LOCUS       NM_001034863            3500 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus TLC domain containing 5 (Tlcd5), transcript variant 1,
            mRNA.
ACCESSION   NM_001034863 XM_134834 XM_916497
VERSION     NM_001034863.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3500)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3500)
  AUTHORS   Sundberg,J.P., Dadras,S.S., Silva,K.A., Kennedy,V.E., Garland,G.,
            Murray,S.A., Sundberg,B.A., Schofield,P.N. and Pratt,C.H.
  TITLE     Systematic screening for skin, hair, and nail abnormalities in a
            large-scale knockout mouse program
  JOURNAL   PLoS One 12 (7), e0180682 (2017)
   PUBMED   28700664
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3500)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   4  (bases 1 to 3500)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 3500)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK158698.1 and AC110169.7.
            
            On Nov 15, 2007 this sequence version replaced NM_001034863.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK158698.1, BC139046.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1973              AK158698.1         2-1974
            1974-3500           AC110169.7         57201-58727
FEATURES             Location/Qualifiers
     source          1..3500
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 24.2 cM"
     gene            1..3500
                     /gene="Tlcd5"
                     /gene_synonym="Gm184; Tmem136"
                     /note="TLC domain containing 5"
                     /db_xref="GeneID:235300"
                     /db_xref="MGI:MGI:2685030"
     exon            1..94
                     /gene="Tlcd5"
                     /gene_synonym="Gm184; Tmem136"
                     /inference="alignment:Splign:2.1.0"
     exon            95..294
                     /gene="Tlcd5"
                     /gene_synonym="Gm184; Tmem136"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..833
                     /gene="Tlcd5"
                     /gene_synonym="Gm184; Tmem136"
                     /note="transmembrane protein 136"
                     /codon_start=1
                     /product="TLC domain-containing protein 5"
                     /protein_id="NP_001030035.1"
                     /db_xref="CCDS:CCDS23090.1"
                     /db_xref="GeneID:235300"
                     /db_xref="MGI:MGI:2685030"
                     /translation="MAVGLCVQVLCSLGGWLSLYTSFCCLNKHRSCEWSCRLVTFTHG
                     VLSIGLSAYIGFIDGPWPFTHPGSPNTPLQVHVLCLTLGYFIFDLGWCIYFQSEGPLM
                     LAHHTLSILGIIMALALGESGTEVNAVLFGSEITNPLLQMRWFLRETGHYHSFTGDVV
                     DFLFVALFTGVRIGVGAHLLFCEMVSPTPKWFVKVGGVAMYAVSWCFMVSIWRFAWKK
                     SIKKYHAWRSRRNEERQLRHNGHLKTH"
     exon            295..3500
                     /gene="Tlcd5"
                     /gene_synonym="Gm184; Tmem136"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtctccccct ccctctacag cttcctgtcg ccgtgatccg agccctgggc tgtgggcgcc
       61 cgggcgccgg aggcttcccg gtgcgctccg ccaggatggc agtaggtctc tgtgtgcagg
      121 tgctgtgcag cctgggtggc tggctctcac tctatacatc tttctgctgc ctgaacaagc
      181 accgaagctg tgagtggagc tgtcggctgg tgaccttcac ccacggagtc ctctccatag
      241 gtctgtctgc ttatattggc ttcatcgatg gcccttggcc ttttacccac ccaggctcac
      301 cgaacacacc tctccaagtt cacgttctgt gtcttacctt gggctacttc atcttcgact
      361 tgggctggtg catctatttc cagtccgagg gtcccctgat gctggctcat cacacactga
      421 gcatcctggg gatcatcatg gccctagcac ttggggagtc gggcacagag gtcaatgctg
      481 tactctttgg aagtgagatc accaacccgc tgctccagat gcgatggttt ctccgggaaa
      541 ctggccacta tcacagtttc acgggggatg tggtggactt cctctttgtg gctctgttca
