14; Grg-1; Grg1; Tle4l"
                     /note="major polyA site"
     regulatory      4869..4874
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tle1"
                     /gene_synonym="C230057C06Rik; Estm14; Grg-1; Grg1; Tle4l"
                     /note="hexamer: ATTAAA"
     regulatory      4873..4878
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tle1"
                     /gene_synonym="C230057C06Rik; Estm14; Grg-1; Grg1; Tle4l"
                     /note="hexamer: AACAAA"
     polyA_site      4887
                     /gene="Tle1"
                     /gene_synonym="C230057C06Rik; Estm14; Grg-1; Grg1; Tle4l"
     polyA_site      4891
                     /gene="Tle1"
                     /gene_synonym="C230057C06Rik; Estm14; Grg-1; Grg1; Tle4l"
     regulatory      9294..9299
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tle1"
                     /gene_synonym="C230057C06Rik; Estm14; Grg-1; Grg1; Tle4l"
                     /note="hexamer: ATTAAA"
     polyA_site      9325
                     /gene="Tle1"
                     /gene_synonym="C230057C06Rik; Estm14; Grg-1; Grg1; Tle4l"
     regulatory      11510..11515
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tle1"
                     /gene_synonym="C230057C06Rik; Estm14; Grg-1; Grg1; Tle4l"
                     /note="hexamer: AATAAA"
     polyA_site      11538
                     /gene="Tle1"
                     /gene_synonym="C230057C06Rik; Estm14; Grg-1; Grg1; Tle4l"
ORIGIN      
        1 cggggtgctg gtttgctagc gagtgtgaaa ccgcgtgtta atgtaagcgg cgcaagaggc
       61 gcgggcggcg gcaggagcag cggcggggac cccgcgtccc ggggcagaag ccgggactcg
      121 ccttcgacgt ggcccgccgc ggagggagac agagcggcag cgcgctctca gtcgcgtgga
      181 cgtttgcctc cgggtcgtga gaactttgcg gtggcaggag ctggtcagcc ctttgctaag
      241 agccgaggag gggaaggcag gcgcagggag cgcccgagcc gcggagagcg accggcggcc
      301 tgatgcccgg ggtagaggcg cggcgggcgg ccaaagagct gcaccgggat cactagccat
      361 cgactggagg gaggacgcat actggcgtga ccctgccagg accccgctag gcttcgaagc
      421 tccacgcccc gccggagact cggcaacgcc ggtggagagc cgccggtgac ccggagctta
      481 ccgtcgtggg agcgggtgac ctcccgaccc gagacgcggc tctcgccgct ggctgtctac
      541 gtgggtttta gccaaggcgc cacctgcacg accgccgacg cagggaggag acacacagcc
      601 ttcctgcatt tgtgagccgc agaagggagc gcgccggggg caccgggtgg agggccaccg
      661 gaggtccggg cgcccccgct gcgcagactc gcaagcgcgg ggccggccga gccgcccgca
      721 atgtggccct gagggcgggg gccgcacccg tcgcgccctg gccttgcatc ccgagtgccc
      781 cgtgcgccgg cctgctgcgc tgcttcacgt tcctcggcgg gattcaagtt ggaagtggcg
      841 cggaggatag agctatcccg gaacagagcc gcggctgccg ccagagcgat gttcccgcag
      901 agccggcacc caacgccgca ccaagctgca ggccagccct ttaagttcac tatcccggag
      961 tctctggacc ggattaaaga ggaattccag ttcctgcagg cgcagtatca cagtcttaaa
     1021 ttggagtgtg agaaactggc aagtgaaaag acagaaatgc agaggcacta cgtgatgtat
     1081 tatgaaatgt catatggatt aaacattgaa atgcacaaac agactgaaat cgccaagaga
     1141 ttgaacacca tttgtgccca agtcatccca tttctgtctc aggaacatca acaacaggtg
     1201 gcccaggctg tggaacgtgc caaacaggtg accatggcag agttgaatgc catcatcggg
     1261 cagcagcagt tgcaagctca gcatctctcc catggccatg gacccccagt acctctcacg
     1321 cctcaccctt caggacttca gcctcctggc atcccgcccc ttgggggcag tgccagcctt
     1381 ctcgcgctgt ctagtgctct gagtgggcag tctcacttgg caataaaaga tgacaagaag
     1441 caccatgatg cagagcgcca cagagacaga gagcctggca cgagtaattc cctcttggtc
     1501 ccagacagcc taagaggcac agataagcgc agaaatggtc cagagttttc cagtgacatc
     1561 aaaaaaagga aggtggatga taaggataac tatgacagtg atggggacaa gagtgatgac
     1621 aacttagttg tggatgtgtc taacgaggac ccttcttctc cacatgcaag ccccacacac
     1681 tcaccccggg aaaacggaat tgacaaaaac cgtctgctga agaaagatgc ttcaggtagc
     1741 ccggcatcca cagcctcctc tggaagttcc tcttccctga aatccaaaga agtgagcctg
     1801 catgaaaaag ccaacactcc tgttctgaaa tccagcacac cgacgcctcg gagcgacatg
     1861 ccaaccccag gcaccagcgc tactccaggc ctccgtccag gtcttggcaa gcctccagcc
     1921 atggaacccc ttgtcaacca agcagcagct ggcctgagga cgcccctggc ggtgcctggc
     1981 ccataccctg ccccctttgg catggtgccc catgcgggca tgaacggaga gctgaccagc
     2041 cctggtgctg cctatgcagg tctacacagc atgtctccac agatgagcgc tgcagctgct
     2101 gcagctgctg ctgctgtggt ggcctatggg cgctccccaa tggttggttt tgatcctcct
     2161 cctcacatga gagtaccttc tatccccccc aacctggcag gaatacctgg agggaaacca
     2221 gcatactcct tccacgttac tgctgatggc caaatgcagc ctgttccttt tccccctgat
     2281 gccctcattg gacctgggat tccccgacat gctcggcaga tcaacaccct caaccacggg
     2341 gaggtggtgt gtgcagtgac catcagcaac cccacaaggc acgtgtacac aggtggcaag
     2401 ggctgcgtta aggtgtggga catcagccac cccggcaaca agagccccgt ctctcagctg
     2461 gattgtctga atagagataa ctacatccgt tcctgtaaat tgctacctga tggctgtact
     2521 ctcatagtgg gaggggaagc cagtactcta tccatctggg acttggcagc tccaactccc
     2581 cgcataaagg cagagctgac atcctcagcc cctgcctgtt atgctctggc catcagcccc
     2641 gactccaagg tctgcttctc atgctgcagt gacggcaaca tcgcagtgtg ggacctgcac
     2701 aaccagaccc tggtgaggca attccagggc cacacagacg gagccagctg tattgacatt
     2761 tctaatgatg gcaccaagct ctggacaggc ggtttagaca acactgtgag gtcctgggac
     2821 ctgagagaag ggaggcagct gcagcagcat gacttcactt cacagatctt ctctttggga
     2881 tattgcccaa ctggggagtg gcttgctgtg ggcatggaaa gcagcaacgt ggaagttctg
     2941 catgtgaaca agcctgacaa gtaccagctg cacctccacg agagctgcgt gctgtcccta
     3001 aagtttgctt attgtggcaa atggtttgtg agtactggaa aagacaacct cctaaatgcc