      601 ctggtgtgag gattggtgtg ggcgctcatc tccttttctg tgaaatggtc tcacccaccc
      661 ccaagtggtt tgtgaaggtt gggggtgtgg cgatgtatgc tgtgtcttgg tgcttcatgg
      721 ttagcatctg gcgctttgca tggaagaaaa gcatcaagaa gtaccatgcg tggagaagca
      781 gacggaatga agagcggcag ctaagacaca atgggcatct caagacacac tagtcaaggc
      841 ttgtccccag tcagtggatt ggattgaatt ggtcatggga ccagggtcag aaacagagct
      901 aagcttatag ggcttagaaa gcgagcactt aggtttcaaa aaagggctaa aggtatggtt
      961 atgacttcag tcattttcca ggctaagcat atgcagtctt gaaacaccta ctcctgtagt
     1021 ggcacttgta caccctcagt gatgattgac aagtgggcag agctgtttag tgatgaccac
     1081 tgtcacttgt tttttgggtc cccatgttca ttggagacct tggtattcag acatctctga
     1141 aaagaacttg agtcaaatca gtgctgtttc ttgttctttt ggaaataact ccttccccac
     1201 acttactcct gatttccacg agacatttta agtatgttca tcccatgtaa agggagggac
     1261 tctcaggaag gggcatgggt caggcattca agtatctgtg aatgggagct gttatgccaa
     1321 gagggacaga gaggagggag tgaagctaac aatggcagga acttctcact gcgtctccct
     1381 tcactaactg tgccagaggt taccaaggac accctcggct tccatgattc atcaagaaga
     1441 ctcagggctt tcatctgcaa tgatgaaagg atacggagaa gactcagcaa agggaaaaga
     1501 acctttgtcc aagctcatgg gatctaagca ctcgcttcta gtctcttgct tggatataca
     1561 ggagtgattc acaacaacac acatgaaagt catcaaacac ttggtgtccc aaactttgat
     1621 ggcagtaggt catgtgcttc taagtagcgt gaggcaacat tccagatccc ccaaagcggt
     1681 catttggcat aagccatagt gtttcagaaa cagtttagga acagtgaggc aatcttaaca
     1741 gtttctggtg ggagccctca ccaacgttac aagcaggcct ttgcaaggat agcagctcag
     1801 ggttcctgtg ttaactctgt gtgcacagaa actgtagagc tagtgcttca gatgcaagat
     1861 gagtgagatg tgggtagatt tagatttact tggtccagtt gtacgggttc tgcccgacca
     1921 ggaagagtat gccagttctc agggcttttg tgaattaatc tgctaggcat gagaggccat
     1981 ggctaaattc cacggggatt taccatgtgg attccactgt acttgagatg gagttcaggt
     2041 ttcagctcct ggtacatact gcaaactaga accaaagatt ttcatgtatg tgatagcctc
     2101 aggctccttc cttccttcct tccttccttc cttccttcct tccttccttc cttcctccct
     2161 tcctcccttc ctcccttcct cccttcctcc cttcctccct tcgtttcttc ttcctctacc
     2221 tccttctttt cttacttttt ctttgtttta gatccccccc ccccccttaa atcacctttt
     2281 cccttctcct gagacactgt cttgcttgta tagttcaggc tggccttgaa ctctattttt
     2341 ccacttaagc ttcctcaggg ctaggattac aatcctgtgc caccatgcct ggctccaatg
     2401 tagggcttta atggaaaaaa aaaagtatta tctgtttgtg catttgttgt ctttcctata
     2461 ttatttagat caatggtgac tggttaattc aggtggtaag ccaggagatg gtgctactga
     2521 agaagcaagg ttaaaggtca gagagaagtg tcagcccatt ctatagtcac tggggacact
     2581 aacccagtga gcagcattac ctacaaaaac cagtcacaag ggaggttgaa aacgtagaca
     2641 ttcttgcaaa tggaaaggtt ctttaacagt aagtagctaa agaggtatct tttagctgtc
     2701 gggctttcgt ttttgttttc tggacagata acaccatgct tccttttctc tgatttgtgt
     2761 catagatatg ttggtgtgtt cctttgagaa gtcttttttt ttttcctttt tcagagctga
     2821 ggaccgaacc cagggccttg cgcttgcgag gcaaagcact ctacccaatc cctggtggtg
     2881 gtgtgttcct ttccagcaaa actgtgggca gaactggaaa ctggggaatg ctgacttcag
     2941 caaaagcaga gtcaataaga gtggcttggc acataggcat aaagaaaaaa acaaaacaaa
     3001 actggctttt gtattttggc cccgtgtaac ctgctccaga ccagaccagg gagcaggctt
     3061 aatcaaattc atgctggttc ctttctccct ccctcctcag aaggaaagga ttgtagatct
     3121 ttctgtttga ggcaaactca agcaaatgcc tgtaggtttt tatttattta tttatttttg
     3181 ataacaaggc acctgaacga gcgataagtg gggaggaatt cctcatttca gctcttcttg
     3241 atggtctaac tagtaactat gaggaaagtc agagattaaa aacctcttga agatgactca
     3301 gcagttaaga ggttgcctgt ttttacaacc caggtaaatg aagggcagac tagtgtgcga
     3361 tgtgtcccca gacacaaaag gggacactta tttgcatttg aattactgtg taatcatccc
     3421 tgatattgct caagaaggat ttatatttca atacgatttg tactaaattt tatagaaata
     3481 aaataacttt ctataaaccc
//