     3061 tggcggacac catatggagc cagcatcttc cagtccaaag aatcttcatc agtgcttagc
     3121 tgtgacatct ctgtggatga taaatacata gtcactggct caggggacaa aaaggctacc
     3181 gtttatgagg tcatctactg agaataccac ggcttcatat ttacagttgg attgggccaa
     3241 atgtttggaa tttgtagaaa tagaagttat aatttaaaaa aaaaaaaaca gaaacaacat
     3301 caagaaacct gaagaaacct gtttccaaat cttgacacag aactgctttg agtctacaaa
     3361 gagaaggcaa caagtcttat cagtagacag tcgcctgtct aactttgggc accacaatca
     3421 cacagaagcc aggtgtggga tagaggagct acctgctgcc tgtcagtcct gccttagcca
     3481 actgtgagct tacatttctg ttccttgcaa ttcggttcac cttgagtcct ttgtagagca
     3541 gtggtgtcta caatgaactt gtttcttggt tttgcatctt gtgatttttt ttttcttttt
     3601 gtaatttttt tgttgtttca acatttgtat aaattgtaaa tatatttggt ttattacagt
     3661 aaaaccttta gtaccagtaa gtggtcttcc tccttgactc tttttaatca atacattcga
     3721 gtcctagatg tgggttttgc aattaaagtc catacacaca taggtaagtc ctttgtacac
     3781 ttgtttttgc agaaatatat tcagctatga acatctgctg tattgggact gatcccatca
     3841 agtccttggg gatcaacaga gactcaggat cagaagtgga attgtcagtt catgacagct
     3901 ttaataggcg aaattggaat tacctttaat actcattctt tgaggctctt gtgattaaga
     3961 tttaaaacta ttactatgac ttttattttg tttttacagg ctcttacact atattttatg
     4021 ctcaccttaa gctggtagct atcctcttgt cttagcctgg agtactagtg tgtgccaccc
     4081 ttgtgagttt tttaacttag ataatgtatc aaacaatgat cctgttttca cacattttca
     4141 tccctcctgt cttctttctc cctcatcctt acccctgaga aacctcatct gatgtatgcg
     4201 gttaaatcta agagtgtgtg gtcacaaatt aaagttgtgc cttttcctag tatcctactg
     4261 acaaaccaaa ccattattgt aggaaggccc agtcttatct acattctttc tcttgtattt
     4321 caaggaatat attgatgatt tatgttttgt tttctgatgt gtgctgttca gaaagctctg
     4381 gagttcacgt ccctggaaaa ctgaagtgga aagtcagctg gttatgtctc attagtactt
     4441 acttgatcta ttatactgat ttgcttaatc cagcaagctt tgccccgttc atctcattaa
     4501 gactgtccct gcagctctgg atattgcagt ctggaattaa tcttttgtcc ttatttttat
     4561 agacacattt ttactaattt gattaggtga tatctgtaac cctgggctct taataagcta
     4621 ccaagcatgt tttcttttga aaaggctata caacttatgc tttttatatt tgctgttgac
     4681 ttctatgtat taggaaaaca catggttagt aagtagctaa ggaatttcct gtgcccttgt
     4741 ttatttacga ttcagtgaat ttgtagttgt tctttatgct tttcatttgt catcaagacc
     4801 tttttatatg tttaaaaata ctagttttca cccaaaaacg ttttttcaag gtttattaaa
     4861 tatttttcat taaacaaata gcaaatacta atggccaaag ctgatttctc tctcccttct
     4921 ctacattgtg gagtgggttt ctccttgact tgcagcaaga caaccagcta catagtgatg
     4981 gaatatttgt ttctctcctg ccttaggctc gggcacaggc cagcagtatt gctataggtc
     5041 tacagattga cttccaacta caagtagaga aggatggaag tccagggaga taaacctgtg
     5101 aatagaatct attaaatccc tttcattcac cagtacgtta gccagaacaa acaaggtgag
     5161 tccagcctaa agggtagcag ctttaggagc tgagaatgga aagttggaat ttgggaaact
     5221 gttcaggtca tcatttctca cttgtagaat gtgaatgtta aaaatcctgt gcctattgct
     5281 caaggtattg cgaaccataa gttgatactc agcatgatat agtgacacgt gtctcataaa
     5341 tgcagcatga atggagtcat tgtcttttcc tttatagtat aactccacat tagttgtgtg
     5401 tgtgtttgta tgtgtgtgtc tacatacaca taggagcttt ttcgtttgta ggtttctatg
     5461 tgactggttg gaaggtcttt aatgttatta atctttctgt tttccttcct ctgccctctc
     5521 ctcctaatcc caacccaaac ttaatccttc atgtttcatt attccagttc aaccctttat
     5581 gcaaccatgt gctatgttgt ctcccttgaa agcctccccc accacatata cactagtttc
     5641 ctaacatctg tgggtattcc agatatacac atctgaagat tcaaagtcaa tacctacaaa
     5701 taaaagaaaa cattaagtgt ttgtgagtct ggagttacct tactcaaaat gattatttct
     5761 agcttttgtt aatttaccta tacatttcaa aagtttgtct ttttttcttt tgtaacaact
     5821 aaataaaatt gcagtgtgta accatatttc cttttcaata tccattcatc agttgatgga
     5881 tatttaggtt gtttccatat cctgactatt gtgagaagag cagctatgaa tattgataag
     5941 caggtctctc tatagtagcc tatagagtcc tttgggtctg tgtccaagag tgaatagctg
     6001 tatcctgtgg atatctattt ctagtatttt aagaattatc tgattttcct agtggttata
     6061 cctgtttgta ctcccatcag cagtgattag cattcttctt tctccatatc taaatcaaca
     6121 tttgttgttg cttgctcttt tttattttag ccatctgtct ccactgtaag gtgaaatctt
     6181 aaagtaatgt taatttgcat ttctctgatg gctaagaatg ttgaacatta aaaaaccaaa
     6241 atgtgtttca gccatttgta gttcctatct tcagaacatt ctgttgatgc ctgtgctata
     6301 tatgtcatta gttttcttga tgtttactgt tttgggttct ttgtgtattc tagatacaaa
     6361 cctctgtcag atgtatagct gatagagttt tttcccctta ttctctaggc tgtcttccct
     6421 caggtgatgg tgtgctttgt tgtacagccc ttttagatta gtgaggttgt acttatttat
     6481 tagtgttaag gtactaccag aatcctattg ggaaagacct ctccgatgcc tgtgagcaca
     6541 agcaccttcc cttcttactc ctttctcaga tttaaggtat caggtctaat gttgagatcc
     6601 gtgatcttgt cgccattgac ttttataagg gaagatagaa ggagcgagct tcctttacat
     6661 atcactgtcc agtttgacca gcagcatttg ttgaggatgt catttgtcca gtatgttgtt
     6721 ggcctctttg tccaaagttt ggtagctata aggattgtga acttatatgc tggactttag
     6781 ttctattaca ttgatcaata tgtctgcttt atgccagtgc catgttgttt gtattgtgat
     6841 agctttttta caccttaaaa tctgaggtgt tgacaactac tagcattttg ttgttcaaaa
     6901 ctgtttcagt tttcctgggt atttggaatt tccatatagg atttaagatt tttttttttt
     6961 aatttctgtg aagaattgtg ttggagtttt gatggaatct gcactgtatt ggtagattac
     7021 ttttgatagg atggccattt tcacactact ctaccaacca ataaacatgt gggggtaggg
     7081 ggtgactttc tgttttcaca tctttcatat tttcttcaat tttgtttttc actgtcttaa
     7141 agttttttat tgtgtaagtc tttcacttcc ttagatttat tccaaggttt gtttgcttgt
     7201 ttctgaagct gttgtgaatg gaattgtttg cctgatttct ttctcagtgt gttgcttact
     7261 tgtacttagg aaggctacta gttttttgtg ttaattttgt gtcctcttac tttgtcaagt
     7321 atgtttatca gctgtaggaa atttctgttt gagtccttag ggtcttttct gggtagatgt
     7381 atatcatcta caaataagga tactttgtct attcttttca tatttacagg gcctttatct
     7441 ccttcacttg cttaattagc ctgaataggt tggaggagag tgggcatgga aatgattttt
     7501 ctttttttcc ccatttggga tgatgttggc tgtgagcttg ctgtatattg cctttttttt
     7561 taggttaagc tatgtcccct gtattcctag attctttggg acttttctca tgaaagtatg
     7621 ttggatttta tcaaaggttt ttctctgtct aaagagataa tcattagatt ttcattactc
     7681 agtctatctg tgtagtagat tatacttatt tctatgtatg aggtagatta catttattta
     7741 tgtatgtata ttgaacaatc tctgtatccc tggggtgaaa ctgacttcat tataatgggt
     7801 aatctttatg atgtgttctt gaattcagtt tgcaaattga aatgtaaact taagggtttt
     7861 ttggaaagtc agttgtgttg gatggtattt tcttggagca aacacttgaa ggagtatttt
     7921 actgaagcag acacagatga aaggatgttt tgctaaatca agcatgtggg acatgtgaag
     7981 gattcatcac taatgagatg cctatattga tctgacttac actgcacagc tgagctctgt
     8041 ttgttgtgac ttcatagaat tgcatcaaaa aaactaaaca aaacaaaaca aaaaaaaaaa
     8101 ctttaggctg attggcaaag tgatgtcagc tgatacagat tcaagtgaag ttttgctaag
     8161 tcagattcac atgctcaggc aagatgtggt gaggcaagca agacccatga aggacatgta
     8221 atacttggag ggaatgtaag taggactcaa caggctgtga gagaggcttg ggtaggcttg
     8281 gcttgcttgc tagtagagct agctgtacaa atcatcttca catcttcact gagagaggca
     8341 cagccaagaa cttctggcat tccccttggc cttgattctt cctgcggaat cgtggcgatt
     8401 aggctgaggc ctggctgtct ctgctaggtc atgctaccac tgatgattca agtttgctat
     8461 tctgactcta ttgaactagc tggtttgttg gtatattcat gaaggatttg caagtggatt
     8521 gagctgccat tgctgagctg aactgaactg ctgatctcct gacaatgcag atgggatttg
     8581 ctccaaagaa ccatttctaa acaggtgcac cccctcccca cctccatcca accctctgta
     8641 tcctttcttt tcctcgacct ctggtgggtg gaggtggagg actacaaaga aagttaaagg
     8701 gtttaagaac caacattaaa agtaggccct gaaaaaaatt aacattattc taaggggttt
     8761 tattgagagt ttttccattc attcatattt atcaaagaga ttgaactatg attctctttt
     8821 gtgtataagg aggtctttct ctgattttgg tataagggtg atactggcat tgtaaaaatg
     8881 atgaaatgtc ctttaatttc ctattttgtg gaataatttg aggcgtattt gtatgagttc
     8941 ttttgaaggt gttagaaatc tgtggcgaat ccatccatct ggtactatgc tgttttgaat
     9001 tggaggattt taattactgg atctttctcg ttggatgtta tagttctatt taaattattt
     9061 atttcatctt gatatagatt tagcttttat aggtgatatg tatctagaaa ttaatttatg
     9121 tctttcagat tttctattat gttagaatat agatattttt aaaaatattg tcatgattct
     9181 ctgaatttcc tttttatata actttctgta tattataatg actattaatt tgaatccttc
     9241 ttttcattga tttgtctaaa ggtttgtcaa tcttttcaaa gaaccaacac cttattaaat
     9301 tgattctttg ttttgttttg ttttctattt cattcatttt cagagctgat ttgattgtct
     9361 ctgcccatct actttgtttt tttttttccc aaggactttg tgtgtattat taatttgaga
     9421 tgccttgctt gcttgcttgc ttgcttggtt acttgcttcc tttctttctt ctttctcccc
     9481 ccaccctctt cctctttctc tttctttttc ttccttcctt ccttccttcc ttccttcctt
     9541 ccttccttcc ttttagctgt agtgttatgg aattttttct taggacttac tgtcttcatt
     9601 gtgtcccata gattttggga tgttatgttt tcattcagta gttttaggaa ttaataaaat
     9661 tcttaatttc tttctttctt cattcagtta acactcagtg agattttatt tattgtctac
     9721 aagcttgtga actgtctgtg gtttctgtga ttgatacata gctttatacc attgtggcaa
     9781 gataggaaat ggggtgtaat ttgaagtttg ctgcatattt tagacctttt tttgtatcat
     9841 aataagtagt tgattttgga gaatgtttca ctggctcctg agaaattatt cttgtgataa
     9901 ttagcttaaa atcgcatgta aaacaaagca tacctgaatc tctttgatac agattatgtg
     9961 tgattacatc aaaacacttt ataaagtata tatgacactc tccataaaga taaattttgt
    10021 agattggtag aaatgtccgt gagctacaca tattgaaaca aaggtcacca ggctagagag
    10081 cacctccagt ccagccttct cagtagaaag ggggctttgc attctttctc tgaaagaaca
    10141 tccctgtgtg cttgatattc tgggttccca gagtacatat gtgtaagcac aaagatacct
    10201 ctgtatttaa tgcatagttt tgttaggtct agtaatcttg tttgaaacat gggattgttc
    10261 aggacttgga atacatgcag gctcttctgg ctttaatatg ttctattcta atgtatgtgc
    10321 ctttatctct ctcatagagc tttcagtgct ctatgagagc tctttagtct gtgttcttaa
    10381 tatttgaacc ataaaatatg aattactttc ttctctggac ttgtctattt ggtattctgt
    10441 acgcctgttt tgtacctaga tgagcataat tttaggtttg ggaaatagtc ttgtatggat
    10501 ttactgaaga tattctatgc atttgctgta gcattctgta tttcttttta tgcctttaat
    10561 tcaggaagtt gaggtttggt ttttgttggt ttctttcttt cttttttttt ttttcctttt
    10621 atccccagtt tatagaattt tggccttctg atagttttgg ttgactctct gtattctttt
    10681 ggtatgtgtt tcatcacttt tggccttggt ctatactggt ttttgccatg tgctcaattt
    10741 tattttggct ttttacattg tagagctttg ggatacatta ttaggttatt tattagtgtg
    10801 aacactttca gccataacct ttcctctaag gattgcttag gtatgtccca gaggttctga
    10861 aaagtgttgt tttcattttc attatgtttc catttgttaa gacctccaag gtttcttcag
    10921 tttaaaagtg tgctgttcag tctccaagta tgttttctga ggttatcatt gtttttgatt
    10981 tctagtttga ttgtactggg gtctgacaga tgcaggaatc gtttgctttt cctttcctct
    11041 tccttgcatc cttccttttg ctttgtgttc tacaatgtgt tcaaaaaagt gtcatgtgcc
    11101 actgatgaaa ctgcattatt tatctgttag gtgcaatgtt tgtagctcta ccaagtaagt
    11161 ttagttcacc tgtggtatga cttaacccta aggtttcttt gttgaatttt ttttgactgt
    11221 tgtttttggt gggtatttgg ggttttttgt tttcttgaga ctggttttct ctgtttaact
    11281 ttggctgtcc tggaactcac tgtagagtag ggtagatctc aaactcccag agatctagct
    11341 gcctctacct cctgagtgct gggaactaaa ggtgtgtacc accacggatg gtctttgctg
    11401 aatttgattt ggaggacaca tctacctagt gtgaaagtga ggtcctatct ccaggcctct
    11461 gcagtgatgt gtaccgttta atgtcaggac tcagaaaata tgtggaccca ataaagcctc
    11521 agtgtgtctt ttgagcaaca aaaaaaaaaa
//
